LOCUS       NM_001081219            3353 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus myosin IA (Myo1a), mRNA.
ACCESSION   NM_001081219 XM_006542881 XM_011251968 XM_483962
VERSION     NM_001081219.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Reynders,A., Anissa Jhumka,Z., Gaillard,S., Mantilleri,A.,
            Malapert,P., Magalon,K., Etzerodt,A., Salio,C., Ugolini,S.,
            Castets,F., Saurin,A.J., Serino,M., Hoeffel,G. and Moqrich,A.
  TITLE     Gut microbiota promotes pain chronicity in Myosin1A deficient male
            mice
  JOURNAL   Brain Behav Immun 119, 750-766 (2024)
   PUBMED   38710336
  REMARK    GeneRIF: Gut microbiota promotes pain chronicity in Myosin1A
            deficient male mice.
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3353)
  AUTHORS   Hegan,P.S., Kravtsov,D.V., Caputo,C., Egan,M.E., Ameen,N.A. and
            Mooseker,M.S.
  TITLE     Restoration of cytoskeletal and membrane tethering defects but not
            defects in membrane trafficking in the intestinal brush border of
            mice lacking both myosin Ia and myosin VI
  JOURNAL   Cytoskeleton (Hoboken) 72 (9), 455-476 (2015)
   PUBMED   26286357
  REMARK    GeneRIF: Myo1a and Myo6 play essential roles in response to
            intestinal mucosal injury
REFERENCE   4  (bases 1 to 3353)
  AUTHORS   Kravtsov,D.V., Caputo,C., Collaco,A., Hoekstra,N., Egan,M.E.,
            Mooseker,M.S. and Ameen,N.A.
  TITLE     Myosin Ia is required for CFTR brush border membrane trafficking
            and ion transport in the mouse small intestine
  JOURNAL   Traffic 13 (8), 1072-1082 (2012)
   PUBMED   22510086
  REMARK    GeneRIF: The data indicates that Myo1a is an important regulator of
            CFTR traffic and anion transport in the brush border membrane of
            villus enterocytes.
REFERENCE   5  (bases 1 to 3353)
  AUTHORS   Mazzolini,R., Dopeso,H., Mateo-Lozano,S., Chang,W., Rodrigues,P.,
            Bazzocco,S., Alazzouzi,H., Landolfi,S., Hernandez-Losa,J.,
            Andretta,E., Alhopuro,P., Espin,E., Armengol,M., Tabernero,J.,
            Ramon y Cajal,S., Kloor,M., Gebert,J., Mariadason,J.M., Schwartz,S.
            Jr., Aaltonen,L.A., Mooseker,M.S. and Arango,D.
  TITLE     Brush border myosin Ia has tumor suppressor activity in the
            intestine
  JOURNAL   Proc Natl Acad Sci U S A 109 (5), 1530-1535 (2012)
   PUBMED   22307608
REFERENCE   6  (bases 1 to 3353)
  AUTHORS   Cordonnier,M.N., Dauzonne,D., Louvard,D. and Coudrier,E.
  TITLE     Actin filaments and myosin I alpha cooperate with microtubules for
            the movement of lysosomes
  JOURNAL   Mol Biol Cell 12 (12), 4013-4029 (2001)
   PUBMED   11739797
  REMARK    GeneRIF: Actin filaments and myosin I alpha cooperate with
            microtubules for the movement of lysosomes
REFERENCE   7  (bases 1 to 3353)
  AUTHORS   Sellers,J.R.
  TITLE     Myosins: a diverse superfamily
  JOURNAL   Biochim Biophys Acta 1496 (1), 3-22 (2000)
   PUBMED   10722873
  REMARK    Review article
REFERENCE   8  (bases 1 to 3353)
  AUTHORS   Skowron,J.F. and Mooseker,M.S.
  TITLE     Cloning and characterization of mouse brush border myosin-I in
            adult and embryonic intestine
  JOURNAL   J Exp Zool 283 (3), 242-257 (1999)
   PUBMED   9933937
REFERENCE   9  (bases 1 to 3353)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   10 (bases 1 to 3353)
  AUTHORS   Sherr,E.H., Joyce,M.P. and Greene,L.A.
  TITLE     Mammalian myosin I alpha, I beta, and I gamma: new widely expressed
            genes of the myosin I family
  JOURNAL   J Cell Biol 120 (6), 1405-1416 (1993)
   PUBMED   8449986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF009960.1, AC160970.7, AK008176.1 and CF929471.1.
