LOCUS       NM_001291213            7562 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus myosin XVIIIA (Myo18a), transcript variant 1, mRNA.
ACCESSION   NM_001291213 XM_006533599 XM_011249090
VERSION     NM_001291213.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7562)
  AUTHORS   Guan,Z., Worth,B., Umstead,T.M., Amatya,S., Booth,J. and
            Chroneos,Z.C.
  TITLE     Disruption of the SP-A/SP-R210L (MYO18Aalpha) pathway prolongs
            gestation and reduces fetal survival during
            lipopolysaccharide-induced parturition in late gestation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (4), L508-L513 (2024)
   PUBMED   38349123
  REMARK    GeneRIF: Disruption of the SP-A/SP-R210L (MYO18Aalpha) pathway
            prolongs gestation and reduces fetal survival during
            lipopolysaccharide-induced parturition in late gestation.
REFERENCE   2  (bases 1 to 7562)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7562)
  AUTHORS   Yang,Q., Liu,H., Zhong,D., Li,Z., Li,J., Xiao,K. and Liu,W.
  TITLE     Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes
            liquid-liquid phase separation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119650 (2024)
   PUBMED   38092135
  REMARK    GeneRIF: Tanc1/2 TPR domain interacts with Myo18a C-terminus and
            undergoes liquid-liquid phase separation.
REFERENCE   4  (bases 1 to 7562)
  AUTHORS   Yau,E., Chen,Y., Song,C., Webb,J., Carillo,M., Kawasawa,Y.I.,
            Tang,Z., Takahashi,Y., Umstead,T.M., Dovat,S. and Chroneos,Z.C.
  TITLE     Genomic and epigenomic adaptation in SP-R210 (Myo18A)
            isoform-deficient macrophages
  JOURNAL   Immunobiology 226 (6), 152150 (2021)
   PUBMED   34735924
  REMARK    GeneRIF: Genomic and epigenomic adaptation in SP-R210 (Myo18A)
            isoform-deficient macrophages.
REFERENCE   5  (bases 1 to 7562)
  AUTHORS   Cheung,M.B., Enyindah-Asonye,G., Matsui,K., Kosik,I., Dvorina,N.,
            Baldwin,W.M. 3rd, Yewdell,J.W. and Gupta,N.
  TITLE     Cutting Edge: Myosin 18A Is a Novel Checkpoint Regulator in B Cell
            Differentiation and Antibody-Mediated Immunity
  JOURNAL   J Immunol 206 (11), 2521-2526 (2021)
   PUBMED   34001658
  REMARK    GeneRIF: Cutting Edge: Myosin 18A Is a Novel Checkpoint Regulator
            in B Cell Differentiation and Antibody-Mediated Immunity.
REFERENCE   6  (bases 1 to 7562)
  AUTHORS   Mori,K., Furusawa,T., Okubo,T., Inoue,T., Ikawa,S., Yanai,N.,
            Mori,K.J. and Obinata,M.
  TITLE     Genome structure and differential expression of two isoforms of a
            novel PDZ-containing myosin (MysPDZ) (Myo18A)
  JOURNAL   J Biochem 133 (4), 405-413 (2003)
   PUBMED   12761286
REFERENCE   7  (bases 1 to 7562)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 7562)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   9  (bases 1 to 7562)
  AUTHORS   Ji,H., Zhai,Q., Zhu,J., Yan,M., Sun,L., Liu,X. and Zheng,Z.
  TITLE     A novel protein MAJN binds to Jak3 and inhibits apoptosis induced
            by IL-2 deprival
  JOURNAL   Biochem Biophys Res Commun 270 (1), 267-271 (2000)
   PUBMED   10733938
REFERENCE   10 (bases 1 to 7562)
  AUTHORS   Furusawa,T., Ikawa,S., Yanai,N. and Obinata,M.
  TITLE     Isolation of a novel PDZ-containing myosin from hematopoietic
            supportive bone marrow stromal cell lines
  JOURNAL   Biochem Biophys Res Commun 270 (1), 67-75 (2000)
   PUBMED   10733906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591065.17.
