LOCUS       NM_001408252            7958 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus myosin VI (Myo6), transcript variant 1, mRNA.
ACCESSION   NM_001408252 XM_006510835
VERSION     NM_001408252.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7958)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 7958)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   3  (bases 1 to 7958)
  AUTHORS   Young,C.A., Burt,E. and Munnamalai,V.
  TITLE     A cochlear progenitor pool influences patterning of the mammalian
            sensory epithelium via MYBL2
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39254648
REFERENCE   4  (bases 1 to 7958)
  AUTHORS   Beaulac,H.J. and Munnamalai,V.
  TITLE     Localization of cadherins in the postnatal cochlear epithelium and
            their relation to space formation
  JOURNAL   Dev Dyn 253 (8), 771-780 (2024)
   PUBMED   38264972
REFERENCE   5  (bases 1 to 7958)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 7958)
  AUTHORS   West,M.F., Verrotti,A.C., Salles,F.J., Tsirka,S.E. and
            Strickland,S.
  TITLE     Isolation and characterization of two novel, cytoplasmically
            polyadenylated, oocyte-specific, mouse maternal RNAs
  JOURNAL   Dev Biol 175 (1), 132-141 (1996)
   PUBMED   8608859
REFERENCE   7  (bases 1 to 7958)
  AUTHORS   Gillespie,P.G.
  TITLE     Deaf and dizzy mice with mutated myosin motors
  JOURNAL   Nat Med 2 (1), 27-29 (1996)
   PUBMED   8564830
  REMARK    Review article
REFERENCE   8  (bases 1 to 7958)
  AUTHORS   Avraham,K.B., Hasson,T., Steel,K.P., Kingsley,D.M., Russell,L.B.,
            Mooseker,M.S., Copeland,N.G. and Jenkins,N.A.
  TITLE     The mouse Snell's waltzer deafness gene encodes an unconventional
            myosin required for structural integrity of inner ear hair cells
  JOURNAL   Nat Genet 11 (4), 369-375 (1995)
   PUBMED   7493015
REFERENCE   9  (bases 1 to 7958)
  AUTHORS   Russell,L.B.
  TITLE     Definition of functional units in a small chromosomal segment of
            the mouse and its use in interpreting the nature of
            radiation-induced mutations
  JOURNAL   Mutat Res 11 (1), 107-123 (1971)
   PUBMED   5556347
REFERENCE   10 (bases 1 to 7958)
  AUTHORS   Deol,M.S. and Green,M.C.
  TITLE     Snell's waltzer, a new mutation affecting behaviour and the inner
            ear in the mouse
  JOURNAL   Genet Res 8 (3), 339-345 (1966)
   PUBMED   5980120
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159738.2 and AC120388.11.
            
            On Jun 14, 2022 this sequence version replaced XM_006510835.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC159738.2         50283-50472
            191-332             AC159738.2         102859-103000
            333-402             AC159738.2         106261-106330
            403-476             AC159738.2         111435-111508
            477-606             AC159738.2         114101-114230
            607-712             AC159738.2         127408-127513
            713-768             AC159738.2         130378-130433
            769-866             AC159738.2         130883-130980
            867-1031            AC159738.2         131638-131802
            1032-1112           AC159738.2         137010-137090
            1113-1293           AC159738.2         140123-140303
            1294-1438           AC159738.2         143656-143800
            1439-1596           AC159738.2         146022-146179
            1597-1679           AC159738.2         147517-147599
            1680-1688           AC120388.11        117619-117627       c
            1689-1761           AC120388.11        115720-115792       c
            1762-1889           AC120388.11        113731-113858       c
            1890-1985           AC120388.11        110262-110357       c
            1986-2159           AC120388.11        109817-109990       c
            2160-2198           AC120388.11        106023-106061       c
            2199-2292           AC120388.11        103583-103676       c
            2293-2423           AC120388.11        98393-98523         c
            2424-2501           AC120388.11        98224-98301         c