            
            On or before Feb 15, 2015 this sequence version replaced
            XM_011251968.1, XM_006542881.1, NM_001081219.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AF009960.1         1-230
            231-325             AC160970.7         166864-166958
            326-430             AC160970.7         167860-167964
            431-1164            AF009960.1         431-1164
            1165-1269           AC160970.7         173803-173907
            1270-1961           AF009960.1         1270-1961
            1962-2055           AC160970.7         176290-176383
            2056-2205           AC160970.7         176672-176821
            2206-2591           AF009960.1         2206-2591
            2592-3348           AK008176.1         307-1063
            3349-3353           CF929471.1         272-276
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.62 cM"
     gene            1..3353
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /note="myosin IA"
                     /db_xref="GeneID:432516"
                     /db_xref="MGI:MGI:107732"
     CDS             1..3132
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /note="myosin-Ia; BBMI; MIHC; myosin I heavy chain; brush
                     border myosin I; myosin, heavy polypeptide-like (110kD);
                     brush border myosin 1"
                     /codon_start=1
                     /product="unconventional myosin-Ia"
                     /protein_id="NP_001074688.1"
                     /db_xref="CCDS:CCDS36083.1"
                     /db_xref="GeneID:432516"
                     /db_xref="MGI:MGI:107732"
                     /translation="MPLLEGPVGVEDLILLEPLDEESLIKNLQLRYENKEIYTYIGNV
                     VISMNPYEQLPIYGPEFIAKYRDYTFYELKPHIYALANVAYQSLKDRDRDQCILITGE
                     SGAGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQSNPVLEAFGNAKTIRNNNSSRFG
                     KYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNFHIFYQLLAGADAQLLKALKL
                     EEDTSVYGYLNGEVSKVNGMDDASNFRAVQHAMSVIGFSEEEIRQVLEVTALVLKLGN
                     VKLTDEFQANGIPASGICDGKGIQEIGEMMGLNSTELERALCSRTMETGKEKVVTVLN
                     VTQAQYARDALAKNIYSRLFDWIVKRINESIKVGTGEKKKVMGVLDIYGFEILEDNSF
                     EQFVINYCNERLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICNLIEHSQRGIL
                     AMLDEECLRPGVVSDSTFLAKLNQLFSKHSHYESKVSQNAQRQYDRTMGLSCFRISHY
                     AGKVTYNVTGFIDKNNDLLFRDLSQTMWKAQHPLLKSLFPEGNPKEASLKRPPTAGTQ
                     FKNSVAVLMKNLYSKNPNYIRCIKPNDQQQKGRFTSEMVMVQARYLGLLENVRVRRAG
                     YAFRQGYKPFLERYRLLSRSTWPRWNGDDREGVEKVLGSLTLSSEELAYGKTKIFIRS
                     PKTLFYLEEQRRLRLQQLATLIQKVYRGWRCRTHYQQMRKSQILISAWFRGNKQKKHY
                     GKIRSSVLLIQAFVRGWRARKNYRKYFRSGAALTLANFIYQSMAQKFLLNLKKNLPST
                     KVLDNTWPAAPYRCFNTANQELQRLFYQWKCKKFRDQLSPKQVQTLREKLCASELFKG
                     KKASYPQSVPIPFRGDYIGLQGNPKLQRLKGREEGPVLVADTVKKVNRGNGKTSARIL
                     LLTKGHVILTDAKKSQAQIVIGLEDVAGVSVSSLQDGLFSLHLSEMSSAVSKGDILLV
                     SDHVVELLTKMYQAVLDATQRQLSVTVTEKFSVRFKEGSVAVKVIQGPEGGGNRKLIC
                     KKKGSNAMEVTVR"
     exon            1..114
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            115..230
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            231..325
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            326..430
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            431..477
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            478..541
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            542..640
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            641..744
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            745..892
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1011
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1098
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1164
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1269
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1332
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1533
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1760
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1961
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2055
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2205
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2274
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2349
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2484
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2591
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2724
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2877