            
            On or before Dec 22, 2022 this sequence version replaced
            XM_011249090.2, NM_001291213.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC145257.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL591065.17        11982-12065
            85-1164             AL591065.17        25921-27000
            1165-1308           AL591065.17        64542-64685
            1309-1396           AL591065.17        66305-66392
            1397-1503           AL591065.17        66585-66691
            1504-1680           AL591065.17        66788-66964
            1681-1894           AL591065.17        67267-67480
            1895-2037           AL591065.17        67597-67739
            2038-2138           AL591065.17        68663-68763
            2139-2202           AL591065.17        69484-69547
            2203-2347           AL591065.17        69728-69872
            2348-2359           AL591065.17        71349-71360
            2360-2530           AL591065.17        71962-72132
            2531-2621           AL591065.17        72448-72538
            2622-2814           AL591065.17        72779-72971
            2815-2895           AL591065.17        73789-73869
            2896-3037           AL591065.17        76222-76363
            3038-3197           AL591065.17        76477-76636
            3198-3384           AL591065.17        77863-78049
            3385-3628           AL591065.17        78306-78549
            3629-3738           AL591065.17        81080-81189
            3739-3804           AL591065.17        85103-85168
            3805-3933           AL591065.17        89367-89495
            3934-4077           AL591065.17        90134-90277
            4078-4167           AL591065.17        90605-90694
            4168-4287           AL591065.17        90834-90953
            4288-4399           AL591065.17        91143-91254
            4400-4527           AL591065.17        91790-91917
            4528-4682           AL591065.17        92203-92357
            4683-4806           AL591065.17        94082-94205
            4807-5007           AL591065.17        94294-94494
            5008-5118           AL591065.17        95058-95168
            5119-5223           AL591065.17        95577-95681
            5224-5370           AL591065.17        95978-96124
            5371-5484           AL591065.17        96611-96724
            5485-5601           AL591065.17        98056-98172
            5602-5685           AL591065.17        98908-98991
            5686-5823           AL591065.17        99432-99569
            5824-6009           AL591065.17        101903-102088
            6010-6149           AL591065.17        102438-102577
            6150-6272           AL591065.17        106409-106531
            6273-7562           AL591065.17        113377-114666
FEATURES             Location/Qualifiers
     source          1..7562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..7562
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /note="myosin XVIIIA"
                     /db_xref="GeneID:360013"
                     /db_xref="MGI:MGI:2667185"
     exon            1..84
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            85..1164
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..6417
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin containing a PDZ domain; unconventional
                     myosin-XVIIIa; surfactant protein receptor SP-R210;
                     molecule associated with JAK3 N-terminus; myosin XVIIIb"
                     /codon_start=1
                     /product="unconventional myosin-XVIIIa isoform 1"
                     /protein_id="NP_001278142.1"
                     /db_xref="CCDS:CCDS70253.1"
                     /db_xref="GeneID:360013"
                     /db_xref="MGI:MGI:2667185"
