LOCUS       NM_001080774            5243 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus myosin IC (Myo1c), transcript variant 2, mRNA.
ACCESSION   NM_001080774 XM_622553 XM_903185 XM_903186
VERSION     NM_001080774.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5243)
  AUTHORS   Aslund,A., Bokhari,M.H., Wetterdal,E., Martin,R., Knolker,H.J. and
            Bengtsson,T.
  TITLE     Myosin 1c: A novel regulator of glucose uptake in brown adipocytes
  JOURNAL   Mol Metab 53, 101247 (2021)
   PUBMED   33965643
  REMARK    GeneRIF: Myosin 1c: A novel regulator of glucose uptake in brown
            adipocytes.
REFERENCE   2  (bases 1 to 5243)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5243)
  AUTHORS   Li,K., Zhang,K., Wang,H., Wu,Y., Chen,N., Chen,J., Qiu,C., Cai,P.,
            Li,M., Liang,X. and Su,D.
  TITLE     Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice
  JOURNAL   Metabolism 114, 154349 (2021)
   PUBMED   32888949
REFERENCE   4  (bases 1 to 5243)
  AUTHORS   Ji,H.H. and Ostap,E.M.
  TITLE     The regulatory protein 14-3-3beta binds to the IQ motifs of
            myosin-IC independent of phosphorylation
  JOURNAL   J Biol Chem 295 (12), 3749-3756 (2020)
   PUBMED   31811090
  REMARK    GeneRIF: The regulatory protein 14-3-3beta binds to the IQ motifs
            of myosin-IC independent of phosphorylation.
REFERENCE   5  (bases 1 to 5243)
  AUTHORS   Arif,E., Solanki,A.K., Srivastava,P., Rahman,B., Tash,B.R.,
            Holzman,L.B., Janech,M.G., Martin,R., Knolker,H.J.,
            Fitzgibbon,W.R., Deng,P., Budisavljevic,M.N., Syn,W.K., Wang,C.,
            Lipschutz,J.H., Kwon,S.H. and Nihalani,D.
  TITLE     The motor protein Myo1c regulates transforming growth
            factor-beta-signaling and fibrosis in podocytes
  JOURNAL   Kidney Int 96 (1), 139-158 (2019)
   PUBMED   31097328
  REMARK    GeneRIF: The motor protein Myo1c regulates transforming growth
            factor-beta-signaling and fibrosis in podocytes.
REFERENCE   6  (bases 1 to 5243)
  AUTHORS   Hamilton,B.A., Smith,D.J., Mueller,K.L., Kerrebrock,A.W.,
            Bronson,R.T., van Berkel,V., Daly,M.J., Kruglyak,L., Reeve,M.P.,
            Nemhauser,J.L., Hawkins,T.L., Rubin,E.M. and Lander,E.S.
  TITLE     The vibrator mutation causes neurodegeneration via reduced
            expression of PITP alpha: positional complementation cloning and
            extragenic suppression
  JOURNAL   Neuron 18 (5), 711-722 (1997)
   PUBMED   9182797
REFERENCE   7  (bases 1 to 5243)
  AUTHORS   Crozet,F., el Amraoui,A., Blanchard,S., Lenoir,M., Ripoll,C.,
            Vago,P., Hamel,C., Fizames,C., Levi-Acobas,F., Depetris,D.,
            Mattei,M.G., Weil,D., Pujol,R. and Petit,C.
  TITLE     Cloning of the genes encoding two murine and human cochlear
            unconventional type I myosins
  JOURNAL   Genomics 40 (2), 332-341 (1997)
   PUBMED   9119401
REFERENCE   8  (bases 1 to 5243)
  AUTHORS   Whitmer,J.D., Koslovsky,J.S., Bahler,M. and Mercer,J.A.
  TITLE     Chromosomal location of three unconventional myosin heavy chain
            genes in the mouse
  JOURNAL   Genomics 38 (2), 235-237 (1996)
   PUBMED   8954808
REFERENCE   9  (bases 1 to 5243)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   10 (bases 1 to 5243)
  AUTHORS   Sherr,E.H., Joyce,M.P. and Greene,L.A.
  TITLE     Mammalian myosin I alpha, I beta, and I gamma: new widely expressed
            genes of the myosin I family
  JOURNAL   J Cell Biol 120 (6), 1405-1416 (1993)
   PUBMED   8449986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591440.7.
            
            On Nov 15, 2022 this sequence version replaced NM_001080774.1.