            2502-2631           AC120388.11        96400-96529         c
            2632-2722           AC120388.11        94163-94253         c
            2723-2873           AC120388.11        93552-93702         c
            2874-3082           AC120388.11        91768-91976         c
            3083-3161           AC120388.11        90040-90118         c
            3162-3322           AC120388.11        87467-87627         c
            3323-3349           AC120388.11        86431-86457         c
            3350-3379           AC120388.11        86010-86039         c
            3380-3418           AC120388.11        83303-83341         c
            3419-3522           AC120388.11        80735-80838         c
            3523-3654           AC120388.11        79318-79449         c
            3655-3681           AC120388.11        76685-76711         c
            3682-3900           AC120388.11        72806-73024         c
            3901-7958           AC120388.11        68255-72312         c
FEATURES             Location/Qualifiers
     source          1..7958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.98 cM"
     gene            1..7958
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /note="myosin VI"
                     /db_xref="GeneID:17920"
                     /db_xref="MGI:MGI:104785"
     exon            1..190
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            191..332
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..4100
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /note="isoform 1 is encoded by transcript variant 1;
                     unconventional myosin-6; tailchaser; Snell's waltzer;
                     unconventional myosin-VI; protein twist"
                     /codon_start=1
                     /product="unconventional myosin-VI isoform 1"
                     /protein_id="NP_001395181.1"
                     /db_xref="GeneID:17920"
                     /db_xref="MGI:MGI:104785"
                     /translation="MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLAL
                     INQVFPAEEDSKKDVEDNCSLMYLNEATLLHNVKVRYSKDRIYTYVANILIAVNPYFD
                     IPKIYSSDTIKSYQGKSLGTMPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTEN
                     TKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKS
                     SVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNR
                     GCTRFFANKETDKQILQNRKSPEYVKAGSLKDPLLDDHGDFIRMCTAMKKIGLDDEEK
                     LDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKSAPSLEYCAELLGLDQDDLRVSLTT
                     RVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSY
                     FIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHY
                     VDNQDCIDLIEVKLVGILDILDEENRLPQPSDQHFTSVVHQKHKDHFRLTIPRKSKLA
                     VHRNLRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRALFESS
                     TNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEG
                     AQILSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKYMPEKLARLDPRLFCKALFK
                     ALGLNEVDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNLWLVCSRWKKVQW
                     CSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKKRLDKFNEV
                     VSALKDGKPEVNRQIKNLEISIDALMAKIKSTMMTREQIQKEYDALVKSSEDLLSALQ
                     KKKQQEEEAERLRRIQEEMEKERKRREEDEERRRKEEEERRMKLEMEAKRKQEEEERK
                     KREDDEKRIQAEVEAQLARQREEESQQQAVLAQECRDRELALRIAQNESELISDEAQG
                     DMALRSLSSCPATSKTNGTRPQMTPEQMAKEMSEILSRGPAVQATKAAAGTKKHDLSK
                     WKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDY
                     DFAPFLNNSPQQNPAAQLPARQQEIDMKRQQRFFRIPFIRPADQYKDPQNKKKGWWYA
                     HFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIW
                     ERCGGIQYLQSAIESRQARPTYATAMLQNLLK"
     exon            333..402
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            403..476
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            477..606
