LOCUS       NM_201600               6647 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus myosin VB (Myo5b), mRNA.
ACCESSION   NM_201600 XM_357031 XM_357032 XM_357040 XM_358327
VERSION     NM_201600.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6647)
  AUTHORS   Burman,A., Momoh,M., Sampson,L., Skelton,J., Roland,J.T., Ramos,C.,
            Krystofiak,E., Acra,S., Goldenring,J.R. and Kaji,I.
  TITLE     Modeling of a Novel Patient-Based MYO5B Point Mutation Reveals
            Insights Into MVID Pathogenesis
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (4), 1022-1026 (2023)
   PUBMED   36592862
REFERENCE   2  (bases 1 to 6647)
  AUTHORS   Carton-Garcia,F., Brotons,B., Anguita,E., Dopeso,H., Tarragona,J.,
            Nieto,R., Garcia-Vidal,E., Macaya,I., Zagyva,Z., Dalmau,M.,
            Sanchez-Martin,M., van Ijzendoorn,S.C.D., Landolfi,S.,
            Hernandez-Losa,J., Schwartz,S. Jr., Matias-Guiu,X., Ramon Y
            Cajal,S., Martinez-Barriocanal,A. and Arango,D.
  TITLE     Myosin Vb as a tumor suppressor gene in intestinal cancer
  JOURNAL   Oncogene 41 (49), 5279-5288 (2022)
   PUBMED   36316444
  REMARK    GeneRIF: Myosin Vb as a tumor suppressor gene in intestinal cancer.
REFERENCE   3  (bases 1 to 6647)
  AUTHORS   Dooley,S.A., Engevik,K.A., Digrazia,J., Stubler,R., Kaji,I.,
            Krystofiak,E. and Engevik,A.C.
  TITLE     Myosin 5b is required for proper localization of the
            intermicrovillar adhesion complex in the intestinal brush border
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 323 (5), G501-G510 (2022)
   PUBMED   36218265
  REMARK    GeneRIF: Myosin 5b is required for proper localization of the
            intermicrovillar adhesion complex in the intestinal brush border.
REFERENCE   4  (bases 1 to 6647)
  AUTHORS   Kaji,I., Roland,J.T., Rathan-Kumar,S., Engevik,A.C., Burman,A.,
            Goldstein,A.E., Watanabe,M. and Goldenring,J.R.
  TITLE     Cell differentiation is disrupted by MYO5B loss through Wnt/Notch
            imbalance
  JOURNAL   JCI Insight 6 (16), e150416 (2021)
   PUBMED   34197342
  REMARK    GeneRIF: Cell differentiation is disrupted by MYO5B loss through
            Wnt/Notch imbalance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6647)
  AUTHORS   Engevik,A.C., Krystofiak,E.S., Kaji,I., Meyer,A.R., Weis,V.G.,
            Goldstein,A., Coutts,A.W., Melkamu,T., Saqui-Salces,M. and
            Goldenring,J.R.
  TITLE     Recruitment of Polarity Complexes and Tight Junction Proteins to
            the Site of Apical Bulk Endocytosis
  JOURNAL   Cell Mol Gastroenterol Hepatol 12 (1), 59-80 (2021)
   PUBMED   33548596
  REMARK    GeneRIF: Recruitment of Polarity Complexes and Tight Junction
            Proteins to the Site of Apical Bulk Endocytosis.
REFERENCE   6  (bases 1 to 6647)
  AUTHORS   Simoneaux,D.K., Leach,R.J. and O'Connell,P.
  TITLE     Galanin receptor 1 gene (Galnr1) is tightly linked to the myelin
            basic protein gene on chromosome 18 in mouse
  JOURNAL   Mamm Genome 8 (11), 875 (1997)
   PUBMED   9337411
REFERENCE   7  (bases 1 to 6647)
  AUTHORS   Zhao,L.P., Koslovsky,J.S., Reinhard,J., Bahler,M., Witt,A.E.,
            Provance,D.W. Jr. and Mercer,J.A.
