LOCUS       NM_001161817            5053 bp    mRNA    linear   ROD 29-JAN-2023
DEFINITION  Mus musculus myosin IB (Myo1b), transcript variant 1, mRNA.
ACCESSION   NM_001161817
VERSION     NM_001161817.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5053)
  AUTHORS   Yu Y, Ren Y, Li Z, Li Y, Li Y, Zhang Y, Gui R, Cui Y, Qian L and
            Xiong Y.
  TITLE     Myo1b Promotes Premature Endothelial Senescence and Dysfunction via
            Suppressing Autophagy: Implications for Vascular Aging
  JOURNAL   Oxid Med Cell Longev 2023, 4654083 (2023)
   PUBMED   36654782
  REMARK    GeneRIF: Myo1b Promotes Premature Endothelial Senescence and
            Dysfunction via Suppressing Autophagy: Implications for Vascular
            Aging.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5053)
  AUTHORS   Hooper JE, Jones KL, Smith FJ, Williams T and Li H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5053)
  AUTHORS   Lee S, Sears MJ, Zhang Z, Li H, Salhab I, Krebs P, Xing Y, Nah HD,
            Williams T and Carstens RP.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5053)
  AUTHORS   Iuliano O, Yoshimura A, Prosperi MT, Martin R, Knolker HJ and
            Coudrier E.
  TITLE     Myosin 1b promotes axon formation by regulating actin wave
            propagation and growth cone dynamics
  JOURNAL   J Cell Biol 217 (6), 2033-2046 (2018)
   PUBMED   29588377
  REMARK    GeneRIF: a myosin 1 plays a major role in neuronal symmetry
            breaking and argue for a mechanical control of the actin
            cytoskeleton both in actin waves and in the growth cones by this
            myosin.
REFERENCE   5  (bases 1 to 5053)
  AUTHORS   Yu Y, Xiong Y, Montani JP, Yang Z and Ming XF.
  TITLE     Arginase-II activates mTORC1 through myosin-1b in vascular cell
            senescence and apoptosis
  JOURNAL   Cell Death Dis 9 (3), 313 (2018)
   PUBMED   29472548
  REMARK    GeneRIF: The senescent vascular smooth muscle cells showed elevated
            endogenous Arg-II and silencing Myo1b prevents Arg-II-mediated
            lysosomal positioning, dissociation of TSC from lysosome, mTORC1
            activation and cell apoptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5053)
  AUTHORS   Dumont RA, Zhao YD, Holt JR, Bahler M and Gillespie PG.
  TITLE     Myosin-I isozymes in neonatal rodent auditory and vestibular
            epithelia
  JOURNAL   J Assoc Res Otolaryngol 3 (4), 375-389 (2002)
   PUBMED   12486594
REFERENCE   7  (bases 1 to 5053)
  AUTHORS   Kawamoto S, Matsumoto Y, Mizuno K, Okubo K and Matsubara K.
  TITLE     Expression profiles of active genes in human and mouse livers
  JOURNAL   Gene 174 (1), 151-158 (1996)
   PUBMED   8863742
REFERENCE   8  (bases 1 to 5053)
  AUTHORS   Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM,
            Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP,
            Mooseker MS, Copeland NG and Jenkins NA.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   9  (bases 1 to 5053)
  AUTHORS   Koslovsky JS, Qian C, Jiang X and Mercer JA.
  TITLE     Molecular cloning of a mouse myosin I expressed in brain
  JOURNAL   FEBS Lett 320 (2), 121-124 (1993)
   PUBMED   8458427
REFERENCE   10 (bases 1 to 5053)
  AUTHORS   Sherr EH, Joyce MP and Greene LA.
  TITLE     Mammalian myosin I alpha, I beta, and I gamma: new widely expressed
            genes of the myosin I family
  JOURNAL   J Cell Biol 120 (6), 1405-1416 (1993)
   PUBMED   8449986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108840.13, BC054786.1, BY759345.1, BE950809.1 and BB768105.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by
            NM_001161817.3.
