LOCUS       NM_008663               7361 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus myosin VIIA (Myo7a), transcript variant 2, mRNA.
ACCESSION   NM_008663
VERSION     NM_008663.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7361)
  AUTHORS   Underhill,A., Webb,S., Grandi,F.C., Jeng,J.Y., de Monvel,J.B.,
            Plion,B., Carlton,A.J., Amariutei,A.E., Voulgari,N., De Faveri,F.,
            Ceriani,F., Mustapha,M., Johnson,S.L., Safieddine,S., Kros,C.J. and
            Marcotti,W.
  TITLE     MYO7A is required for the functional integrity of the
            mechanoelectrical transduction complex in hair cells of the adult
            cochlea
  JOURNAL   Proc Natl Acad Sci U S A 122 (1), e2414707122 (2025)
   PUBMED   39746042
REFERENCE   2  (bases 1 to 7361)
  AUTHORS   O'Connor,A.P., Amariutei,A.E., Zanella,A., Hool,S.A., Carlton,A.J.,
            Kong,F., Saenz-Roldan,M., Jeng,J.Y., Lecomte,M.J., Johnson,S.L.,
            Safieddine,S. and Marcotti,W.
  TITLE     In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic
            efferent innervation in inner hair cells
  JOURNAL   JCI Insight 9 (23), e182138 (2024)
   PUBMED   39641274
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7361)
  AUTHORS   Fritzsch,B., Weng,X., Yamoah,E.N., Qin,T., Hui,C.C.,
            Lebron-Mora,L., Pavlinkova,G. and Sham,M.H.
  TITLE     Irx3/5 Null Deletion in Mice Blocks Cochlea-Saccule Segregation and
            Disrupts the Auditory Tonotopic Map
  JOURNAL   J Comp Neurol 532 (12), e70008 (2024)
   PUBMED   39655644
REFERENCE   4  (bases 1 to 7361)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   5  (bases 1 to 7361)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (bases 1 to 7361)
  AUTHORS   Brown,K.A., Sutcliffe,M.J., Steel,K.P. and Brown,S.D.
  TITLE     Close linkage of the olfactory marker protein gene to the mouse
            deafness mutation shaker-1
  JOURNAL   Genomics 13 (1), 189-193 (1992)
   PUBMED   1349573
REFERENCE   7  (bases 1 to 7361)
  AUTHORS   Rinchik,E.M., Johnson,D.K., Margolis,F.L., Jackson,I.J.,
            Russell,L.B. and Carpenter,D.A.
  TITLE     Reverse genetics in the mouse and its application to the study of
            deafness
  JOURNAL   Ann N Y Acad Sci 630, 80-92 (1991)
   PUBMED   1952626
REFERENCE   8  (bases 1 to 7361)
  AUTHORS   MacSwiney,F.J. and Wallace,M.E.
  TITLE     Genetics of warfarin-resistance in house mice of three separate
            localities
  JOURNAL   J Hyg (Lond) 80 (1), 69-75 (1978)
   PUBMED   621381
REFERENCE   9  (bases 1 to 7361)
  AUTHORS   Eicher,E.M. and Coleman,D.I.
  TITLE     Influence of gene duplication and X-inactivation on mouse
            mitochondrial malic enzyme activity and electrophoretic patterns
  JOURNAL   Genetics 85 (4), 647-658 (1977)
   PUBMED   863237
REFERENCE   10 (bases 1 to 7361)
  AUTHORS   Wallace,M.E. and MacSwiney,F.J.
  TITLE     A major gene controlling warfarin-resistance in the house mouse
  JOURNAL   J Hyg (Lond) 76 (2), 173-181 (1976)
   PUBMED   1063212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115022.11, AY821853.1 and AC157792.4.
            
            On Oct 4, 2006 this sequence version replaced NM_008663.1.
