LOCUS       NM_001085515            4192 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus myogenesis regulating glycosidase (putative) (Myorg),
            mRNA.
ACCESSION   NM_001085515 XM_001476939 XM_283952
VERSION     NM_001085515.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4192)
  AUTHORS   Cheng,X., Zhao,M., Chen,L., Huang,C., Xu,Q., Shao,J., Wang,H.T.,
            Zhang,Y., Li,X., Xu,X., Yao,X.P., Lin,K.J., Xue,H., Wang,H.,
            Chen,Q., Zhu,Y.C., Zhou,J.W., Ge,W.P., Zhu,S.J., Liu,J.Y.,
            Chen,W.J. and Xiong,Z.Q.
  TITLE     Astrocytes modulate brain phosphate homeostasis via polarized
            distribution of phosphate uptake transporter PiT2 and exporter XPR1
  JOURNAL   Neuron 112 (18), 3126-3142 (2024)
   PUBMED   39019040
REFERENCE   2  (bases 1 to 4192)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4192)
  AUTHORS   Yao,X.P., Cheng,X., Wang,C., Zhao,M., Guo,X.X., Su,H.Z., Lai,L.L.,
            Zou,X.H., Chen,X.J., Zhao,Y., Dong,E.L., Lu,Y.Q., Wu,S., Li,X.,
            Fan,G., Yu,H., Xu,J., Wang,N., Xiong,Z.Q. and Chen,W.J.
  TITLE     Biallelic Mutations in MYORG Cause Autosomal Recessive Primary
            Familial Brain Calcification
  JOURNAL   Neuron 98 (6), 1116-1123 (2018)
   PUBMED   29910000
  REMARK    GeneRIF: In mice, Myorg mRNA was expressed specifically in
            S100beta-positive astrocytes, and knockout of Myorg induced the
            formation of brain calcification at 9 months of age.
REFERENCE   4  (bases 1 to 4192)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 4192)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4192)
  AUTHORS   Ogaki,S., Harada,S., Shiraki,N., Kume,K. and Kume,S.
  TITLE     An expression profile analysis of ES cell-derived definitive
            endodermal cells and Pdx1-expressing cells
  JOURNAL   BMC Dev Biol 11, 13 (2011)
   PUBMED   21362171
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4192)
  AUTHORS   Datta,K., Guan,T. and Gerace,L.
  TITLE     NET37, a nuclear envelope transmembrane protein with glycosidase
            homology, is involved in myoblast differentiation
  JOURNAL   J Biol Chem 284 (43), 29666-29676 (2009)
   PUBMED   19706595
REFERENCE   8  (bases 1 to 4192)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY283520.1, BY246173.1, AL831723.9 and CO044386.1.
            
            On Nov 22, 2011 this sequence version replaced NM_001085515.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173117.1, BC140956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY283520.1         1-44
            45-377              BY246173.1         2-334
            378-3581            AL831723.9         22204-25407         c
            3582-4192           CO044386.1         1-611               c
FEATURES             Location/Qualifiers
     source          1..4192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.69 cM"
     gene            1..4192
                     /gene="Myorg"
                     /gene_synonym="Gm762; Kiaa1161; NET37"
                     /note="myogenesis regulating glycosidase (putative)"
                     /db_xref="GeneID:329828"
                     /db_xref="MGI:MGI:2140300"
     exon            1..85
                     /gene="Myorg"
                     /gene_synonym="Gm762; Kiaa1161; NET37"
                     /inference="alignment:Splign:2.1.0"
     exon            86..4175
                     /gene="Myorg"
                     /gene_synonym="Gm762; Kiaa1161; NET37"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2298
                     /gene="Myorg"
