LOCUS       NM_178440               3307 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus myosin IG (Myo1g), mRNA.
ACCESSION   NM_178440
VERSION     NM_178440.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3307)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3307)
  AUTHORS   Watanabe,K., Nakayama,K., Ohta,S., Matsumoto,A., Tsuda,H. and
            Iwamoto,S.
  TITLE     ILDR2 stabilization is regulated by its interaction with GRP78
  JOURNAL   Sci Rep 11 (1), 8414 (2021)
   PUBMED   33863978
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3307)
  AUTHORS   Cruz-Zarate,D., Lopez-Ortega,O., Giron-Perez,D.A.,
            Gonzalez-Suarez,A.M., Garcia-Cordero,J.L., Schnoor,M. and
            Santos-Argumedo,L.
  TITLE     Myo1g is required for efficient adhesion and migration of activated
            B lymphocytes to inguinal lymph nodes
  JOURNAL   Sci Rep 11 (1), 7197 (2021)
   PUBMED   33785780
  REMARK    GeneRIF: Myo1g is required for efficient adhesion and migration of
            activated B lymphocytes to inguinal lymph nodes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3307)
  AUTHORS   Lopez-Ortega,O., Ovalle-Garcia,E., Ortega-Blake,I., Antillon,A.,
            Chavez-Munguia,B., Patino-Lopez,G., Fragoso-Soriano,R. and
            Santos-Argumedo,L.
  TITLE     Myo1g is an active player in maintaining cell stiffness in
            B-lymphocytes
  JOURNAL   Cytoskeleton (Hoboken) 73 (5), 258-268 (2016)
   PUBMED   27106882
  REMARK    GeneRIF: The results described here reveal a novel molecular
            mechanism by which Myo1g mediates and regulates cell stiffness in
            B-lymphocytes.
REFERENCE   5  (bases 1 to 3307)
  AUTHORS   Gerard,A., Patino-Lopez,G., Beemiller,P., Nambiar,R., Ben-Aissa,K.,
            Liu,Y., Totah,F.J., Tyska,M.J., Shaw,S. and Krummel,M.F.
  TITLE     Detection of rare antigen-presenting cells through T cell-intrinsic
            meandering motility, mediated by Myo1g
  JOURNAL   Cell 158 (3), 492-505 (2014)
   PUBMED   25083865
  REMARK    GeneRIF: Study found that the unconventional myosin 1g (Myo1g)
            motor generates membrane tension, enforces cell-intrinsic
            meandering search, and enhances T-DC interactions during lymph-node
            surveillance. Increased turning and meandering motility, as opposed
            to ballistic motility, is enhanced by Myo1g. Myo1g acts as a
            'turning motor' and generates a form of cellular 'flanerie.'
REFERENCE   6  (bases 1 to 3307)
  AUTHORS   Maravillas-Montero,J.L., Lopez-Ortega,O., Patino-Lopez,G. and
            Santos-Argumedo,L.
  TITLE     Myosin 1g regulates cytoskeleton plasticity, cell migration,
            exocytosis, and endocytosis in B lymphocytes
  JOURNAL   Eur J Immunol 44 (3), 877-886 (2014)
   PUBMED   24310084
  REMARK    GeneRIF: Myosin 1g regulates cytoskeleton plasticity, cell
            migration, exocytosis, and endocytosis in B lymphocytes.
REFERENCE   7  (bases 1 to 3307)
  AUTHORS   Dart,A.E., Tollis,S., Bright,M.D., Frankel,G. and Endres,R.G.
  TITLE     The motor protein myosin 1G functions in FcgammaR-mediated
            phagocytosis
  JOURNAL   J Cell Sci 125 (Pt 24), 6020-6029 (2012)
   PUBMED   23038771
REFERENCE   8  (bases 1 to 3307)
  AUTHORS   Olety,B., Walte,M., Honnert,U., Schillers,H. and Bahler,M.
  TITLE     Myosin 1G (Myo1G) is a haematopoietic specific myosin that
            localises to the plasma membrane and regulates cell elasticity
  JOURNAL   FEBS Lett 584 (3), 493-499 (2010)
   PUBMED   19968988
  REMARK    GeneRIF: Data propose that Myo1G regulates cell elasticity by
            deformations of the actin network at the cell cortex.
REFERENCE   9  (bases 1 to 3307)
  AUTHORS   Dumont,R.A., Zhao,Y.D., Holt,J.R., Bahler,M. and Gillespie,P.G.
  TITLE     Myosin-I isozymes in neonatal rodent auditory and vestibular
            epithelia
  JOURNAL   J Assoc Res Otolaryngol 3 (4), 375-389 (2002)
   PUBMED   12486594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030825.1, AK152797.1 and AK171505.1.