            
            Transcript Variant: This variant (2) lacks an in-frame segment in
            the coding region, compared to variant 1. The resulting isoform (2)
            is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMN00849374,
                              SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AC115022.11        298-515
            219-278             AC115022.11        2016-2075
            279-6784            AY821853.1         115-6620
            6785-7361           AC157792.4         154105-154681       c
FEATURES             Location/Qualifiers
     source          1..7361
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.57 cM"
     gene            1..7361
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /note="myosin VIIA"
                     /db_xref="GeneID:17921"
                     /db_xref="MGI:MGI:104510"
     exon            1..218
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            219..278
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            279..392
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            393..545
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            546..730
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            731..852
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            853..995
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1109
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1263
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1340
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1460
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1603
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1814
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1950
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2057
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2195
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2354
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2447
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2542
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2627
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2846
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2954
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3164
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3368
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3545
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3635
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3763
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..3890
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4010
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4184
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            4185..4412
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            4413..4583
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            4584..4701
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            4702..4828
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            4829..4998
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5189
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5190..5314
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5315..5472
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5473..5626
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5627..5782
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5783..5888
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5889..6002
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            6003..6090
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            6091..6197
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            6198..6383
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            6384..6500
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            6501..6584
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            6585..6704
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     exon            6705..7361
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7342..7347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /note="hexamer: CATAAA"
     polyA_site      7361
                     /gene="Myo7a"
                     /gene_synonym="Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B"
                     /note="major polyA site"
ORIGIN      
        1 agtgcaggct ggacagctgc cctgaacaga aagaaagagt gacccaggga gacaagaaac
       61 agagtagccc aagggaagcc cacagcagca gcagatcaag gctcaagctg gagctgaaaa
      121 tttgcaggct ccagcctcag cttccagagt cctcctgacc tgtgacccct ggctcctggc
      181 tgggaggtgg tgactcggag ggtgtggata aaacccagag ctgtgtctgg tcactccggc
      241 aggtgtgctg acgtagaagc atggttattc tgcagaaggg ggactatgta tggatggacc
      301 tgaagtcagg ccaggagttt gatgtgccca tcggggccgt ggtgaagctc tgcgactcgg
      361 gccagatcca ggtggtggat gatgaagaca atgaacactg gatatcccct cagaatgcca
      421 cgcacatcaa gccaatgcac cccacatcgg tgcacggcgt ggaggacatg atccgcctgg
      481 gggatctcaa cgaggcaggc atccttcgaa accttctcat tcgctaccgg gaccacctca
      541 tctatacgta cacaggttcc atcctggtgg ccgtgaaccc ctaccagctg ctctccatct
      601 actcgccaga gcacatccgc cagtacacca acaagaagat aggggagatg cccccccaca
      661 tcttcgccat tgctgacaac tgctacttca acatgaaacg caacaaccgg gaccagtgct
      721 gtattatcag cggggagtcg ggagctggca agacagagag cacaaagttg atcctgcagt
      781 tcctggcagc catcagtgga cagcactcat ggatcgagca gcaggtgctg gaggccaccc
      841 cgatcctgga agcatttggg aacgccaaga ccatccgcaa cgacaactct agccgctttg
      901 gcaagtacat tgacatccac tttaacaagc gtggtgccat cgagggcgcc aaaatagagc
      961 aatacctgct ggagaagtca cgtgtctgcc gccaggcccc tgacgagagg aactatcacg
     1021 tgttctactg tatgctggag ggcatgaatg aggaggagaa gaagaaactg ggcctaggcc
     1081 aggccgctga ctacaactac ttggccatgg gtaactgcat cacctgtgag ggccgcgtgg
     1141 acagtcagga gtatgccaac atccgctctg ccatgaaggt tctcatgttc acagacacgg
     1201 agaactggga gatctcgaag cttctggctg ccatcctaca catgggcaat ctgcagtatg
     1261 aggcccggac atttgagaac ttggatgcgt gtgaagtcct cttctcccca tcgctggcca
     1321 cggcagcttc tctgctcgag gtgaaccccc cagacctgat gagctgcctc accagccgca
     1381 ccctcatcac ccgtggggag acggtgtcca cccctctcag cagggaacag gcgctggatg
     1441 tgcgagatgc ctttgtcaag ggcatctatg ggcggctctt tgtgtggatt gtggagaaga
     1501 tcaacgcagc aatctacaag ccaccccccc tggaagtgaa gaactctcgc cggtccatcg
     1561 gtctcctgga catctttgga tttgagaact tcactgtgaa cagcttcgag cagctctgca
     1621 ttaactttgc caatgagcac ctgcagcaat tcttcgtgcg gcacgtgttc aagctggagc
     1681 aggaggagta cgacctggag agcatcgact ggttgcacat tgagttcact gacaaccagg
     1741 aagcactgga catgattgcc aaccggccta tgaacgtcat ctccctcatc gatgaggaga
     1801 gcaagttccc caagggcacg gatgccacca tgctgcataa gctgaactca cagcacaagc
     1861 tcaatgccaa ctacgtgcca cccaagaaca gccacgagac ccagtttgga atcaaccact
