LOCUS       NM_177376               6265 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus myosin IIIB (Myo3b), mRNA.
ACCESSION   NM_177376
VERSION     NM_177376.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6265)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6265)
  AUTHORS   Ebrahim,S., Avenarius,M.R., Grati,M., Krey,J.F., Windsor,A.M.,
            Sousa,A.D., Ballesteros,A., Cui,R., Millis,B.A., Salles,F.T.,
            Baird,M.A., Davidson,M.W., Jones,S.M., Choi,D., Dong,L.,
            Raval,M.H., Yengo,C.M., Barr-Gillespie,P.G. and Kachar,B.
  TITLE     Stereocilia-staircase spacing is influenced by myosin III motors
            and their cargos espin-1 and espin-like
  JOURNAL   Nat Commun 7, 10833 (2016)
   PUBMED   26926603
  REMARK    Erratum:[Nat Commun. 2017 Aug 14;8:16133. doi:
            10.1038/ncomms16133.. PMID: 28805204]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6265)
  AUTHORS   Lelli,A., Michel,V., Boutet de Monvel,J., Cortese,M.,
            Bosch-Grau,M., Aghaie,A., Perfettini,I., Dupont,T., Avan,P.,
            El-Amraoui,A. and Petit,C.
  TITLE     Class III myosins shape the auditory hair bundles by limiting
            microvilli and stereocilia growth
  JOURNAL   J Cell Biol 212 (2), 231-244 (2016)
   PUBMED   26754646
  REMARK    GeneRIF: results uncover the critical role that class III myosins
            play redundantly in hair-bundle morphogenesis
REFERENCE   4  (bases 1 to 6265)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 6265)
  AUTHORS   Merritt,R.C., Manor,U., Salles,F.T., Grati,M., Dose,A.C.,
            Unrath,W.C., Quintero,O.A., Yengo,C.M. and Kachar,B.
  TITLE     Myosin IIIB uses an actin-binding motif in its espin-1 cargo to
            reach the tips of actin protrusions
  JOURNAL   Curr Biol 22 (4), 320-325 (2012)
   PUBMED   22264607
  REMARK    GeneRIF: When myosin IIIB (MYO3B) is coexpressed with espin-1
            (ESPN1), MYO3B targets and carries ESPN1 to COS7 cell filopodia
            tips. This tip localization is lost when the ESPN1 C terminus
            actin-binding site is removed.
REFERENCE   6  (bases 1 to 6265)
  AUTHORS   Dalal,J.S., Stevens,S.M. Jr., Alvarez,S., Munoz,N., Kempler,K.E.,
            Dose,A.C., Burnside,B. and Battelle,B.A.
  TITLE     Mouse class III myosins: kinase activity and phosphorylation sites
  JOURNAL   J Neurochem 119 (4), 772-784 (2011)
   PUBMED   21895655
REFERENCE   7  (bases 1 to 6265)
  AUTHORS   Katti,C., Dalal,J.S., Dose,A.C., Burnside,B. and Battelle,B.A.
  TITLE     Cloning and distribution of myosin 3B in the mouse retina:
            differential distribution in cone outer segments
  JOURNAL   Exp Eye Res 89 (2), 224-237 (2009)
   PUBMED   19332056
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929249.15, AL845263.10 and AL929164.12.
