LOCUS       NM_021503               1153 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus myozenin 2 (Myoz2), transcript variant 1, mRNA.
ACCESSION   NM_021503
VERSION     NM_021503.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1153)
  AUTHORS   Eden,M., Leye,M., Hahn,J., Heilein,E., Luzarowski,M., Volschow,B.,
            Tannert,C., Sossalla,S., Lucena-Porcel,C., Frank,D. and Frey,N.
  TITLE     Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates
            cardiomyocyte growth and survival and is upregulated in human
            cardiomyopathy
  JOURNAL   J Biol Chem 300 (5), 107255 (2024)
   PUBMED   38579991
REFERENCE   2  (bases 1 to 1153)
  AUTHORS   de Groot,N.E., van den Hoogenhof,M.M.G., Najafi,A., van der
            Made,I., van der Velden,J., Beqqali,A., Pinto,Y.M. and
            Creemers,E.E.
  TITLE     Heterozygous loss of Rbm24 in the adult mouse heart increases
            sarcomere slack length but does not affect function
  JOURNAL   Sci Rep 10 (1), 7687 (2020)
   PUBMED   32376900
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1153)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   4  (bases 1 to 1153)
  AUTHORS   Rangrez,A.Y., Hoppe,P., Kuhn,C., Zille,E., Frank,J., Frey,N. and
            Frank,D.
  TITLE     MicroRNA miR-301a is a novel cardiac regulator of Cofilin-2
  JOURNAL   PLoS One 12 (9), e0183901 (2017)
   PUBMED   28886070
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1153)
  AUTHORS   Wang,H., Yang,S., Yang,E., Zhu,Z., Mu,Y., Feng,S. and Li,K.
  TITLE     NF-kappaB mediates the transcription of mouse calsarcin-1 gene, but
            not calsarcin-2, in C2C12 cells
  JOURNAL   BMC Mol Biol 8, 19 (2007)
   PUBMED   17341303
  REMARK    GeneRIF: study defined proximal promoter region of calsarcin-1
            (CS-1)& calsarcin-2 (CS-2)genes; data suggest NF-kappaB is required
            for transcription of CS-1 gene, but not CS-2
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1153)
  AUTHORS   Heineke,J., Ruetten,H., Willenbockel,C., Gross,S.C., Naguib,M.,
            Schaefer,A., Kempf,T., Hilfiker-Kleiner,D., Caroni,P., Kraft,T.,
            Kaiser,R.A., Molkentin,J.D., Drexler,H. and Wollert,K.C.
  TITLE     Attenuation of cardiac remodeling after myocardial infarction by
            muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc
  JOURNAL   Proc Natl Acad Sci U S A 102 (5), 1655-1660 (2005)
   PUBMED   15665106
REFERENCE   7  (bases 1 to 1153)
  AUTHORS   Frey,N., Barrientos,T., Shelton,J.M., Frank,D., Rutten,H.,
            Gehring,D., Kuhn,C., Lutz,M., Rothermel,B., Bassel-Duby,R.,
            Richardson,J.A., Katus,H.A., Hill,J.A. and Olson,E.N.
  TITLE     Mice lacking calsarcin-1 are sensitized to calcineurin signaling
            and show accelerated cardiomyopathy in response to pathological
            biomechanical stress
  JOURNAL   Nat Med 10 (12), 1336-1343 (2004)
   PUBMED   15543153
  REMARK    GeneRIF: calsarcin-1 negatively modulates the functions of
            calcineurin.
REFERENCE   8  (bases 1 to 1153)
  AUTHORS   Frey,N. and Olson,E.N.
  TITLE     Calsarcin-3, a novel skeletal muscle-specific member of the
            calsarcin family, interacts with multiple Z-disc proteins
  JOURNAL   J Biol Chem 277 (16), 13998-14004 (2002)
   PUBMED   11842093
REFERENCE   9  (bases 1 to 1153)
  AUTHORS   Faulkner,G., Pallavicini,A., Comelli,A., Salamon,M., Bortoletto,G.,
            Ievolella,C., Trevisan,S., Kojic',S., Dalla Vecchia,F., Laveder,P.,
            Valle,G. and Lanfranchi,G.
  TITLE     FATZ, a filamin-, actinin-, and telethonin-binding protein of the
            Z-disc of skeletal muscle
  JOURNAL   J Biol Chem 275 (52), 41234-41242 (2000)
   PUBMED   10984498
REFERENCE   10 (bases 1 to 1153)
  AUTHORS   Frey,N., Richardson,J.A. and Olson,E.N.
