LOCUS       NM_001083934            5319 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus myomesin 1 (Myom1), transcript variant 2, mRNA.
ACCESSION   NM_001083934
VERSION     NM_001083934.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5319)
  AUTHORS   Li,C., Warren,D.T., Zhou,C., De Silva,S., Wilson,D.G.S.,
            Garcia-Maya,M., Wheeler,M.A., Meinke,P., Sawyer,G., Ehler,E.,
            Wehnert,M., Rao,L., Zhang,Q. and Shanahan,C.M.
  TITLE     Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in
            the cardiomyocyte sarcomere
  JOURNAL   J Biol Chem 300 (5), 107254 (2024)
   PUBMED   38569934
REFERENCE   2  (bases 1 to 5319)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5319)
  AUTHORS   Wu,T., Xu,Y., Zhang,L., Liang,Z., Zhou,X., Evans,S.M. and Chen,J.
  TITLE     Filamin C is Essential for mammalian myocardial integrity
  JOURNAL   PLoS Genet 19 (1), e1010630 (2023)
   PUBMED   36706168
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5319)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5319)
  AUTHORS   Zhang,X., Wang,Z., Xu,Q., Chen,Y., Liu,W., Zhong,T., Li,H.,
            Quan,C., Zhang,L. and Cui,C.P.
  TITLE     Splicing factor Srsf5 deletion disrupts alternative splicing and
            causes noncompaction of ventricular myocardium
  JOURNAL   iScience 24 (10), 103097 (2021)
   PUBMED   34622152
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5319)
  AUTHORS   Carlsson,L., Li,Z., Paulin,D. and Thornell,L.E.
  TITLE     Nestin is expressed during development and in myotendinous and
            neuromuscular junctions in wild type and desmin knock-out mice
  JOURNAL   Exp Cell Res 251 (1), 213-223 (1999)
   PUBMED   10438587
REFERENCE   7  (bases 1 to 5319)
  AUTHORS   Steiner,F., Weber,K. and Furst,D.O.
  TITLE     M band proteins myomesin and skelemin are encoded by the same gene:
            analysis of its organization and expression
  JOURNAL   Genomics 56 (1), 78-89 (1999)
   PUBMED   10036188
REFERENCE   8  (bases 1 to 5319)
  AUTHORS   Reddy,K.B., Gascard,P., Price,M.G., Negrescu,E.V. and Fox,J.E.
  TITLE     Identification of an interaction between the m-band protein
            skelemin and beta-integrin subunits. Colocalization of a
            skelemin-like protein with beta1- and beta3-integrins in non-muscle
            cells
  JOURNAL   J Biol Chem 273 (52), 35039-35047 (1998)
   PUBMED   9857037
REFERENCE   9  (bases 1 to 5319)
  AUTHORS   Schiaffino,S. and Reggiani,C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
REFERENCE   10 (bases 1 to 5319)
  AUTHORS   Price,M.G. and Gomer,R.H.
  TITLE     Skelemin, a cytoskeletal M-disc periphery protein, contains motifs
            of adhesion/recognition and intermediate filament proteins
  JOURNAL   J Biol Chem 268 (29), 21800-21810 (1993)
   PUBMED   8408035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154187.2, AC154717.2 and AC154218.2.
