LOCUS       NM_148413               5082 bp    mRNA    linear   ROD 16-DEC-2022
DEFINITION  Mus musculus myosin IIIA (Myo3a), mRNA.
ACCESSION   NM_148413 XM_890884
VERSION     NM_148413.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5082)
  AUTHORS   Li P, Wen Z, Zhang G, Zhang A, Fu X and Gao J.
  TITLE     Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive
            Hearing Loss and Hair Cell Degeneration in the Inner Ear
  JOURNAL   Neural Plast 2018, 4372913 (2018)
   PUBMED   30123247
  REMARK    GeneRIF: Results showed that Myo3a is essential for normal hearing
            by maintaining the intact structure of hair cell stereocilia, and
            the kinase domain plays a critical role in the normal functions of
            Myo3a.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5082)
  AUTHORS   Ebrahim S, Avenarius MR, Grati M, Krey JF, Windsor AM, Sousa AD,
            Ballesteros A, Cui R, Millis BA, Salles FT, Baird MA, Davidson MW,
            Jones SM, Choi D, Dong L, Raval MH, Yengo CM, Barr-Gillespie PG and
            Kachar B.
  TITLE     Stereocilia-staircase spacing is influenced by myosin III motors
            and their cargos espin-1 and espin-like
  JOURNAL   Nat Commun 7, 10833 (2016)
   PUBMED   26926603
  REMARK    Erratum:[Nat Commun. 2017 Aug 14;8:16133. PMID: 28805204]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5082)
  AUTHORS   Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch-Grau M,
            Aghaie A, Perfettini I, Dupont T, Avan P, El-Amraoui A and Petit C.
  TITLE     Class III myosins shape the auditory hair bundles by limiting
            microvilli and stereocilia growth
  JOURNAL   J Cell Biol 212 (2), 231-244 (2016)
   PUBMED   26754646
  REMARK    GeneRIF: results uncover the critical role that class III myosins
            play redundantly in hair-bundle morphogenesis
REFERENCE   4  (bases 1 to 5082)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 5082)
  AUTHORS   Merritt RC, Manor U, Salles FT, Grati M, Dose AC, Unrath WC,
            Quintero OA, Yengo CM and Kachar B.
  TITLE     Myosin IIIB uses an actin-binding motif in its espin-1 cargo to
            reach the tips of actin protrusions
  JOURNAL   Curr Biol 22 (4), 320-325 (2012)
   PUBMED   22264607
REFERENCE   6  (bases 1 to 5082)
  AUTHORS   Walsh VL, Raviv D, Dror AA, Shahin H, Walsh T, Kanaan MN, Avraham
            KB and King MC.
  TITLE     A mouse model for human hearing loss DFNB30 due to loss of function
            of myosin IIIA
  JOURNAL   Mamm Genome 22 (3-4), 170-177 (2011)
   PUBMED   21165622
  REMARK    GeneRIF: The phenotype of the Myo3a knockout mice parallels the
            phenotype of human DFNB30.
REFERENCE   7  (bases 1 to 5082)
  AUTHORS   Katti C, Dalal JS, Dose AC, Burnside B and Battelle BA.
  TITLE     Cloning and distribution of myosin 3B in the mouse retina:
            differential distribution in cone outer segments
  JOURNAL   Exp Eye Res 89 (2), 224-237 (2009)
   PUBMED   19332056
REFERENCE   8  (bases 1 to 5082)
  AUTHORS   Lelli A, Asai Y, Forge A, Holt JR and Geleoc GS.
  TITLE     Tonotopic gradient in the developmental acquisition of sensory
            transduction in outer hair cells of the mouse cochlea
  JOURNAL   J Neurophysiol 101 (6), 2961-2973 (2009)
   PUBMED   19339464
REFERENCE   9  (bases 1 to 5082)
  AUTHORS   Komaba S, Inoue A, Maruta S, Hosoya H and Ikebe M.
  TITLE     Determination of human myosin III as a motor protein having a
            protein kinase activity
  JOURNAL   J Biol Chem 278 (24), 21352-21360 (2003)
   PUBMED   12672820
REFERENCE   10 (bases 1 to 5082)
  AUTHORS   Walsh T, Walsh V, Vreugde S, Hertzano R, Shahin H, Haika S, Lee MK,
            Kanaan M, King MC and Avraham KB.
