LOCUS       NM_053214               3833 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus myosin IF (Myo1f), mRNA.
ACCESSION   NM_053214 NM_008660
VERSION     NM_053214.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3833)
  AUTHORS   Liu,W., Yang,H., Xu,Q., Lee,J., Sun,J., Xue,S., Yang,X., Sun,X. and
            Che,C.
  TITLE     Role of MYO1F in neutrophil and macrophage recruitment and
            pro-inflammatory cytokine production in Aspergillus fumigatus
            keratitis
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113094 (2024)
   PUBMED   39276460
  REMARK    GeneRIF: Role of MYO1F in neutrophil and macrophage recruitment and
            pro-inflammatory cytokine production in Aspergillus fumigatus
            keratitis.
REFERENCE   2  (bases 1 to 3833)
  AUTHORS   Martinez-Vargas,I.U., Sanchez-Bello,M.E., Miguel-Rodriguez,C.E.,
            Hernandez-Cazares,F., Santos-Argumedo,L. and Talamas-Rohana,P.
  TITLE     Myo1f has an essential role in gammadeltaT intraepithelial
            lymphocyte adhesion and migration
  JOURNAL   Front Immunol 14, 1041079 (2023)
   PUBMED   37207213
  REMARK    GeneRIF: Myo1f has an essential role in gammadeltaT intraepithelial
            lymphocyte adhesion and migration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3833)
  AUTHORS   Sun,W., Ma,X., Wang,H., Du,Y., Chen,J., Hu,H., Gao,R., He,R.,
            Peng,Q., Cui,Z., Zhang,H., Wang,J., Jia,X., Martin,B.N.,
            Zhang,C.J., Li,X. and Wang,C.
  TITLE     MYO1F regulates antifungal immunity by regulating acetylation of
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 118 (30) (2021)
   PUBMED   34301894
REFERENCE   4  (bases 1 to 3833)
  AUTHORS   Barger,S.R., Reilly,N.S., Shutova,M.S., Li,Q., Maiuri,P.,
            Heddleston,J.M., Mooseker,M.S., Flavell,R.A., Svitkina,T.,
            Oakes,P.W., Krendel,M. and Gauthier,N.C.
  TITLE     Membrane-cytoskeletal crosstalk mediated by myosin-I regulates
            adhesion turnover during phagocytosis
  JOURNAL   Nat Commun 10 (1), 1249 (2019)
   PUBMED   30890704
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3833)
  AUTHORS   Piedra-Quintero,Z.L., Serrano,C., Villegas-Sepulveda,N.,
            Maravillas-Montero,J.L., Romero-Ramirez,S., Shibayama,M.,
            Medina-Contreras,O., Nava,P. and Santos-Argumedo,L.
  TITLE     Myosin 1F Regulates M1-Polarization by Stimulating Intercellular
            Adhesion in Macrophages
  JOURNAL   Front Immunol 9, 3118 (2019)
   PUBMED   30687322
  REMARK    GeneRIF: Study demonstrated that intercellular adhesion is mediated
            by integrin-alphaVbeta3 and relies in the presence of the
            unconventional class I myosin 1F (Myo1F). Intercellular adhesion
            mediated by alphaVbeta3 stimulates M1-like phenotype in macrophages
            through hyperactivation of STAT1 and STAT3 downstream of
            ILK/Akt/mTOR signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3833)
  AUTHORS   Kim,S.V., Mehal,W.Z., Dong,X., Heinrich,V., Pypaert,M., Mellman,I.,
            Dembo,M., Mooseker,M.S., Wu,D. and Flavell,R.A.
  TITLE     Modulation of cell adhesion and motility in the immune system by
            Myo1f
  JOURNAL   Science 314 (5796), 136-139 (2006)
   PUBMED   17023661
  REMARK    GeneRIF: Myo1f-deficient mice exhibited abnormally increased
            adhesion and reduced motility, resulting from augmented exocytosis
            of beta2 integrin-containing granules; Myo1f directs immune cell
            motility and innate host defense against infection
REFERENCE   7  (bases 1 to 3833)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
REFERENCE   8  (bases 1 to 3833)
  AUTHORS   Dumont,R.A., Zhao,Y.D., Holt,J.R., Bahler,M. and Gillespie,P.G.