            
            [WARNING] On Jul 25, 2024 this sequence was replaced by
            NM_001083934.2.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central coding region, compared to variant 1. The resulting isoform
            (2) lacks an internal segment, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC060378.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC154187.2         196701-196795
            96-445              AC154187.2         199992-200341
            446-586             AC154187.2         211715-211855
            587-836             AC154187.2         213418-213667
            837-994             AC154187.2         214360-214517
            995-1087            AC154187.2         221630-221722
            1088-1176           AC154187.2         222688-222776
            1177-1236           AC154187.2         222881-222940
            1237-1277           AC154187.2         224868-224908
            1278-1401           AC154717.2         54546-54669         c
            1402-1563           AC154717.2         49659-49820         c
            1564-1705           AC154717.2         41168-41309         c
            1706-1905           AC154717.2         37787-37986         c
            1906-1962           AC154717.2         35065-35121         c
            1963-2087           AC154717.2         30227-30351         c
            2088-2271           AC154717.2         24994-25177         c
            2272-2446           AC154717.2         24495-24669         c
            2447-2568           AC154717.2         21539-21660         c
            2569-2765           AC154717.2         18000-18196         c
            2766-2892           AC154717.2         14864-14990         c
            2893-3077           AC154717.2         12427-12611         c
            3078-3192           AC154717.2         10220-10334         c
            3193-3349           AC154717.2         2324-2480           c
            3350-3456           AC154717.2         1334-1440           c
            3457-3501           AC154717.2         1166-1210           c
            3502-3638           AC154218.2         101638-101774       c
            3639-3783           AC154218.2         100889-101033       c
            3784-3843           AC154218.2         98877-98936         c
            3844-3911           AC154218.2         98544-98611         c
            3912-4025           AC154218.2         97397-97510         c
            4026-4113           AC154218.2         96443-96530         c
            4114-4152           AC154218.2         95388-95426         c
            4153-4258           AC154218.2         95188-95293         c
            4259-4422           AC154218.2         89780-89943         c
            4423-4459           AC154218.2         86555-86591         c
            4460-4482           AC154218.2         86089-86111         c
            4483-4538           AC154218.2         84625-84680         c
            4539-5319           AC154218.2         80381-81161         c
FEATURES             Location/Qualifiers
     source          1..5319
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 41.87 cM"
     gene            1..5319
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /note="myomesin 1"
                     /db_xref="GeneID:17929"
                     /db_xref="MGI:MGI:1341430"
     exon            1..95
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            96..445
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..4832
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     skelemin; myomesin family member 1"
                     /codon_start=1
                     /product="myomesin-1 isoform 2"
                     /protein_id="NP_001077403.1"
                     /db_xref="CCDS:CCDS50176.1"