            
            On Mar 10, 2021 this sequence version replaced NM_177376.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL929249.15        173618-173650
            34-76               AL929249.15        173796-173838
            77-260              AL845263.10        35452-35635
            261-395             AL845263.10        36656-36790
            396-500             AL845263.10        45672-45776
            501-600             AL845263.10        45949-46048
            601-677             AL845263.10        48917-48993
            678-823             AL845263.10        67142-67287
            824-889             AL845263.10        129838-129903
            890-1045            AL845263.10        157310-157465
            1046-1142           AL845263.10        172688-172784
            1143-1259           AL845263.10        173791-173907
            1260-1364           AL845263.10        174669-174773
            1365-1448           AL845263.10        178112-178195
            1449-1651           AL845263.10        179052-179254
            1652-1750           AL845263.10        185142-185240
            1751-1865           AL845263.10        185589-185703
            1866-1992           AL845263.10        192032-192158
            1993-2203           AL845263.10        193266-193476
            2204-2351           AL845263.10        194688-194835
            2352-2505           AL845263.10        195542-195695
            2506-2594           AL845263.10        196784-196872
            2595-2724           AL845263.10        198258-198387
            2725-2804           AL929164.12        13481-13560
            2805-2882           AL929164.12        19247-19324
            2883-3088           AL929164.12        21698-21903
            3089-3200           AL929164.12        45632-45743
            3201-3363           AL929164.12        46604-46766
            3364-3444           AL929164.12        47678-47758
            3445-3553           AL929164.12        63160-63268
            3554-3638           AL929164.12        81215-81299
            3639-3735           AL929164.12        82227-82323
            3736-3842           AL929164.12        157901-158007
            3843-3889           AL929164.12        158382-158428
            3890-6265           AL929164.12        159151-161526
FEATURES             Location/Qualifiers
     source          1..6265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 41.05 cM"
     gene            1..6265
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /note="myosin IIIB"
                     /db_xref="GeneID:329421"
                     /db_xref="MGI:MGI:2448580"
     exon            1..33
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..4028
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /EC_number="2.7.11.1"
                     /note="myosin IIIB1; myosin IIIB2"
                     /codon_start=1
                     /product="myosin-IIIb"
                     /protein_id="NP_796350.2"
                     /db_xref="CCDS:CCDS38139.1"
                     /db_xref="GeneID:329421"
                     /db_xref="MGI:MGI:2448580"
                     /translation="MAAASEVSGEHTGDKTGKHLYGLFHYNPMMLGLESLPDPMETWE
                     IIETIGKGTYGKVYKVANKRDGSLAAVKVLDPVSDMDEEIEAEYNILQFLPSHPNVVK
                     FYGMFYKADRCVGGQLWLVLELCNGGSVTELVKGLLRCGKRLDEAVISYILYGALLGL
                     QHLHCHRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEV
                     IACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFKIPRNPPPTLLHPD
                     SWCEEFNHFISQCLIKDFEKRPSVTHLLDHPFIKGTQGKVLCLQKQLAKVLQDQKHRN
                     PVAKTRHERMHTGRPHRVEDAGKCCLEDDLVNLEVLDEDTIIYWLQKRYADALIYTYV
                     GDILIALNPFQNLSIYSPQFSRLYHGVKRSSNPPHIFASADNAYQCLVTFSKDQCIVI
                     SGESGSGKTESAHLIVQHLTFLGKADNQTLRQKILQVNSLVEAFGNARTAINDNSSRF