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            607..712
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            713..768
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            769..866
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1031
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1112
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1293
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1438
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1596
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1688
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1761
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1889
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1985
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2159
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2198
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2292
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2423
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2501
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2631
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2722
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2873
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3082
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3161
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3322
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3349
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3379
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3418
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3522
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3654
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3681
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3682..3900
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..7958
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5596..5601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /note="hexamer: AATAAA"
     polyA_site      5622
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /note="major polyA site"
     regulatory      7934..7939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
                     /note="hexamer: AATAAA"
     polyA_site      7958
                     /gene="Myo6"
                     /gene_synonym="Myo6<rsv>; rsv; sv; Tlc"
ORIGIN      
        1 actctgcagg gctctctggc cggcgggtgg agaccgatcc gggatctgtc ccagcaggaa
       61 gcgtatcccg gccgccgtcg tgctgtcgtc tccggtgctc gctctcggcc gcggtgtcgc
      121 gcttgccctt cgcgcccgca gcccggcagc ctctccacgg ccgcgacccc tcgcgcacct
      181 gcctcgccgg gagatagtgg ataacctcct tcaaaatgga agatggaaag cccgtttggg
      241 caccccaccc cacagatgga tttcagatgg gcaatattgt ggatattggc cctgacagct
      301 taacaattga acctttgaac caaaaaggca agacattttt ggctctcata aaccaagtat
      361 ttcctgcaga agaggacagc aaaaaagatg tggaagataa ctgttcactg atgtacttaa
      421 atgaagccac actcctccac aatgtcaaag ttcggtacag taaagacaga atctatacat
      481 atgtggccaa cattctgatt gcagtgaatc catactttga tatacctaag atatattctt
      541 cagatacaat aaagtcatat caaggaaaat ctcttgggac gatgccaccc catgtctttg
      601 ccattgctga taaagctttc cgagacatga aggtgctcaa gatgagccag tctatcatcg
      661 tatctggaga atcaggagct ggcaaaacag aaaatacaaa gtttgttcta agatacctga
      721 cagaatctta tggaacaggt caagatattg atgatagaat tgttgaagcg aatccacttt
      781 tagaagcatt tggaaatgca aagactgttc gcaacaataa tagcagtcga tttggaaaat
      841 ttgtagaaat tcatttcaat gaaaagagtt cggttgttgg aggatttgtt tcccattacc
      901 ttctagagaa gtctaggatc tgtgttcaag gcaaagagga gcggaattac catattttct
      961 acaggctctg tgctggggct tcagaagaca tcagggagaa gcttcacttg agctccccag
     1021 ataatttccg gtatttaaac cggggctgca ctagattctt cgctaacaaa gaaacggaca
     1081 aacagatttt acagaaccga aaaagtcctg agtatgttaa ggcaggttcc ttgaaggatc
     1141 ctctattaga cgaccatgga gattttatca ggatgtgcac agccatgaaa aaaattggtt
     1201 tggatgatga agaaaaactt gatctgtttc gagttgtagc tggtgtcctg caccttggaa
     1261 atattgattt tgaggaagcc ggaagcactt caggtggctg caatctgaag aacaaatctg
     1321 ccccatccct ggaatactgt gctgagctgc tgggcttgga ccaagatgat cttcgagtca
     1381 gtttaaccac tcgagtcatg ctcaccacag cagggggcac caaaggaacc gttataaagg