                     /db_xref="GeneID:17929"
                     /db_xref="MGI:MGI:1341430"
                     /translation="MSLPFYQRSHQHYDLSYRNKDLRTTMSHYQQEKKRSAVYTHGST
                     AYSSRSLAARRQESEAFSQASATSYQQQASQTYSLGASSSSRHSQGSEVSRKTASAYD
                     YGYSHGLTDSSLLLEDYSSKLSPQTKRAKRSLLSGEETGSLPGNYLVPIYSGRQVHIS
                     GIRDSEEERIKEAAAYIAQKTLLASEEAIAASKQSTASKQSATSKRTTSTLQREETFE
                     KKSRNIAIREKAEELSLKKTLEETQTYHGKLNEDHLLHAPEFIIKPRSHTVWEKENVK
                     LHCSVAGWPEPRLTWYKNQVPINVHANPGKYIIESRYGMHTLEISKCDFEDTAQYRAS
                     AMNVQGELSAYASVVVKRYKGELDESLLRGGVSMPLSFAVTPYGYASKFEIHFDDKFD
                     VSFGREGETMSLGCRVVITPEIKHFQPEVQWYRNGAPVSPSKWVQPHWSGDRATLTFS
                     HLNKEDEGLYTIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVVSLDANKDYIII
                     SWKQPAVDGGSPILGYFIDKCEVGTDTWSQCNDTPVKFARFPVTGLIEGRSYIFRVRA
                     VNKTGIGLPSRVSEPVAALDPAEKARLKSHPSAPWTGQIIVTEEEPTEGVIPGPPTDL
                     SVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCDVGAENWQRVNTELPVKSPRFALFDL
                     VEGKSYRFRVRCSNSAGVGEPSETTEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWE
                     ESRDAKELVGYYIEASVVGSGKWEPCNNNPVKGSRFTCHGLTTAQSYIFRVRAVNAAG
                     LSEYSQDSEAIEVKAAIAVPSAPYDITCLESFRDSMVLGWKQPDTTGGAEITGYYVNY
                     REVVGEVPGKWREANIKAVSDAAYKISNLKENTLYQFQVSAMNIAGLGAPSTVSECFK
                     CEEWTIAVPGPPHSVKLSEVRKNSLVLQWKPPVYSGRTPVTGYFVDLKEASAKDDQWR
                     GLNEAAIVNKYLRVQGLKEGTSYVFRVRAVNQAGVGKPSDLAGPVVAETRPGTKEVVV
                     SVDDDGVISLNFECDQMTPKSEFVWSKDYVPTEDSPRLEVENKGDKTKMTFKDLGTDD
                     LGTYSCDVTDTDGIASSYLIDEEEMKRLLALSQEHKFPTVPTKSELAVEILEKGQVRF
                     WMQAEKLSSNAKVSYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQI
                     QDGKATGHSTLVLIGDVYKKLQKEAEFQRQEWIRKQGPHFAEYLSWEVTGECNVLLKC
                     KVANIKKETHIVWYKDEREISVDEKHDFKDGICTLLITEFSKKDAGFYEVILKDDRGK
                     DKSRLKLVDEAFQDLMTEVCKKIALSATDLKIQSTAEGIRLYSFVCYYLDDLKVNWSH
                     NGTGIKYTDRVKSGVTGEQIWLQINEPTPNDKGKYVMELFDGKTGHQKTVDLSGQAFD
                     EAFAEFQRLKQAAIAEKNRARVLGGLPDVVTIQEGKALNLTCNVWGDPPPEVSWLKNE
                     KPLTSDDHCSLKFEAGKTAFFTISGVSTADSGKYGLVVKNKYGSETSDFTVSVFIPEE
                     ELRKGAMEPPKGNQKSK"
     exon            446..586
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            587..836
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            837..994
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1087
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1176
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1236
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1401
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1563
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1705
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1905
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1962
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2087
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2271
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2446
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2568
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2765
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2892
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3077
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3192
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3349
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3456
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3501
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3638
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3783
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3843