                     /translation="MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSMRRG
                     FFNLNRSSKRESKTRLEISNPIPIKVASGSDLHLTDIDSDSNRGSIILDSGHLSTASS
                     SDDLKGEEGSFRGSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHS
                     AAPSPQVEVRTLEGQLMQHPGLGIPRPGPRSRVPELVTKRFPADLRLPALVPPPPPAL
                     RELELQRRPTGDFGFSLRRTTMLDRAPEGQAYRRVVHFAEPGAGTKDLALGLVPGDRL
                     VEINGQNVENKSRDEIVEMIRQSGDSVRLKVQPIPELSELSRSWLRTGEGHRREPADL
                     DPEAASPAYSQVGCSCPTQEPSAFSSDNPPPPPCTWAGVCARASCWSAKTEEQIAAEE
                     AWYETEKVWLVHRDGFSLASQLKSEELSLPEGKARVKLDHDGAILDVDEDDIEKANAP
                     SCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLSTRGAPAVYSEKVMH
                     MFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIVLLGSSGSGKTTSFQHLVQYLATI
                     AGTSGTKVFSVEKWQALSTLLEAFGNSPTIMNGSATRFSQILSLDFDQAGQVASASIQ
                     TMLLEKLRVARRPASEATFNVFYYLLACGDATLRTELHLNHLAENNVFGIVPLSKPEE
                     KQKAAQQFSKLQAAMKVLAISPEEQKTCWLILASIYHLGAAGATKEAAEAGRKQFARH
                     EWAQKAAYLLGCSLEELSSAIFKHQLKGGTLQRSTSFRQGPEESGLGEGTKLSALECL
                     EGMASGLYSELFTLLISLVNRALKSSQHSLCSMMIVDTPGFQNPEWGGSARGASFEEL
                     CHNYAQDRLQRLFHERTFLQELERYKEDNIELAFDDLEPVADDSVAAVDQASHLVRSL
                     AHADEARGLLWLLEEEALVPGATEDALLDRLFSYYGPQEGDKKGQSPLLRSSKPRHFL
                     LGHSHGTNWVEYNVAGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSG
                     SIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQIKLQVDALIDTIKRSKMHFV
                     HCFLPVAEGWPGEPRSASSRRVSSSSELDLPPGDPCEAGLLQLDVSLLRAQLRGSRLL
                     DAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDEKRAVEELLESLDLEK
                     SSCCLGLSRVFFRAGTLARLEEQRDEQTSRHLTLFQAACRGYLARQHFKKRKIQDLAI
                     RCVQKNIKKNKGVKDWPWWKLFTTVRPLIQVQLSEEQIRNKDEEIQQLRSKLEKVEKE
                     RNELRLSSDRLETRISELTSELTDERNTGESASQLLDAETAERLRTEKEMKELQTQYD
                     ALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQE
                     LEDKMEVEQQSRRQLERRLGDLQADSDESQRALQQLKKKCQRLTAELQDTKLHLEGQQ
                     VRNHELEKKQRRFDSELSQAHEETQREKLQREKLQREKDMLLAEAFSLKQQMEEKDLD
                     IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGSIQ
                     MLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQK
                     ALREKRELESKLSTLSDQVNQRDFESEKRLRKDLKRTKALLADAQIMLDHLKNNAPSK
                     REIAQLKNQLEESEFTCAAAVKARKAMEVEMEDLHLQIDDIAKAKTALEEQLSRLQRE
                     KNEIQNRLEEDQEDMNELMKKHKAAVAQASRDMAQMNDLQAQIEESNKEKQELQEKLQ
                     ALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFEKTQVKRLENLASRLKETMEKLT
                     EERDQRAAAENREKEQNKRLQRQLRDTKEEMSELARKEAEASRKKHELEMDLESLEAA
                     NQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVDGVKSWL
                     SKNKGPSKAPSDDGSLKSSSPTSHWKPLAPDPSDDEHDPVDSISRPRFSHSYLSDSDT
                     EAKLTETSA"
     exon            1165..1308
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1396
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1503
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1680
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1894
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2037
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2138
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2202
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2347
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2359
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2530
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2621
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2814
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2895
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3037
