LOCUS       NM_032394               6591 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus myosin VIIB (Myo7b), mRNA.
ACCESSION   NM_032394
VERSION     NM_032394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6591)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6591)
  AUTHORS   Duran Alonso,M.B., Vendrell,V., Lopez-Hernandez,I., Alonso,M.T.,
            Martin,D.M., Giraldez,F., Carramolino,L., Giovinazzo,G.,
            Vazquez,E., Torres,M. and Schimmang,T.
  TITLE     Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis
            of the Cochlea
  JOURNAL   Front Cell Dev Biol 9, 679325 (2021)
   PUBMED   34124068
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6591)
  AUTHORS   Choi,M.S., Graves,M.J., Matoo,S., Storad,Z.A., El Sheikh
            Idris,R.A., Weck,M.L., Smith,Z.B., Tyska,M.J. and Crawley,S.W.
  TITLE     The small EF-hand protein CALML4 functions as a critical myosin
            light chain within the intermicrovillar adhesion complex
  JOURNAL   J Biol Chem 295 (28), 9281-9296 (2020)
   PUBMED   32209652
REFERENCE   4  (bases 1 to 6591)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6591)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 6591)
  AUTHORS   Henn,A. and De La Cruz,E.M.
  TITLE     Vertebrate myosin VIIb is a high duty ratio motor adapted for
            generating and maintaining tension
  JOURNAL   J Biol Chem 280 (47), 39665-39676 (2005)
   PUBMED   16186105
  REMARK    GeneRIF: cloned, expressed and purified the catalytic motor domain,
            and characterized its actin-activated ATPase cycle
REFERENCE   7  (bases 1 to 6591)
  AUTHORS   Pang,A.L., Taylor,H.C., Johnson,W., Alexander,S., Chen,Y., Su,Y.A.,
            Li,X., Ravindranath,N., Dym,M., Rennert,O.M. and Chan,W.Y.
  TITLE     Identification of differentially expressed genes in mouse
            spermatogenesis
  JOURNAL   J Androl 24 (6), 899-911 (2003)
   PUBMED   14581517
REFERENCE   8  (bases 1 to 6591)
  AUTHORS   Chen,Z.Y., Hasson,T., Zhang,D.S., Schwender,B.J., Derfler,B.H.,
            Mooseker,M.S. and Corey,D.P.
  TITLE     Myosin-VIIb, a novel unconventional myosin, is a constituent of
            microvilli in transporting epithelia
  JOURNAL   Genomics 72 (3), 285-296 (2001)
   PUBMED   11401444
REFERENCE   9  (bases 1 to 6591)
  AUTHORS   Oliver,T.N., Berg,J.S. and Cheney,R.E.
  TITLE     Tails of unconventional myosins
  JOURNAL   Cell Mol Life Sci 56 (3-4), 243-257 (1999)
   PUBMED   11212352
  REMARK    Review article
REFERENCE   10 (bases 1 to 6591)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC138341.1, AK220152.1 and AC131761.4.
            
            On Oct 21, 2009 this sequence version replaced NM_032394.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138338.1, AF242411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6439              BC138341.1         1-6439
            6440-6587           AK220152.1         3021-3168
            6588-6591           AC131761.4         8597-8600
FEATURES             Location/Qualifiers
     source          1..6591
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 17.89 cM"
     gene            1..6591
                     /gene="Myo7b"
                     /note="myosin VIIB"
                     /db_xref="GeneID:17922"
                     /db_xref="MGI:MGI:107709"
     exon            1..59
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            60..100
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..6424
                     /gene="Myo7b"
                     /note="myosin-VIIb"
                     /codon_start=1
                     /product="unconventional myosin-VIIb"
                     /protein_id="NP_115770.2"
