LOCUS       NM_001142322            7297 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus myosin IXb (Myo9b), transcript variant 1, mRNA.
ACCESSION   NM_001142322
VERSION     NM_001142322.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7297)
  AUTHORS   Zhang,J., Zou,Y., Chen,L., Sun,F., Xu,Q., Zhou,Q., Wang,Y., Luo,X.,
            Wang,N., Li,Y., Zhang,S., Xiong,F., Yang,P., Liu,S., Yang,T.,
            Weng,J., Eizirik,D.L., Yan,J., Zhou,Z. and Wang,C.Y.
  TITLE     Myo9b mutations are associated with altered dendritic cell
            functions and increased susceptibility to autoimmune diabetes onset
  JOURNAL   Nat Commun 14 (1), 5977 (2023)
   PUBMED   37749140
  REMARK    GeneRIF: Myo9b mutations are associated with altered dendritic cell
            functions and increased susceptibility to autoimmune diabetes
            onset.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7297)
  AUTHORS   Cipriani,S., Guerrero-Valero,M., Tozza,S., Zhao,E., Vollmer,V.,
            Beijer,D., Danzi,M., Rivellini,C., Lazarevic,D., Pipitone,G.B.,
            Grosz,B.R., Lamperti,C., Marzoli,S.B., Carrera,P., Devoto,M.,
            Pisciotta,C., Pareyson,D., Kennerson,M., Previtali,S.C.,
            Zuchner,S., Scherer,S.S., Manganelli,F., Bahler,M. and Bolino,A.
  TITLE     Mutations in MYO9B are associated with Charcot-Marie-Tooth disease
            type 2 neuropathies and isolated optic atrophy
  JOURNAL   Eur J Neurol 30 (2), 511-526 (2023)
   PUBMED   36260368
  REMARK    GeneRIF: Mutations in MYO9B are associated with Charcot-Marie-Tooth
            disease type 2 neuropathies and isolated optic atrophy.
REFERENCE   3  (bases 1 to 7297)
  AUTHORS   Hemkemeyer,S.A., Liu,Z., Vollmer,V., Xu,Y., Lohmann,B. and
            Bahler,M.
  TITLE     The RhoGAP-myosin Myo9b regulates ocular lens pit morphogenesis
  JOURNAL   Dev Dyn 251 (11), 1897-1907 (2022)
   PUBMED   36008362
  REMARK    GeneRIF: The RhoGAP-myosin Myo9b regulates ocular lens pit
            morphogenesis.
REFERENCE   4  (bases 1 to 7297)
  AUTHORS   Yi,F.S., Zhang,X., Zhai,K., Huang,Z.Y., Wu,X.Z., Wu,M.T., Shi,X.Y.,
            Pei,X.B., Dong,S.F., Wang,W., Yang,Y., Du,J., Luo,Z.T. and Shi,H.Z.
  TITLE     TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant
            Pleural Effusion by Regulating TH1/TH17 Cell Response
  JOURNAL   J Immunol 205 (10), 2926-2935 (2020)
   PUBMED   33046503
  REMARK    GeneRIF: TSAd Plays a Major Role in Myo9b-Mediated Suppression of
            Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response.
REFERENCE   5  (bases 1 to 7297)
  AUTHORS   Moalli,F., Ficht,X., Germann,P., Vladymyrov,M., Stolp,B., de
            Vries,I., Lyck,R., Balmer,J., Fiocchi,A., Kreutzfeldt,M.,
            Merkler,D., Iannacone,M., Ariga,A., Stoffel,M.H., Sharpe,J.,
            Bahler,M., Sixt,M., Diz-Munoz,A. and Stein,J.V.
  TITLE     The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of
            protective CD8+ T cells
  JOURNAL   J Exp Med 215 (7), 1869-1890 (2018)
   PUBMED   29875261
  REMARK    GeneRIF: Myo9b is critical for the CD8(+) T cell adaptation from
            lymphoid to nonlymphoid tissue surveillance and the establishment
            of protective tissue-resident T cell populations.