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3197
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3384
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3628
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3738
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            3739..3804
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3933
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4077
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4167
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..4287
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4399
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            4400..4527
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4682
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            4683..4806
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..5007
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..5118
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            5119..5223
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            5224..5370
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            5371..5484
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            5485..5601
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            5602..5685
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            5686..5823
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            5824..6009
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            6010..6149
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            6150..6272
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     exon            6273..7562
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7538..7543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /note="hexamer: AATAAA"
     polyA_site      7562
                     /gene="Myo18a"
                     /gene_synonym="MAJN; MyoPDZ; MysPDZ; SP-R210"
                     /note="major polyA site"
ORIGIN      
        1 gctgcgctcc agccgggacc cggccggggc cgctggatgc cgcgtctccg ctcctgctgc
       61 ctgccgggcg ggctccggcg gccgctacaa ggtggggtcc aaagaccctg tgttaagcac
      121 tcatagtcag ctggggatac aacccctaaa aacagcacac ccaccatgtt taacctcatg
      181 aagaaagata aggacaaaga tggcgggcgg aaggagaaga aggaaaaaaa ggagaagaag
      241 gagaggatgt ctgcggcaga actgcggagc ctggaagaga tgagcatgcg ccgtggcttt
      301 ttcaacttga accggtcctc caagcgggaa tctaagacgc gcctggaaat ctccaacccc
      361 atccctatca aggtggccag tggctctgac ctgcacctga cggacattga ctctgacagc
      421 aatcggggta gcatcatcct ggactcagga cacctaagca cagccagctc cagtgatgac
      481 ctcaagggtg aagaaggcag cttccggggc tctgtgctgc agcgggcagc caagttcggt
      541 tcactggcca agcagaactc tcagatgatt gtcaaacgtt tttccttctc tcaacggagc
      601 cgggatgaga gtgcctcgga gacctcaacc ccctcagagc actctgcagc cccatcacct
      661 caggtagagg tgcggacgct tgagggacag ctaatgcagc atcctgggct aggcattcct
      721 cgaccaggac cacggtctcg agtccctgag ctggtgacta aaagattccc agctgatcta
      781 cgtcttcccg ctctggtgcc accaccacct cctgctctcc gggagctgga gttacaacga
      841 agacccacag gagactttgg cttctcactg cggcgcacaa ccatgctgga tcgggcccct
      901 gagggtcagg cttatcgacg ggtggttcac tttgctgagc caggggcagg caccaaggac
      961 ctggccttgg ggctggtacc aggagatcga ctggtggaga ttaatggaca gaatgtggag
     1021 aataaatcca gggatgaaat tgtggagatg atccggcagt ctggggacag tgtgcggctc
     1081 aaggtacagc ccatcccaga gcttagcgag ctgagccgga gctggcttcg gactggcgag
     1141 ggacaccgca gggagccggc tgatctggac cccgaggccg cctctcctgc ctacagccag
     1201 gtagggtgct cctgccccac ccaggagccc tctgctttct ccagtgacaa cccaccaccc
     1261 ccaccctgta cctgggctgg cgtctgtgct cgggcctcct gctggagtgc caagacggaa
     1321 gagcagattg ccgctgaaga ggcctggtat gagacggaga aggtgtggct ggtccataga
     1381 gatggattct ccttagccag ccagctcaag tctgaggagc tcagcctacc cgaggggaag