  TITLE     From flies' eyes to our ears: mutations in a human class III myosin
            cause progressive nonsyndromic hearing loss DFNB30
  JOURNAL   Proc Natl Acad Sci U S A 99 (11), 7518-7523 (2002)
   PUBMED   12032315
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929064.11, AL929036.8, AEKQ02036924.1, AEKQ02036923.1 and
            AL928693.9.
            
            [WARNING] On Apr 14, 2023 this sequence was replaced by
            NM_148413.4.
            
            On Mar 19, 2010 this sequence version replaced NM_148413.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849377, SAMN00849384
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AL929064.11        25686-25825
            141-325             AL929064.11        39234-39418
            326-460             AL929064.11        43699-43833
            461-565             AL929064.11        64240-64344
            566-665             AL929064.11        65287-65386
            666-742             AL929064.11        80770-80846
            743-888             AL929064.11        89989-90134
            889-954             AL929064.11        92656-92721
            955-1110            AL929064.11        95746-95901
            1111-1210           AL929036.8         2355-2454
            1211-1327           AL929036.8         11152-11268
            1328-1432           AL929036.8         12209-12313
            1433-1516           AL929036.8         12409-12492
            1517-1719           AL929036.8         18895-19097
            1720-1818           AL929036.8         40374-40472
            1819-1933           AL929036.8         40810-40924
            1934-2060           AL929036.8         75003-75129
            2061-2271           AL929036.8         78543-78753
            2272-2416           AL929036.8         86091-86235
            2417-2570           AEKQ02036924.1     4419-4572           c
            2571-2659           AEKQ02036923.1     8433-8521           c
            2660-2789           AEKQ02036923.1     6476-6605           c
            2790-2869           AEKQ02036923.1     4634-4713           c
            2870-2947           AEKQ02036923.1     4115-4192           c
            2948-3153           AL928693.9         199773-199978       c
            3154-3265           AL928693.9         193091-193202       c
            3266-3428           AL928693.9         190342-190504       c
            3429-3552           AL928693.9         183840-183963       c
            3553-4441           AL928693.9         179964-180852       c
            4442-4586           AL928693.9         178336-178480       c
            4587-4693           AL928693.9         158005-158111       c
            4694-4734           AL928693.9         157043-157083       c
            4735-4878           AL928693.9         155931-156074       c
            4879-5082           AL928693.9         139941-140144       c
FEATURES             Location/Qualifiers
     source          1..5082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..5082
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /note="myosin IIIA"
                     /db_xref="GeneID:667663"
                     /db_xref="MGI:MGI:2183924"
     exon            1..140
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..4999
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="myosin-IIIa"
                     /protein_id="NP_680779.3"
                     /db_xref="CCDS:CCDS84477.1"
                     /db_xref="GeneID:667663"
                     /db_xref="MGI:MGI:2183924"
                     /translation="MQMTETFEMLPLIGKTIIFDNFPDPSDTWEIIETIGKGTYGKVF