REFERENCE   6  (bases 1 to 7297)
  AUTHORS   Grewal,P.K., Jones,A.M., Maconochie,M., Lemmers,R.J., Frants,R.R.
            and Hewitt,J.E.
  TITLE     Cloning of the murine unconventional myosin gene Myo9b and
            identification of alternative splicing
  JOURNAL   Gene 240 (2), 389-398 (1999)
   PUBMED   10580159
REFERENCE   7  (bases 1 to 7297)
  AUTHORS   Lutz,C.M., Richards,J.E., Scott,K.L., Sinha,S., Yang-Feng,T.L.,
            Frankel,W.N. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes mapped in human and mouse: receptors
            with high affinity for pancreatic polypeptide are not clustered
            with receptors specific for neuropeptide Y and peptide YY
  JOURNAL   Genomics 46 (2), 287-290 (1997)
   PUBMED   9417917
REFERENCE   8  (bases 1 to 7297)
  AUTHORS   Lutz,C.M., Frankel,W.N., Richards,J.E. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to
            conserved linkage groups on mouse chromosomes 3 and 8
  JOURNAL   Genomics 41 (3), 498-500 (1997)
   PUBMED   9169155
  REMARK    Erratum:[Genomics 1997 Sep 1;44(2):251-2]
REFERENCE   9  (bases 1 to 7297)
  AUTHORS   Whitmer,J.D., Koslovsky,J.S., Bahler,M. and Mercer,J.A.
  TITLE     Chromosomal location of three unconventional myosin heavy chain
            genes in the mouse
  JOURNAL   Genomics 38 (2), 235-237 (1996)
   PUBMED   8954808
REFERENCE   10 (bases 1 to 7297)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157609.6.
            
            On Jul 30, 2020 this sequence version replaced NM_001142322.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC157609.6         94176-94291         c
            117-1011            AC157609.6         75869-76763         c
            1012-1106           AC157609.6         51786-51880         c
            1107-1169           AC157609.6         45161-45223         c
            1170-1269           AC157609.6         43972-44071         c
            1270-1370           AC157609.6         43640-43740         c
            1371-1500           AC157609.6         43012-43141         c
            1501-1590           AC157609.6         41063-41152         c
            1591-1707           AC157609.6         39009-39125         c
            1708-1842           AC157609.6         38325-38459         c
            1843-1964           AC157609.6         36176-36297         c
            1965-2106           AC157609.6         33610-33751         c
            2107-2311           AC157609.6         33174-33378         c
            2312-2390           AC157609.6         32611-32689         c
            2391-2504           AC157609.6         27985-28098         c
            2505-2544           AC157609.6         26206-26245         c
            2545-2667           AC157609.6         24121-24243         c
            2668-2748           AC157609.6         23312-23392         c
            2749-2859           AC157609.6         22805-22915         c
            2860-2982           AC157609.6         20853-20975         c
            2983-3299           AC157609.6         19075-19391         c
            3300-4163           AC157609.6         17811-18674         c
            4164-4224           AC157609.6         16810-16870         c
            4225-4346           AC157609.6         15957-16078         c
            4347-4474           AC157609.6         14991-15118         c