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3005
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3353
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3321..3326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /note="hexamer: AATAAA"
     polyA_site      3351
                     /gene="Myo1a"
                     /gene_synonym="BBM-I; Myhl"
                     /note="major polyA site"
ORIGIN      
        1 atgcctctcc tggaaggtcc cgtgggggtg gaagacctca tcctcctgga gcccctagat
       61 gaggagtctc tgatcaagaa cctccaactc cgttatgaaa acaaagagat ttatacatac
      121 attgggaatg tggtgatctc aatgaacccc tacgagcagc ttcccatcta tggaccagag
      181 ttcattgcca aataccggga ctatactttc tatgagctga agcctcacat ctatgctttg
      241 gcaaatgtgg cctaccagtc actgaaggat cgggaccggg accagtgtat cctcatcaca
      301 ggcgagagtg gagctggcaa gactgaggcg agtaagctag tgatgtccta cgtggctgct
      361 gtctgtggga aaggagagca ggtgaactct gtgaaggagc agctgcttca gtcaaaccca
      421 gtgctggaag catttggcaa tgccaagacc atccgcaata acaactcctc tcgatttgga
      481 aagtacatgg acatcgagtt tgacttcaaa gggtcccccc tgggcggtgt catcaccaac
      541 tatctgcttg agaagtcccg agtggtgaag caactcaaag gggagaggaa tttccatatc
      601 ttctatcaac tgctggctgg agcagacgca cagctgctga aggccctaaa gcttgaggag
      661 gacacgagtg tatacggcta cctgaatggg gaggtgtcca aggtgaacgg tatggacgac
      721 gcctccaact tcagggctgt gcagcatgcg atgtcagtga ttggcttctc agaggaggaa
      781 attagacaag tgctggaggt gacagccctg gtgctgaagc tggggaacgt gaagctgaca
      841 gacgagttcc aggccaatgg gatcccagcc agtggcatct gtgatgggaa aggtattcag
      901 gagattgggg agatgatggg cttgaactct acggaactag agagagcgct gtgctcaaga
      961 actatggaga caggcaaaga gaaggtggtc acggtgctga atgtcacaca ggctcaatat
     1021 gctcgggatg ccctggcaaa gaatatttac agccgcctct tcgactggat agtgaaacgc
     1081 atcaacgaga gcatcaaggt gggcactggg gagaagaaga aggttatggg ggtcctggat
     1141 atctacggct ttgagatatt ggaggataac agctttgagc agttcgtgat caactactgc
     1201 aatgagaggc tacagcaggt gttcatagaa ctgaccctga aggaagaaca ggaggaatac
     1261 aagagagaag gcataccgtg gacaaaggtg gaatactttg acaacggcat catctgtaac
     1321 ctcattgaac atagtcagcg aggtatcctg gccatgctgg acgaggagtg cctgagaccc
     1381 ggggtggtta gtgactccac cttcttagcg aagctgaacc agctcttctc taagcacagt
     1441 cactacgaga gtaaagtctc ccagaatgcc cagcgccagt acgaccgcac catgggcctc
     1501 agctgcttcc gcatcagcca ctacgcgggc aaggtgacct acaacgtgac cggcttcatc
     1561 gacaagaata acgacctact cttccgagac ctatcccaga caatgtggaa ggcccagcat
     1621 cccctcctga agtccttgtt tccagagggg aaccccaagg aagcgtctct caaacgaccc
     1681 ccgactgccg ggacccagtt taagaattcg gtggctgtac tcatgaagaa cctgtattct
     1741 aagaacccca actacatcag gtgcataaag cccaatgacc agcagcagaa aggcaggttc
     1801 acctcagaga tggttatggt ccaggcgcga tacctggggc tgctggagaa tgttcgggtg
     1861 cgcagggctg gctatgcctt ccgccagggc tataagcctt tcctggaaag gtaccgattg
     1921 ctgagccgga gcacctggcc tcgctggaat ggggatgatc gggaaggtgt ggagaaggta
     1981 ctcgggtctc tgactttgtc ctcagaggag ctggcctacg ggaagacaaa gatcttcatc
     2041 agaagcccca aaactctttt ctacctggaa gaacaaaggc gcctgaggct tcagcagctg
     2101 gccaccctca tacagaaggt ctaccgcggc tggcgctgtc ggacccacta ccagcagatg
     2161 cggaagagcc aaatcctcat ctcggcttgg tttcggggca acaagcaaaa gaagcactat
     2221 gggaagatac ggtcgtcagt gctgctgatc caggctttcg tgaggggctg gagggcccgc
     2281 aagaactatc gaaaatactt ccggtcaggt gctgccctca ccttggcaaa ttttatctac
     2341 cagagcatgg cacagaaatt cctcttgaat ctgaagaaga atttgccatc caccaaagtg
     2401 ttggacaaca catggccagc cgccccttac aggtgcttca acacagccaa tcaggagctg
     2461 cagcgcctct tctaccagtg gaagtgcaag aagttccgag atcagctgtc cccgaagcag
     2521 gtgcagacac tgcgggaaaa gctctgtgcc agtgaactgt ttaagggcaa gaaggcttcc
     2581 tacccccaga gtgtgcctat cccgttccgt ggtgattaca tcgggctgca agggaacccc
     2641 aagctgcaga gactgaaggg cagggaggag gggcctgtcc tggtggcaga caccgtgaag
     2701 aaggtcaacc gtggcaatgg caagacatcg gcgcggattc tcctcctgac caaggggcac
     2761 gtgattctca cggatgcgaa gaagtcccag gcccagattg tcataggact ggaggatgtg
     2821 gctggggtgt cagtcagcag cctccaggac gggctcttta gcttgcatct gagtgagatg
     2881 tcatcggcag tctccaaggg ggacatcctg ctagtgagcg accatgtggt tgaactgctg
     2941 acaaaaatgt accaagcagt gttggatgcc acacagaggc agctctctgt cactgtgact
     3001 gagaagttct cagtgaggtt caaggagggc agtgtggctg tcaaggttat ccagggcccc
     3061 gaggggggtg ggaacagaaa actgatttgc aagaagaagg ggagtaatgc catggaggtg
     3121 actgtgcggt gaggaggttg gggcctcctg gaggtgcagt ttcttcctct ggagcagaac
     3181 ttcgtagtgt ctcactcttc tgaccgtgag gtgggactca gagatgaaga acccttgaag
     3241 atggcccttc tgttccctag acctttctag aattcttacc caaatgcagc atcctcccag
     3301 cttcagcccg tctgcccatt aataaatcgt ttccttcttt ccttgctcag ata
//