  TITLE     Cloning and characterization of myr 6, an unconventional myosin of
            the dilute/myosin-V family
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10826-10831 (1996)
   PUBMED   8855265
REFERENCE   8  (bases 1 to 6647)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   9  (bases 1 to 6647)
  AUTHORS   Espreafico,E.M., Cheney,R.E., Matteoli,M., Nascimento,A.A., De
            Camilli,P.V., Larson,R.E. and Mooseker,M.S.
  TITLE     Primary structure and cellular localization of chicken brain
            myosin-V (p190), an unconventional myosin with calmodulin light
            chains
  JOURNAL   J Cell Biol 119 (6), 1541-1557 (1992)
   PUBMED   1469047
REFERENCE   10 (bases 1 to 6647)
  AUTHORS   Huang,W.M., Reed-Fourquet,L., Wu,E. and Wu,J.Y.
  TITLE     Molecular cloning and amino acid sequence of brain L-glutamate
            decarboxylase
  JOURNAL   Proc Natl Acad Sci U S A 87 (21), 8491-8495 (1990)
   PUBMED   2236059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147992.3, CJ052777.1, CV558709.1, AC148001.6, CF741517.1,
            AC148002.3, BQ557090.1, CD352410.1, BY245557.1, BU610647.1,
            DV655888.1 and AK033484.1.
            
            On May 12, 2006 this sequence version replaced NM_201600.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC118525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC147992.3         79836-80024         c
            190-617             CJ052777.1         119-546
            618-1218            CV558709.1         28-628
            1219-1484           AC148001.6         21960-22225         c
            1485-1566           AC148001.6         12711-12792         c
            1567-1707           AC148001.6         12082-12222         c
            1708-2255           CF741517.1         43-590
            2256-2367           AC148002.3         56387-56498
            2368-2736           BQ557090.1         42-410
            2737-2976           AC148002.3         62460-62699
            2977-3429           CD352410.1         96-548
            3430-3753           BY245557.1         24-347
            3754-4094           BU610647.1         125-465
            4095-4670           DV655888.1         67-642
            4671-4924           AK033484.1         524-777
            4925-5210           AC148002.3         120042-120327
            5211-6647           AK033484.1         1064-2500
FEATURES             Location/Qualifiers
     source          1..6647
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 50.7 cM"
     gene            1..6647
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /note="myosin VB"
                     /db_xref="GeneID:17919"
                     /db_xref="MGI:MGI:106598"
     exon            1..189
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..5619
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /note="myosin-Vb"
                     /codon_start=1
                     /product="unconventional myosin-Vb"
                     /protein_id="NP_963894.1"
                     /db_xref="CCDS:CCDS37858.1"
                     /db_xref="GeneID:17919"
                     /db_xref="MGI:MGI:106598"
                     /translation="MSYSELYTRYTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLED
                     DTILEYPVDVQNNQVPFLRNPDILVGENDLTALSHLHEPAVLHNLKVRFLESNHIYTY
                     CGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSII
                     VSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSS
                     RFGKFIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKE
                     LALTCAEDFFYTAHGGNTTIEGVNDADDFEKTRQALTLLGVRDSHQISIFKIIASILH
                     LGSVEIQSERDGDSCSISPQDEHLSNFCSLLGIEHSQMEHWLCHRKLVTTSETYVKTM
                     SLQQVVNARDALAKHIYAQLFSWIVEHINKALHTSLKQHSFIGVLDIYGFETFEINSF
                     EQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILD
                     LLDEECKVPKGTDQNWAQKLYERHSNSQHFQKPRMSNTAFIVNHFADKVEYLSDGFLE
                     KNRDTVYEEQINILKASKFPLVADLFHDDKDSAPATNTAKNRSSSKINVRSSRPLIKV
                     PNKEHKKSVGYQFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRAC
                     GVLETIRISAAGYPSRWTYHDFFNRYRVLMKKRELTNTDKKNICKSVLESLIKDPDKF
                     QFGRTKIFFRAGQVAYLEKLRADKFREATIMIQKSVRGWLQRVKYRRLRAATLSLQRF
                     CRGYLARRLAEHLRRTRAAIVFQKQYRMLKARRAYRRVCRATVIIQSFTRAMFVRRNY
                     RQVLMEHKATIIQKYARGWMARKRFLRERDAAIVIQCAFRRLKARQELKALKIEARSA
                     EHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQLSAVTSSHAVEVEKLKKELAHYQQ
                     NQEADTSLQLQEEVQSLRTELQKAHSERRVLEDAHNKENGELRKRVADLEHENALLKD
                     EKEYLNNQILCQSKAESSQSSVEENLLMKKELEEERSRYQNLVKEYSQLEQRYENLRD
                     EQTPGHRKNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGIEKAAMDMTVFLKL
                     QKRVRELEQERKKLQAQLEKGQQDSKKGQVEQQNNGLDVDQDADIAYNSLKRQELESE
                     NKKLKNDLNELRKAVADQAMQDNSTHSSPDSYSLLLNQLKLANEELEVRKEEVLILRT
                     QIMNADQRRLSGKNMEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQ
                     SLEHEEEVEHLKAQVEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLD
                     FKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSDRRHHELTRQVTVQRKEKDF
                     QGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSL
                     LSSTINGIKKVLKKHNDDFEMTSFWLSNTCRFLHCLKQYSGDEGFMTQNTAKQNEHCL
                     KNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVRPTGYRK
                     RSSSMVDGENSYCLEAIVRQMNSFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLL
                     LRKDACSWSTGMQLRYNISQLEEWLRGKNLHQSGAVQTMEPLIQAAQLLQLKKKTHED
                     AEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVSFIRTIQAQLQERNDPQQLLLDS
                     KHVFPVLFPYNPSALTMDSIHIPACLNLEFLNEV"
     exon            190..300
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            301..472
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            473..617
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            618..774
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            775..918
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1000
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1108
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1218
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1484
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1566
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1707
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1830
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1914
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2070
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2168