            4475-4650           AC157609.6         14660-14835         c
            4651-4749           AC157609.6         13165-13263         c
            4750-4923           AC157609.6         12870-13043         c
            4924-4965           AC157609.6         12450-12491         c
            4966-5077           AC157609.6         12178-12289         c
            5078-5151           AC157609.6         11694-11767         c
            5152-5344           AC157609.6         11118-11310         c
            5345-5473           AC157609.6         10911-11039         c
            5474-5579           AC157609.6         10615-10720         c
            5580-5711           AC157609.6         10353-10484         c
            5712-5835           AC157609.6         8769-8892           c
            5836-5883           AC157609.6         8342-8389           c
            5884-6014           AC157609.6         7912-8042           c
            6015-6142           AC157609.6         7553-7680           c
            6143-7297           AC157609.6         6293-7447           c
FEATURES             Location/Qualifiers
     source          1..7297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..7297
                     /gene="Myo9b"
                     /note="myosin IXb"
                     /db_xref="GeneID:17925"
                     /db_xref="MGI:MGI:106624"
     exon            1..116
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            117..1011
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..6558
                     /gene="Myo9b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     unconventional myosin-9b; unconventional myosin-IXb"
                     /codon_start=1
                     /product="unconventional myosin-IXb isoform 1"
                     /protein_id="NP_001135794.1"
                     /db_xref="CCDS:CCDS52580.1"
                     /db_xref="GeneID:17925"
                     /db_xref="MGI:MGI:106624"
                     /translation="MSAHEAGSSGRRQQATYHLHIYPQLSSAGSQTSCRVTATKDSTT
                     SDVIQDVVASLHLDGSKHYVLVEVKESGGEEWVLDASDSPVHRVLLWPRRAQDEHPQE
                     DGYYFLLQERNADGSIQYLPIQLLAQPTAACRLVERGLLPRPQADFDDLCNLPELTEA
                     NLLQNLKLRFMQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFAL
                     ADVAYYAMLRKHVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAG
                     PVLEAFGNAKTAHNNNSSRFGKFIQVNYLENGIVRGAVVEKYLLEKSRLVSQEKDERN
                     YHVFYYLLLGVSEEERLEFQLKQPQDYFYLNQHNLNIEDGEDLKHDFERLQQAMEMVG
                     FLPATKKQIFSVLSAILYLGNVTYKKRATGRDEGLEVGPPEVLDTLSQLLKVKRETLV
                     EVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDME
                     EAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFTQHIFKLEQEEYQGEGIS
                     WHNIDYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSHTLLAKFKQQHEDNKYFLGT
                     PVLEPAFIIQHFAGRVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAV
                     FRWAVLRAAIRAMAVLREAGRLRAERAEKAAGISSPATRSHMEELPRGASTPSEKLYR
                     DLHNQIIKSLKGLPWQGEDPRRLLQSLSLFQKPRTSFLKSKGIKQKQIIPKNLLDSKS
                     LRLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSN
                     AEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLPKDVQPCR
                     EAIAALLEKLQVDRQNYQIGKTKVFLKETERQTLQEKLHGEVLRRILQLQSWFRMVLE
                     RKHFVQMKHAALTIQACWRSYRVRRALERTQAAVYLQAAWRGYLQRQAYHHQRHSIIR
                     LQSLCRGHLQRRSFSQMVSEKQKAEQAREAAGGKLSEGEPGPVAAGEQLSEHPVEDPE
                     SLGVEAETWMNKSPDGMSPKKETPSPEMETAAQKTVPAESHEKVSSSREKRESRRQRG
                     LEHVERQNKHIQSCREESSTHREPSRRASLEIGESFPEGTKGPREDGLEAWTETTAPS
                     SSKQAQVVGDPPGSPSPVQRPTTLALDSRVSPMLPSSSLEVSPVLPSSSLESPKDKDK
                     DESSTKAQDKPESPSGSTQIQRYQHPDTERLATAVEIWRGKKLASAVLSQSLDLSEKH
                     RATGAALTPTEERRISFSTSDVSKLSPVKVQTSAEIDGDFSSKKPSIHKKKSGDPSAG
                     PDAGLSPGSQGDSKSAFKRLFLHKAKDKKPSLEGVEETESNGGQAAQETPARKTLDVP
                     SSQQHRHTTGEKPLKGKKNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKV
                     NDLRSQKTPIESLFIEATERFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLAAER
                     GEKDTNLVLNVFQSLLDEFTRSYNKTDFERAKQSKAQKKKRKQERAVQEHNGHVFASY
                     QVNIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSYCSYTGRRKSELGAEPG
                     HFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDP
                     AAVKLEDFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLSAIYAVLD
                     HLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDV
                     LKITTCVEMLIKEQMRKYKMKMEEINHLEAAESIAFRRLSLLRQNAPWPLKLGFSSPY
                     EGVRIKSPRTPVVQDLELGALPEEAAGGDEDREKEILMERIQSIKEEKEDITYRLPEL
                     DPRGSDEENLDSETSASTESLLEERGVRGAVEGPPAPALPCPISPTLSPLPEAAAPPR
                     GRPTSFVTVRVKTPRRTPIMPMANIKLPPGLPLHLTSWAPALQEAVVPVKRREPPARR
                     QDQVHSVYIAPGADLPSQSTLIALDHDTILPGTKRRYSDPPTYCLPPSSGQANG"
     exon            1012..1106
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1169
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1269
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1370
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1500
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1590
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1707
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1842
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1964
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2106
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2311
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2390
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2504
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2544
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2667
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2748
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2859
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2982
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3299
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..4163
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            4164..4224
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4346
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..4474
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..4650
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            4651..4749
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            4750..4923
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            4924..4965
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            4966..5077