                     /db_xref="CCDS:CCDS50244.1"
                     /db_xref="GeneID:17922"
                     /db_xref="MGI:MGI:107709"
                     /translation="MSVFRLGDHVWLDPPSSSKTGVAIGGIVKETKLGKTLIEDDEGK
                     EHWVHAEDLSTLRPMHPNSAQGVDDMIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSIL
                     VAVNPFQMLPLYTLEQVQIYYSRHMGELPPHIFAIANSCYFNMKKNKRDQCCIISGES
                     GAGKTETTKLILQFLATVSGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYID
                     IHFNSSGVIEGASIEHFLLEKSRVCRQAPEERNYHIFYCMLMGMSPEEKQMLSLGMPS
                     EYHYLTMGSCTSSEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFM
                     AAVFENLDSSDVMETPAFPLAMKLLEVQHQALRDCLIKHTIPVLGEFVSRPVNIAQAT
                     DRRDAFVKGIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFE
                     QLCINFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIIS
                     LLDEESRFPQGTDVTMLQKLNSIHANNKSFLSPRSIHDTRFGIAHFAGDVYYQAEGFL
                     EKNRDVLSTDILILIHSSKNKFLKEIFNVDSSQTKLGHGTICQVKAGSQLFKSSDSIK
                     RPVTLASQFKQSLDQLMRILTNCQPYFVRCIKPNEYKKPLLFDRELCIQQLRYSGMME
                     TVHIRKSGFPIRYTFDEFSQRFRVLLPSPERMQFQNKPRQMTLHIADLCLGTDKDWKV
                     GKTKIFLKDHQDTVLEIRRSQALDGAAIRIQRVLRGHKYRKEFLRQRRAAVTLQAGWR
                     GYSQRKNFKLILVGFERLQAIARSHLLMRQFQAMRQRIVQLQARCRGYLVRQQVQAKR
                     RAVVIIQAHARGMVVRKSYWQQKSTGPQVILAKEPKAQVAVHERKRKSIYDTVTDTAM
                     VEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQKLHEVDLDTVPMMAMPEEEVDSLAEYT
                     FPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALDVWIIILRFMGDLPEPVVY
                     GRNSLTGSSVMRQIHDKLGKDSVTQHNRSSQVASQLNFGEEAFKFDGPISDRPMSNLE
                     KVHFIVGYAIMRPGLRDEIYCQICKQLSENYKTSSRARGWILLSLCLGCFPPSERFMK
                     YLLNFISQGPPSYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVILATGR
                     SLTISVDSASTSREICQHVAQKQGLRDNLGFSLQVAVYDKFWSLGSGCDHLMDAVAQC
                     EQLARERGESQRQAPWRIYFRKEFFTPWHDSQEDPVSTELIYHQVLRGVWSGEYNFEK
                     EEELVELLARHCYVQLGATVKSNAVQELLPSCVPSKLYRTKSPEKWASLVTAAHAKAQ
                     YTQSKATPLAVREQTVEAARLLWPLLFSRLFEVTTLSGPRLPKTQLVLAINWKGMYFL
                     DQKERTLLGLSFAEVMGLVANRDAPGGKKLLLATLQEEYEFVSPSSVAIAEMVALFLG
                     GLKERSVFAMALQDRRATDDITLLPFKKGDLLILTKKQGLLASENWALGQNDRTGKTG
                     LVPTACLYTIPSVTKPSTQLLSLLAMSPEKRKLAAQEVRALEPPLEDQLTESPYTLEE
                     FSYQFFRAPEKETISRAAMPMARSRGHLWAYSPEPLRQPLLKSVHDKAKLRDAACQIF
                     LAILKYTGDYPSRQSWHSLELTDQMFSLALQDPALQDELYCQILKQLTHNSIRFSEER
                     AWQLLWLCTGLFPPGKTLLPHAQKFIDSRKKKPLALDCSRRLHRVLRVGPRKQPPHDV
                     EVKAAEQNVSKLHHEVYLPNDTSKSMEVGSSSRVRDLCEGIGTRLQLASWDGCSLFIK
                     ITDKVISLKEGDFFFDSLRQVSDWVKKNRPQKEGASVTLPYQVFFMRKLWLNVTPGKD
                     VNADTILHYHQELPKYLRGFHKCSREDAIHLGGLICKIQFGSDSSQLASVSKVLKELV
                     PQNLTRLMSSEEWKKSLLLECDKNKRKTVAEAKVEFLKYMYRWPTFGSAFFEVKQTSE
                     PSYPDILLIAINRHGLLLIHPKTKELLNTYPFTKISSWSSGNTYFHMALGSLGQGSRL
                     LCETSLGYKMDDLLTSYVQQLLNTVNKQRGFRAPAPANP"
     exon            101..214
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            215..367
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            368..552
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            553..674
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            675..817
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            818..931
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1085
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1162