                     /gene_synonym="Gm762; Kiaa1161; NET37"
                     /note="full=Nuclear envelope transmembrane protein 37;
                     nuclear envelope transmembrane protein 37"
                     /codon_start=1
                     /product="myogenesis-regulating glycosidase"
                     /protein_id="NP_001078984.1"
                     /db_xref="CCDS:CCDS38716.1"
                     /db_xref="GeneID:329828"
                     /db_xref="MGI:MGI:2140300"
                     /translation="MSQNLQETSQAYPRHRPGSHAGPKSLKVTPRATMYTFLPDNFSP
                     AKPKPTKELRPLLCSAVLGLLLVLAAVVAWCYYSASLRKAERLRAELLDLNRGGFSIR
                     NQKGEQVFRLAFRSGALDLDSCSRDGALLGCSRAADGRPLHFFIQTVRPKDTVMCYRV
                     RWEEAVPGRAVEHAMFLGDAAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVYSSDA
                     AFGGILERYWLSSRAAAIKVNDSVPFHLGWNSTERSMRLQARYHDTSYKPPAGRTAAP
                     ELSYRVCVGSDVTSIHKYMVRRYFNKPSRVPASEAFRDPIWSTWALHGRAVDQNKVLQ
                     FAQQIRQHRFNSSHLEIDDMYTPAYGDFNFDEGKFPNASDMFRRLRDAGFRVTLWVHP
                     FVNYNSSSFGEGVERELFVREPTGRLPALVRWWNGIGAVLDFTHPEAREWFQGHLRRL
                     RLRYNVTSFKFDAGEVSYLPRDFSTYRPLSDPSVWSRRYTEMAEPFFSLAEVRVGYQS
                     QNISCFFRLVDRDSVWGYDLGLRSLIPAVLTVSMLGYPFILPDMIGGNAVPERTAGRQ
                     DGPGPERELYVRWLEVAAFMPAMQFSIPPWQYDAEVVAIAHKFAALRASLVAPLLLEL
                     AGEITDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDTLLVAPVLEPGKQERDVYLPAG
                     KWRSYKGELFDKTPVLLTDYPVDLDEVAYFTWAS"
     regulatory      4150..4155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myorg"
                     /gene_synonym="Gm762; Kiaa1161; NET37"
                     /note="hexamer: AATAAA"
     polyA_site      4172
                     /gene="Myorg"
                     /gene_synonym="Gm762; Kiaa1161; NET37"
                     /note="major polyA site"
ORIGIN      
        1 agggctgtgg ctgatcaact cctgctagcg tagaaagatc agccggagga cccttctccc
       61 tttcttccgt gtggcggtca ctgagacttc agcctgacag attcagatgg gccccggagt
      121 ggtggttcct tccttcgcta ggaactgatg tcccagaacc ttcaggagac aagccaggcc
      181 tacccccgac atcgacctgg tagccacgca ggccctaaaa gtctcaaagt taccccacga
      241 gcaaccatgt acactttcct gcctgacaat ttttcacctg ccaaacccaa gcccactaaa
      301 gagctgagac ctctgctgtg ctccgcggta ctgggactgc tactggtgtt ggccgcagtt
      361 gtggcctggt gctactacag tgcctcccta cgcaaagctg aacgcctgcg cgcggagctg
      421 ctggacctga accgtggcgg cttctccatc cgtaaccaga agggtgagca agtcttccgc
      481 ttggccttcc gttccggtgc tctagacctt gactcctgca gccgggatgg tgcgctgctt
      541 ggctgctccc gagcggccga cggacgcccg ttgcacttct ttattcagac agtacgacct
      601 aaggacactg taatgtgcta ccgcgtgcgc tgggaggaag ctgtgccagg gcgtgctgtg
      661 gagcacgcga tgtttctggg agatgctgcg gcgcactggt atggcggcgc agagatgagg
      721 acgcaacact ggcccatccg cctagatggc cagcaagaac cgcagccatt tgtcacgagc
      781 gacgtctatt catctgacgc cgcattcggg ggcatccttg agcgctactg gttatcttca
      841 cgcgccgctg ccatcaaagt caatgattca gtgcccttcc acctgggctg gaatagcacg
      901 gagcgttcga tgagactgca ggcacgctac cacgacacat cttacaagcc accagctggc
      961 cgtactgccg cgccagagct cagctaccgc gtgtgcgtgg gctcagatgt cacttccatc
     1021 cacaagtaca tggttcgacg ttacttcaac aagccatcca gggtaccagc gtcagaggcc
     1081 ttccgagacc ccatttggtc cacgtgggca ctgcatgggc gcgctgtgga ccagaacaag
     1141 gtgctgcaat tcgcccagca gatccgccag caccgcttta atagcagcca cctggaaatc
     1201 gatgacatgt acacgcccgc ctatggcgac tttaatttcg acgagggcaa gtttcccaac
     1261 gccagtgaca tgttccgccg cctgcgagat gccggcttcc gcgtcacact ttgggtgcat
