LOCUS       NM_019472               8098 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus myosin X (Myo10), transcript variant 1, mRNA.
ACCESSION   NM_019472 XM_001006806
VERSION     NM_019472.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8098)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8098)
  AUTHORS   Yim,Y.I., Pedrosa,A., Wu,X., Chinthalapudi,K., Cheney,R.E. and
            Hammer,J.A.
  TITLE     Mechanisms underlying Myosin 10's contribution to the maintenance
            of mitotic spindle bipolarity
  JOURNAL   Mol Biol Cell 35 (2), ar14 (2024)
   PUBMED   38019611
REFERENCE   3  (bases 1 to 8098)
  AUTHORS   Hall,E.T., Dillard,M.E., Cleverdon,E.R., Zhang,Y., Daly,C.A.,
            Ansari,S.S., Wakefield,R., Stewart,D.P., Pruett-Miller,S.M.,
            Lavado,A., Carisey,A.F., Johnson,A., Wang,Y.D., Selner,E.,
            Tanes,M., Ryu,Y.S., Robinson,C.G., Steinberg,J. and Ogden,S.K.
  TITLE     Cytoneme signaling provides essential contributions to mammalian
            tissue patterning
  JOURNAL   Cell 187 (2), 276-293 (2024)
   PUBMED   38171360
REFERENCE   4  (bases 1 to 8098)
  AUTHORS   Granados-Aparici,S., Volodarsky-Perel,A., Yang,Q., Anam,S.,
            Tulandi,T., Buckett,W., Son,W.Y., Younes,G., Chung,J.T., Jin,S.,
            Terret,M.E. and Clarke,H.J.
  TITLE     MYO10 promotes transzonal projection-dependent germ line-somatic
            contact during mammalian folliculogenesisdagger
  JOURNAL   Biol Reprod 107 (2), 474-487 (2022)
   PUBMED   35470858
  REMARK    GeneRIF: MYO10 promotes transzonal projection-dependent germ
            line-somatic contact during mammalian folliculogenesisdagger.
REFERENCE   5  (bases 1 to 8098)
  AUTHORS   Mayca Pozo,F., Geng,X., Tamagno,I., Jackson,M.W., Heimsath,E.G.,
            Hammer,J.A., Cheney,R.E. and Zhang,Y.
  TITLE     MYO10 drives genomic instability and inflammation in cancer
  JOURNAL   Sci Adv 7 (38), eabg6908 (2021)
   PUBMED   34524844
REFERENCE   6  (bases 1 to 8098)
  AUTHORS   Tanaka,M., Hara,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Miyajima,A.
  TITLE     Reconstitution of the functional mouse oncostatin M (OSM) receptor:
            molecular cloning of the mouse OSM receptor beta subunit
  JOURNAL   Blood 93 (3), 804-815 (1999)
   PUBMED   9920829
REFERENCE   7  (bases 1 to 8098)
  AUTHORS   Sweet,H.O., Brilliant,M.H., Cook,S.A., Johnson,K.R. and
            Davisson,M.T.
  TITLE     A new allelic series for the underwhite gene on mouse chromosome 15
  JOURNAL   J Hered 89 (6), 546-551 (1998)
   PUBMED   9864865
REFERENCE   8  (bases 1 to 8098)
  AUTHORS   Uchida,K., Yoshimura,A., Inazawa,J., Yanagisawa,K., Osada,H.,
            Masuda,A., Saito,T., Takahashi,T., Miyajima,A. and Takahashi,T.
  TITLE     Molecular cloning of CISH, chromosome assignment to 3p21.3, and
            analysis of expression in fetal and adult tissues
  JOURNAL   Cytogenet Cell Genet 78 (3-4), 209-212 (1997)
   PUBMED   9465889
REFERENCE   9  (bases 1 to 8098)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   10 (bases 1 to 8098)
  AUTHORS   Hasson,T. and Mooseker,M.S.
  TITLE     Vertebrate unconventional myosins
  JOURNAL   J Biol Chem 271 (28), 16431-16434 (1996)
   PUBMED   8690736
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK089482.1, AK028552.1 and AK122371.1.