                     KVLNKKSGQKAAVKILDPIHDIDEEIEAEYNILRTLSDHPNVVRFYGIYFKKDKINGD
                     KLWLVLELCNGGSVTDLVKGFLKRGERMSEPVIAYILHEALMGLQHLHSNKTIHRDVK
                     GNNILLTTEGGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPEVIACEQQLDTTYDAR
                     CDTWSLGITAIELGDGDPPLAELHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCL
                     TKDYEKRPTVSDLLKHKFITQIEGKDVILQKQLMEFIDIHQCLGSTEKARHERIHTKK
                     GNLNRSLISSLKDVDDLATLDVLDENTVSEHLEKCYSRDQIYIYVGDILIALNPFQSL
                     GIYSTKLSRLYIGAKRTANPPHIFAMADLGYQSMVTYNADQCIVISGESGAGKTESAH
                     LLVQQLTVLGKANNRTLQEKILQMNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGA
                     VVGAQISEYLLEKSRVIHQAIGEKNFHIFYYIYAGLAEKKKLALYKLPENKPPRYLQN
                     DNLRTVQDMMNNSFYKSQYELIEQCFKVIGFTMEQLGSVYSVLAAILNVGNIEFSSVA
                     TEYQMDKSYICNHTALENSASLLCIQADELQEALTSHCVVTRGETIIRPNTVEKAADV
                     RDAMAKTLYGRLFSWIVNCINSLLKHDTSPSGDEELNIGILDIFGFENFKRNSFEQLC
                     INIANEQIQYYFNQHVFAWEQNEYLNEDVDARVIEYEDNRPLLDMFLQKPMGLLSLLD
                     EESRFPKATDQTLIEKFEDNLKSQYFWRPKRMELSFGIHHYAGKVLYSASGFLAKNRD
                     TFPTDIVLLLRSSENSVIRQLVNHPLTKTGNLPLSKTKNIVNYQMWNSEKSTNLTKGE
                     TRDVTCHACETTNVKTQTVSSYFRYSLMDLLSKMVVGQPHFVRCIKPNNERQARKYDK
                     EKVLLQLRCTGILETARIRRLGYSHRILFANFIKRYYILCYKSSEEPPVSPDTCAAIL
                     EKAGLDNWALGKTKVFLKYYHVEQLNLMRKEATNKLVLIQASVRAFLGARRYQELQQK
                     RKSSAVIIQSAARRHLLRKHGKETSNVKSAAGRSIRAKDQEFDYKKNFETKRESFVKK
                     QTENAVPTNESNTSTPNNKESPSAGKTAPFRAESKATNVESNNRRYHTQKKMSNVYAE
                     GQNQELYIVEDTWAEVSPRQKYVQDLEESRKMRKEEKGDAVIQSYCQWYTEGSNFEES
                     KATCLEGRETWERTSCPGLWLTEEIYLRKTLDPTLSQKSVYQNADGKEKEHKVSVVTQ
                     NAPLGNLERDYHLLGFLGEEDTGPVPQAQEEHKAVSIHSKYQSSKKKQQLGKDRLAPP
                     FKNQKILSSSTEVAKTTHNVYPCPTKQEGVHHSKMVDERDSKMASKKEAWDLAMFSRQ
                     ISKLSEEYFILQKNLNEIILAQQLKPFYLGIYRHKPINRHVSTHQYLSGVSKGEEPKI
                     LRPPRRPRKPKTLNNPEDSTYYYLLHKSTQEEKRRPGKDSQGKLLGLEDFYYKEFLPT
                     HYGPKAHSSNAREWKALKEPQAQPIESNERCWTTSENESLEEERISANPYDYRRLLRK
                     TSQRQRLVQQL"
     exon            141..325
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            326..460
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            461..565
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            566..665
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            666..742
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..888
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            889..954
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1110
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1210
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1327
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1432
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1516
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1719
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1818
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1933
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2060
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2271
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2416
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2570
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2659
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2789
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2869