     1321 ccgtttgtca actataactc gtcgagcttc ggcgaaggtg tggagcgcga gctgttcgtg
     1381 cgcgagccca cgggccggct gcccgcgctg gtgcgctggt ggaacggtat tggcgcagtg
     1441 ctggacttca cgcacccaga ggcccgagag tggttccagg gacacctacg gcgcctgcgc
     1501 ttgcgctaca acgtgacctc ctttaagttc gacgcgggtg aggtcagcta cctgcccagg
     1561 gacttcagca cctacaggcc tctgtctgac cccagtgtgt ggagcaggcg gtacaccgag
     1621 atggcggagc ccttcttctc gctagccgag gtccgcgtgg ggtaccagtc acagaacatc
     1681 tcctgcttct tccgtctagt ggaccgcgac tcggtatggg gctacgacct ggggctgcgc
     1741 tctcttatcc ctgcggtgct caccgtcagt atgctgggct atccgttcat cttgcccgat
     1801 atgataggtg gcaacgcggt gccggagcgc acagccggcc gccaagatgg gccggggcca
     1861 gagcgcgagc tctacgtgcg ctggctggag gtggccgcct tcatgcctgc catgcagttt
     1921 tcaatccctc cttggcagta cgacgcagaa gtggtagcca tcgcacacaa attcgctgct
     1981 ctgcgcgcct ccctcgtggc gccactgctg ctagagcttg ctggtgagat caccgacact
     2041 ggcgacccca tcgtgcgccc cctgtggtgg atcgcaccgg gggatgaaac ggcccatcgc
     2101 attgactcac agtttctcat cggggacacg ctgttggtgg cgccggtgct agagcctggt
     2161 aagcaagagc gtgatgtcta cctgcctgcc ggcaaatggc gaagctacaa gggtgaactt
     2221 tttgacaaga cgccggtgct gctcacggat taccctgtcg acctggatga ggtcgcctat
     2281 ttcacctggg cttcctgacc cagctcagaa cctaggaatc ccacagccct aaccccagcc
     2341 ttcatacaga cttttaatcc tctaccacat gcgaatgctg aaccctcagg aagacccacc
     2401 tctataccat ctaggaagtg ggcactgact ttaaagcgct ccagccaaca gctgtaggtg
     2461 agacctggga ggggaggaac tgcaccagcg cacaatccta agagcctcgg ctccttgccc
     2521 attcacttca gtctgcagaa agcctcttcc ctgggttgtc agccagaaaa aaggagaggt
     2581 caaaggtctg ttcttcctgc tacacagggt ctggttttaa aagtagaggg aaacctctcc
     2641 tcccctggtc tttgtagcca tctttgtcct ctgaaatgag gaaccgatcc tctttaaagt
     2701 tcccaaatag ttttctacca tatttagaaa gtatacgttt agcccagagg tggtggcgca
     2761 cgcctttaat cccagcactc aggaggcaga ggcaggtgga tcttcgagat caaggccagc
     2821 ctggtctata gagtgagttc caggacagca gagaaaccct tccaaaaact aaggaaggaa
     2881 ggaagaaagg aagaagacaa agtgtacctc cttgatggca gcagctaggc catgagttcc
     2941 caacacacag tgattgacct ggtcccactc cattggggaa gaaaagatac agatgtttgg
     3001 tttggccagc tgacaaggaa gcagtccata gaagagatgg gctcagcctg aactagttgt
     3061 ctgtgaaaag actcctaacg ttgcgttaac atatttgtat atatgctggt ctcaactttg
     3121 gatctagacc tggggccaga tgtatctagt ggatagactt gcagggccat gcaggccgga
     3181 ctcgttgcct taattcaaga acctgtgtct atgtgtatgt acacatactt ctgtcagaga
     3241 gagagagaca cccaccatgg gtctttgatg ctagataagc ctagagggaa gataaagggg
     3301 caggatcaag gctttgtttg atcattgacc tacccccccc ctcaggtaga ttccctagga
     3361 caatgccaaa cccagtttaa gagttccgaa actggagagt cgggctgagg aactgagtta
     3421 ggttgaactt gggaaagcaa gcccaagttc aacctaactc ctgctgtaaa atggagagaa
     3481 ctgtagcaaa tgaacagccc tttaagatta cctagctgcc tctctgaaca cacacacaca
     3541 cacacacaca cacacacacg cacgcacgca cgcgcgtgct ctgagtgaag ccttagtggg
     3601 aaaaccatgt tctaattctg gccgagatgt gcttggcaca tgaatgacat tacacactga
     3661 tgcctgccaa cacacgcatg gggtaagggc tttcatctca gtaattctct tgttctaagg
     3721 agatcagctc caactatggt ggggtgagtt tttcctgact tggaggcttg ccagagaagg
     3781 tggagaatga agtagaactc agcttccctc tcagagcctg tgcccgaatc tttaatgttc
     3841 tctgggtgaa aggtcctggg gagagcttcg gggctccccc gatgcccatc tccaatgcca
     3901 attctttggt ttcttcttct tggcagtgtt gaagctagaa ctcagggcgc tgaatactaa
     3961 gcaagcattc ttccgggagc catattcgca gtcttcgttt gtcagtcagc tgggtgacct
     4021 tgaataagct gctgcttacc ccactgagcc tcagtttttc ctatgtaaga gtgatataaa
     4081 acctacctct gaggtcattt aataataagc acagacatgt ggaaagtgcc tgacacaaag
     4141 caggtgctca ataaaagaga gctattgaag tagtaaaaaa aaaaaaaaaa aa
//
