LOCUS       NM_001319151            7252 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus myosin XVI (Myo16), mRNA.
ACCESSION   NM_001319151 XM_011242053
VERSION     NM_001319151.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7252)
  AUTHORS   Roesler,M.K., Lombino,F.L., Freitag,S., Schweizer,M.,
            Hermans-Borgmeyer,I., Schwarz,J.R., Kneussel,M. and Wagner,W.
  TITLE     Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic
            Spines of Purkinje Cells and Affects Presynaptic Organization
  JOURNAL   Front Cell Neurosci 13, 330 (2019)
   PUBMED   31474830
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7252)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   3  (bases 1 to 7252)
  AUTHORS   Yokoyama,K., Tezuka,T., Kotani,M., Nakazawa,T., Hoshina,N.,
            Shimoda,Y., Kakuta,S., Sudo,K., Watanabe,K., Iwakura,Y. and
            Yamamoto,T.
  TITLE     NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling
            in neurons
  JOURNAL   EMBO J 30 (23), 4739-4754 (2011)
   PUBMED   21946561
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7252)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   5  (bases 1 to 7252)
  AUTHORS   Vats,K.R., Ishwad,C., Singla,I., Vats,A., Ferrell,R., Ellis,D.,
            Moritz,M., Surti,U., Jayakar,P., Frederick,D.R. and Vats,A.N.
  TITLE     A locus for renal malformations including vesico-ureteric reflux on
            chromosome 13q33-34
  JOURNAL   J Am Soc Nephrol 17 (4), 1158-1167 (2006)
   PUBMED   16565260
REFERENCE   6  (bases 1 to 7252)
  AUTHORS   Chiellini,C., Costa,M., Novelli,S.E., Amri,E.Z., Benzi,L.,
            Bertacca,A., Cohen,P., Del Prato,S., Friedman,J.M. and Maffei,M.
  TITLE     Identification of cathepsin K as a novel marker of adiposity in
            white adipose tissue
  JOURNAL   J Cell Physiol 195 (2), 309-321 (2003)
   PUBMED   12652657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072580.1, BC172122.1, AK034257.1 and BC082311.1.
            
            On Jan 27, 2016 this sequence version replaced XM_011242053.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082311.1, BC151049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BC072580.1         1-57
            58-6160             BC172122.1         1-6103
            6161-7225           AK034257.1         3021-4085
            7226-7252           BC082311.1         7081-7107
FEATURES             Location/Qualifiers
     source          1..7252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 4.77 cM"
     gene            1..7252
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /note="myosin XVI"
                     /db_xref="GeneID:244281"
                     /db_xref="MGI:MGI:2685951"
     exon            1..336
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            337..600
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..6134
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /note="neuronal tyrosine phosphorylated adaptor for
                     phosphoinositide 3-kinase adaptor 3; unconventional
                     myosin-16; neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter 3"
                     /codon_start=1
                     /product="unconventional myosin-XVI"
                     /protein_id="NP_001306080.1"
                     /db_xref="CCDS:CCDS40218.2"
                     /db_xref="GeneID:244281"
                     /db_xref="MGI:MGI:2685951"
                     /translation="MEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKVFQKQEGP
                     LKRSKPGKRQKVRFGLADMIQDAVIHHHDKEVLQLLKEGADPHTLVSSGGSLLHLCAR
                     YDNVFIAEVLIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLILAGANVFLQDVNGN
                     IPLDYAVEGTESSAILLAYLDEKGVDLSSLRQIKLQRPLSMLTDVRHFLSSGGDVNEK
                     NDDGVTLLHMACASGYKEVVLLLLEHGGDLNGTDDRYWTPLHLAAKYGQTTLVKLLLA
                     HQANPHLVNCNGEKPSDIAASESIEEMLLKAEIAWEEKMKESPSAPSLAQEELYEILH
                     DLPDLSSKLSPLVLPIAKQDSLLEKDIMFKDTTKGLCKQESQDGPPETSMTSNCGKPE
                     QVQVMPPAPSDDLATLSELNDSSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYS
                     TMVSQMYLSPTGQRSPSLPPHLFSCAERAFHRLFQERKPQNIILSGERGSGKTQASKQ
                     IMKYLTSRASSSCTMFDSRLRHAIYIVEAFGHAKTTLNNVSSCLIQYWELQCCQRRKH
                     ITGARISTYMLEKSRVVAQPPGQGTFLIFSWLMDGLSSEEKCGLHLNNFCAHRYVSQG
                     MREDVSTAEHSLNKERLAALKHALNVIGFSTLEVENLFVILSAILHIGDIQFTALTEA
                     DSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDVIIRRHTIQMAAFYRDLLA
                     KSLYSRLFGFLINTVNCCLQNQDEYKSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTN
                     EKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQAGVLDFFFQKPSGFFSLLDEESQ
                     VIWSGEPNLPRKLQGLLESSNTNAVYSPVKDGNGNVAFKGQGAAFTVMHYAGRVMYEM
                     GGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSQTGSLISSYPSFKFGGHKSTLL
                     SKRTASSMVGVNKNYLELSKLLKKKGTSTFLQRLERGEPATAASQLTKSLADITAKLQ
                     RGSPHFILCIKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRSGYPVRPSFEDFLSR
                     YEPLASVLLGETKGQAAEERCRLVLQRCKLQGWQIGVHKVFLKYWHVDQLSDLWLQLQ
                     RKIVTCQKVIRGFLARQHLLQRMSIKQQEVTSIKSFLQSTEDMALKTYDALVIQNASD
                     IAREHDRLRKEVHTAYHRNRQEEGTKRAEDQGGCRHVHSNSVPVPMVVDSLAQALTGP
                     STRPPSLHSVFSMDDSTGLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAKDAAGE
                     ALTRPRPHSDDYSTMKKIPPRKPKRSPHTKLSGSYEEIWGPPRPSGTMGQGGRHQAPG
                     TLSVQWARPDSVPQCTPQLPLHLPLPQGDYDDDAEPVYIEMVGNAARAGGSETDSPDQ
                     GESVYEEMKYILPEEGCGLGMLTFLPASPPLFLETRKAIILEAAEGNCQPSKDTCDIP
                     PPFPNLLPHRPPLLVFPPTPVTRSPASDESPLTPLEVKKLPVLETNLKYPVQSEGSSP
                     LSPQYSKAQKGDNDQLASPGFPVFNGPSRISPPATPPPPPGPPPAPCGPPPAPCGPPP
                     APCGPPPAPCGPPPAPCGPPPAPCGAASASCGVAPAPCRPPTHFAFPPESVLVTAAKA
                     LTNSDLPRTQPKPSSAPVPGPCSSFVKAPYSPGKTARADLRKTSSTFSPPSPYSPPNS
                     RPLSSPLDELASLFNSGRSVLRRSAVGRRIREAEGFETNMNLSSRDEPSSSEMASETQ
                     DRNANNHGTQLSSSLSSDVTAENGNPVTNGLAEDDGCSRLCLSGMGTSSFQRNRESHT
                     TQVIHQLRLSENESVALQELLDWRRKLCEAREGWQEALQHPEPRAPPPPPCKKPTLLK
                     KPEGGSCTRLPSQLWDSSM"
     exon            601..671
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..815
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..924
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1049
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1175
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1251
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1402
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1553
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1664
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1730
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1858
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1964
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2082
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2230