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..2947
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3153
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3265
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3428
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3552
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..4441
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4442..4586
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4587..4693
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4694..4734
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4735..4878
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4879..5082
                     /gene="Myo3a"
                     /gene_synonym="9030416P08Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctctgtag gggacccggc ggcgcgctag ggcggtgcaa aatcccagta ttgggccagc
       61 agaggaattg gagtggccac actgtgcacc cacctgggga aggagcctgc agaccttaga
      121 acgcctggct catatgcaga tgacagaaac ctttgagatg cttccattaa ttggaaaaac
      181 aatcatcttt gataactttc ctgatccttc tgatacatgg gaaatcattg aaaccatcgg
      241 caaaggaact tatgggaagg ttttcaaagt cctgaataag aaaagtggcc agaaagcagc
      301 agtcaaaatt ttggatccaa tccatgatat cgatgaagag attgaagcag agtataacat
      361 cttaagaaca ctttctgacc acccaaatgt ggtcagattc tacgggattt actttaaaaa
      421 ggacaagata aatggagata agctatggct ggttctggag ctgtgcaatg gaggatcagt
      481 gactgatctt gtgaaaggat ttctgaagag gggagaaaga atgagcgagc ctgtaattgc
      541 atatatttta cacgaagcac taatgggact tcagcatctt catagcaaca aaaccatcca
      601 ccgtgatgtc aaaggaaata acatcctgtt gactactgaa ggtggagtaa aactagtaga
      661 ttttggtgtg tctgcacagc tcagcagcac ccggcaccgc ctgaacacct ccgtaggaac
      721 accattttgg atggctcctg aggtgattgc ttgtgaacag caactagata ccacttacga
      781 tgctagatgt gacacatggt ccctgggtat cacggctatt gagcttggtg atggagatcc
      841 tccactagct gagctgcatc ccatgagagc actcttcaaa ataccaagga atccaccccc
      901 taaactccgg cagcctgagc tgtggtccgc agagttcaat gacttcatta gcaaatgctt
      961 gaccaaagat tatgaaaagc gtccaacagt gtcagatctt ttgaagcata aatttattac
     1021 tcagatcgag ggcaaagatg tgatactaca aaaacaacta atggaattca ttgatatcca
     1081 tcaatgcctg ggaagcacag agaaggccag gcatgaacga attcatacca agaaaggtaa
     1141 tttaaataga tctctcattt ccagtctgaa ggatgtagac gatttggcaa ccctagatgt
     1201 tctggatgag aacacagtgt ctgaacatct tgagaaatgt tattccagag atcagatcta
     1261 tatttatgtg ggagatattc tcattgcact gaaccctttt cagagtctgg gtatttattc
     1321 cacaaagctt tctaggttgt atattggagc aaagagaact gccaacccac ctcacatttt
     1381 tgcaatggct gatttgggat accagtctat ggtcacatat aatgcagacc agtgcatcgt
     1441 tatttctgga gaaagtggtg ctggcaagac agagagcgct catcttctgg ttcaacagct
     1501 cactgtgctt ggaaaggcta ataacagaac cctgcaagag aagattttac aaatgaacaa
     1561 tttggttgaa gcctttggca atgcctgcac tattataaat gacaactcca gcagatttgg
     1621 aaaatactta gaaatgaaat ttacttcttc tggagctgta gttggggcac agatttctga
     1681 ataccttctg gaaaaatccc gtgtcattca ccaagccatt ggagaaaaaa attttcatat
     1741 tttttactac atttatgctg ggttagcaga aaagaagaaa ctagctcttt acaaattgcc
     1801 tgaaaacaag ccacccaggt acttacaaaa tgacaacctc agaacagtac aggacatgat
     1861 gaacaatagt ttctataaat cccagtatga attaattgaa caatgtttca aagtcatagg
     1921 ttttacaatg gagcaacttg gaagtgtata tagtgtactc gccgccatct tgaacgttgg
     1981 aaacattgaa ttctcctcgg tggcaactga ataccagatg gacaagagct acatttgcaa
     2041 tcacactgct ctggaaaact ccgcttcttt gctttgcatt caagcagatg agctgcagga
     2101 agctctcacc tcacactgtg tggtcactag aggagaaaca attattcgac ccaacacagt
     2161 ggaaaaggct gctgatgtcc gagatgccat ggccaaaact ttatatggcc gtctctttag