            
            On Nov 11, 2009 this sequence version replaced NM_178440.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088011.1, AK030825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-832               AK030825.1         2-833
            833-2475            AK152797.1         827-2469
            2476-3307           AK171505.1         2450-3281
FEATURES             Location/Qualifiers
     source          1..3307
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.3 cM"
     gene            1..3307
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /note="myosin IG"
                     /db_xref="GeneID:246177"
                     /db_xref="MGI:MGI:1927091"
     exon            1..217
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3179
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /note="myosin-Ig; myosin 1G"
                     /codon_start=1
                     /product="unconventional myosin-Ig"
                     /protein_id="NP_848534.2"
                     /db_xref="CCDS:CCDS24421.1"
                     /db_xref="GeneID:246177"
                     /db_xref="MGI:MGI:1927091"
                     /translation="MLAVGRMEDEEGPEYGKPDFVLLDQLTMEDFMKNLELRFEKGRI
                     YTYIGEVLVSVNPYQELPLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRDT
                     CIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVLLKSTCVLEAFGNARTN
                     RNHNSSRFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSE
                     DQELQGLHLERNPAVYNFTRQGAGLNMGVHNALDSDEKSHQGVMEAMRIIGFSPDEVE
                     SIHRILAAILHLGNIEFVETEENGPQKGGLEVADEALVGYVAKLTATPRDLVLRTLLA
                     RTVASGGREVIEKSHTVAEASYARDACAKAMYQRLFEWVVNKINSIMEPRNRDPRCDG
                     KDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGIAWQT
                     IEYFNNATIVELVEQPHRGILAVLDEACSTAGPITDRIFLQTLDTHHRHHPHYSSRQL
                     CPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYNSVDPTLRAMWP
                     DGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGRLDEAHC
                     RHQVEYLGLLENVRVRRAGFASRQPYPRFLLRYKMTCEYTWPNHLLGSDRDAVSALLE
                     QHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWHCRRLR
                     AIYTIMRWFRRHKVRAHLIELQRRFQAARQPPLYGRDLVWPTPPAVLQPFQDTCRVLF
                     SRWRARQLVKNIPPSDMIQIKAKVAAMGALQGLRQDWGCQRAWARDYLSSDTDNPTAS
                     HLFAEQLKALREKDGFGSVLFSSHVRKVNRFRKSRDRALLLTDRYLYKLEPGRQYRVM
                     RAVPLEAVTGLSVTSGRDQLVVLHAQGYDDLVVCLHRSQPPLDNRIGELVGMLAAHCQ
                     GEGRTLEVRVSDCIPLSQRGARRLISVEPRPEQPEPDFQSSRSTFTLLWPSH"
     exon            218..426
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..520
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            521..686
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            687..740
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            741..851
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            852..968
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1193
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1339
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1454
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1625
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1696
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1771
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1904
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2071
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2279
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2503
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2648
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2753
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2867
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3022
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3307
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3283..3288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3307
                     /gene="Myo1g"
                     /gene_synonym="E430002D17Rik"
                     /note="major polyA site"
ORIGIN      