                     GKYLEMMFTPTGAVMGARISEYLLEKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEF
                     RLPEEKPPRYIAGETERVMQDITSKESYRTQFEAIQHCFKIIGFADKEVHSVYRILAG
                     ILNIGSIEFAAISSQHQTDKSEVPNPEALENAACVLCISSEELQEALTSHCVVTRGET
                     IVRANTVDRAEDVRDAMSKALYGRLFSWIVNRINTLLQPDKNICSAEDRMNVGILDIF
                     GFEDFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYKNEGVDAVLVQYEDNRPLLD
                     MFLQKPLGLLALLDEESRFPQGTDQTLVDKFEDNLRCKFFWRPKGVELCFGIQHYAGP
                     VLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRAKITASSR
                     SLPPHFSAGRAKVDTLEVIRHPEETTNMKRQTMASYFRYSLMDLLSKMVVGQPHFIRC
                     IKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRIFFEEFVKRYYYLAFRAH
                     QTPPANKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVMGRVVMLQAYTK
                     GWLGARRYKRAKEKREKGAITIQSAWRGYDARRKLKQRSRRRSESEAHIHTVLQTTPD
                     QKYCPDSGGESNRGHEETSRNCPAEADTDGHPQAQSPPTGCDVTSGHADTAAGYTVAE
                     LSVAGTDVSPSLVYHTASAHQRLSPCEDSLKPGSEEGLSQKQRAPRRRCQQPKMLSSP
                     EDTMYYNQLNGTLEYQGSQRKPRKLGQIKVLDGEDQYYKCLSPGACAPEETHSVHPFF
                     FSSSPREDPFAQH"
     exon            34..76
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            77..260
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            261..395
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            396..500
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            501..600
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            601..677
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            678..823
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            824..889
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1045
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1142
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1259
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1364
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1448
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1651
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1750
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1865
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1992
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2203
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2351
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2505
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2594
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2724
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2804
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2882
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3088
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3200
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3363
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3444
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3553
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3638
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3735
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3842
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3889
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..6265
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6217..6222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6240
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
     regulatory      6243..6248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      6265
                     /gene="Myo3b"
                     /gene_synonym="A430065P19Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtcccatct ctgggccgct tgaacaatgg cagcagcctc ggaggtgagc ggtgagcaca
       61 caggagacaa aaccgggaag cacctgtatg gattatttca ctataacccc atgatgcttg