     1441 gcgcgtgtga agctggacca tgacggagcc atcctggatg tggatgaaga tgatatagag
     1501 aaggctaatg ctccttcatg tgaccgtcta gaagatctgg cctcactggt atacctcaac
     1561 gagtctagcg tcctgcatac actgcgccag cgctatgggg ctagcctgct acacacctat
     1621 gctggcccca gcctgcttgt ccttagcacc cgaggggctc ctgctgtgta ttcagagaag
     1681 gtgatgcaca tgttcaaggg gtgtcggcgg gaggacatgg caccccacat ctacgctgta
     1741 gcccagactg catatagggc gatgttgatg agtcgtcagg accagtccat tgtccttctg
     1801 ggtagtagtg gcagtggcaa gactaccagc tttcagcatc tggtgcagta tctggctacc
     1861 atcgcgggta ccagtgggac caaggtgttc tcagtggaga agtggcaggc tctgtccacc
     1921 ctcctggaag cctttgggaa cagccccacc atcatgaatg gcagtgccac ccgcttctcc
     1981 cagatcctct ccctggactt tgaccaagct ggccaggtgg cttcggcctc catccagaca
     2041 atgctcctgg agaagctgcg tgtggcccgg cgcccagcca gtgaggctac tttcaatgtc
     2101 ttctactact tgctggcctg tggggatgcc accctcagga cagagctcca cctgaaccac
     2161 ttggcagaga acaatgtgtt tggaattgtg ccactgtcca agcctgagga gaagcagaag
     2221 gctgcacagc agttcagtaa gctccaggct gccatgaagg tgctggccat ctcccccgag
     2281 gaacagaaga cctgctggct catcctggct tccatctacc acctgggggc tgctggagct
     2341 accaaagaag ctgctgaagc tggacgaaag cagtttgccc gccacgaatg ggcccagaag
     2401 gcagcatacc tgctgggctg cagcttggaa gagctgtcct cggctatctt caaacaccag
     2461 ctaaaaggag gcaccctgca acggtccacc tccttccgtc agggccctga ggagagcggc
     2521 ctgggagagg gcaccaaact gagtgctctg gagtgcttag agggtatggc gtctggcctc
     2581 tacagtgagc tctttactct cctcatctcc ctggtaaaca gggctctcaa gtccagccag
     2641 cactcactct gttccatgat gatcgtggac acaccaggct tccagaaccc tgaatggggc
     2701 ggctcggccc gtggagcctc cttcgaggag ctgtgccaca actatgccca ggacaggctg
     2761 cagaggctgt tccacgagcg caccttcctc caggagttgg agagatacaa ggaggataac
     2821 atagaactgg cgtttgatga cttggagcca gttgcagatg actccgtggc tgctgtggac
     2881 caggcttccc acctggttcg ctcactggcc catgccgatg aggcaagagg gctactgtgg
     2941 ctcctggaag aggaggcact ggtgcctggt gcgacagagg atgccctcct tgatcgtctt
     3001 ttctcctatt atggccccca ggagggtgac aaaaaaggcc agagtcctct tctgcgaagt
     3061 agcaaacctc ggcactttct cctgggccac agccacggta ccaactgggt ggagtacaac
     3121 gtggctggct ggctgaatta caccaagcag aacccagcca cccagaatgc accccggctt
     3181 ctgcaggact cccagaaaaa gatcatcagt aacctgtttc tgggccgggc gggcagtgcc
     3241 acggtgctct caggctcgat tgcaggcctg gaaggtggct cccagctggc cttgcgccgg
     3301 gcaaccagca tgaggaaaac cttcaccacc ggcatggccg ctgtcaagaa gaagtcgctg
     3361 tgcatacaga ttaagctgca agtagatgcc ctcattgata ccatcaagag gtccaagatg
     3421 catttcgtgc actgcttcct tcctgtggcc gagggctggc ctggggagcc ccggtctgcc
     3481 tcttcccgca gagtcagcag cagcagtgag ctggacctgc ccccgggaga cccctgtgag
     3541 gctgggctgc tacaactgga tgtgtccctg ctccgagccc agctccgggg atcccgcctg
     3601 cttgatgcga tgcgcatgta ccgccaaggt tacccagacc acatggtgtt ttctgagttc
     3661 cgccggcgct ttgatgtcct ggctccacac ctgaccaaga aacatggtcg taactacatc
     3721 gtggtggatg agaagcgggc tgtggaagag ctgctggagt ccctggacct ggaaaagagc
     3781 agctgctgtc tgggcctaag ccgggtgttc ttccgggcag gcacgttggc acggttggaa
     3841 gaacaacgag acgagcaaac cagcaggcac ctgaccctgt tccaggcagc ctgccggggc
     3901 taccttgccc gccagcactt caagaagaga aagatccagg acctggccat tcgctgtgtg
     3961 cagaagaaca tcaagaagaa caagggggtg aaggactggc cctggtggaa gctcttcacc
     4021 accgtgcggc ccctcatcca agttcagctg tcagaggagc agatccgaaa caaagacgag
     4081 gagatccagc agctgcgcag caagcttgag aaggtggaga aggagaggaa cgagctccga
     4141 ctcagcagtg accggctaga gacccggatc tcagaactga catcggagct gactgatgaa
     4201 cgcaacacgg gagagtccgc ctcccagctg ctggacgcgg agacagccga gaggctccgg
     4261 accgagaagg agatgaaaga gctacagacc cagtatgacg cactgaagaa gcagatggag
     4321 gtgatggaga tggaagtgat ggaagcccgg ctcattcggg cagccgagat caacggggag
     4381 gtggatgatg atgatgcagg gggagagtgg aggctgaagt acgagcgagc tgttcgggag
     4441 gtggacttca ccaagaagcg gctccagcag gagctggaag acaagatgga ggtggaacag