        1 acttcctact ttactgaagt actgcagtag tcaggcaggg ctgggcctcc cctttctgcc
       61 ttccccttca cctctgtaca gaaagctctg gcgacctgcc ttggatgctt gcagtgggca
      121 ggatggagga cgaagaaggc cctgagtatg ggaaaccaga cttcgtgctt ttggatcaac
      181 tgaccatgga ggacttcatg aagaacctag agctcaggtt tgagaagggc cgtatctata
      241 cctacattgg tgaggtgctc gtatccgtga acccctacca ggaactgcca ttgtatgggc
      301 cagaggccat tgccaagtac cagggccgcg agctctatga gcgaccacct catctttacg
      361 ccgtggccaa tgctgcttac aaggcaatga agcgcagatc cagggacacc tgcatcgtca
      421 tctcagggga gagtggggca gggaagacag aagccagcaa gcacatcatg cagtacattg
      481 ctgctgtcac caacccaagc cagagggctg aggtggagag ggtgaagaat gtgctcctca
      541 agtccacctg tgtgctcgaa gcctttggca atgcccgcac caatcgcaac cacaactcca
      601 gccgctttgg caagtacatg gacatcaact tcgacttcaa gggggatcct gttggtggac
      661 acatccacag ctacctgctg gagaagtcta gggttctcaa gcaacatgta ggtgagagga
      721 acttccatgc cttctaccag ttgcttcgag gcagtgagga ccaagagctg caaggactgc
      781 atctggaaag aaatcctgct gtgtataatt tcacgcgtca gggagctggg ctcaacatgg
      841 gtgtgcacaa tgccttggac agtgatgaga agagccacca aggagtgatg gaggccatga
      901 ggatcatcgg cttcagtcct gacgaggtgg agtccatcca tcgcatcctt gccgccatat
      961 tacacctggg aaacatcgag tttgtggaga cagaggaaaa tggaccacag aaaggaggcc
     1021 tggaagtggc tgatgaggcc ctggtaggat atgtggccaa gctgacagcc actcccagag
     1081 accttgttct gcgaaccctg ctggctcgaa cagtggcttc aggaggccga gaagtcattg
     1141 agaagagcca caccgtggct gaggccagct atgcccggga tgcctgtgca aaggcgatgt
     1201 accagcgact gtttgagtgg gttgtgaaca agatcaatag catcatggaa ccccgaaacc
     1261 gagaccctcg gtgtgatggc aaggatactg tcattggggt gctggacatt tacggctttg
     1321 aggtgttccc tgtcaacagc tttgagcagt tctgcatcaa ctactgcaac gagaagctgc
     1381 agcagctctt tatccagctt atcctgaagc aagagcagga ggagtatgag cgagagggca
     1441 tcgcctggca gaccatcgag tacttcaaca acgctaccat tgtggaactt gtagagcagc
     1501 cccacagagg catcctggct gtgttagatg aagcctgcag cacggcaggc cccatcactg
     1561 accgaatctt cctgcagacc ctggacacac accaccgcca ccacccacac tattccagcc
     1621 gccagctttg ccctacggac aagaccatgg agtttggccg agacttccag atcaaacact
     1681 atgcaggcga tgtcacgtac tctgtggaag gcttcattga caagaataga gactctctct
     1741 tccaggactt caaacggctg ctgtacaata gtgtggatcc caccttgcga gccatgtggc
     1801 ctgacgggca acaggacatc acggaagtga ccaagcgtcc cctgacagcc ggcacactct
     1861 ttaagaattc catggttgcc ctggtggaaa acttggcttc caaggaaccc ttctatgtcc
     1921 gctgcatcaa acccaacgaa gacaaggtgg ctgggcggct cgatgaagcc cactgtcgtc
     1981 accaggtcga atacctggga ctattggaga atgtgagggt ccgcagggct ggctttgctt
     2041 cccggcagcc ctaccctcga ttcctgctca ggtacaagat gacctgtgag tacacgtggc
     2101 ccaaccacct gctgggctct gaccgggatg cggtgagcgc cctgctggaa cagcatgggc
     2161 tgcaagggga tgtggccttt ggccacagca agctgttcat ccgatcccca aggacgctgg
     2221 tcactctgga gcagagccga gctcgcctga ttcccatcat tgtgttattg ctgcagaagg
     2281 cttggcgggg caccctggct aggtggcact gccggcgact aagggccatc tacaccatca
     2341 tgcgctggtt ccggaggcac aaggtgcgtg ctcacctgat tgaactacag cgccggttcc
     2401 aggctgcacg gcagccccca ctctatggcc gtgaccttgt gtggcccaca cctcctgctg
     2461 tgctgcagcc cttccaggac acttgccgtg ttctcttcag caggtggcgg gcacggcagt
     2521 tagtgaagaa catccctcct tcagacatga tccagatcaa ggccaaggtg gctgctatgg
     2581 gggccttgca aggattgcgg caggactggg gttgccagcg ggcctgggcc cgagactacc
     2641 tgtcctctga cactgacaac cccacagctt cccatctgtt tgctgagcaa ctaaaggcac
     2701 ttcgggagaa agatggcttt ggctctgtgc ttttctccag ccatgtgcgc aaggtgaatc
     2761 gcttccgcaa gagccgggac cgggcccttc tgctcacaga tcggtatctg tacaagctgg
     2821 agcctggacg acagtaccgg gtgatgcggg ctgtgcctct ggaggcggtg acagggctga
     2881 gtgtgaccag tggaagagat cagctggtgg tgttacatgc ccaaggctat gatgatcttg
     2941 tagtgtgtct acaccgttcc caaccaccac tggacaatcg aattggggag ctggtgggca
     3001 tgctggctgc acactgccag ggagagggac gaactctgga ggtccgtgtc tctgactgca
     3061 tcccactgag ccagcgtggt gcccggcgcc tcatttctgt ggagcccagg ccagagcagc
     3121 ctgagccaga tttccaaagc agccgtagca cctttaccct cctctggcca agccactgag
     3181 caaggccaaa ccagtttaac ctggtttcca cgctgttcta aatacctggt cttgactgca
     3241 ctaaaggcca ggacttgtct acccttacat ggaacattgc aaaataaaga tgttatattt
     3301 gttttca
//