            
            Summary: This gene encodes a member of the unconventional myosin
            protein family, which are actin-based molecular motors. The protein
            is found in the cytoplasm, and one isoform with a unique N-terminus
            is also found in the nucleus. The protein functions in
            intracellular vesicle transport to the plasma membrane. The nuclear
            isoform associates with RNA polymerase I and II and functions in
            transcription initiation. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166638.1, SRR17253011.6563996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL591440.7         63755-63892         c
            139-294             AL591440.7         58451-58606         c
            295-410             AL591440.7         58230-58345         c
            411-609             AL591440.7         57548-57746         c
            610-690             AL591440.7         57379-57459         c
            691-870             AL591440.7         55748-55927         c
            871-969             AL591440.7         55567-55665         c
            970-1083            AL591440.7         55086-55199         c
            1084-1155           AL591440.7         54930-55001         c
            1156-1275           AL591440.7         54484-54603         c
            1276-1358           AL591440.7         54282-54364         c
            1359-1464           AL591440.7         53971-54076         c
            1465-1545           AL591440.7         53783-53863         c
            1546-1637           AL591440.7         53435-53526         c
            1638-1732           AL591440.7         50486-50580         c
            1733-1779           AL591440.7         50359-50405         c
            1780-1860           AL591440.7         50181-50261         c
            1861-1966           AL591440.7         47812-47917         c
            1967-2084           AL591440.7         47571-47688         c
            2085-2198           AL591440.7         46977-47090         c
            2199-2275           AL591440.7         46824-46900         c
            2276-2344           AL591440.7         46249-46317         c
            2345-2429           AL591440.7         46067-46151         c
            2430-2589           AL591440.7         45808-45967         c
            2590-2673           AL591440.7         45472-45555         c
            2674-2767           AL591440.7         44812-44905         c
            2768-2823           AL591440.7         44663-44718         c
            2824-2959           AL591440.7         44376-44511         c
            2960-3030           AL591440.7         44223-44293         c
            3031-3128           AL591440.7         44043-44140         c
            3129-3228           AL591440.7         43847-43946         c
            3229-5243           AL591440.7         41474-43488         c
FEATURES             Location/Qualifiers
     source          1..5243
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..5243
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /note="myosin IC"
                     /db_xref="GeneID:17913"
                     /db_xref="MGI:MGI:106612"
     exon            1..138
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            139..294
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..3255
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /note="isoform b is encoded by transcript variant 2;
                     myosin-Ic; unconventional myosin-Ic; myosin I beta;
                     nuclear myosin I beta; MMI-beta; myosin-Ibeta"
                     /codon_start=1
                     /product="unconventional myosin-Ic isoform b"
                     /protein_id="NP_001074243.1"
                     /db_xref="CCDS:CCDS25054.1"
                     /db_xref="GeneID:17913"
                     /db_xref="MGI:MGI:106612"
                     /translation="MESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTY
                     IGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVM
                     ISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNS
                     SRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEETLR
                     RLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVMRKALSVIDFTEDEVEDLLSIVASV
                     LHLGNIHFAADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRKIIAKGEELLSPL
                     NLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIYGFEV
                     FQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEE
                     KFKGIISILDEECLRPGEATDLTFLEKLEDTVKPHPHFLTHKLADQKTRKSLDRGEFR
                     LLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSMNPIMAQCFDKSELSDKKRPETVA
                     TQFKMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRR
                     AGFAYRRKYEAFLQRYKSLCPETWPMWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFI
                     RFPKTLFATEDSLEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRR
                     KAAKRKWAAQTIRRLIRGFILRHSPRCPENAFFLDHVRASFLLNLRRQLPRNVLDTSW
                     PTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQS
                     VPRLFISTRLGTEEISPRVLQSLGSEPIQYAVPVVKYDRKGYKPRPRQLLLTPSAVVI
                     VEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQREDNKQKGDVVLQSDHVIETLTKTA
                     LSADRVNNININQGSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAVVAPRLNSR"
     exon            295..410
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            411..609
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            610..690
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            691..870
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            871..969
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1083
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1155
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1275
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1358
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1464
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1545
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1637
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1732
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1779
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1860
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1966
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2084
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2198
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2275
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2344
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2429
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2589
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2673
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2767
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2823
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2959
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3030
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3128
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3228
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..5243
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4506..4511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /note="hexamer: AATAAA"
     polyA_site      4529
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /note="major polyA site"
     regulatory      5221..5226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /note="hexamer: CATAAA"
     regulatory      5226..5231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
                     /note="hexamer: AATAAA"
     polyA_site      5239
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
     polyA_site      5243
                     /gene="Myo1c"
                     /gene_synonym="mm1beta; MMIb; MYO1E; myr2; NMI"
ORIGIN      
        1 agtctcccgg cagtctgaca aggaagcaga cgattagtac ttaatttagt aaggaggagg
       61 ctgtgtgtta gaggaaaata agaaggcgct atggcgaagg tgattcctga gctgactctt
      121 cggtgatgac taagtgaggc cctgggcagt gacggggttc gagtgaccat ggagagcgcc
      181 ttgactgccc gagaccgggt aggggtgcag gactttgtcc tgctggagaa tttcaccagt
      241 gaggctgcct tcattgagaa cctccggcgg cggttccggg agaacctcat ttatacctac
      301 atcggtcctg tcctagtctc tgtcaatccc taccgagacc tacagatcta cagccggcag
      361 catatggaac gctaccgtgg tgtcagtttc tatgaagtac cacctcattt gtttgcagtg
      421 gctgacactg tataccgggc acttcgtact gagcgtcggg accaggcagt gatgatttct
      481 ggagagagtg gggcaggcaa gacagaggcc accaagagac tgctccagtt ctatgcagag
      541 acctgcccag cccctgaacg gggtggcgca gtgcgagacc gcctgttgca gagcaacccc
      601 gtgttagagg cctttgggaa tgccaagact ctccgcaacg ataactccag ccggtttgga
      661 aagtacatgg atgtgcagtt tgacttcaag ggtgcccccg tgggaggcca cattctcagt
      721 tacctcctgg aaaagtcccg ggtggtgcac caaaatcacg gagagcggaa cttccacgtc
      781 ttttaccagc tactggaggg gggcgaggag gagactctcc gtcggctggg cttggaacgg
      841 aacccccaga gctacttgta cctggtgaag ggccagtgtg ccaaggtctc ctccatcaac
      901 gacaagagtg actggaaggt tatgaggaag gcgctgtccg tcattgactt cactgaggat
      961 gaagtggagg acttgctcag catcgtggcc agcgtcctac atctgggcaa catccacttt
     1021 gctgctgacg aggacagcaa tgcccaggtt actactgaga accagctcaa atatctgacc
     1081 aggctccttg gtgtggaagg tacaacactt agggaagccc tgacccacag gaagatcatc
     1141 gccaaggggg aagagctcct gagcccactg aaccttgaac aggcggcata tgcaagggat
     1201 gcgcttgcca aggctgtgta cagccggaca ttcacctggc tggtcagaaa gatcaatagg
     1261 tcactggcct ctaaggacgc tgagagcccc agctggcgaa gcaccacggt tcttgggctc
     1321 ctggacattt acggctttga agtgtttcag cataacagct tcgagcagtt ctgcatcaac
