LOCUS       NM_021508               1294 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus myozenin 1 (Myoz1), mRNA.
ACCESSION   NM_021508
VERSION     NM_021508.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1294)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1294)
  AUTHORS   Ren,R.M., Liu,H., Zhao,S.H. and Cao,J.H.
  TITLE     Targeting of miR-432 to myozenin1 to regulate myoblast
            proliferation and differentiation
  JOURNAL   Genet Mol Res 15 (4) (2016)
   PUBMED   28002607
  REMARK    GeneRIF: Results provide insights into the potential functions of
            miR-432 as well as its proposed target, MYOZ1, during muscle
            development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1294)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1294)
  AUTHORS   Chen,J.Q., Mori,H., Cardiff,R.D., Trott,J.F., Hovey,R.C.,
            Hubbard,N.E., Engelberg,J.A., Tepper,C.G., Willis,B.J., Khan,I.H.,
            Ravindran,R.K., Chan,S.R., Schreiber,R.D. and Borowsky,A.D.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1294)
  AUTHORS   Richard,A.F., Demignon,J., Sakakibara,I., Pujol,J., Favier,M.,
            Strochlic,L., Le Grand,F., Sgarioto,N., Guernec,A., Schmitt,A.,
            Cagnard,N., Huang,R., Legay,C., Guillet-Deniau,I. and Maire,P.
  TITLE     Genesis of muscle fiber-type diversity during mouse embryogenesis
            relies on Six1 and Six4 gene expression
  JOURNAL   Dev Biol 359 (2), 303-320 (2011)
   PUBMED   21884692
REFERENCE   6  (bases 1 to 1294)
  AUTHORS   Wang,H., Yang,S., Yang,E., Zhu,Z., Mu,Y., Feng,S. and Li,K.
  TITLE     NF-kappaB mediates the transcription of mouse calsarcin-1 gene, but
            not calsarcin-2, in C2C12 cells
  JOURNAL   BMC Mol Biol 8, 19 (2007)
   PUBMED   17341303
  REMARK    GeneRIF: study defined proximal promoter region of calsarcin-1
            (CS-1)& calsarcin-2 (CS-2)genes; data suggest NF-kappaB is required
            for transcription of CS-1 gene, but not CS-2
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1294)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   8  (bases 1 to 1294)
  AUTHORS   Frey,N. and Olson,E.N.
  TITLE     Calsarcin-3, a novel skeletal muscle-specific member of the
            calsarcin family, interacts with multiple Z-disc proteins
  JOURNAL   J Biol Chem 277 (16), 13998-14004 (2002)
   PUBMED   11842093
REFERENCE   9  (bases 1 to 1294)
  AUTHORS   Faulkner,G., Pallavicini,A., Comelli,A., Salamon,M., Bortoletto,G.,
            Ievolella,C., Trevisan,S., Kojic',S., Dalla Vecchia,F., Laveder,P.,
            Valle,G. and Lanfranchi,G.
  TITLE     FATZ, a filamin-, actinin-, and telethonin-binding protein of the
            Z-disc of skeletal muscle
  JOURNAL   J Biol Chem 275 (52), 41234-41242 (2000)
   PUBMED   10984498
REFERENCE   10 (bases 1 to 1294)
  AUTHORS   Frey,N., Richardson,J.A. and Olson,E.N.
  TITLE     Calsarcins, a novel family of sarcomeric calcineurin-binding
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14632-14637 (2000)
   PUBMED   11114196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY790048.1, AK009077.1, AK041896.1 and AV250577.1.