     1921 ttgcgggtgt tgtctattat gagagtcaag gcttcctgga gaagaaccga gacaccctgc
     1981 atggggacat catccagctg gtccactctt cccggaacaa gttcataaag cagattttcc
     2041 aagctgacgt tgccatgggt gccgagacca ggaagcgctc gcctacactc agcagccagt
     2101 tcaagcggtc tctggagctg ctgatgcgca cactgggcgc ctgccagccc ttctttgtgc
     2161 gttgtatcaa acccaatgag ttcaagaagc ccatgctctt cgaccggcac ttgtgtgtac
     2221 gccagctgcg atattcgggc atgatggaga caatccgcat ccgccacgca ggctacccca
     2281 ttcgctacag ctttgtggag tttgtggagc gctaccgggt actgctgcct ggtgtgaagc
     2341 cagcatacaa gcagggtgac ctccgaggga catgccagcg catggctgag gctgtgctgg
     2401 gcacgcacga tgactggcag attggcaaaa ccaagatctt tctgaaggac caccatgaca
     2461 tgttgctgga ggtggagcgg gacaaggcca tcacagacag agtcattctc ctccagaagg
     2521 ttatccgggg cttcaaagac aggtccaact tcctgagact gaagagtgct gccacactga
     2581 tccagaggca ctggcggggc caccactgta ggaaaaacta tgagctgatt cgtcttggct
     2641 tcctgcggct gcaggccctg caccgctccc ggaagctgca caagcagtac cgcctggcca
     2701 gacagcgcat aatagagttc caggcccgct gccgggccta tctggtgcgc aaggccttcc
     2761 gccaccgcct ctgggccgtg atcaccgtgc aggcctatgc ccgaggcatg attgcccgcc
     2821 ggctacaccg ccgcctccgg gttgagtacc agcggcgcct cgaggcagag aggatgcgtc
     2881 tggcagagga ggagaaactc cgaaaggaga tgagtgccaa gaaggccaaa gaggaggctg
     2941 agcgcaagca tcaggagcgc ctggctcagc tagcccgcga ggatgcggag cgggaactga
     3001 aggagaagga ggaggctcgg aggaagaagg aactgctgga gcagatggag aaggcccgcc
     3061 acgaacccat caaccactca gatatggtgg acaagatgtt tggcttcctg gggacttcag
     3121 gcagcctgcc aggccaggaa ggccaggcgc ctagtggctt tgaggaccta gagcgcggac
     3181 ggagggagat ggtggaagag gatgttgacg ctgccctgcc cctgcctgat gaagacgagg
     3241 aggacctttc tgagtacaaa ttcgccaagt ttgctgccac ctacttccag ggcacaacca
     3301 cacactccta cacccggagg cctctcaagc agccgctgct ctaccacgac gatgagggtg
     3361 accagctggc ggcgctggct gtctggatca ccatcctccg gttcatgggg gacctcccag
     3421 agcccaagta ccacacagcc atgagcgacg gcagtgagaa gatcccagtg atgactaaga
     3481 tctacgagac cctaggcaag aagacatata agagggagct gcaggccttg cagggcgagg
     3541 gcgagaccca gctccctgag gggcagaaga agaccagtgt gagacacaag ttggtacact
     3601 tgacactgaa gaaaaagtcc aaactcacag aagaggtgac caagaggctg aacgatgggg
     3661 aatccacggt acagggcaac agcatgctgg aggatcggcc cacctcaaat ctagagaagc
     3721 tgcacttcat catcggcaac ggcatcctgc ggcctgcgct gcgggacgag atttactgcc
     3781 agatcagtaa gcagctcaca cacaacccat ccaagagcag ctatgccagg ggctggatcc
     3841 tcgtgtcgct ctgtgtgggc tgcttcgccc cctctgagaa gttcgttaag tacctgcgga
     3901 acttcatcca cggaggccca cctggctatg ctccttactg tgaggagcgc ctgaggagga
     3961 cctttgtcaa cggaactcgg acacagccac ccagctggct ggagctgcag gccaccaagt
     4021 ccaagaagcc catcatgttg cccgtgacct tcatggatgg gaccaccaag accctgctaa
     4081 cagattcagc aactacagcc agggagctgt gcaatgctct ggctgacaag atctcactca
     4141 aggaccgctt tggcttctcc ctctacatcg ctctgttcga taaggtgtcc tccctgggca
     4201 gcggcagtga ccatgtcatg gatgccatct ctcagtgtga gcagtacgcc aaggagcagg
     4261 gtgctcagga gcgcaacgcc ccatggaggc tcttctttag aaaggaggtc ttcacaccct
     4321 ggcacaaccc ctcggaggac aacgtggcca cgaacctcat ctaccagcag gtggtgcgag
     4381 gagtcaagtt tggggagtac aggtgtgaga aggaggacga cctggctgag ctggcttctc
     4441 agcagtactt tgtggactat ggttctgaga tgattctgga gcgcctgctg agcctcgtgc
     4501 ccacttacat ccctgaccgt gagatcacac cgctgaagaa tcttgagaag tgggcacagc
     4561 tggccattgc tgcccacaag aagggaattt atgcccagag gagaactgac tcccagaagg
     4621 tcaaagagga tgtggtcaat tatgcccgtt tcaagtggcc cttgctcttc tccaggtttt