  TITLE     Myosin-I isozymes in neonatal rodent auditory and vestibular
            epithelia
  JOURNAL   J Assoc Res Otolaryngol 3 (4), 375-389 (2002)
   PUBMED   12486594
REFERENCE   9  (bases 1 to 3833)
  AUTHORS   Crozet,F., el Amraoui,A., Blanchard,S., Lenoir,M., Ripoll,C.,
            Vago,P., Hamel,C., Fizames,C., Levi-Acobas,F., Depetris,D.,
            Mattei,M.G., Weil,D., Pujol,R. and Petit,C.
  TITLE     Cloning of the genes encoding two murine and human cochlear
            unconventional type I myosins
  JOURNAL   Genomics 40 (2), 332-341 (1997)
   PUBMED   9119401
REFERENCE   10 (bases 1 to 3833)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030734.24, BY196585.1, AK158333.1, CT033847.5, AK036840.1 and
            BE691075.1.
            
            On Aug 4, 2009 this sequence version replaced NM_053214.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046502.1, AK158333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CT030734.24        220851-220852
            3-351               BY196585.1         3-351
            352-1071            AK158333.1         267-986
            1072-1072           CT033847.5         54011-54011
            1073-1922           AK158333.1         988-1837
            1923-3476           AK036840.1         1756-3309
            3477-3827           BE691075.1         1-351               c
            3828-3833           AK036840.1         3662-3667
FEATURES             Location/Qualifiers
     source          1..3833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..3833
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /note="myosin IF"
                     /db_xref="GeneID:17916"
                     /db_xref="MGI:MGI:107711"
     exon            1..150
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            151..288
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            289..378
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            379..473
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            474..561
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            562..651
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            652..783
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            784..918
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1051
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1248
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1329
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1416
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1503
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1671
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1757
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1839
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1946
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2045
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2190
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2305
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2475
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2621
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2768
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2917
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3001
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3197
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3367
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3833
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3810..3815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3831
                     /gene="Myo1f"
                     /gene_synonym="C330006B10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcaaaggaag taaaagaggg gctgttacaa gaggaactag ggccaagagc ctgtgaagga
       61 ggagagccat gccagagcca ccccctagaa ccctctgagc ctgcacccct gtcattaccc
      121 acaggagcct acataccatc cctcaccatg ggcagcaagg agcgctttca ctggcagagt
      181 cacaacgtga agcagagtgg agtggatgac atggtgctgc tgccccagat caccgaggac
      241 gccattgtga gcaacctccg caaacgcttc atggatgact acatttttac atacattggc
      301 tcagtgctaa tctctgtaaa ccccttcaag cagatgccct acttcactga ccgagaaatt
      361 gacctctatc agggcgcggc tcaatatgag aatcccccgc acatctatgc cctcaccgac
      421 aacatgtacc ggaatatgct gatcgactgt gagaaccagt gtgtcattat cagtggggag