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1282
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1425
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1636
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1772
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1936
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2074
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2227
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2326
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2421
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2506
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2725
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2896
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3106
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3265
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3393
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3520
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3640
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            3641..3814
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..4042
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            4043..4210
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4328
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4455
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4619
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            4620..4801
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            4802..4932
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            4933..5090
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            5091..5244
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            5245..5400
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            5401..5506
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            5507..5620
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            5621..5708
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            5709..5815
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            5816..6001
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            6002..6118
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            6119..6202
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            6203..6322
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     exon            6323..6591
                     /gene="Myo7b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6570..6575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo7b"
                     /note="hexamer: AATAAA"
     polyA_site      6588
                     /gene="Myo7b"
                     /note="major polyA site"
ORIGIN      
        1 gatctttcag ggtgcccagg gtgtagtcaa aagggctgct ctactctgat cttgacaagg
       61 ctgaaggaac tgctgacctg ggatgtccgt gttccggctg ggtgaccatg tgtggctgga
      121 ccctccctcc agcagcaaga ctggtgtggc cattgggggc attgtcaaag aaacaaaact
      181 gggaaagacc ttgattgagg atgacgaggg caaggaacac tgggtccatg cagaagacct
      241 cagcaccctc aggcctatgc accccaactc agcccaagga gtggatgaca tgatccgcct
      301 aggggacctg aatgaggctg gtgtggtgca caacctcctg atccggtacc agcagcacaa
      361 gatctatacc tacacaggct ccatcctggt ggctgtgaac ccattccaga tgctgcccct
      421 gtacaccctg gagcaggtac aaatctacta cagccgccac atgggcgagc tgcctcccca
      481 catcttcgcc attgccaaca gctgctactt caacatgaag aagaacaaga gggaccagtg
      541 ctgtatcatc agtggcgagt ctggggccgg gaagaccgag accaccaagc ttatccttca
      601 gttcctcgcc acggtcagtg gccagcattc gtggatcgag caacaggtcc tggaggccaa
      661 ccccatcctg gaagcctttg gcaatgccaa gaccatccgc aatgacaact ccagccgctt