     2221 ctggatagtc aattgtatta acagcttgct gaagcatgac acatcaccta gtggggatga
     2281 ggagctaaac atcggcattc ttgacatatt cggctttgaa aacttcaaaa gaaattcctt
     2341 tgagcagctg tgcattaaca ttgcaaatga acagatccag tattatttta atcagcacgt
     2401 gtttgcatgg gagcagaatg aatacctaaa tgaagatgta gatgctagag ttattgaata
     2461 cgaagacaac cggcccctct tggacatgtt tctacagaag cccatgggct tattgtctct
     2521 gcttgatgag gaaagcagat ttcccaaggc cactgaccag actctcatag aaaaatttga
     2581 agacaacctg aagtcacagt acttctggag acccaaaaga atggaactca gttttggcat
     2641 tcaccactat gcaggaaaag tcctctatag tgctagtggg ttcttggcta aaaacagaga
     2701 cactttccca actgatattg tgctgctttt gaggtcatca gaaaacagtg taattcggca
     2761 acttgtcaac caccctctga ccaaaacagg taatctgcca ctttctaaaa ctaaaaacat
     2821 agtaaactat cagatgtgga attcagagaa atccacaaac ctgaccaagg gtgaaactag
     2881 agatgtcaca tgccatgcct gtgaaaccac caatgtgaaa acacaaacgg tctcatccta
     2941 ttttagatac tccttgatgg atttattatc taaaatggta gtgggccaac ctcattttgt
     3001 ccgttgcatc aaaccaaata atgagcgaca ggcaagaaag tatgacaagg agaaagttct
     3061 gctccagctg cgttgcacag ggattttgga aacagcaaga attcgaaggc ttggttattc
     3121 acatcggata ctcttcgcta actttataaa gaggtattac attctctgct acaaatcgag
     3181 tgaagagccc ccagtgagcc cagacacctg tgctgccatt ttggaaaagg ctggtcttga
     3241 taactgggct cttggaaaaa cgaaagtgtt ccttaaatat tatcatgtgg aacagttgaa
     3301 tctaatgcga aaggaagcta ccaacaagct tgttttgatt caagccagtg tcagagcatt
     3361 cttgggtgca agaagatacc aagaacttca gcagaagagg aagagtagtg ctgtaataat
     3421 acagtcagct gcaagaagac atctcttgcg aaaacatgga aaagaaacat ctaatgtgaa
     3481 aagtgcagca ggaaggagca ttcgggctaa ggatcaggaa tttgactaca agaaaaattt
     3541 tgaaaccaaa agggaatctt ttgtgaagaa acagacagaa aacgcagtgc ctactaatga
     3601 atccaacact tcaactccaa acaacaaaga gagcccatct gctgggaaga cagctccctt
     3661 cagagcagag tcaaaggcca ccaatgttga gagtaacaac agaagatacc atactcagaa
     3721 gaaaatgagc aatgtgtatg cagaaggaca gaatcaagag ctatatattg tggaggacac
     3781 ttgggcagaa gtaagcccca ggcagaagta tgtgcaagac ctggaagaaa gcagaaagat
     3841 gaggaaagag gagaaaggag atgctgtgat ccagagttac tgtcagtggt acacagaggg
     3901 aagcaacttt gaagaatcaa aagcaacatg tctagaagga agggagacat gggaaaggac
     3961 aagctgccca gggctgtggc tgactgagga gatttacctg agaaaaactt tggatcctac
     4021 tcttagccaa aagtcagtct atcaaaatgc agatggcaaa gaaaaagaac ataaagtatc
     4081 tgtggttacc cagaatgcac cgctgggcaa cctggagaga gactatcact tgctagggtt
     4141 ccttggagaa gaagacactg gaccagtgcc tcaggcccag gaagaacaca aggctgtgtc
     4201 cattcatagc aaataccaga gttccaagaa aaagcaacag ctgggaaagg acaggctggc
     4261 acctcccttt aagaatcaaa agatcctttc atcgtccaca gaagtagcaa aaaccactca
     4321 caatgtctat ccctgtccga caaagcagga gggagtccat catagcaaga tggtggatga
     4381 gagagactca aaaatggctt caaaaaaaga agcgtgggat ttagcaatgt tttcaagaca
     4441 gatatcaaag ttatctgaag agtatttcat tctgcagaaa aacttgaatg aaattatttt
     4501 ggcccagcaa ctgaagccat tttatctagg tatctatcgc cataaaccaa tcaacagaca
     4561 tgtttctact caccaatacc tctcaggtgt ctctaaaggg gaagaaccaa aaatactgag
     4621 acctccaaga cgacctcgga aacccaaaac attaaataac cctgaagact ccacatacta
     4681 ctatctactc cataagtcaa cccaagaaga aaaacggaga ccaggaaaag acagtcaagg
     4741 gaagttatta ggtttggaag atttctatta taaggaattt ttgcctactc attacggacc
     4801 caaggcacat agctctaatg caagagaatg gaaagcactg aaggaacccc aggctcaacc
     4861 cattgagagt aatgagaggt gttggaccac ctcagagaat gagagcctgg aggaagagag
     4921 gatttcagcc aacccttatg actacaggag gctcctgcgc aaaacctccc agcggcagcg
     4981 cctggtgcag cagttgtagc tcacctacgg agcttcagaa agtgaagcaa ggatcaaagc
     5041 agcagcaggg taacctctca aacaggaccg cacaggcgct gc
//