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2255
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2367
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2579
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2736
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2976
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3210
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3295
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3429
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3549
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3687
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3753
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3993
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4094
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4293
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            4294..4387
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            4388..4531
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            4532..4683
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            4684..4773
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            4774..4924
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            4925..5210
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            5211..5385
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            5386..5466
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     exon            5467..6647
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5955..5960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /note="hexamer: ATTAAA"
     polyA_site      5975
                     /gene="Myo5b"
                     /gene_synonym="mKIAA1119"
                     /note="major polyA site"
ORIGIN      
        1 cacccgagaa aggagcgcgg aggaactggg accggtctgg gaagactgcg ccagccagcc
       61 gtgcactgag atcgcggggg cagcgaggag ccgggcctcg gcgctcagcc tggacccagc
      121 gtcccgcgag gtgcccgggg ctccggcccg gcccgcgggg tcatgtcgta cagcgagctc
      181 tacacccggt acacaagggt ctggatccct gacccagatg aggtgtggcg ctcggctgaa
      241 ttaaccaagg actacaaaga aggggataag agcctgcagc tcagactaga agatgacaca
      301 attctagaat acccagttga tgtccaaaat aaccaggtgc cattcttgcg gaatccagat
      361 atcttagtag gagaaaacga cctcactgcc ctcagccacc tccacgagcc cgcagttctg
      421 cataacttaa aggtccgttt cctggaatcc aaccacatct acacttactg tggaattgtg
      481 cttgttgcca tcaaccccta cgagcagctg ccaatctacg gacaggatgt catctatgcc
      541 tacagtggcc aaaacatggg tgacatggac ccccacatct ttgctgtggc agaagaagcc
      601 tacaagcaga tggccagaga tgaaaagaac caatccatca tagtcagcgg agagtctgga
      661 gcaggcaaga cggtgtcggc caagtacgcc atgcgctatt ttgccaccgt tggtggctca
      721 gccagtgata ccaacattga agagaaggtc ctagcatcca gccccatcat ggaggccatt
      781 gggaacgcca agactactcg caacgacaac agcagccgat ttgggaaatt cattgagatt
      841 ggctttgata aaaagtacca catcattggg gccaacatga ggacctactt gctggagaag
      901 tccagggtgg tctttcaggc ggatgacgag aggaactacc acatctttta ccagctctgt
      961 gctgctgcca gccttcctga atttaaagag ctcgccctaa cgtgcgcaga ggactttttc
     1021 tatacagccc atggaggaaa cacgaccatc gagggtgtga atgatgcaga cgactttgag
     1081 aagactagac aagccctcac actcctggga gtgcgggatt cccatcaaat aagcatcttt
     1141 aagataattg cttctatctt gcacctggga agtgtggaga ttcagtctga gcgggacggg
     1201 gattcctgca gcatttcacc ccaggatgaa cacttgagca acttctgcag cctgctagga