            
            On Mar 21, 2014 this sequence version replaced NM_001161817.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054786.1, SRR9219380.80563.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC108840.13        165933-165982
            51-4215             BC054786.1         1-4165
            4216-4619           BY759345.1         80-483
            4620-5046           BE950809.1         11-437              c
            5047-5053           BB768105.1         522-528
FEATURES             Location/Qualifiers
     source          1..5053
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.58 cM"
     gene            1..5053
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /note="myosin IB"
                     /db_xref="GeneID:17912"
                     /db_xref="MGI:MGI:107752"
     exon            1..218
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            219..362
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..3638
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin-Ib; molecular motor; MMI-alpha; myosin I alpha;
                     Myosin IA (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L);
                     unconventional myosin-Ib"
                     /codon_start=1
                     /product="unconventional myosin-Ib isoform 1"
                     /protein_id="NP_001155289.1"
                     /db_xref="CCDS:CCDS48254.1"
                     /db_xref="GeneID:17912"
                     /db_xref="MGI:MGI:107752"
                     /translation="MAKMEVKSSLLDNMIGVGDMVLLEPLNEETFIDNLKKRFDHNEI
                     YTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQ
                     CILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRN
                     DNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEE
                     LLYKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFLDHEAEAVLEVVA
                     AVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTSIDQVVLERAFSFRTVEAKQE
                     KVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFE
                     IFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIE
                     NNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHS
                     CFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHSLIKSLFPEGNPAKVNLKR
                     PPTAGSQFKASVATLMRNLQTKNPNYIRCIKPNDKKAAHIFNESLVCHQIRYLGLLEN
                     VRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEHSFGR
                     SKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKRSQVVIAAWYRR
                     YAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQKRCKEAATTIAAYWHGTQARRE
                     LRRLKDEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRRE
                     YRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKEL
                     KRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINK
                     NPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVP
                     LVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQK
                     LNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP"
     exon            363..478
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            479..573
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            574..678
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            679..725
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            726..789
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            790..888
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            889..992
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1140
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1259
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1346