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..3911
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4025
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4113
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4114..4152
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4258
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4422
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4423..4459
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4482
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4538
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4539..5319
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5294..5299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5319
                     /gene="Myom1"
                     /gene_synonym="D430047A17Rik"
                     /note="major polyA site"
ORIGIN      
        1 aactttttct tggattcaac ctaggtgggc cctcattctc tcctgctcct cgactgcggc
       61 agggcagtgg gccgtaaccc ccaccccaga aaccggtctt ctcgtcccct ggagggccca
      121 ggatgtctct gcccttttat cagcggtccc atcagcacta tgatctcagt taccggaaca
      181 aggaccttcg cacgaccatg agccactacc aacaggagaa gaagcgctct gctgtctaca
      241 cccatggctc cactgcctac agcagccgct ccttggcagc acgccgccag gagtcagagg
      301 ccttcagtca agcatcagcc acctcttacc agcagcaggc ctcacagacc tacagtcttg
      361 gagcatcatc atcatcccgg cattctcaag ggtctgaagt cagccggaag acagcctctg
      421 catatgatta cggctattcc cacggactca cagattccag tctgctatta gaagattatt
      481 catccaagtt gagcccccaa acaaagagag ccaagcggag ccttctgtct ggagaggaga
      541 ctggaagctt gccaggcaac tacctggtgc ctatctactc tggacggcaa gtgcacatca
      601 gtgggatcag agactcggaa gaagaaagaa ttaaagaggc tgctgcttat atcgctcaga
      661 agactctcct tgcgagtgag gaagctattg cagcttccaa acagagcaca gcctccaaac
      721 agtccgcaac ctccaaacgg accacgtcca cccttcaacg agaggaaacg tttgaaaaga
      781 agtcgaggaa cattgcaatt cgagaaaagg cggaagagct gtcactgaag aaaacattag
      841 aagagaccca aacatatcac ggcaagctaa atgaagacca tctccttcat gctcctgagt
      901 ttatcattaa gcctcgttct cacacagttt gggagaagga gaatgtgaag ttgcactgct
      961 ctgtagcagg gtggccagag cctcggctca cgtggtataa gaaccaggtg cctataaatg
     1021 tccatgcaaa cccgggaaag tacatcattg aaagccgata cggaatgcat actcttgaga
     1081 tcagcaaatg tgactttgaa gacacagctc agtaccgggc ctcggcgatg aatgttcaag
     1141 gagagctgtc agcatatgcc tcagtcgtag taaagagata taagggagaa ctggatgagt
     1201 ctctcctccg tggtggggtt tccatgcctc tcagctttgc tgtgacccct tacggttatg
     1261 catccaagtt tgagatccac ttcgatgaca agtttgatgt gtcttttggg agagaaggag
     1321 agaccatgag tctgggctgt cgcgtagtca tcactcctga gataaagcac tttcagcccg
     1381 aggtccagtg gtatagaaat ggagcacctg tttctccatc aaaatgggtg cagccacact
     1441 ggagtggaga ccgggcgaca cttacgttct ctcacctcaa caaagaagat gaaggtctct
     1501 acacgatccg agtgcgaatg ggagagtatt acgaacagta cagtgcttac gtctttgttc
     1561 gagatgctga tgcagagatc gaaggagccc cagctgcacc cttggatgtg gtgtctttgg
     1621 atgctaacaa ggattacatc atcatctctt ggaagcagcc agctgtggat ggagggagcc
     1681 ctatcctggg atactttatc gataagtgtg aggtgggcac agatacctgg tctcagtgca
     1741 atgacacacc tgtgaagttt gctcggtttc cagtcactgg cttgatagaa ggccgttcct
     1801 acatattcag agtccgagct gtgaataaaa ctggaatagg cctgccatcc cgagtttctg
     1861 agcctgtggc ggctttggat ccagctgaga aagctagact aaaaagtcat ccttcagcac
     1921 cctggactgg acagatcatt gtcacggaag aagagcctac agagggtgtc attcctggcc
     1981 cccccacaga cctctctgtc accgaggcca cccggagcta cgtagtgctg agctggaaac
     2041 cccctgggca gcgaggccat gagggcatta tgtattttgt agaaaagtgt gatgtgggag
     2101 cagaaaactg gcagcgggtc aacacagaac tcccggtgaa gtctcctcgc tttgctctgt
     2161 ttgacctggt ggaggggaag tcttaccgct tccgtgtccg ctgctcaaat tcagcaggag
     2221 ttggtgagcc ctcagaaacg actgaagtga ccgtcgtagg ggacaaactt gatatcccaa
     2281 aggcccctgg caaaatcatc ccaagtagaa atacagatac ctcagtggtg gtatcttggg