     1261 atagaacaca gccagatgga gcactggctg tgtcatcgga agctggtcac cacctcagag
     1321 acctacgtca agaccatgtc cctgcagcaa gtggtcaatg cacgtgatgc cttagccaag
     1381 cacatctatg ctcagctgtt ctcctggatt gtggagcaca tcaacaaagc cctgcacacc
     1441 tcccttaagc agcactcctt catcggggtc ctggatatct atgggtttga gaccttcgag
     1501 atcaatagct ttgaacagtt ttgtatcaac tacgccaatg aaaagctcca gcaacagttc
     1561 aattcgcatg tgttcaagct ggagcaagaa gaatatatga aggagcagat cccgtggact
     1621 ttgattgact tctacgataa ccaaccgtgt atagacctca tagaggcaaa gctgggcatc
     1681 ctggacctgt tggatgagga gtgtaaggtc cccaaaggaa ctgatcagaa ctgggcccag
     1741 aaactctacg aacgacactc caacagccag cacttccaga aaccacgcat gtccaacacg
     1801 gccttcattg tcaaccactt tgcagataag gtggagtacc tttcagatgg ttttctagag
     1861 aaaaacaggg atacagtata tgaagaacag atcaacatcc tgaaggccag caagttccca
     1921 ttagtggctg atttgttcca cgatgacaag gactctgctc cagccaccaa cacagctaag
     1981 aatcgatcat cttcaaagat caacgttcgc tcttccagac ccctcatcaa agtccctaac
     2041 aaggagcaca agaaatccgt gggctaccag tttcgtactt ccctaaacct gcttatggag
     2101 accctgaatg ccacaacgcc acactatgtc cggtgcatca agcccaacga tgaaaagctt
     2161 cccttccact ttgaccccaa gagagctgta cagcaactcc gagcctgcgg tgtgctggag
     2221 accattcgga tcagcgcggc aggctaccca tccaggtgga cctaccatga cttcttcaac
     2281 cggtatcggg tgttgatgaa gaagagagag ctcaccaaca ccgacaagaa gaatatctgc
     2341 aagtctgtcc tggagagtct catcaaggac ccagacaagt tccagtttgg ccgcaccaag
     2401 atcttcttcc gagcaggcca ggtggcctac ctggagaagc ttcgggcaga caagttccgg
     2461 gaagctacta tcatgatcca gaagtcggtc aggggatggc tgcagagagt gaagtaccgt
     2521 aggctgaggg cagctacctt atccctgcag aggttctgca ggggatacct agcccgcagg
     2581 ctggccgaac acttgaggag aacccgggcc gccatcgtgt tccagaagca gtaccgcatg
     2641 ctgaaggccc gccgagccta ccgcagggtc tgcagggcta ccgtcatcat ccagtccttc
     2701 acacgggcca tgtttgtgcg caggaactac cgccaggtcc tcatggagca caaagccacc
     2761 atcatccaga agtacgcccg aggctggatg gcacggaagc gttttctgcg ggagcgggat
     2821 gcagccattg tcatccagtg tgccttccgg agactcaagg ccaggcagga gctgaaggcc
     2881 ctcaagattg aggcccgctc ggcagagcat ctgaaacgcc tcaacgtggg catggagaac
     2941 aaagtcgtcc agctacagcg gaagattgat gaccagaaca aagagttcaa gactctgtca
     3001 gagcagctgt ctgcagtcac ctccagtcat gccgtggagg tggagaagct gaagaaggag
     3061 ctggcacatt accagcagaa ccaggaggct gataccagcc ttcagctgca ggaggaggtt
     3121 cagagcctgc gcactgaact acagaaggct cattcggagc gcagggtcct ggaggatgct
     3181 cacaacaagg agaatggcga gctgagaaag cgagttgcag acctggaaca tgaaaatgcc
     3241 ctcttgaagg atgaaaaaga ataccttaac aaccaaatcc tgtgccagtc aaaagctgaa
     3301 tcttcgcaga gctctgtgga agagaacctc ctgatgaaga aggagctgga ggaggaacgg
     3361 tccaggtacc agaacctcgt gaaggagtac tcccagctgg agcagagata tgagaacctt
     3421 cgggacgagc aaactccggg ccacaggaag aacccatcga accaaagcag cttagaatct
     3481 gactccaatt acccctccat ttccacttcc gaaatcggag acactgagga tgcccttcag
     3541 caggtggagg agattggcat agagaaggca gccatggaca tgaccgtctt cctgaagctg
     3601 cagaagagag tgcgcgaact tgagcaggag aggaagaagc tgcaggcaca gctagaaaag
     3661 ggacagcagg acagcaagaa agggcaggta gaacaacaga acaatggctt agatgtggac
     3721 caggacgcag atatagccta caatagtctg aagagacagg agcttgagtc agagaacaag
     3781 aagctgaaga atgacctgaa tgagctgagg aaggctgtcg ctgaccaagc catgcaggat
     3841 aactccaccc acagctcccc agacagctac agcctcctcc tgaaccagct caagctggcc
     3901 aatgaggagc tcgaggtccg caaagaggag gtgctgatcc tcaggaccca gatcatgaat