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1412
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1517
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1580
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1781
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..2008
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2209
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2303
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2453
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2522
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2609
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2696
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2783
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2858
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2993
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3100
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3233
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3386
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3514
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..5053
                     /gene="Myo1b"
                     /gene_synonym="MIH-L; MMIa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagtggc cgcgccgccg ccgcgcctct agccagcgca ctcggagccc agccggcgga
       61 cgcggtgtgg gtgcactgaa cgcacggtcg gctgagcggc gcgggatccc cggcagcaac
      121 tgtggcacaa gccccgcatc ggatctgacc cgcgttcccc aggcggcggc cagcgagcag
      181 cacgcggaga cggagtggcc gagcggttgc cgggcgagct ggaaaccatg gccaaaatgg
      241 aggtgaaatc ctcacttctg gacaatatga tcggtgttgg agatatggtt cttttagagc
      301 cgctcaatga ggagacgttc atcgacaacc tgaagaagcg cttcgaccac aatgagatat
      361 atacatacat tgggagcgtg gttatatctg ttaaccccta ccggtccttg cccatatatt
      421 cgccggagaa agtggaagat tacagaaata gaaacttcta tgaactgagc cctcacatct
      481 ttgctttgtc ggatgaagca tacagatccc tccgtgatca agataaagat caatgcattc
      541 tcattactgg ggagagtgga gcaggaaaaa cagaggccag caagctcgtc atgtcctatg
      601 tcgctgccgt gtgcggaaaa ggagcagaag tcaatcaggt caaggaacag cttctgcagt
      661 ccaaccctgt cctggaagct tttggaaatg ccaagactgt gaggaatgac aactcatcta
      721 gattcggcaa atacatggat attgaatttg actttaaagg cgatccgctg ggaggagtga
      781 taagtaacta tcttttagag aaatctcgtg ttgttaagca gccaagaggt gaaagaaact
      841 tccatgtgtt ctatcagctg ctctcaggcg cctctgagga gctcctctac aagcttaagc
      901 tggagcggga tttcagcaga tacaactatc tgagtctgga ctctgctaaa gttaatggtg
      961 tggatgatgc tgccaatttc agaactgtta ggaatgcgat gcagatcgtg ggctttctgg
     1021 atcatgaggc cgaggctgtc ctggaggtag tggcagccgt tttgaaactg gggaacatcg
     1081 agttcaagcc tgaatcacga gtgaatggtt tggatgaaag caaaatcaaa gataaaaatg
     1141 agttaaaaga aatttgcgag ttgaccagca tcgatcaggt ggttttagaa agagcgttca
     1201 gtttccgaac agttgaagcg aagcaggaga aagtttcaac cacgctgaat gtggctcagg
     1261 cttattatgc ccgtgatgcc ctggctaaaa acctctacag ccgcttgttt tcatggttgg
     1321 taaatcgtat caacgaaagc attaaggcac aaacaaaagt gagaaagaag gtcatgggtg
     1381 ttctggacat ttatggcttt gaaatatttg aggataacag cttcgagcag tttattatta
     1441 actattgtaa tgaaaagctt caacaaatct tcatcgaact taccctcaaa gaagagcaag
     1501 aggaatatat tcgggaggac atagaatgga ctcacattga ctacttcaac aatgctatca
     1561 tttgtgacct aatagaaaat aacacaaatg gaatcttggc catgctggat gaagagtgcc
     1621 tgagacccgg cactgttaca gatgagacct tcctggaaaa gctgaaccaa gtctgtgcca
     1681 cccaccagca ctttgagagc aggatgagca agtgttcccg ctttctcaac gacacaaccc
     1741 tgccccacag ctgcttcaga atccagcatt atgctggcaa ggtgctctac caggtggaag
     1801 gatttgttga caagaacaat gaccttctgt accgggacct gtctcaagcc atgtggaagg
     1861 ccggccactc cctcatcaag tctctgtttc ctgaaggaaa tcctgcaaag gtcaacctga
     1921 agagacctcc caccgcaggc tcccagttca aggcgtctgt ggccacgctg atgagaaacc
     1981 tgcagaccaa gaacccgaac tacatcaggt gcatcaagcc aaatgataaa aaggcagctc