  TITLE     Calsarcins, a novel family of sarcomeric calcineurin-binding
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14632-14637 (2000)
   PUBMED   11114196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121540.14.
            
            On Jun 18, 2009 this sequence version replaced NM_021503.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024360.1, SRR5189679.5639.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AC121540.14        129200-129367
            169-257             AC121540.14        129907-129995
            258-427             AC121540.14        137955-138124
            428-557             AC121540.14        147509-147638
            558-741             AC121540.14        150404-150587
            742-1153            AC121540.14        157570-157981
FEATURES             Location/Qualifiers
     source          1..1153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 53.78 cM"
     gene            1..1153
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /note="myozenin 2"
                     /db_xref="GeneID:59006"
                     /db_xref="MGI:MGI:1913063"
     exon            1..168
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /inference="alignment:Splign:2.1.0"
     exon            169..257
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..976
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myozenin-like 2; FATZ-related protein 2; calsarcin-1"
                     /codon_start=1
                     /product="myozenin-2 isoform 1"
                     /protein_id="NP_067478.1"
                     /db_xref="CCDS:CCDS17816.1"
                     /db_xref="GeneID:59006"
                     /db_xref="MGI:MGI:1913063"
                     /translation="MLSHSAMVKQRKQQASAITKEIHGHDVDGMDLGKKVSIPRDIMI
                     EELSHFSNRGARLFKMRQRRSDKYTFENFQYESRAQINHNIAMQNGRVDGSNLEGGSQ
                     QGPSTPPNTPDPRSPPNPENIAPGYSGPLKEIPPERFNTTAVPKYYRSPWEQAIGSDP
                     ELLEALYPKLFKPEGKAELRDYRSFNRVATPFGGFEKASKMVKFKVPDFELLLLTDPR
                     FLAFANPLSGRRCFNRAPKGWVSENIPVVITTEPTEDATVPESDDL"
     exon            258..427
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..557
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..741
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1153
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1126..1131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /note="hexamer: ATTAAA"
     polyA_site      1146
                     /gene="Myoz2"
                     /gene_synonym="1110012I24Rik; Fatz-2; Myozl2"
                     /note="major polyA site"
ORIGIN      
        1 agtcttctca gaaaggctca gtcccctgtt tgagtcagat cgagggacca tgccgttcca
       61 ggttcaagga taaaacccat tgggcccaag tgccgtcata ttccaccttc agtgccttcc
      121 tccacaattg ggattcaccc ctgctgaaaa gcgcagcctg acagcaaggg aacaaaaaac
      181 tatgctatca catagtgcca tggtgaagca aaggaaacag caagcatcag ccatcacgaa
      241 ggaaatccat ggacatgatg ttgacggcat ggacctgggc aaaaaagtta gcatccccag
      301 agacatcatg atagaagaat tgtcccattt cagtaatcgt ggggccaggc tgtttaagat
      361 gcgtcaaaga agatctgaca aatacacctt tgaaaatttc cagtatgaat ctagagcaca
      421 aattaatcac aatatcgcca tgcagaatgg gagagttgat ggaagcaacc tggaaggtgg
      481 ctcacagcaa ggcccctcaa ctccgcccaa cacccccgat ccacgaagcc ccccaaatcc
      541 agagaacatc gcaccaggat attctggacc actgaaggaa attcctcctg aaaggtttaa
      601 cacgacggcc gttcctaagt actaccggtc tccatgggag caggcgattg gcagcgatcc
      661 ggagctcctg gaggctttgt acccaaaact tttcaagcct gaaggaaaag cagaactgcg
      721 ggattacagg agctttaaca gggttgccac tccatttgga ggttttgaaa aagcatcaaa
      781 aatggtcaaa ttcaaagttc cagattttga actactgctg ctgacagatc ccaggttctt
      841 ggcctttgcc aatcctcttt cgggcagacg atgctttaac agggcgccaa aggggtgggt
      901 atctgagaat atccccgtcg tgatcacaac tgagcctaca gaagacgcca ctgtaccgga
      961 atcagatgac ctgtgagagg gaagctgggg atgccacagg aagttctgca catagaagct
     1021 gctgttggtc tgcttagggc aaagccattg gagttgctca cctctaaagt cactcaatag
     1081 cagttaagta catttcatct tatggcactt aatttgaact ggacaattaa attcttattt
     1141 taaaaacttt taa
//