     4501 cagagcagga ggcagctgga gaggcggctt ggggacctgc aagcagatag tgatgagagt
     4561 caacgggcac tgcagcagct caagaagaag tgccaaaggc tcacagctga gctgcaggac
     4621 accaagctgc acctggaggg ccagcaggtc cgaaaccacg agctggagaa gaagcagagg
     4681 aggttcgaca gtgagctttc ccaggcccac gaggagacgc agcgggagaa gctgcagagg
     4741 gagaaactcc agcgggagaa ggacatgctc ctggctgagg ctttcagctt gaagcagcaa
     4801 atggaggaaa aagacttgga cattgcgggg tttacccaga aggtggtttc cttggaggct
     4861 gagcttcagg acatttcttc tcaagagtct aaggatgagg cttctctggc caaggtcaag
     4921 aagcagctcc gggacttgga ggccaaggtc aaggaccagg aagaggagct ggatgagcag
     4981 gctgggagta tacagatgct ggagcaggcc aagctgcgtc tggagatgga gatggagaga
     5041 atgagacaga cccattccaa ggagatggag agtcgggatg aggaggtgga agaggcccgg
     5101 cagtcatgtc agaagaagtt aaaacagatg gaagtgcagc tcgaggagga gtatgaagac
     5161 aagcagaagg cgctgcggga gaaacgggag ctggagagca agctctccac gctcagtgac
     5221 caggtgaacc agcgggactt tgaatcagag aagcggctac ggaaagacct gaagcgcacc
     5281 aaagcgctgc tggcagatgc ccagatcatg ctggaccact taaagaacaa tgccccgagc
     5341 aagagggaga ttgcccagct gaagaaccag ctggaagagt cggaattcac ctgtgcagca
     5401 gctgtaaagg cacggaaagc gatggaggtg gagatggaag acctgcacct gcagattgat
     5461 gacatcgcca aagccaagac agcgctggag gagcaactga gtcgacttca gcgtgagaaa
     5521 aacgagattc aaaaccggct ggaagaggat caggaggaca tgaatgagct gatgaagaag
     5581 cacaaggcag ctgtggccca ggcctcccgg gacatggcac agatgaacga tctccaggct
     5641 cagattgaag agtccaacaa ggagaagcaa gagctacagg agaagctaca agctctgcag
     5701 agccaggtgg agttcctgga gcagtccatg gtggacaagt ccctcgtcag caggcaggaa
     5761 gcgaagatca gggagctgga gacacgcctg gagttcgaaa agacccaagt gaagcgcctg
     5821 gagaacctgg ccagtcggct caaagaaacc atggagaagc tgactgagga acgggaccag
     5881 cgcgccgcag ctgagaaccg tgagaaggag cagaacaaga ggctccagcg acagcttcgt
     5941 gacaccaagg aggagatgag cgagcttgcc aggaaggaag ccgaggctag ccgcaagaag
     6001 catgaactgg agatggacct ggagagcctg gaagctgcta accaaagcct gcaagccgac
     6061 ctaaagctgg cgttcaaacg cattggggac ttgcaagctg ccattgagga tgagatggaa
     6121 agtgacgaga acgaggacct catcaacagt gagggggact cagatgtgga ctcagagctg
     6181 gaggaccggg tcgacggggt caagtcctgg ttgtcaaaga acaagggacc ttctaaggca
     6241 ccttctgacg atggcagctt gaagagttcc agcccaacca gccactggaa gccactcgcc
     6301 cctgacccat cggatgatga gcatgatcct gtggacagca tctccagacc ccggttctcc
     6361 cacagctatc tgagtgacag cgacacagag gccaagctga cagagaccag tgcatagcct
     6421 gggatggctc acgactctcc caccccacag cctctcccag gatagagggg caccactgcc
     6481 cccacctgac tgccgatctg catggaaaac accttggctt tctgtcaggg ggactttcca
     6541 ggctgtgggc gtctgacagc tccacgcggc agaggtgggc gaagcagagt ctctccaaag
     6601 agagcttccg ctcttgcctc tgaacgccat gctcttagct cccgctctgg gccactatgg
     6661 accacgtcag gtggcctggc attccatgga gccggtggtg gacctccatc tcagcctcct
     6721 gctcagggat ggtggatagg ttacctgctg ggccgctcga agtcgctggg ccccatggga
     6781 aagagtcagg agggagcagt gatgcctccc ctctgctggg gtgagggctt tctcttctca
     6841 gtgcctgctg tctttttact gtttaattta aatacccaaa cctccatgca gctgcatccc
     6901 tgagagtggg aggggctgcc gctgcagctg gggcctgtgg gatgccttgg gaatctcccc
     6961 tccatcttca cttctccaga ggcccttttc tcctgcagcc tgctgccagg ggacagcggt
     7021 tagcagagcc ggggccctgg ttctttggag gcagggtggg gaggatggca gctgggtgct
     7081 tctggcttgg accgagccag cctcgttaga gtattaagtg caatgagcag ttatttaaga
     7141 gctgatctct tccacctgca cccacccgcg gcttccagct ctgcctgcct ctgaccgtat
     7201 tatagccggg gccgctcatt cggcgctgag gacctgtggt gggcacagtg gaaggtagat
     7261 gttttggtct gtttatcaga ctggagtcct aaccctttgt catctttctt ctgcccataa
     7321 ccctgtcccc acacacttac cccagacaca gcaacaagtg gtctgttact tgttacttct
     7381 cggtttctta ccataaagct catctgactt ttccactgga tctgggggcc ccaaggcagt
     7441 acctggtgct ggacctgttt gccatccccc ttcccttctg ccattgcttt gtactcattg
     7501 ggctgtgctc tccctgtgga cctgattgat gtaaggaaat aaaaggcccc ttccctcctg
     7561 gc
//