     1381 tactgcaatg agaagctgca gcagctcttc atcgagctga ctctcaagtc ggagcaggag
     1441 gaatacgagg ctgagggcat cgcgtgggaa cctgtccagt acttcaacaa caagatcatc
     1501 tgtgacctgg tagaggagaa gttcaagggc atcatctcca tcttggatga agagtgcctg
     1561 cgtcctgggg aggccacgga cctgaccttt ctggagaagt tggaggacac tgtcaagccc
     1621 caccctcact tcctgacgca caagctcgct gaccagaaga ccaggaaatc tctagaccga
     1681 ggggagttcc gccttctgca ttatgctgga gaggtgacct acagtgtgac tgggtttctg
     1741 gataaaaaca atgacctcct cttccggaac ctgaaggaga ccatgtgcag ctcaatgaac
     1801 cccatcatgg cccagtgctt tgacaagagt gagctcagtg acaagaagcg gccagagacg
     1861 gtggccaccc agttcaagat gagcctcctg cagctcgtgg agatcctgag gtctaaggag
     1921 cctgcctata tccggtgcat caagccaaac gacgccaagc agccgggtcg ctttgatgag
     1981 gtgctcatcc gacatcaggt gaagtacctg ggactgatgg agaatctgcg cgtgcgcaga
     2041 gctggctttg cctatcgtcg caaatatgag gctttcctgc agaggtacaa gtcactgtgc
     2101 ccagagacat ggcccatgtg ggcaggacgg ccccaggatg gtgtggccgt gttggtcaga
     2161 cacctcggct acaagccaga agagtacaaa atgggcagga ctaagatctt catccgattt
     2221 cccaagacct tgtttgccac agaggactcc ctggaagtcc ggcggcagag tctagccacc
     2281 aagatccagg cggcctggag gggctttcat tggcgacaga aatttctccg ggtgaagcga
     2341 tcagccatct gtatccagtc atggtggcgt ggcacactgg gccggaggaa ggcagccaag
     2401 aggaagtggg cagcccagac catccgtcga ctcatccgtg gcttcatttt gcgccattca
     2461 ccccggtgcc ctgagaatgc cttcttcttg gaccacgtgc gcgcctcatt tttgcttaac
     2521 ctgaggcggc aactgccccg gaatgttctg gacacctcct ggcccacacc cccacctgcc
     2581 ctgagagagg cctcagaact gctacgggaa ctgtgcatga agaacatggt gtggaagtac
     2641 tgccggagca tcagccctga gtggaagcag cagctgcagc aaaaggcggt ggctagtgaa
     2701 attttcaagg gcaagaagga caactacccc cagagtgtcc ccagactctt cattagcaca
     2761 cggcttggca cagaggagat cagccccaga gtgcttcaat ccttgggctc tgaacccatc
     2821 cagtatgccg tgcccgtggt aaaatacgac cgtaagggtt acaagcctcg cccccggcag
     2881 ctgctgctca cgcccagtgc tgtggtcatt gtggaggatg ctaaagtcaa gcagagaatt
     2941 gattatgcca acctaaccgg aatctctgtc agtagcctga gtgatagcct atttgtgctt
     3001 cacgtgcagc gtgaagacaa caagcagaag ggagatgtgg tgctgcagag tgatcatgtg
     3061 atcgagacac taaccaagac ggccctcagt gctgaccgcg tgaacaatat caacatcaac
     3121 cagggcagca taacgtttgc agggggtcca ggcagggacg gcatcattga cttcacatcg
     3181 ggctcagagc ttctcatcac caaggctaag aatggccacc tggctgtggt ggccccacgg
     3241 ctgaattctc ggtgatgaag gcttcagtgg acccctcctg actcctgatg cttcgcttag
     3301 tcccctcctc ccctcccagt taccaaagac tcaagcttcc agacagggat ccatggacac
     3361 cctcaaaacc cacctgcaaa ctcctgcctc ctgctcgccc cctctcgagg tgatcaggag
     3421 ccagggagct accccatgag tgggccaggc cgggccacag caatagaaaa gcagaggcct
     3481 gagcaggcca ggccagccct ctgctgatgc caaatatcta agagaaggga attttaactg
     3541 aggttttctc tgagattttt tgatgcttta taggaaacta tttttttaag aaagccattt
     3601 tcctacccta aacacactgg atgtgttttt ccctgcctcg aacagggcaa ggaatgtaac
     3661 tgaaagactg actgggctgg gctggaaggt cctcttctct ggccaagcct ctcctcattc
     3721 ccttgtctgt ctgtccatcc acctgcacct tttgcagccc actatgacct ccaccaaaag
     3781 gctgaggcca cctctgccta ccccatattc ctgccttaag aatgtccttt taggggctgg
     3841 ggtatagccc agtggtagaa ctggtgctaa gcatgtgtga gaccctgggc tcaatcccca
     3901 gcattaaaaa ataaaaaata ggtttttaat attttcaccc cagtctgagg gcatccctaa
     3961 agtgggggaa aagtcttaag agtttggaag tcttcagaga cagtgtctgg tccaggctcc
     4021 tggaatctac agagctggag acagaggcac acagagggag ggaagacttg cctagtagaa
     4081 gactgaagca aatcctaaag tgaagcccgc cctcagcaca tctcactgcc tttcccaggg
     4141 acagggaggc ccataaggca agggtcgcgt ctcatgtatg cacctggctc tctgaccagc
     4201 aatcaccctt gggagctacc gggtgggagg gactcttctg cctgggtcta tgccttagga
     4261 tgacaacctc catacacata catactttcg acccaattta agaatggtag ggtcttttat
     4321 tggccttggg tgcctctgtg acctgggagc ctagggacag ggctggcctt ggaggaactg
     4381 caggggcatc acctctttct gctgcttctc tccaccccag aggtccttgg gtttgcccag
     4441 ctccctctgt gccctctggg gctctcagcc cactgctgac acttctgcaa tccagagaaa
     4501 cactaaataa agcaatatgt atttgccaac acagtcttcc tgtgagtgtg gaaaaggggc
     4561 cctagaaggt agacattctt aaggggcttg gcactacaga agaaaggaga cagacctact
     4621 taggagcaat agagagaaac caagttaggt gtggtattgt gagccttagt gctcaggaag
     4681 cagggacagg aggattggat ttcttagttc taggccagcc tggtctacaa atcaagttcc
     4741 agggctatat agacaggcac ggggctttgg atttgggcaa ataaatacct ggtctggcag
     4801 caccgctgga ctaaggagac ctagcatggg caatataagc ccaggggcct gtgctgatgc
     4861 aagactcagg tggggagggt cagcacttca taaggaagct ggtgtttgag gtatctcagg
     4921 ggcttgcttc cagttctggg gataaagaat ccagtccaaa gtggctggag cggtaaaggc
     4981 cacttgtcaa caatggccat tttattgtcc tggggagatc tacttctagg tgatcaaaag
     5041 acattgttag gaaaatgtct tgggggctag agagatggct cagtggttaa gagaactgac
     5101 tgctcttctg aaggtcctga gttcaattcc cagcaactac acggtggctc acaaccatct
     5161 gtaatggggt ctgatgcctt ctggtgtgtc taaagggagc aatggtgatg tactcatatg
     5221 cataaaataa atgaataaat aaa
//