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            5078..5151
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            5152..5344
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            5345..5473
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            5474..5579
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            5580..5711
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            5712..5835
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            5836..5883
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            5884..6014
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            6015..6142
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
     exon            6143..7297
                     /gene="Myo9b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgaaa tcgcacggtg cagcggcggg cgaggctggt cgcttcgggg cggggcggcc
       61 gggagcagcg ggcaggctgg ccggggaccg gtggcgcgca gcggcccgag gtccagttac
      121 aggaggtgtg cacccgccgg tgaggtatgc tgaggccagg aggccggcag tatgagtgcg
      181 cacgaggctg gcagctcggg ccgtcggcag caggccacct accacctgca catctacccg
      241 cagctgtcca gcgctgggag ccagacctca tgccgtgtga ccgccaccaa ggacagcaca
      301 acaagcgatg tcatccagga tgtggtggcc agcctacacc tggatggctc gaagcactac
      361 gtgctggtgg aggtgaagga gtcaggcggg gaggagtggg tgttggatgc cagcgactca
      421 cctgtacacc gagtgctact gtggcctcgg cgagctcagg acgagcaccc tcaggaggat
      481 ggctactact tcttgctgca ggaacgcaat gctgatggca gtattcagta cctgcccata
      541 cagctgctgg ctcagcctac agctgcatgt cgcctggtag agcgagggct gttgccgagg
      601 cctcaagcag actttgatga cctgtgcaac ctgccagagc tgactgaagc caacctgctg
      661 cagaacctga agctgcgctt catgcagcaa aagatctaca catacgcggg cagcatcctg
      721 gtggccatca acccctttaa gttcctgccc atttacaacc ccaagtatgt gaagatgtat
      781 gagaaccaac agctgggcaa actggagcca catgtgttcg ctctggccga tgtagcctac
      841 tacgccatgc tgcgcaagca cgtgaaccag tgtatcgtca tctctggtga gagtggctct
      901 ggcaagacac agagcaccaa cttcctcatc cactgcctca cagcgctcag ccagaagggc
      961 tatgccagtg gcgtcgaaag gaccatcctg ggagcagggc ctgtgctgga ggcttttggg
     1021 aatgccaaga cagcccacaa caacaactcc agccgcttcg ggaagttcat ccaagtcaac
     1081 tacctagaaa atggcattgt gaggggagct gttgtggaaa aataccttct tgaaaagtct
     1141 cgcctggttt cccaggagaa ggatgagcgg aactaccatg tgttttatta tctgctgctg
     1201 ggtgtcagtg aggaggagcg cctggaattt cagctgaagc agcctcaaga ctatttctac
     1261 ctcaaccagc ataacttgaa tattgaagat ggagaagacc tcaaacatga ctttgaaagg
     1321 cttcagcagg ccatggagat ggtgggcttc ctgcctgcca ccaagaagca gatcttctct
     1381 gtcctctcag ccatcctgta ccttggcaat gtcacctaca agaagagagc cacaggccga
     1441 gatgaaggcc tggaggtcgg tcctccagag gtgttggaca ccctctccca gctcttaaag
     1501 gtaaagcggg agaccctggt ggaggtctta accaagagaa aaacagttac agtcaatgac
     1561 aaactcatcc tgccttacag cctcagtgag gccataactg cacgagactc catggccaag
     1621 tccctataca gtgccctatt tgactggatt gtgctaagga tcaaccacgc cctcctcaac
     1681 aagaaggaca tggaagaggc tgtttcctgc ttgtccattg gcgtcctgga catctttgga
     1741 tttgaggact tcgaaaggaa tagctttgag cagttttgca tcaactatgc caatgagcag
     1801 ttgcagtact acttcaccca gcacatcttc aagctggagc aggaggagta ccagggtgag
     1861 ggcatctcgt ggcacaacat tgactacacc gacaacgtgg gctgtatcca cctcatcagc
     1921 aagaagccca ctggcctctt ctacctgctg gacgaggaga gcaacttccc acatgccaca