     2041 acattttcaa tgagagtctc gtatgccatc agatcaggta cctgggtctt ttggagaacg
     2101 ttcgagtgag acgggcaggc tatgccttca ggcaggccta tgaaccttgc ctggaaagat
     2161 acaagatgct ttgcaaacaa acgtggcctc actggaaggg accagcaagg tctggcgtgg
     2221 aggttctgtt taatgagcta gagattcctg tggaagagca ctccttcggg agatccaaga
     2281 tattcatccg aaacccacgg acattattcc aactagaaga cctaaggaag cagcggctgg
     2341 aggacctggc cactctcatt cagaagattt atcgaggatg gaaatgccgt acacattttc
     2401 tgctcatgaa aagaagccaa gttgtgattg ctgcctggta caggagatat gcgcaacaaa
     2461 agcggtacca gcagataaag agttcagccc tggtgattca gtcgtacatc cggggctgga
     2521 aggctcgaaa aatcctgcgg gagctgaagc atcagaagcg ctgtaaggag gcagccacca
     2581 ccatcgcggc gtactggcat ggcacccagg cgcgaaggga gctgagacgg ctgaaggacg
     2641 aggctaggaa taagcacgct attgcagtta tttgggctta ctggcttgga tcgaaggcac
     2701 ggagggagtt gaaacgcttg aaggaggagg ctaggcgtaa gcatgcagtt gctgtcattt
     2761 gggcttactg gcttggactg aaggtacgca gggaatacag gaaattcttt agagcaaatg
     2821 ctggaaagaa aatctatgag tttacacttc aaagaattgt gcaaaaatac ttgttggaaa
     2881 tgaaaaataa aatgccttcc ttgtcaccga tagataaaaa ttggccatca agaccttacc
     2941 tgttcttgga ttcgactcac aaggagctaa aaaggatctt ccacttgtgg aggtgtaaaa
     3001 aatacaggga tcaattcaca gaccagcaga aacttattta tgaagagaag ctcgaggcca
     3061 gcgaactctt caaagacaag aaggctttat atccttctag tgttgggcaa ccattccaag
     3121 gagcttacct ggaaatcaac aagaacccaa aatataagaa actcaaagat gccattgaag
     3181 agaagatcat tattgctgag gttgtgaaca aaattaatcg ggctaatggg aagagtacat
     3241 ctcggatttt cctcttaaca aacaataacc ttctccttgc tgaccaaaag tctgggcaga
     3301 tcaagtccga ggtccccctg gtagatgtga ccaaggtttc catgagttcc cagaacgatg
     3361 gtttctttgc agtgcacctc aaggagggtt cagaagcggc tagtaaaggg gactttctct
     3421 tcagcagtga ccacctgatt gaaatggcaa ccaagctgta tcgcacgact ctcagccaaa
     3481 ctaaacagaa gctcaacatc gagatttccg atgagttcct ggtacagttc agacaggaca
     3541 aagtatgtgt gaagtttatt caaggcaacc agaaaaatgg gagcgtgcca acctgcaaac
     3601 gaaagaacaa cagactcctt gaagtcgctg tcccttaagt gaggcttcct ctctgctctc
     3661 acggacttgt ttcctcgtaa cagtgcaatt ttactttgtt ttatttgggg ttcactgtat
     3721 gtttgggaat tgccaaaggc taactgttag cgtcctcttg gcacaattaa aagtatttga
     3781 ctaatgagtt ttaattatca gaatagttca ttcctaagtc cacattctgt cctgggcaga
     3841 attctagaaa ttaacagtgt ctgtctccat ggtttatgtg ttttctcctt agttacctag
     3901 acttgtgtac cctaaaccca catattaccc ataaatcact agtacatgtc agcacaggag
     3961 gggagcttac agtcagttat cagatattta ttgaatgcct actttttgct gggccctgtg
     4021 ctgaacttat tcggagattt ctatttttaa agctgttgcc ttctggctga tttgtgctgt
     4081 ggaagcaaca gctaagaaag ttgaagagat tgggtcaaat gagactataa atgacggcca
     4141 ctggtaggaa cccagtagtg tggcgtaaac agtacactca ctgagaagta gaggtcctgg
     4201 gtggattgga gataggtaat tgggtagaat tctcctgaga ggtttggaga tagatgattg
     4261 ggtggaattc ctctgtgttt gtttgtttgt ttgtttttca taaatctatt tgaaaaagag
     4321 ataaccaaca tttaaacata cacatttatt ggttcagatc cgttttcact ttagaaaaag
     4381 tcactgaagc agggctgtag aatgctttgt tcctgttcca gagaagcatg agataggacc
     4441 ctggatgtgc acagtgtatc cacccagggt cattagcttt tgaaactgca tgataagaag
     4501 aggctgagag ccgttcagac tggcagatct tctctttgat gtgcaataaa acatccaaga
     4561 tcacttttga aagttttatt tataatatgc attttttttg tatgagagag ctgattggta
     4621 caaggtgtgt attttagtca gatcaaaatt aagttagaat tcgttttcag ggctttttga
     4681 ttttttttct tcaaaattaa caataaggat tcattttgga aaccacattt taaactctgg
     4741 aattaaattg tttcttattt gggaggataa tgtaaataca ttgggattat gttaataata
     4801 aaattgttct aatttggtgc catttgctgg attacaactg tatttttgta tctcaagcta
     4861 ttttcatacg ttagtgtcaa agtgatgtgt cacagaaagg atttccattc agatattata
     4921 tggtctctgt gttaacagat ttccactgat ctttttgtac cactatcagt caatgaaaaa
     4981 gttctctggg gattttcttt tgatttttgt acttaaaaag aaaaaaaaaa agttctgata
     5041 aagaaattct ccg
//