      121 gcctggaatc actccccgat cccatggaga cctgggagat tatagagacg attggcaaag
      181 gcacttatgg caaggtctac aaggtagcca acaagagaga tgggagcctg gctgccgtga
      241 aggttctgga ccccgtcagt gatatggatg aggagattga ggctgaatac aacattctgc
      301 agtttctccc cagccatccc aacgttgtaa agttttatgg gatgttttac aaagccgatc
      361 gctgtgtggg aggacagcta tggctggttc tggagctgtg taatgggggc tctgtcactg
      421 agcttgtcaa gggccttctg aggtgcggca agaggctgga cgaagctgtg atttcctaca
      481 ttctgtatgg agccctcttg ggccttcagc atttgcactg ccaccgaatc atccaccgag
      541 atgtgaaggg gaataacatt cttctgacga cagaaggagg agttaagctc gttgactttg
      601 gtgtctctgc tcaacttaca agcacacggc tgcggagaaa cacatcagtt gggaccccat
      661 tctggatggc tcctgaggtc attgcttgcg agcagcagta tgactcgtcc tatgacgctc
      721 gttgtgacgt ctggtccttg ggcatcacag ccattgagct gggagatgga gaccctcccc
      781 tctttgaaat gcatcctgtg aaaatgctct ttaagatacc aagaaaccct ccacccactt
      841 tgctgcaccc tgacagctgg tgtgaggaat ttaaccactt catttcacag tgtcttatta
      901 aagattttga aaagcggcct tcggtcaccc atctcttgga ccacccattc attaaaggaa
      961 ctcaaggcaa ggttttgtgt ctgcaaaaac agctggccaa ggtgctccag gaccagaagc
     1021 atcgaaaccc tgttgctaaa accaggcatg aaaggatgca tactggaaga ccccatcgag
     1081 tagaggatgc cggcaagtgc tgccttgagg atgacctggt caatctcgag gtcctggacg
     1141 aggacacgat tatctactgg ctgcagaagc ggtatgcaga tgcactgatc tacacctatg
     1201 ttggagacat tctaattgcc ttaaacccct tccagaatct aagtatatac tctccacagt
     1261 tttccaggct ttatcatggg gtgaaacgtt cctcgaatcc cccccacata tttgcatcag
     1321 cagacaacgc ttatcagtgt ttggttactt tcagcaaaga ccagtgtatt gtcatcagtg
     1381 gagaaagcgg atcggggaag acggaaagcg cccatctgat tgttcagcat cttactttct
     1441 taggaaaggc tgacaatcag accctacgcc agaaaatcct ccaagtgaac tccctggtgg
     1501 aagccttcgg gaacgcccgc acagccatca atgataactc cagccgcttc gggaagtatc
     1561 tagaaatgat gttcacacca actggagctg tcatgggggc aagaatctcc gagtatcttc
     1621 ttgagaaatc cagagttata cagcaggcag cgggagagaa aaattttcat atattttact
     1681 atatttatgc tggtctttat caccaaaaga aactcgctga gttcagactt cccgaggaaa
     1741 agcctcctag atatatagct ggggaaactg aaagagtcat gcaggacatc acctccaaag
     1801 agtcttaccg gacacagttt gaggccattc agcactgctt caagattatt ggattcgctg
     1861 acaaggaggt acactctgtg tacagaattc tggcggggat tttgaatatt ggcagcattg
     1921 aattcgcagc tatttcctct caacaccaaa ctgataaaag tgaggtacct aatccagaag
     1981 ctctggaaaa cgctgcctgc gtgctctgca ttagctccga agagcttcag gaggccctca
     2041 cttcccactg tgtggtcaca cgaggggaga ccattgtcag agccaacaca gtggacaggg
     2101 ctgaagacgt cagggacgcc atgtctaagg ccctctatgg gaggctgttc agctggattg
     2161 tgaatcgaat caacacactc ctgcagccag ataaaaacat atgtagtgca gaggacagga
     2221 tgaatgtggg catcttggac atttttggct ttgaggattt ccagaggaat tcctttgaac
     2281 agctctgcat aaatattgcc aatgaacaga tccagtacta cttcaatcag catgtgtttg
     2341 ctcttgagca gatggagtac aagaatgaag gtgtcgatgc tgtcctcgtg cagtatgaag
     2401 acaatcgccc actcctggac atgttcctcc aaaaaccctt gggccttctg gcacttctgg
     2461 atgaagaaag tcgatttccc caagggacag accagacctt ggttgataaa tttgaagaca
     2521 acctacggtg taagttcttc tggaggccca aaggtgtgga actctgtttt ggcattcagc
     2581 actatgctgg accggtgtta tacgatgctt ctggggttct tgagaaaaac agagacaccc
     2641 tccctgctga cgtggtggta gtcctgagga cgtctgagaa caaactcctt cagcaactgt
     2701 tctcaattcc tttgaccaaa acaggtaatt tggcacaaac cagagctaag atcacagcat
     2761 cctcgagatc tttgcctcca catttcagtg ctgggagggc caaggtagac accctggagg
     2821 tgattcgaca tccagaagaa accaccaaca tgaagagaca aaccatggct tcttacttcc
     2881 ggtattctct gatggacctg ctctccaaaa tggtggtcgg acagcctcac tttattcgtt
     2941 gcattaagcc taatgatgac cgcaaggccc tgcagttctc ccaagacaga gtcttggccc
     3001 agcttcgctc cacgggcatc ctggagaccg tcagcatccg caggcagggc tactcccatc
     3061 gcatcttctt tgaagagttt gttaaaaggt attattactt ggcattccga gcacatcaaa
     3121 cacctcctgc taacaaagag agctgtgttg ctatcttgga aaagtccaga ttagatcact