      721 cgggaagtac attgacatcc acttcaattc tagtggggtg attgagggcg caagcattga
      781 acacttcctc ctggagaagt ccagagtctg ccggcaggct ccagaggaac gcaactacca
      841 catcttctac tgcatgctga tggggatgag cccggaagag aagcaaatgc tgagtctggg
      901 catgccctct gagtaccatt acctgaccat ggggagctgc acatcctccg aggggctcag
      961 cgatgccaag gactacgcac acgtccgctc ggccatgaag atcctccagt tctcagactc
     1021 agagaactgg gacatcagca agctgctggc agccatcctc cacctgggga atgtggggtt
     1081 catggctgca gtctttgaga acctggattc gtctgatgtg atggaaactc cagccttccc
     1141 cttggcaatg aagttgctag aggtgcagca ccaggctctc cgagactgtt tgatcaaaca
     1201 cacaatccct gtccttggag agtttgtctc caggcctgtg aacatcgccc aggctacaga
     1261 ccggagggat gcctttgtca agggcatcta tgggcgcctc ttccagtgga ttgtcaagaa
     1321 aatcaatgct gcgatcttca ctccccaagc ccaggatccc caaaatgtgc ggagggccat
     1381 cggtctcctg gacatatttg gctttgaaaa cttccagaac aatagctttg agcaactctg
     1441 catcaacttt gccaacgagc accttcagca attcttcgtg aagcacgtgt tcacgatgga
     1501 gcaggaagag tacctgtctg agaacatcac ctggaactac atccactaca ccgacaacca
     1561 gcccatcctg gacatgctgg ccctcaagcc catgagcatc atctctctcc tagatgagga
     1621 gagccgcttc ccacagggga cagatgtcac tatgctgcag aaactgaaca gtatccatgc
     1681 caacaacaag tccttcctga gccccaggag catccatgac acccgatttg ggatcgcaca
     1741 cttcgcgggc gatgtatact accaggcaga aggctttctg gagaagaatc gagatgtgct
     1801 gagcacagat atcctaatcc tgattcattc ctcgaaaaac aagtttctga aggagatatt
     1861 taacgtggac tcatcacaga ctaagctggg gcacggcacc atctgccagg tgaaggcagg
     1921 aagccagctc ttcaagtcat cagactccat caagcgcccc gtcaccctcg cgagccagtt
     1981 caagcagtct ctggaccagc tgatgagaat cctgaccaac tgccagccct attttgtccg
     2041 ctgcattaaa cccaatgagt acaagaagcc actgctgttt gaccgagagc tgtgcattca
     2101 gcagctgcgt tattccggca tgatggagac tgtgcacatc cgcaagtcag gttttcccat
     2161 ccgctacaca tttgatgagt tctcacagag attccgtgtg ctgctgccca gcccggagcg
     2221 tatgcagttt cagaacaagc cccgccagat gaccttgcac attgctgacc tatgcctggg
     2281 gacagacaaa gactggaaag tcggaaagac caaaatcttc ctgaaggatc atcaggacac
     2341 agtgctggag atccgcagga gccaggccct ggacggagca gcgatccgga tccagagagt
     2401 cctccgggga cacaagtaca ggaaggagtt cctgaggcag agacgtgcag ctgtgaccct
     2461 ccaggcaggg tggcgaggct atagccaaag aaagaatttc aagctgatcc tagtgggctt
     2521 tgaacgcctg caggccatcg cccggagcca cctgctgatg agacagttcc aggccatgcg
     2581 acagaggata gtgcagctgc aggcccgatg caggggctac ctggtgcgac agcaagtcca
     2641 ggccaagagg agggcagtgg tgatcattca agcacatgcc aggggcatgg ttgtccggaa
     2701 gagctactgg caacagaaaa gcactgggcc tcaggtcatt ctggctaagg aaccaaaggc
     2761 tcaagttgcg gtccatgaga ggaagcgtaa gtccatctat gacactgtca ctgacacagc
     2821 gatggtggag aaagtgtttg gcttcctccc agccatgatt ggaggtcagg agggtccagc
     2881 cccaacacgc tttgaggatc tggaagtaaa gacccagaaa cttcatgagg ttgatctgga
     2941 tacagtgccc atgatggcga tgccagaaga ggaggtggac agcctggctg agtatacctt
     3001 ccccaagttt gctgtgactt acttccagaa gtcagccagc cacacccaca tccagaagcc
     3061 ccttcgatac ccactcctct accatgaaaa tgacactgac cactcggctg ctctagatgt
     3121 ttggattatc atcctgaggt tcatgggtga ccttccagag ccagtggtct atggcaggaa
     3181 cagcctgact ggcagctcag tgatgcggca gatccatgac aaactgggca aggacagtgt
     3241 cactcagcac aacagatcct cacaggtggc cagccagctg aactttggtg aagaggcatt
     3301 caagtttgat ggccctatct cagacagacc catgtctaac ctagagaagg tgcacttcat
     3361 tgtgggctac gccatcatgc gtcctggact cagagatgaa atctactgtc agatctgcaa
     3421 gcagctctcc gagaactaca aaacaagtag ccgggcccgg ggctggatcc tgctcagcct
     3481 ctgtctggga tgcttcccac cctcagagag gttcatgaag tatctgctga atttcattag
     3541 tcaagggcca cccagctatg ggcccttctg tgctgaacgg ctgcaacgca ccttcgccaa
     3601 tggggtgcgc gcagaacccc ccacctggct ggagctgcag gctgtcaagt ccaagaagca