     2341 aggagtccag agacgccaag gaactggttg ggtactacat cgaggccagt gtcgttggct
     2401 ctggcaagtg ggaaccctgc aataacaacc cggtgaaggg ctcacgattt acttgtcatg
     2461 gactgacgac tgctcagagc tatattttcc gggtcagagc agtgaatgca gctggactta
     2521 gcgaatattc acaggattcg gaagctattg aagtcaaagc tgctatcgcc gtgccatctg
     2581 cgccctatga catcacttgt cttgaaagtt ttcgggactc catggttctt ggatggaagc
     2641 agccagatac gaccggaggg gcagagatta caggctatta tgtgaactat cgtgaggtgg
     2701 ttggtgaggt accaggaaaa tggagggaag ctaacatcaa ggccgtcagc gatgcagcgt
     2761 acaagattag caacttgaag gaaaacacac tgtaccagtt ccaagtgtca gcaatgaaca
     2821 ttgcagggct gggagcgccc tccacggtga gcgagtgctt caagtgtgaa gagtggacca
     2881 ttgctgttcc aggaccacca cacagcgtga agctcagtga agtcaggaag aactccctgg
     2941 ttctccagtg gaagcctcca gtctactcag gccggactcc agtcacgggt tactttgtgg
     3001 acctgaagga agccagtgcc aaagatgacc aatggcgagg acttaatgag gcagccattg
     3061 tgaacaagta cctgagggtg caaggcctca aagagggtac cagctacgtg ttccgtgtac
     3121 gtgctgtcaa ccaggcaggc gttggaaagc cttcagacct tgctggacct gttgtggctg
     3181 aaacacgtcc aggcaccaaa gaggttgtgg tgagtgtgga tgatgacgga gtcatttcct
     3241 tgaactttga atgtgatcag atgactccca agtcagaatt cgtctggtcc aaagattatg
     3301 tacctactga agactctcca cgattagaag tcgaaaacaa aggcgataag acaaaaatga
     3361 cctttaaaga cctcgggaca gatgatttgg gcacctattc ttgtgatgtg acagacacgg
     3421 atgggatagc gtcaagctac ctgatagacg aggaggaaat gaaacgtctg cttgccctca
     3481 gccaggagca caagttcccg actgtcccaa ctaagtctga gttggcagtt gaaattttgg
     3541 agaaaggtca ggtccggttt tggatgcagg ctgagaagct gtctagcaat gccaaagtca
     3601 gctacatatt taacgagaag gaaattttcg aggggccgaa atacaagatg cacatagacc
     3661 gaaacacggg catcattgaa atgttcatgg agaagctaca ggacgaggat gaagggacgt
     3721 acacattcca aattcaagat ggaaaagcaa ctggccattc gactcttgtt ctcattggag
     3781 acgtttataa gaagctacag aaagaagctg aattccagcg acaagaatgg atcaggaagc
     3841 aaggcccaca tttcgctgag tatttgagct gggaagtgac tggtgaatgt aacgtgctgt
     3901 tgaaatgcaa ggtggcaaat attaaaaaag agactcacat tgtatggtac aaagatgaac
     3961 gggagatctc cgtggacgag aaacatgact ttaaggatgg catttgtacc ctgctcatca
     4021 cagagttttc caagaaagac gctggatttt atgaagttat cctgaaagat gaccgaggaa
     4081 aagataagag cagattgaag ctcgtggatg aagccttcca agacttgatg actgaagtat
     4141 gcaagaagat agcgttgtct gccacagacc tgaaaatcca gagcacagcg gagggcatcc
     4201 ggctatactc ctttgtctgt tattacctgg atgacttgaa agttaactgg tcccacaatg
     4261 ggacggggat taagtacaca gacagagtca agagtggcgt gactggggag cagatctggc
     4321 tgcagatcaa cgagcccact ccgaatgata aagggaaata cgtgatggag ctctttgacg
     4381 gcaagactgg acaccagaag acggtggatc tctctggaca agcatttgat gaggcctttg
     4441 ctgaattcca gaggttaaaa caagctgcca ttgctgaaaa aaatcgggcc cgggtgttag
     4501 gtggtctccc tgatgttgtc accattcaag agggcaaggc actcaatctc acttgcaatg
     4561 tgtggggtga cccgccccct gaggtgtcct ggctgaaaaa cgagaagcca ctgacctctg
     4621 acgaccactg cagcctcaag tttgaggccg ggaaaaccgc cttcttcacc atctcaggcg
     4681 tgagcacggc agactccggc aagtacgggc tggtggtgaa gaacaaatat ggctcggaga
     4741 ccagcgactt caccgttagt gtgttcatcc cagaggagga gttgaggaag ggagcaatgg
     4801 agcctcccaa gggcaaccag aagtccaagt gagcagagac tgggggagtt ttgaggagag
     4861 ccaggaccag ctggccaccc atcatgctgc tgtcgtgaaa aggattgggc tacagacgat
     4921 gaaatcctcc tggtggctcc attttgtgct ggcttaggag gaagtcatca gatctcttat
     4981 tcctatagat gaggaggcac cattgaagaa cacattaagg gttttaatct acaatttatg
     5041 tagtaagaaa acattaggaa atgatttcaa ggaagaaggg cagaggatgt tggagaagtg
     5101 ctgagcgaga gcagaagtga ggccagcatg gaagccggtg acgctttacc tgtaagctct
     5161 taggaattgt gtccatacct catgttctat caaaatagag gcatgtgcct gtaggcttga
     5221 gtatggtggg tccctgttag tagaggtggt gcatttctga tagcagcctt gtgaactggc
     5281 ctcccccagt gtgaataaag tctcctgcct ttcctcttt
//