     3961 gccgaccagc gccgcctgtc tggcaagaac atggagccga acatcaatgc cagaacaagt
     4021 tggcccaaca gtgagaagca cgtggaccag gaagacgcca ttgaggccta tcacggggtc
     4081 tgccagacaa acaggttgct ggaggcccag ctgcaggccc agagcctgga gcatgaggag
     4141 gaggtggaac atctcaaggc ccaggtggaa gccctgaaag aggagatgga caaacagcag
     4201 cagaccttct gccagaccct gctgctctcc ccagaggccc aggtagaatt tggtgtccag
     4261 caggagatat cccggctgac caatgagaac ctggatttta aggaattggt ggaaaagctg
     4321 gagaagaatg agaggaagct gaagaagcag ctgaagattt acatgaagaa ggtccaggac
     4381 ttagaagctg ctcaggcgtt ggcacagagt gacaggagac accatgaact cacaagacag
     4441 gtcacagtcc aacgaaaaga gaaggacttc caaggcatgc tggagtacca caaagaggac
     4501 gaagccctcc tcatccggaa cctggtgaca gacctgaagc ctcagatgct gtcgggcacc
     4561 gtgccctgtc tgcctgcata catactctat atgtgcatca ggcacgcgga ttacaccaac
     4621 gatgacctca aggtgcactc gttgctgagc tccaccatca acggcattaa gaaagtcctc
     4681 aagaagcaca atgatgactt tgagatgacg tcattctggc tatccaacac ctgccgcttc
     4741 cttcactgtc tgaagcaata cagtggtgat gagggtttca tgacacagaa cactgcgaag
     4801 cagaatgagc actgtctcaa gaactttgac ctcactgaat accgccaggt gctaagcgac
     4861 ctttccattc agatctatca gcagctcatt aaaatcgccg agggcttgct gcagcctatg
     4921 atagtttctg ccatgttgga aaatgagagt atccaggggc tgtctggtgt gagaccaact
     4981 ggttaccgga agcgctcctc cagcatggtg gatggagaga attcgtattg cctggaggcc
     5041 atcgtccgcc agatgaattc tttccataca gtcctgtgtg accagggtct ggaccccgag
     5101 attatcctgc aggtgttcaa acagctcttc tacatgatca acgctgtgac tcttaacaac
     5161 ctactcctgc ggaaagacgc ctgctcctgg agcacaggca tgcaactcag gtacaacata
     5221 agtcaactgg aagagtggct tcggggcaaa aaccttcacc aaagtggagc agttcagacc
     5281 atggagcccc tcatccaggc agcccagctc ctccagctga agaagaaaac ccacgaggat
     5341 gctgaggcca tctgctctct gtgcacctcc ctcagcaccc agcagattgt caaaatttta
     5401 aacctctaca ctcccttgaa tgaatttgag gaacgggtca cagtgtcctt catacgaaca
     5461 atccaggctc agctacaaga gaggaatgac cctcagcagc tcctgctgga ctccaagcac
     5521 gtgttcccag ttctgtttcc atataaccca tctgctctga ccatggactc gatccacatc
     5581 ccggcctgtc tcaacctgga gtttctcaat gaagtctgag gatgcgtgtt tccgaggcga
     5641 gcgagaagga agcatgtgct gtcagccgag agaatgctag gtgtgttaaa tattcccagc
     5701 gtagatcaaa ccatgttaga gactggcggg agcacagaac taaacagcgg ggtgcacagt
     5761 tgtcgccaat gctgctcaga aaacacccgg aaggtggatt tgttaaagct gtgctttcag
     5821 gttaaaccaa gacacgtcag aacgaacagc cactctgcag ctccagtcgc catataaaaa
     5881 tgccagttct acagagtgga agtgcctagc tttgatcttt gtatatatct tgagaatgtt
     5941 caaactgaga taatattaaa aacacatgac gtaaattgcc tttgtgggtc tttcaagaaa
     6001 tgatgggact aataaccata agattgacac atattgataa accaaaggtg tggatgatct
     6061 taggggaaga tgttttgaga acaaaagtat gggcttacac ctcaggagac tcctccagtg
     6121 aattggtatt cactgatgcc tggtgaacaa ggggcgctgg ggtggaacac tgtttccaag
     6181 caaactggat gacccagctc ttgcgatagt ctcaggtttg tgggagagtt gcactaaaca
     6241 tactgccatc aaaggtgcca agggtgagga agatggaaga gtgcagtctc cgctgctagt
     6301 cagtgcggag acgggcaagc ttccgccacg attcaagtat ggaaatggta ggtgaggatg
     6361 gctagctttt atttgcaggt ataaaagcaa accagtgtgc tgctgattcc aggcctcaag
     6421 atcataaggg aagcagagcc aagaacccaa ttgtctgaag agcgtctgaa ggagactgca
     6481 cagccattaa gtcttagcca aagatttgtg ggtttgtttc tttttaattg ctttgaaaga
     6541 ttgcagttgc ttaggccagc tttcccttct caagttattt tcaacatttg tttttcaaag
     6601 tttgaaatca atgtaaacac tctgctatga aataaaagac gtaagag
//