     3661 catcccgatc caggtcatcc tggcaaccgg aaggagcctg accatctctg tggactccgc
     3721 ctccacatca cgagaaatct gccagcacgt cgctcagaaa cagggtctca gggacaatct
     3781 gggcttctcc ctccaggtcg ctgtatatga taagttctgg tccttgggca gcggctgtga
     3841 ccatttgatg gatgctgtgg cccagtgtga gcaactggcc cgagagaggg gagagagcca
     3901 gcggcaggcc ccctggcgta tctacttccg gaaggagttc ttcaccccct ggcatgactc
     3961 ccaggaggac cctgtgagca ctgagctcat ttaccaccaa gtcctccgtg gggtgtggtc
     4021 tggcgagtat aactttgaga aggaggagga gcttgtggag ctgctggccc ggcactgcta
     4081 tgtgcagctt ggggccacgg tgaagagtaa cgctgtccag gagctgttgc ccagctgtgt
     4141 tccctccaaa ctgtaccgga ccaagtctcc agagaagtgg gctagccttg tcaccgctgc
     4201 ccatgccaag gcccagtata cccagtcgaa agccacgcca ctggcggtga gggagcagac
     4261 agtggaggct gcccgtcttc tgtggcccct gctcttctcc cggctatttg aagtcaccac
     4321 actctctggt ccccgccttc ccaagacgca gctggtttta gccattaact ggaaggggat
     4381 gtacttcctg gatcagaagg agaggacact gctggggttg tccttcgcag aggtcatggg
     4441 tctggtcgcc aacagggacg ccccaggagg gaagaagctg cttctcgcca cactccagga
     4501 agagtacgag ttcgtctccc ccagcagcgt ggctattgca gagatggtgg ccttgttctt
     4561 gggaggcttg aaggagagat ctgtgttcgc catggccctg caggacagaa gggccacaga
     4621 cgatatcacc cttctgccct tcaagaaagg tgacttactg atcctgacca agaaacaagg
     4681 actgttggcc tcagagaact gggctctggg tcagaatgac agaactggca agacagggct
     4741 ggtgcctact gcctgtctct acaccatccc ctcggtcacc aagccctcaa cccagctgct
     4801 gagcttgctg gccatgtcac cagagaaacg gaagctggca gcccaggagg tgcgggctct
     4861 ggagccacca ctggaggatc agctcacaga gtcgccatac accctggagg aattctccta
     4921 ccagttcttc agggctccgg agaaagagac tatcagcagg gctgcgatgc ccatggcccg
     4981 aagccggggt catctctggg cctactcccc agagccgctg cgccagccac tgctcaaatc
     5041 tgtccacgac aaagccaaac tgcgggatgc agcctgccag atcttccttg ccatcctcaa
     5101 gtacacaggt gactaccctt cccgccagtc ctggcacagc ctggagctca cagaccagat
     5161 gttctcgtta gccctgcagg acccagccct gcaggatgag ctgtactgcc agatcctgaa
     5221 gcagctgacc cacaactcca tcaggttcag tgaagagcga gcttggcagc tactctggct
     5281 ctgcacaggt ctcttcccac ctgggaagac attgctgccc cacgctcaga agttcataga
     5341 ctcccggaag aagaagccgc tggctctcga ctgtagccgc aggctccaca gggttctaag
     5401 ggtgggacct cggaagcagc ccccacatga tgtagaggtg aaagcggctg agcagaatgt
     5461 ctccaaatta caccatgagg tctacctccc caatgacacc agcaagtcca tggaagtggg
     5521 cagcagtagt cgggtgagag acctatgtga gggcataggc accaggctcc agctggcctc
     5581 ctgggatggc tgcagcctct tcatcaagat cacagacaag gtcatcagtc tgaaggaagg
     5641 agacttcttt tttgacagct tgaggcaggt atctgactgg gtgaagaaga acaggcccca
     5701 gaaagaaggg gcctccgtga cacttcccta tcaggtgttc ttcatgcgga aactgtggct
     5761 caacgtgacc cctgggaagg acgtgaatgc agacaccata ctccattacc accaggaact
     5821 acccaagtac ctccgcgggt ttcacaagtg ctcccgggaa gatgccatcc acctgggagg
     5881 tctcatctgt aaaatccagt ttggtagtga cagctcgcaa ctggctagtg tctcaaaggt
     5941 cctgaaggag ctggtacctc agaacctcac acgcctgatg tcctcagaag aatggaaaaa
     6001 gagcctcctt ctggaatgtg acaaaaacaa gcgcaagaca gtggcagagg ccaaagtgga
     6061 gttcttgaag tacatgtaca ggtggcccac ctttgggtct gccttctttg aggtgaagca
     6121 aacctctgag ccttcctacc cagacattct cctcatcgcc atcaaccgac atgggttact
     6181 gctcatccac cccaagacca aggagctgct gaacacctac cctttcacca agatctccag
     6241 ctggagtagt ggcaacacct atttccacat ggcactgggg agcctgggcc agggcagccg
     6301 tttgctgtgt gagacctctc tgggttacaa gatggacgac ctgctgacct catatgtaca
     6361 gcagctcctg aatacagtga acaaacagcg gggcttcagg gctcccgccc cggccaaccc
     6421 ctaacaggtc ccatctgcac acaagccttc cacgctggcc ttctaccccc ttctcagcac
     6481 gcctgagtgc ccctcctggg tgtttcctgc agaggccaag caaggtctcc agcctcctca
     6541 cagatggtgg gtaactcccc tgaatctgca ataaaaatgc acctagcaga a
//