     3181 gggtcctggg gaaaacaaag gttttcctca aatattacca tgtcgagcaa ttaaatttgc
     3241 ttctgcgaga agtcatggga cgagtggtca tgctgcaggc atataccaag ggctggctcg
     3301 gagcaaggag atacaagaga gccaaagaga agagagagaa gggcgccatc accatccagt
     3361 cagcctggag aggctatgat gctcggagga aattgaagca aagaagccgg aggaggagtg
     3421 agtccgaggc tcacattcac acagttctcc aaaccactcc tgatcagaaa tactgtccag
     3481 attcaggagg agagtccaac agaggtcatg aagagacgtc aaggaactgc cccgctgaag
     3541 ccgacacaga tgggcaccca caagcccaga gtcccccaac aggctgtgat gtcacctcag
     3601 gacatgcaga tacagcagct gggtatactg ttgctgagct ctcagttgct ggaaccgatg
     3661 tgtcaccttc tctggtgtac cacactgcct cagctcacca aagactgagc ccctgtgaag
     3721 actctctcaa acctggttcc gaagaaggtc tctcccagaa gcagcgagca cctcgcagac
     3781 ggtgtcagca gcccaaaatg ttgagtagcc ccgaggacac catgtactat aaccagttaa
     3841 atggaactct agaatatcaa gggagccaga ggaagccaag aaaacttgga caaatcaaag
     3901 tgctggatgg ggaggaccag tattacaaat gcctgtcccc tggggcctgt gcccctgagg
     3961 aaacccactc agtccaccct ttcttcttct cctcgtcacc cagagaagac ccctttgctc
     4021 aacactgagt tgccctttcc agccccggtg tgccccaggt aaaagcagcc atggtaactg
     4081 accatctaag aggaaggcac tgttctgagg tcagcttctt tggacacaat ctgggcccta
     4141 aaccttgctg aacaactcaa cagattcctg aaaatgctgt ctcttattcc ccttcacctg
     4201 ccctgcagcc tgagtcacag aacccgtgtt cccttcatcc cttgagaaca cctctgctgg
     4261 ggtaattcag ccttttaggc acccggcagc taagaagagg gaggacagac ccaccacagg
     4321 ccagtcgtga aatcagataa gatgcctagt ttccccaagt ggaatcctgc tggattgcta
     4381 tctcccttct acccttttct accagtcccc catttgctag gcttttctac atctcccctt
     4441 gggtcagggt ttcattgctg aggatattgt ttccaggaag agtggccatg gtttatgctt
     4501 agaaagaaaa ctcaacatct ttcagatgct ctctccatgt caaaatgaat gcctgttgca
     4561 cattgtcatg ttgagaagac tttgccagat tattctacct taccaagaga acccagtcac
     4621 accagcaatg aaaaggagga gaattggggc ctaagtgata cctgattttg tatctgcatt
     4681 ccctggccag ctggctccac aggatgtgag aggcggcaga agagagatcc ccacttgtcc
     4741 atctctgtgt tcctcagacc tagctcagag cctaggagag tgggcaccca gggcataaaa
     4801 aggaatggag agattgcatt atctgcagca gcatggctgg caggcagttc cttgcggtga
     4861 tatgtgatct atgagtaacc acctttctca cagataagtt caaggttgag ctgttcctat
     4921 ttcatgacat tatatgccgt catactctat acagttcagt acaagcagct ttcttgagca
     4981 catacctgtg agaacaaaac aagatggaag gttgctatgt gctgtgacag tgagtccgcg
     5041 tgaagactcc tctagagcag atgttcttaa tattttcttt ctctaaaata ctttgttgat
     5101 ttcagaaaaa tactttaaaa tatagaaaaa gttactattg tcagggtttg ttttgttttg
     5161 ttttgttttc ctttaacgga gggcacaagc aaatatactc tgaacagaaa caattaagtg
     5221 aggttggtgt gctcactttt cccatggagg tgtgggacaa cctctataca caccaagtaa
     5281 gacacccgtg acagacagaa gaaaggaaac cacccaagtc tagcttgctg aagcagtggg
     5341 tttaaccagg cttcctgggg ctggaaggat ggagcagagg ctacgagcac ttgctcttgc
     5401 acaagacctg ggttcagttc ccagcaccct catgtgcaca tacacatata catgcaagca
     5461 agacatatat atatatatat atatatatat atatatatat atatatatat taaaataaat
     5521 aaatctaaga tggctgtagg gctgcttaca gaggtatggg cagctatacc accagagaat
     5581 agctatcccc atagtaacag ctaacccctc agggaaaggc agggtccctc tgaataagta
     5641 cacagctctg cacacctttc ctgcttccac aagagaaatg ttagtgagcc cagtcttgct
     5701 ctgacttcaa gaggacagtg gctacatcgt gtccggagaa cagagttgca caacagagac
     5761 atttaaagag ctcagaaatt ataatattat ttaaaaaagt tatagacaat tttagtagat
     5821 aaattgtgct ttttttttaa aaaaagataa gtctcgggtt tttccagctc ttcgttgaaa
     5881 acgtaacatt tctatggtgt aagagtggag cagacaaaac aaaattaact tagctgctta
     5941 ggaaataatg cttagggtaa ttctgtgatc cagcacttga atgtgcaggg tttaatcccc
     6001 agaacaagaa agatgaagag atgagaggga gagaaaaagc ctagcatgtg cagattttct
     6061 ctgagtgcct tcggaaattc cacttttatc attgattaat ctactttgat gaaacttttt
     6121 caaactgttg ataagaatat tcataacttt ctgcatgtcc acatacaatg taattgtaaa
     6181 tctgccttgt ttctttctca ctaaaatgtg tctatgaata aaggttaaaa gaaaaagaaa
     6241 taaagaaaga atcactaaat cctaa
//