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2342
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2460
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2532
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2674
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2747
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2900
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3101
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3177
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3350
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3431
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3637
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3740
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3837
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..4066
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4335
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4336..5655
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            5656..5814
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            5815..5906
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            5907..7226
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7207..7212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /note="hexamer: AATAAA"
     polyA_site      7226
                     /gene="Myo16"
                     /gene_synonym="C230040D10Rik; Gm1105; mKIAA0865; NYAP3"
                     /note="major polyA site"
ORIGIN      
        1 gcggggcgcg gcggggaggc gggagggcgc caggaccagg cgaccgccct gttcttgcgt
       61 ggagacccaa aggaaccagg aggaccagaa gggacggaac ccagctgtgg actgtgtagg
      121 gagaggggcg gagctcggac cgagtggcag ggacgcggct gcggcccgag gggcgggggc
      181 tgcgagctgc caacgggtgg agtcggggtc cccatcgcgt ctcagcgcag cacatctccg
      241 ccagtctgct ccgtgacccg gcgtccagga gcagagcaga accgccggga ccgtccgttg
      301 ttggatcccg gggcaccggg gatcgttctt cgtcaggttg ctaccagcta tgtaatgttt
      361 ttcgatctca tgagatggaa attgaccagt gcttgctgga gtccctcccc ctgggccagc
      421 ggcagcgtct ggtgaagcgc atgcgctgtg agcaaatcaa agcttactat gagcgagaga
      481 aagtgttcca gaagcaggaa gggcccctga agagaagcaa gcctgggaag aggcagaagg
      541 ttcgcttcgg cctggctgac atgattcagg atgctgtcat ccaccatcat gacaaagagg
      601 tgcttcaact cttgaaggag ggggcagatc cacacactct cgtgtcctca ggagggtctt
      661 tgctacacct gtgtgctaga tacgacaacg tcttcattgc agaagtcctc attgacaggg
      721 gcgtcaatgt caaccatcag gatgaggact tttggacccc aatgcacatt gcctgtgcct
      781 gtgacaaccc tgacattgtc ctgttgctca tattagctgg agccaacgtc tttctgcaag
      841 atgtgaatgg aaacatccct ttagattatg ccgttgaggg gacagaatct agtgctatcc
      901 tgctggccta tctggatgag aaaggggtgg acctcagctc gctgcgccag ataaagctgc
      961 agcgacccct gagtatgcta acggacgtca ggcacttcct gtcttcaggc ggagatgtca
     1021 acgagaaaaa tgatgatgga gtgaccctgc tgcacatggc gtgtgccagt gggtataaag
     1081 aggtggtatt gcttctcctg gaacacggtg gagacctcaa tgggacagac gacaggtact
     1141 ggacacccct gcacttagca gccaagtatg gccagacaac cctggtgaag ctccttctgg
     1201 cacatcaggc aaacccccac cttgtgaact gcaatgggga gaaaccatca gacatcgctg
     1261 cctccgagtc gatcgaggag atgttgctga aagccgaaat cgcctgggaa gagaaaatga
     1321 aagagtctcc gtcagccccc agcttagcac aggaagagct gtacgagatc cttcatgacc
     1381 tcccagatct ctccagtaag ctaagtcccc tggtgctacc aatcgccaag caggacagct
     1441 tactggaaaa agacattatg ttcaaagaca caacgaaagg tctgtgcaag caggagtccc
     1501 aggatggccc tcctgagacc agcatgacaa gcaactgcgg caagccagag caggtccagg
     1561 tcatgcctcc agctcccagc gatgacctag ccacactcag tgagcttaat gacagcagcc