     1981 agccacactt tgctggccaa gttcaagcag cagcatgagg acaataagta cttcctgggc
     2041 acaccagtcc tggagcccgc cttcatcatc cagcacttcg cgggcagagt gaaataccag
     2101 atcaaggact tccgggagaa gaacatggac tacatgcggc ctgacatcgt ggcactgcta
     2161 aggggcagtg acagctccta tgtgcgccag ctcattggca tggacccggt agctgtgttc
     2221 cgctgggctg tactacgagc agccatcagg gccatggctg tgctgcggga ggctgggcgc
     2281 ctgcgtgcag agagagcgga gaaggcagca ggtataagta gccctgccac tcgaagtcac
     2341 atggaagagc taccaagagg agccagtacc ccttcagaaa aactgtaccg cgatttgcat
     2401 aaccaaatca tcaagagcct caaaggactg ccatggcagg gcgaggaccc gaggaggctt
     2461 ctccagtccc tcagtctgtt ccagaagccc cgcacctcct tcctgaagag taaaggtatc
     2521 aaacaaaagc agatcattcc caagaacctg ctggactcga agtccctgag gctcatcatc
     2581 agcatgacac tgcatgaccg aactaccaag tcactgctgc acctgcacaa aaagaagaag
     2641 ccacctagca tcagtgcaca gttccagaca tctcttaaca agctgttgga ggcactgggc
     2701 aaggccgagc ccttcttcat ccgctgcatc cgctccaatg ccgagaagaa ggaactttgc
     2761 tttgatgatg aactggtgct gcagcaactg cgctacacag gcatgctaga gactgtgcgc
     2821 atccgacgct ctggctacag cgccaagtac accttccagg acttcacgga gcagttccag
     2881 gtgttgctgc ccaaggatgt ccagccctgt agggaggcca ttgctgccct gctggagaag
     2941 ctgcaggtgg acaggcagaa ctaccagatt ggaaagacga aggtcttcct gaaggagaca
     3001 gagcgtcaga ccctgcagga gaagctgcat ggtgaggtcc tgcgtagaat cctgcagctg
     3061 cagagttggt tccgtatggt gctggaacgc aagcactttg tacagatgaa gcatgctgcc
     3121 ttgaccatcc aggcctgctg gcggtcttac cgtgtgcgcc gtgcactgga aaggacgcag
     3181 gcagctgtgt acctgcaggc tgcctggagg ggctacctgc agagacaggc ctaccaccac
     3241 cagaggcata gcatcatccg cctgcagagc ctctgccgtg gccacctgca gcgcaggagc
     3301 ttcagccaga tggtgtcaga gaagcagaag gcagagcaag ccagggaggc agcaggagga
     3361 aagctgtcag agggtgagcc tggccccgtg gccgctgggg agcagctatc tgagcaccct
     3421 gtggaagacc ctgagagcct gggtgtggag gctgaaacct ggatgaacaa gtccccagac
     3481 ggcatgtcac ctaagaagga gacacccagc ccagagatgg agaccgcagc ccaaaagaca
     3541 gtgccagctg aaagtcatga gaaagtctcc agtagccgag agaagcgaga gtcacggcgg
     3601 caacgagggt tggagcatgt tgaacgacag aataaacaca tccaatcctg cagggaggag
     3661 agcagcaccc accgagaacc ttccagaagg gcaagcctgg aaatagggga aagcttccct
     3721 gagggcacaa agggacccag agaagatgga cttgaggcat ggactgagac cacagccccc
     3781 tctagttcaa agcaggcaca ggttgtggga gacccacctg ggagtcccag tcccgtgcag
     3841 aggcccacca ccctggccct agacagtagg gttagcccaa tgctccccag cagctccctg
     3901 gaggttagcc cagtgctccc cagcagctcc ctggaatccc ccaaagataa ggacaaggat
     3961 gagagcagca ccaaggctca ggacaagccc gagagtccca gtggctccac ccagatccaa
     4021 cgataccaac acccagacac agagcggctg gccactgctg tagagatatg gcgaggcaag
     4081 aagcttgcca gtgccgtgct gagccaatcc ctggacctga gtgagaagca ccgggctaca
     4141 ggggcagccc tgactcccac agaggagagg cgcatctctt tctccaccag tgacgtctcc
     4201 aagctgtccc cagtcaaggt acagacttca gctgaaatcg atggggactt tagcagcaag
     4261 aagccatcca tccataagaa gaagtcagga gatccatccg ctggtcctga tgcaggcctg
     4321 tctccaggct cccagggtga ctctaaatct gcatttaagc ggctcttcct gcacaaagcc
     4381 aaggataaga agcccagcct ggagggtgta gaggagacag agagcaatgg agggcaggct
     4441 gcacaggaga ccccggccag gaagactcta gacgtacctt ctagccagca gcaccgccat
     4501 accacaggtg agaagcccct aaaagggaag aagaaccgaa atcgcaaagt tggccagatc
     4561 acagtgtccg agaagtggcg agagtcagtg ttccgtaaga tcactaatgc caatgagctc