     4681 acgaagctta caaattctca ggccctcccc tccccaagag cgacgtcatc gtggctgtca
     4741 actggacggg tgtgtacttc gtggacgagc aggagcaggt gcttctggag ctgtccttcc
     4801 cggagatcat ggctgtgtcc agcagtaggg gaacaaagat gatggccccc agctttaccc
     4861 tggccaccat caaaggagat gagtacacct tcacatccag caatgctgag gacatccgtg
     4921 acctggtggt cacctttctg gaggggctac ggaagaggtc taagtatgtg gtggcactgc
     4981 aggacaatcc taaccctgct ggtgaggagt caggcttcct cagcttcgcc aagggagacc
     5041 tcatcatcct tgaccatgat actggtgagc aggtcatgaa ctcaggctgg gccaacggca
     5101 tcaacgagag gaccaagcag cgcggcgact tccccactga ctgtgtatac gtcatgccca
     5161 ctgtcacctt gccaccaagg gagattgtgg ccctggtcac tatgacccca gaccagaggc
     5221 aggatgtcgt ccggctcctg cagcttcgca cagcagagcc agaggtgcgc gccaagccct
     5281 acacgctaga ggagttctcc tacgactact tcaggccccc acccaagcac acgctgagcc
     5341 gtgtcatggt gtccaaggcc cgcggtaagg acaggctgtg gagccacaca cgagagcccc
     5401 tcaagcaggc cctgctcaag aagatcctgg gcagtgaaga actctcccag gaagcctgca
     5461 tggcctttgt agctgtgctc aagtacatgg gcgactaccc atccaagagg atgcgatccg
     5521 tcaatgagct cactgaccag atctttgagt gggcactcaa ggctgagccc ctcaaggatg
     5581 aggcctacgt gcagatcctg aagcagctga ctgacaatca catcaggtac agcgaagaga
     5641 ggggctggga actgctgtgg ctgtgcacgg gcctcttccc gcccagcaac atcctcctgc
     5701 ctcatgttca gcggtttctg cagtcccgca agcactgtcc tcttgccatt gactgcctgc
     5761 agaggctcca gaaagccctg agaaatggct cccggaagta ccctccgcac ctggtggagg
     5821 tggaggccat ccaacataag actacccaga tcttccacaa ggtctacttc cccgatgaca
     5881 cggacgaggc ttttgaggtg gagtccagca ccaaggccaa ggacttctgc cagaacatcg
     5941 ccagccggct gctgctcaag tcttccgagg gattcagcct ttttgtcaaa atcgcagata
     6001 aggtcatcag cgtcccagag aatgatttct tctttgactt tgtccgacac ctgacagact
     6061 ggataaagaa agcacggccc atcaaggacg gaatcgtgcc ctcactaacc taccaggtgt
     6121 tcttcatgaa gaagctgtgg accaccacag tgccgggcaa ggaccccatg gctgactcca
     6181 tcttccacta ttaccaggaa ctgcccaaat atctccgagg ctaccacaag tgcacccggg
     6241 aggaggtgct gcagctgggc gcactcatct acagggtcaa gtttgaggag gacaaatcct
     6301 acttccctag catccccaag ttgctgaggg agctggtacc ccaggaccta atccggcagg
     6361 tctcacctga tgactggaaa cggtctattg tcgcctactt caacaaacat gcggggaagt
     6421 ccaaggagga agccaagctg gccttcctca aactcatctt caagtggccc acctttggct
     6481 cagccttctt tgaggtgaag caaactacag aaccaaactt cccagagatt ctcttaattg
     6541 ccatcaacaa gtacggggtc agcctcatcg atcccagaac caaggacatc ctgactactc
     6601 accccttcac caagatctcc aactggagta gtggcaacac ctacttccac atcaccattg
     6661 ggaacttggt ccgtgggagc aaactgctct gtgagacatc gctgggatac aaaatggatg
     6721 atcttctgac ttcctacatc agccagatgc tcacagccat gagcaagcag aggaactcca
     6781 ggagtggaag gtgaacctca gaggagacgc tggctcaggc cttggccctc taggcaggga
     6841 agctggactg accatatctg ctgggcatct gatctgcctg ccacgaggtc cagactcttc
     6901 tgcatccacc tatggcatct gggtttgctg tcaccctact ttgttgtggc cttcctggtg
     6961 taagagtctg tgttccttgg tcacctctcc tgattcagac cagctccatc aagcaacctc
     7021 ttttgacttt ctgtatatgg atggcacaga ggaatcaagg acaacttagc tctctgcata
     7081 cttggaacaa ccaaactatt tgtacattga acggatgctc tgaaacccaa gggactgggc
     7141 tcagggtcct cagcactggc ccctgtcata agcactacca ctaaggactc tctggaggac
     7201 tcctcagtat catctgctcc aggaagcccc ctagactacc tcctgagtct ggacaaagcc
     7261 tcctgattct acctggatca ctcctgttat gtgacagtta tgtggtgggt ccctgctaaa
     7321 atctccctga ccacctgagg gcataaagca tgtgtcttat t
//