            
            On Mar 23, 2007 this sequence version replaced NM_021508.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009077.1, AK041896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY790048.1         2-38
            38-66               AK009077.1         2-30
            67-519              AK041896.1         23-475
            520-1280            AK009077.1         484-1244
            1281-1286           AK041896.1         1237-1242
            1287-1291           AK009077.1         1251-1255
            1292-1294           AV250577.1         222-224
FEATURES             Location/Qualifiers
     source          1..1294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..1294
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /note="myozenin 1"
                     /db_xref="GeneID:59011"
                     /db_xref="MGI:MGI:1929471"
     exon            1..109
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /inference="alignment:Splign:2.1.0"
     exon            110..200
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1018
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /note="skeletal muscle-specific protein; filamin-,
                     actinin- and telethonin-binding protein; calcineurin-2;
                     calsarcin-2"
                     /codon_start=1
                     /product="myozenin-1"
                     /protein_id="NP_067483.1"
                     /db_xref="CCDS:CCDS36819.1"
                     /db_xref="GeneID:59011"
                     /db_xref="MGI:MGI:1929471"
                     /translation="MPLSGTPAPNKRRKSSKLIMELTGGGRESSGLNLGKKISVPRDV
                     MLEELSLLTNRGSKMFKLRQMRVEKFIYENHPDVFSDSSMDHFQKFLPTVGGQLETAG
                     QGFSYGKGSSGGQAGSSGSAGQYGSDRHQQGSGFGAGGSGGPGGQAGGGGAPGTVGLG
                     EPGSGDQAGGDGKHVTVFKTYISPWDRAMGVDPQQKVELGIDLLAYGAKAELPKYKSF
                     NRTAMPYGGYEKASKRMTFQMPKFDLGPLLSEPLVLYNQNLSNRPSFNRTPIPWLSSG
                     EHVDYNVDVGIPLDGETEEL"
     exon            201..379
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /inference="alignment:Splign:2.1.0"
     exon            380..620
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /inference="alignment:Splign:2.1.0"
     exon            621..786
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1294
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1270..1275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /note="hexamer: AATAAA"
     polyA_site      1294
                     /gene="Myoz1"
                     /gene_synonym="2310001N11Rik; FATZ; Myoz"
                     /note="major polyA site"
ORIGIN      
        1 ggtgctgccc ctacgctcgc tcgccccggc tcaggttctc tagtcactgc agcttagtcc
       61 tccgaagctg ctggaccccg gggagagccg accaccaact gagcagctgg tcagatccac
      121 ctccaccatg ccactctcag gaaccccggc ccctaacaag aggaggaagt caagcaaact
      181 gattatggag ctcactggag gtggccggga gagctcaggc ctgaacctgg gcaagaagat
      241 cagtgtccca agggatgtga tgttggagga gctgtccctt cttaccaacc gaggctccaa
      301 gatgttcaag ctacggcaga tgcgggtgga gaaatttatc tatgagaatc accccgatgt
      361 tttctctgac agctcaatgg atcacttcca gaagtttctt cccacagtgg gaggacagct
      421 ggagacagct ggtcagggct tctcatatgg caagggcagc agtggaggcc aggctggcag
      481 cagtggctct gctggacagt atggctctga ccgtcatcag cagggctctg ggtttggagc
      541 tgggggttca ggtggtcctg ggggccaggc tggtggagga ggagctcctg gcacagtagg
      601 gcttggagag cccggatcag gtgaccaggc aggtggagat ggaaaacatg tcactgtgtt
      661 caagacttat atttccccat gggatcgggc catgggggtt gatcctcagc aaaaagtgga
      721 acttggcatt gacctactgg catacggtgc caaagctgaa ctccccaaat ataagtcctt
      781 caacaggaca gcaatgccct acggtggata tgagaaggcc tccaaacgca tgaccttcca
      841 gatgcccaag tttgacctgg ggcctctgct gagtgaaccc ctggtcctct acaaccagaa
      901 cctctccaac aggccttctt tcaatcgaac ccctattccc tggttgagct ctggggagca
      961 tgtagactac aacgtggatg ttggtatccc cttggatgga gagacagagg agctgtgaag
     1021 tgcctcctcc tgtcatgtgc atcatttccc ttctctggtt ccaatttgag agtggatgct
     1081 ggacaggatg ccccaactgt taatccagta ttcttgtggc aatggagggt aaagggtggg
     1141 gtccgttgcc tttccaccct tcaagttcct gctccgaagc atccctcctc accagctcag
     1201 agctcccatc ctgctgtacc atatggaatc tgctctttta tggaattttc tctgccaccg
     1261 gtaacagtca ataaacttca aggaaatgag cgca
//