      481 agcggagctg ggaagacagt ggctgctaaa tacatcatgg gctacatctc caaggtgtct
      541 ggtgggggag acaaggtcca gcacgtcaaa gacataatcc tacagtcaaa cccactgctt
      601 gaggctttcg gcaatgccaa gaccgtgcgc aacaacaatt ccagccgctt tggcaagtac
      661 tttgagatcc agttcagtcg aggtggagag ccagatggag gcaagatctc caacttcctg
      721 ctggaaaagt ctcgtgtggt catgcagaat gagaatgaga ggaacttcca catctactac
      781 cagcttctgg aaggggcctc ccaggagcag cagcagaacc taggactcat gacgccagac
      841 tactactact acctcaacca atcagacacc tacaaggtgg aaggcactga tgaccgaagt
      901 gacttcagcg agaccctgag cgccatgcaa gtcatcggga ttccgacaag cgtgcagcag
      961 cttgtcttgc agctcgtggc agggatcttg cacctgggga acatcagctt ctgtgaagaa
     1021 gggaattatg cccgcgtgga gagcgtagac ctcttagctt tcccagccta cctgctgggc
     1081 atagacagtg ggcggctgca agagaagctg accagccgta agatggacag caaatggggt
     1141 ggacgcagtg agtccattga tgtgaccctc aatgtggaac aggcagccta cactcgtgac
     1201 gcactggcca agggactcta tgcccgcctc ttcgacttcc tggtggaggc catcaaccgt
     1261 gccatgcaga agcctcagga agaatacagc atcggcgtgc ttgacatcta cggctttgag
     1321 atcttccaga aaaatggctt tgagcagttc tgcatcaact tcgtcaatga aaagctgcag
     1381 cagattttta ttgagctcac gctgaaggca gagcaggagg agtatgtgca agagggcatc
     1441 cgctggaccc ccatcgaata cttcaacaac aaaattgtgt gtgacctcat cgaaaacaag
     1501 ctgagccccc caggcatcat gagcgtgcta gatgatgtgt gtgccacgat gcatgctacc
     1561 ggtggcggcg cggaccagac actgctacaa aagctgcaag cggcagtggg cacccacgag
     1621 cacttcaaca gctggagcgc gggtttcgtc atccatcact atgcaggcaa ggtctcctat
     1681 gatgtcagtg gcttctgtga gaggaatcga gatgtgctgt tctctgatct tatagaactg
     1741 atgcagtcca gtgaccagga cttcctacgg atgctctttc ctgagaagct gaatatagac
     1801 aagaagggcc gccccagtac tgctggctcc aagatcaaga aacaagccaa cgacctggtg
     1861 tccacgctga agaagtgcac accccactac atccgctgca tcaaacctaa cgagaccaag
     1921 cgtccccggg actgggagga aagcagagtg aagcaccagg tggagtacct gggcctgcgg
     1981 gagaacatcc gagtgcgaag ggcaggcttc gcctaccgtc ggcagttctc caaattcctg
     2041 caaaggtatg ccatcctgac ccctgagaca tggccacggt ggcgtggaga tgaacgccag
     2101 ggtgtccagc acctgcttcg tgctgtcaac atggagccag accagtacca gatggggagt
     2161 accaaggtct ttgttaagaa tcctgagtcg cttttcctcc tggaagagat gcgagagagg
     2221 aagtttgacg gcttcgctcg cactatccag aaagcctggc ggcgccatgt agcagtccga
     2281 aagtatgaag agatgcggga agaagcttct aacatcctac tgaacaagaa ggaacgaagg
     2341 cgaaacagca tcaaccgtaa cttcgttggg gactatctgg gactggagga gcggcctgag
     2401 ctgcgccagt tcctggctaa aagggaacga gtggactttg ccgactcagt caccaagtat
     2461 gaccgccgct tcaagcctat caaacgggac ttgatcctga ccccaaagtg tgtgtatgtg
     2521 attgggagag agaaggtgaa aaggggacca gagaagggtc tagtgcgtga agtcctgaag
     2581 aagaaactgg atatccaggc cctccgaggg gtgtctctca gcacccgaca ggatgacttc
     2641 ttcatccttc aagaagaggc tgcggacagc ttcttagaaa gtatcttcaa gaccgagttt
     2701 gtcagccttc tgtgcaagcg ttttgaagag gcagcgcgca ggccccttcc cctcaccttc
     2761 agtgacctac tacagttccg ggtgaagaaa gaaggctggg gcggaggtag tacccgaaat
     2821 gtcaccttct ctcgcgggac aagtgacttg gctgtgctca aggctggggg tcgagctctc
     2881 actatcagca ttggggacgg attgcctaag agcaccaagc ctacacggaa ggggttagcc
     2941 cagggtagac ctcgaaggtc agcgcaggct cccactcgag cagcccctgg gcctcccaga
     3001 ggtttgaatc gaaatggggt accaccctct tcccaggtaa ggtccctacc cctggagatc
     3061 acatctggta ggagttccca gaggcctcca cggggccctc catcctcaac cctaggagcc
     3121 agcagacgtc ctcgagcacg gccaccttca gagcacagta cagaattcct taatgtgcct
     3181 gaccagggtg tggcaggcat gcaaaggaag cgaagtatag ggcagagacc tgtgccagga
     3241 gtgggccggc ctaagcccca accacggaca catggcccga ggtgccgggc actgtaccaa
     3301 tacataggcc aggatgtgga tgagctgagc tttaacgtga acgaagtcat tgagatcctc
     3361 atagaagact cttctggctg gtggaagggt cggcttcatg gccaggaagg tctctttcca
     3421 ggaaactatg tggagaagat ctgatcgtcc atccaccagc ctgcctgctt gcctgcctgg
     3481 gatccaaacc ctgccagtgg aagccttggt tatcttatct gcactggcca gaatactcag
     3541 gctgtggcct caagcccagt gggacccctg tgtatggagg atgagcactg tagcacccca
     3601 tgcctggtac tgccttcctg tgggttgact tgctatctaa gtctccattt tctcctgtgt
     3661 ccaatagtag ttgctgcaaa acctacctcc cagctgcctt gtgtgtatgt aacaaatcat
     3721 gtcctgccct gggagcaaag tgctgtgcac tgcccagagt taggagacgt ggacagttag
     3781 acctttccac tttctctcat cactgaggta ataaacatgt gtcaagtaaa agc
//