     1621 tgctgtatga aattcagaag cgctttggaa atgaccagat acacaccttt atcggagaca
     1681 tctttttgct tgttaaccca ttcaaagaac tcccaattta ctccactatg gtgtcccaga
     1741 tgtatctgag ccccacaggc cagcgcagcc cctcactgcc accccacctc ttctcctgcg
     1801 cagagagagc cttccacaga ctgttccagg agcgaaagcc acagaacatc atcctcagtg
     1861 gagaacgagg gtcagggaag acccaggcca gcaagcagat catgaagtac ctgaccagca
     1921 gggccagctc cagctgtacc atgtttgact ccagactcag gcatgccata tacatcgtgg
     1981 aggccttcgg acatgccaag accacactca acaatgtgtc cagttgcctc atacagtact
     2041 gggaactgca gtgctgtcag aggagaaagc acataactgg agccagaatt tccacttaca
     2101 tgctggagaa gtccagggtt gtggctcagc ctcccggcca gggcaccttt ctgattttct
     2161 cctggttgat ggacgggtta tcttcggaag aaaaatgtgg acttcacctt aataacttct
     2221 gtgcacaccg gtatgtgagc caaggcatgc gggaagatgt gtctacagca gagcattctc
     2281 tgaacaagga gagacttgca gctctgaaac atgctctgaa tgtaattggc ttcagcacct
     2341 tggaggtgga aaacctattc gttatcctat cggcgatact acacatcgga gacattcagt
     2401 tcactgcact aacagaagct gactcggcct ttgtctctga cctccagctt ctggaacaag
     2461 tggcaggtat gttgcaagtg tcgaccgacg agctggcatc cgccctaaca actgatattc
     2521 agtattttaa aggagatgtg ataatacgtc gacacactat ccagatggct gcgttttacc
     2581 gcgacctcct ggccaagtca ctgtacagtc gtttgtttgg ctttctgata aacactgtga
     2641 attgctgcct ccagaatcaa gatgaatata aaagcctaca gacattggat attggaatac
     2701 tggacatttt tggttttgag gaatttcaaa agaatgaatt tgaacaactc tgtgtcaacc
     2761 tgaccaacga aaagatgcac cactatatcc aagaggtgct tttcctacaa gagcaaacag
     2821 agtgtgtaca agagggagtt gccatggaaa ctgcctgttc tcctggtaac caggctggag
     2881 ttttggattt cttcttccag aaaccatcag gattcttctc cttactggat gaggagagtc
     2941 aagtgatttg gtcaggggag ccaaacctcc ccagaaagct gcagggtctc ctggaatcct
     3001 caaacacaaa tgcagtctac tcccctgtga aggacggcaa tggaaatgtt gctttcaaag
     3061 gtcaaggtgc ggccttcact gtcatgcact acgcaggaag ggtcatgtat gaaatgggag
     3121 gagcagttga aagaaacaaa gactctcttt cacagaacct cttatttgta atgaaaacaa
     3181 gtgaaaatgt cgtgatcagt catttgttcc agtcaaagct gtcacaaaca ggatcgctca
     3241 tatcttccta cccatccttt aaatttggag gacacaaatc caccctgctt agcaagagaa
     3301 ccgcctcttc catggttgga gtaaataaga attacctgga acttagcaag ttattaaaaa
     3361 agaagggaac ttccacattc ctacaaagac tggaacgagg agagcctgcc accgctgcat
     3421 cacaactcac gaaatctctg gcagacatta ctgcgaagct gcaaaggggc agcccacact
     3481 tcatcctttg catcaagccc aatacctcgc agctgcctgg tgtgtttgat cacttctacg
     3541 tgtctgccca actgcagtac ctcggtgtcc tggggctggt gaggctattc cgctctgggt
     3601 atccagtgcg cccttccttc gaggacttcc tgtccagata cgagccactg gcttctgttc
     3661 ttctgggcga gacgaagggt caggctgctg aggagaggtg tcgacttgtt ctccagcggt
     3721 gtaaactgca aggttggcag attggagtac acaaagtgtt cctgaagtac tggcacgtgg
     3781 accagctcag cgacctgtgg ctccagctgc aaaggaagat tgtaacttgc cagaaagtta
     3841 taagaggatt tctggcacgc cagcacttac ttcagagaat gagcatcaag caacaagagg
     3901 ttacatccat caagagcttc ttacagagca cagaggacat ggcactgaaa acctatgatg
     3961 ccctggtcat tcagaacgct tccgatatcg cccgggaaca cgacaggctc cggaaggagg
     4021 tccacactgc ctaccacagg aacagacaag aggaaggaac caagagagct gaagaccaag
     4081 gaggatgcag gcacgtccac tccaactccg tgccggtgcc catggtagta gacagcctcg
     4141 cccaggctct caccggacca tctacccggc ccccatcatt gcactctgtg ttcagcatgg
     4201 atgacagcac tggcctccca tcaccacgga aacagcctcc acccaagcca aagagggacc
     4261 ccaacacccg gctgagtgcc tcctatgagg ctgtgagcgc ctgcctttca gctgccaagg
     4321 atgcagccgg tgaagctctg acacggccca gaccccacag tgatgactat agcaccatga
     4381 agaagattcc ccctcggaag ccaaagagaa gtccccacac gaagctcagt ggctcttatg