     1441 tccccctgaa agtggagcag gcaaacaatg ctcgcgatgc tctggcaaag actgtctata
     1501 gccatctctt tgatcacgtg gtgaacaggg taaatcagtg ctttcctttt gaaacatctt
     1561 cttattttat tggagtcctg gatattgctg gtttcgagta ctttgagcac aacagcttcg
     1621 agcaattttg tatcaactat tgcaatgaga aactccaaca gttttttaat gaaaggatcc
     1681 tgaaggagga acaagaactg tatcagaaag agggcctggg tgttaatgaa gtccattacg
     1741 tggacaatca ggactgcata gatttaatcg aagtgaagtt agtggggatc ctggatattc
     1801 tggatgaaga aaatcgtctt ccccagccga gtgaccagca cttcacgtct gtggttcacc
     1861 agaagcacaa agaccacttc cggctcacta ttcccaggaa atctaagctg gcagtccaca
     1921 ggaacctcag agacgatgaa ggctttatca tcaggcactt tgcaggggcc gtgtgctacg
     1981 agacaaccca gtttgtggag aaaaataatg atgcactaca tatgtctctt gaatccttga
     2041 tatgtgagtc cagggataag tttataaggg cattatttga gtcatctaca aataacaaca
     2101 aagatacgaa acagaaggct ggaaaactta gcttcatcag cgtgggaaac aagttcaaga
     2161 cacaattaaa tttgcttctg gataaacttc gaagtaccgg agccagcttc atccgctgca
     2221 tcaaacccaa cttaaagatg acgagtcacc acttcgaagg cgcccagatt ctgtctcaac
     2281 ttcagtgttc aggtatggtg tctgtgttgg acctaatgca agggggtttc ccttcaagag
     2341 cctcgttcca tgaactctat aacatgtaca agaagtacat gccagaaaaa cttgcaagat
     2401 tggatccgag gttattttgt aaggctcttt ttaaagcttt gggattaaat gaagttgact
     2461 acaagtttgg gctgacaaaa gtatttttca gacctggcaa gtttgcagaa tttgatcaga
     2521 ttatgaagtc tgaccctgat cacttagcag agttggtgaa aagagtcaac ctgtggctag
     2581 tctgtagtcg ctggaagaaa gttcagtggt gttcactgtc agtcatcaag ctgaaaaaca
     2641 aaataaaata tcgagctgaa gcatgcatta aaatgcagaa aaccatccga atgtggcttt
     2701 gcaaaaggag gcacaaacca cgcattgacg gcctggttaa ggtgggcaca ctcaagaaac
     2761 gactcgataa gttcaatgaa gtcgtaagtg cgctgaaaga tgggaagccg gaggtgaaca
     2821 gacagatcaa aaatcttgaa atttctattg atgctctaat ggccaaaatt aagtccacca
     2881 tgatgacgag ggagcagata cagaaagagt atgatgcact tgttaaaagc tcagaagatc
     2941 tcctcagtgc actgcagaaa aagaaacagc aagaggagga ggccgagagg ctgaggcgca
     3001 tccaggagga gatggagaaa gaaaggaaga ggcgtgaaga agatgaggaa cgtcggcgga
     3061 aggaggaaga ggagaggcgg atgaaacttg agatggaagc gaagagaaaa caagaagagg
     3121 aagaaaggaa gaagcgggaa gatgatgaaa agcgaatcca ggctgaggtg gaggcacagc
     3181 tggcaagaca gcgggaggag gagtcccagc agcaggcggt cctggcccag gagtgcaggg
     3241 acagggagtt ggccctgcgc atcgcccaga acgagtcgga gctcatcagc gatgaggcac
     3301 agggtgacat ggcactccga agcttgagtt cctgtccagc aacttctaaa actaatggaa
     3361 caagacccca aatgacaccg gaacaaatgg ccaaagaaat gtcagaaatt ttgagtagag
     3421 gtcctgcggt gcaagctacc aaggctgctg ctggtaccaa gaaacatgat ctcagtaaat
     3481 ggaaatacgc agaactacgc gatacaatca atacttcctg tgacattgag ctcctggcag
     3541 cttgcagaga agagtttcac aggagactga aagtgtatca tgcttggaaa tccaagaaca
     3601 agaaaagaaa cactgagacc gagcagcgcg ctcccaagtc ggttactgat tatgattttg
     3661 caccattttt gaacaattca cctcagcaga atcccgcagc tcagctccct gccaggcagc
     3721 aggagattga catgaaacga cagcagcgtt tcttccgcat ccccttcatc cgccctgcgg
     3781 accagtacaa agaccctcag aacaagaaaa agggctggtg gtatgcccat tttgacggac
     3841 cctggattgc tcggcagatg gagctgcacc ctgacaagcc acccatcctt cttgtagctg
     3901 gcaaggatga catggagatg tgtgagctga atctcgagga gacgggtctg actcgcaagc
     3961 gtggtgctga gatcttgccc agacagtttg aagagatctg ggagcgttgt ggaggcatcc
     4021 agtaccttca gagcgccatt gagagcaggc aggcccggcc cacctatgct acggccatgc
     4081 tgcagaacct gctcaagtag accgcagggt tccagcccag ccccgaccct cccaggtgga
     4141 gaggtgaccc gaaggctcac cacttccttg ctcctggtag aaatgcctta tgcaaagcga
     4201 acagatttta ttaatcatgg attttgttaa tttgttcaag gttaattaag gttgaggtag
     4261 tggattcagg acctacagaa agaaaagccc tgattccagc agcgcccctc ccttgcctgc
     4321 tctgttgcgg ggctttctgc acccagacag acgctgataa ttcttgctct gcacactgac
     4381 caccttattg ctgagtattg tcaaggacaa gacttttttt ttttaattca aaacatttga
     4441 ctttttaaag gaaaggatgt cacagtgtct ttataaccga gataatgaaa tcttagctta
     4501 attttgtgca agaattaagg tacttgaatt gattaaggca cagatgtgtt tggtctaaaa
     4561 ggctgtattt tgtctgcttt ttcacaaatc tatggaaatt gatttcccca tcttgcagtg
     4621 tgcttagcgc ccacgatccc caagttctag aattctggaa agagccttca tgtatggaat