     4621 aagtttctgg acgagttcct gctcaacaag gtgaatgacc ttcgctcaca gaagacaccc
     4681 atcgaaagct tgttcattga ggccactgag cgcttcagga gcaacatcaa gaccatgtat
     4741 tcggtgccta atgggaagat ccatgtaggc tacaaggacc tgatggagaa ctaccagatc
     4801 gttgtcagta acctggctgc cgagcgtggg gagaaggaca ccaatctggt cctcaatgtc
     4861 ttccagtcac tgctggatga gttcacccgc agctacaaca agactgactt tgagcgggcc
     4921 aagcagagca aagcccagaa gaagaagcgg aagcaggagc gtgctgtcca ggaacacaat
     4981 ggacatgtgt ttgccagcta ccaggtgaac attccacagt catgtgagca gtgtctgtcc
     5041 tacatctggc tcatggacaa ggctctactg tgcagtgtgt gcaagatgac ctgccacaag
     5101 aaatgcgtgc acaagattca gagctattgc tcctacactg gaaggaggaa gagtgagctg
     5161 ggtgccgaac caggccactt cggtgtgtgt gtagacagcc tgaccagtga caaggcctcc
     5221 gtgcccattg tgctggagaa gcttctggaa cacgtagaga tgcatggcct gtacactgag
     5281 ggcctttacc gcaagtcagg agctgccaac cggacacggg aattacgcca ggcactgcag
     5341 acagaccctg ctgcagttaa gctggaagac ttccctatcc acgctatcac cggggtcctg
     5401 aagcaatggc ttcgtgagct gcctgagcca ctcatgactt ttgcccagta tggagatttc
     5461 ctcagggctg ttgagcttcc agagaagcag gagcagctgt ctgccatcta tgcagtcctg
     5521 gaccacctgc cagaagccaa ccacacctcc ctggagcgac tcatcttcca ccttgtcaaa
     5581 gtggccctgc ttgaagatgt gaaccgcatg tctccgggag ctctagctat catctttgca
     5641 ccctgcctgc ttcgctgccc tgacaactcc gaccccctga ccagcatgaa ggatgtactg
     5701 aagatcacca cgtgtgtgga gatgctcatc aaagaacaga tgaggaagta caagatgaag
     5761 atggaggaaa tcaaccacct ggaggctgct gagagcattg cattccgcag gctctccctg
     5821 ttgaggcaga atgctccgtg gcctctcaaa ctggggtttt catcacccta tgagggggtc
     5881 cggatcaaaa gccccaggac cccagtggtc caagacctgg agctgggggc tctccccgag
     5941 gaggctgcag gtggcgacga ggaccgagaa aaggagattc tcatggagag gatccagtcc
     6001 atcaaggaag agaaggagga catcacatat cgactgccgg agctggaccc acggggttct
     6061 gatgaggaga accttgactc agagacatcg gccagcactg agagcctgct ggaggagagg
     6121 ggcgtgcggg gggccgtgga agggcccccc gcacctgctc tcccctgccc catttcgccc
     6181 accctgagtc ccctccccga ggccgccgcc cctccacgag gaaggccgac atccttcgtc
     6241 acggtcagag tgaagacacc tcggaggacc cccatcatgc ccatggccaa tatcaagctc
     6301 cctccgggcc tgcccttgca cctgacaagc tgggcacctg ctctccagga ggctgttgtt
     6361 ccagtgaagc gccgagagcc acctgcccgc agacaggacc aggtacattc cgtatacatc
     6421 gcccctgggg ctgacctgcc atcacagagt acactgatag ccctggacca tgataccata
     6481 cttcctggga ccaagcgcag gtattcggac ccccctacct actgcctgcc ccccagctcc
     6541 ggccaggcca atggctgagg accatgactg gcagtctgca tctcctaaca tccccgaact
     6601 ggcatcccag ctgtggagct ggccttcact ttctgagaag gatctagaat gaaaagctcc
     6661 caaagggatg cagtggccag ctctgtgtgt tgtggagact gggagctgct ggccaggagc
     6721 catcagagcc ccaacctgca cagcagtggc tcctttgtcc tttcagtaac tgtttctctt
     6781 tttgtggttt acataacttt taagttcata acagccttaa tggaggacca aacttttgta
     6841 tttgtatgtc tgaactttta tattaactct gcacccttgt aacctggaca tgggcagggc
     6901 aagcctgcaa agtggacatg tgggctacag atgactgctg cactcactgc atagtggtag
     6961 agagtgaact cacaggacgt ctgtccatct tgaatgcctc ccagcagtag tcatctgccc
     7021 agagaacctt ccagagattg ctggagcttt ccacagctga aggcaggaca ggagtgggaa
     7081 gtccctgagt gccagggaag cctgaatgta gcttacagct ctgcccactg tgcctgtgaa
     7141 atgcacggag ccagggactt ggaaccttta ggaacaatca gtgcatccgg tgacagcctg
     7201 ggttctttag aggctggctc tcttctcagg ctctacccag tcctggagac aaggaagccc
     7261 cacaggaggt gtgaaataaa agtacttgag aagggtt
//