     4441 aggagatctg gggaccacca cgaccttctg gcaccatggg ccaggggggc aggcatcagg
     4501 ccccagggac actgagtgtg cagtgggcca ggcctgactc agtgccgcag tgcacaccac
     4561 agctgcctct gcacctgcca ttgccacagg gcgactatga cgatgatgct gagcctgtgt
     4621 acatcgagat ggtggggaat gcagccaggg caggtggatc tgagaccgac agccctgacc
     4681 agggcgagtc tgtgtatgag gagatgaagt acatcttgcc agaggagggc tgtggcctag
     4741 ggatgctcac cttcctgcct gcctcacctc ctttgttttt agagactcga aaagccatca
     4801 tcttggaggc tgctgagggg aactgccagc cctcaaagga tacatgtgac atccccccac
     4861 ccttccccaa tctgcttccc cacaggccac cactcctagt ctttcccccc accccagtga
     4921 cccgctcccc agcttctgac gagtctccac tgacaccctt ggaggtgaag aaactgccag
     4981 tcttagagac caacctcaag tacccggtgc agtctgaagg ctccagtccc ttgtcaccac
     5041 agtactcaaa agcacagaag ggagataatg accagctggc atcccctggc tttcctgtgt
     5101 ttaatgggcc cagccgaatc tcaccacctg ccacaccacc gccaccccca gggccacctc
     5161 ctgcaccctg tgggccacct cctgcaccct gtgggccacc tcctgcaccc tgtggaccac
     5221 ctcctgcacc ctgtggacca cctcctgcac cctgtggacc acctcctgca ccctgtggag
     5281 cggcctctgc atcctgtggg gtggcccctg caccctgcag gccacccacc cacttcgcct
     5341 tcccaccaga gtctgtcctg gtcactgcag ctaaagcgct gactaactca gacctgccca
     5401 gaacacagcc aaagcccagt tcggccccag taccgggtcc ctgcagctcc tttgtcaagg
     5461 ctccatattc accgggaaag acagccagag cagacctcag gaagacctca tccaccttct
     5521 ctccaccaag cccttacagc ccacccaaca gcagaccgct gtccagtcct ctggacgagc
     5581 tggccagcct cttcaactcg ggaaggagtg tgctacgcag gtctgcagtg ggacgaagga
     5641 tcagggaggc tgaaggtttt gaaactaaca tgaacctgag tagccgggat gaacccagtt
     5701 catcagaaat ggcttcagag actcaagaca gaaacgccaa caaccatggg actcaactct
     5761 ccagttccct gtctagcgat gtgacggctg aaaatggaaa tcctgtcacc aatggtttag
     5821 ctgaggacga tgggtgctca aggctgtgtc tgagtggcat ggggacttca tcatttcaga
     5881 gaaatcggga gagccacacc acccaggtta tccatcagct gaggctctct gagaatgaaa
     5941 gcgtagctct gcaggagctg ctggactgga ggaggaagct ctgtgaggcc agagaaggct
     6001 ggcaggaagc cctgcagcac ccggagcccc gtgcacctcc gccgccaccc tgcaagaagc
     6061 cgacactcct aaagaagcct gaggggggct cctgcaccag gctgccttcc caactctggg
     6121 acagcagtat gtgatccagc gtggactgtg ggcacctgtc tgagctgtct agtgactgca
     6181 ggctgcttct gcaggaggct gccttccaat gcctgaggtc tcaccaggct tctccacaaa
     6241 agcacaggac actaacgatg actacccgag acctcctgtg tgtgccggtc tgtgtgtgct
     6301 caccagttcc ttctccattt cttgatagca cactgaattt taggaccaca ctgctcccag
     6361 atagccagag gcatggaggc atgtggctga gttcagaggt cagagcagtg gggggggggg
     6421 ggggcggggg gggaggtcct ccaggcagct gtttctaata caccccacag tggccactac
     6481 cctaccagtg gctgtcatat ggtgcagcac ataggacata tgtttcattt ctttgtagtt
     6541 gtctgtcatt agaattacaa acctgatgac cgttttacat gtttatgacc atattttata
     6601 atgttataca cctggtgtgt tccctttctt caaaatacag attttaaaag accatttcta
     6661 ggatttcttt tttaattcta cgtacttatt tttaacccaa agcccctcaa gtcctgggga
     6721 ctatgcgttg ctctggcttt aacagttgcc tacagcaacg ctggtcgaga ggtagagttt
     6781 atgtgccctg tccctccact ctcccctgca ccatgcatct cccttgggta cacatggctt
     6841 tggcattcat tggttaagct tcatccccac ccaacccctc agcttggcgt agacggcagg
     6901 atgtttatgg ttcaaaacgt atggcttcaa gttcctggct ggtgatacag gactttcaac
     6961 agtaccgata agcaggctga atctcacggg acagagcggt gtgttgccct cccctaggga
     7021 cgctgcatga ctctcttgct atgtgcccga ctggctgtca cgtgcgtgtg atagccttgc
     7081 ttctccatgt ctttctgccc actgtccgtg agttctgagc agtggctcca ccagccatct
     7141 gccacctccc ccgccccgcc ccttggactt gttcattcat ttccgccatt gccgggcttc
     7201 tgtgccaata aaagggtgca actgtaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