     4681 gtcttctgtg cagaggaggt gctcagcata ggcggctcag acacggggtg cttctctacc
     4741 acgctctgtg ttaccctggg gacccctctt cctaatccac gtttgagtaa aggatgtttg
     4801 gattccttgg atgactggag tttttgatac aactttgttt cattttggaa gggatgcagg
     4861 gttaaggtgg tgttctgtga ctctattgga ctgaattcca atatttttcc cacttcatct
     4921 caactgcagt ctctcagttt gaaccttgtc caagttattt catgtcactt aagctggtgt
     4981 actgcttcgg acagctctct tgcccctttc cctcttccgg gcatctattt tggccttgga
     5041 gagtggtaga gctgctttgt aaactttgta attccagagc ccttgtactt agacacagtt
     5101 tgtttcacac tgcaggaaac ctttaaaaca ctccctttgt gtgctgttta ctcctgatca
     5161 gatgtcagca gctgggctaa tatttacaac tttaatatta ggaatttaga gacaaagata
     5221 catcaaggag ttatgttgac acccaaagga gtctttgtat tttagaatac aagtaggaag
     5281 taaaactatt cttcacactc ccctttgttt taaaataccc tgatctttga aatttcagga
     5341 tttttcccct tagattcatg ctcagaagcc ttgggtacta ttgtcagaat tgctcctttc
     5401 aaagtgtctt agtactgaag tacttattta ttatgatggc attgtggaaa tgattgtttt
     5461 gtgttaagga aattaagtgg ccttgtctct actaataatt gaaaatgtga atgaggtttt
     5521 cttatggagg ctgtcttact gcttagactt accctctgtt ggtcctgtga ttgatggcag
     5581 aggtgtagtt actgaaataa acaacctgtt cttcctcttt catcgctcac ttttgattgg
     5641 tgtctttatt tgtgcaggat actgagtaag ttttatttcc tagtcaaaat gaatatagtc
     5701 cttggggggt ggatctagtg gcctaatgaa tttagtggcg tgtcagctta gcattgttct
     5761 ctgaagcgct tgtatgtgac ctctggatct gtgaataagc actagatgaa aaatcagtcc
     5821 aaaagtggga tttatgataa tgacatctta atattttaaa gaatttatag ggaatgaaca
     5881 atagcaaagc attgttgaac gtgtgggttt tgactgataa cgctgtcatc tccaaccctt
     5941 cccttcctaa ttatgtcacc gtgctggcct acagtgtaga cgttcagatc gtctcctgag
     6001 ttaactttgc caagcaggag acctgtcctc attcaggcag gcttggggtt ctgcatgtca
     6061 tagcacccag agcctcccag gggaacttta gagcatcatt tttggagaca cagcagaaat
     6121 gatgttccac aagaccttga tccagcttct ctaccgtgtt tcatgggttc aggtccacaa
     6181 gggctatgca agaatttgag gcatcccaat caattaactc ttgttttagt cagccattta
     6241 gaatttaagt ttaaaccagt gtcttgtaca caaagaacta atttctttaa tgtccgccag
     6301 ctcgtttctt ccaccacagt gcgtgtacat ttaagtagaa caaaacaaca gcagcagcag
     6361 cagcaaaatg atgaccagtg tttccatgtt aaattcagtt gtgacacagt acacaatgcc
     6421 agcagcacag taagtgggaa gatatgctct cagcgagtac agggagtttc taaaggcctg
     6481 gtatgttcca aaagattgag ccccttcact gtcatggaga ccacctgtgc acaggtgtat
     6541 gagaagaagc aaaataaatg agcactagtg tgccctaaaa ggtgaccagg gagtcagggt
     6601 ctcaccctgg cctgtaaaaa gccttagcag gccactgatc cctttggttt cacaagcaac
     6661 taggaaaact gcttaaggca aaactaggag ttgcttgtga gatttagata atagaaacca
     6721 caggcaaaat aataatagga gatgtttatt acatgtgatc tttattaatt gattttgttt
     6781 ttcatgctgg ggattgaacc cagggcttca tacaggtgag actctaccac agaggcacct
     6841 ccctggactt tagttggata tttttggaag acagtttcac tcacaggtta ctaatgtggt
     6901 tctcagggga ttcccatatg tagacctttg ggtttttttt ttttttaaat agctttaaaa
     6961 tacatggtcc agcagaatag ttattggact aaccagtcaa ttaatcctaa attaatgata
     7021 atcttatttc tttatatgaa aaaagttgta gcaagccagg aaggtcatat agtttttgat
     7081 actagaccat gaaaaagatg taaatgcctt tgctctagcc gtggagcgaa aacagtgttt
     7141 gtctgctcag ccgatccctg gagacttaca aagggatgtt cctgaacctt actgtttgtc
     7201 ctcaacagcg gtaaataaat attgagtttt aattgcttcc agaagacact ctaacagtgg
     7261 aggggaggag agggcagagg acatttaaca acgaggataa ggatgggctg tgggaacagt
     7321 gataagcaca agggcagagg agagcactca tggaagagaa gggaaatctg catctcctga
     7381 agactgcatg tcagtgggga aacactcaga caccctcgac aaccaacact cttgggtcct
     7441 tgctgagttt taggatgtat ttgctacagt ttagaagcag agactaaggt tggtaaacct
     7501 ggaccgtgag tcacctggca tgtagatctt agcatttaag aatggtgccg ctgaagtgga
     7561 gaagcccagg aaagaacttg gcatctttta tacaattcga gtgcaagggc ctgctgtgtc
     7621 ttctgacaat ttggtccaat tcaaatcagt gtcttgtttc cccagcacta acctgcgtat
     7681 gaaataactt tgattcttag aagtattata ggagatagtt aggaaaaatt aatgcacatt
     7741 gaaaactgca taatctttaa tcttaatttt catcaatata gaaactcaaa gtcaaactac
     7801 aaacaggcat attaatgggc catctttcct ttcatttctg gaagtttgtc tatctgtaat
     7861 tgctaatttt tattcatttc atgaaaagtg tgtgtctaat acttttctaa aatactgatg
     7921 tactggaaat tcaaataaat tgccttatgt gtagaaca
//