            
            On Mar 14, 2007 this sequence version replaced NM_019472.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ249706.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-739               AK089482.1         5-743
            740-2918            AK028552.1         649-2827
            2919-8098           AK122371.1         701-5880
FEATURES             Location/Qualifiers
     source          1..8098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 9.36 cM"
     gene            1..8098
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /note="myosin X"
                     /db_xref="GeneID:17909"
                     /db_xref="MGI:MGI:107716"
     exon            1..481
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..6649
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /note="isoform 1 is encoded by transcript variant 1;
                     unconventional myosin-10; unconventionnal myosin-X;
                     unconventional myosin-X"
                     /codon_start=1
                     /product="unconventional myosin-X isoform 1"
                     /protein_id="NP_062345.2"
                     /db_xref="CCDS:CCDS37049.1"
                     /db_xref="GeneID:17909"
                     /db_xref="MGI:MGI:107716"
                     /translation="MDSFFPEGARVWLRENGQHFPSTVNSCAEGVVVFQTDYGQVFTY
                     KQSTITNQKVTAMHPLHEEGVDDMASLAELHGGSIMYNLFQRYKRNQIYTYIGSIIAS
                     VNPYQPIAGLYERATMEEYSRCHLGELPPHIFAIANECYRCLWKRHDNQCVLISGESG
                     AGKTESTKLILKFLSVISQQTLDLGLQEKTSSVEQAILQSSPIMEAFGNAKTVYNNNS
                     SRFGKFVQLNICQQGNIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLDQGERE
                     EFYLSLPENYHYLNQSGCTEDKTISDQESFRQVITAMEVMQFSKEEVREVLRLLAGIL
                     HLGNIEFITAGGAQIPFKTALGRSADLLGLDPTQLTDALTQRSMILRGEEILTPLSVQ
                     QAVDSRDSLAMALYARCFEWVIKKINSRIKGKDDFKSIGILDIFGFENFEVNHFEQFN
                     INYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINE
                     ESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHYAGEVQYDVRGILEKNRD
                     TFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLMA
                     TLSSSNPFFVRCIKPNTQKMPDQFDQVVVLNQLRYSGMLETVRIRKAGYAVRRPFQDF
                     YKRYKVLMRNLALPDDIRGKCTVLLQVYDASNSEWQLGKTKVFLRESLEQKLEKRREE
                     EIDRAAMVIRAHILGYLARKQYRKVLCGVVTIQKNYRAFLARKKFLHLKKAAIVFQKQ
                     LRGQLARRVYRQLLAEKRELEEKKRREEEKKREEEERERERAQREADLLRAHQEAETR
                     RQQELEALQKSQREADLTRELEKQRENKQVEEILRLEKEIEDLQRMKERQELSLTEAS
                     LQKLQQLRDEELRRLEDEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEISGEELS
                     ELAESASGEKPNFNFSQPYPAEEEVDEGFEADDDAFKDSPNPSEHGHSDQRTSGIRTS
                     DDSSEEDPYMNYTVVPTSPSADSTVLLAASMQDSASLHNSSSGESTYCMPQNNGDLPS
                     PDGDYDYDQDDYEDGAITSGSSVTFSNSYGSQWSPDYRYSVGTYNSSGAYRFSSEGAQ
                     SSFEDSEEDFDSRFDTDDELSYRRDSVYSCVTLPYFHSFLYMKGGLMNSWKRRWCVLK
                     DETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLK
                     GTVEVRTAKEIIDNTSKENGIDIILADRTFHLIAESPEDASQWFSVLSQVHSSTDQEI
                     REMHDEQANPQNAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHH
                     WITLLQRSKGDTRVEGQEFIVRGWLHKEVKNSPKMSSLKLKKRWFVLTHNSLDYYKSS
                     EKNALKLGTLVLNSLCSVVPPDEKIFKETGYWNVTVYGRKHCYRLYTKLLNEATRWSS
                     AIQNVTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPLP
                     YGDINLNLLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDEL
                     YCQLIKQTNKVPHPGSVGNLYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGTE
                     MEKYALFIYESLKKTKCREFVPSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTA
                     GEVVEKLIRGLAMEDSRNMFALFEYNGQVDKAIESRTIVADVLAKFEKLAATSEAGDA
                     PWKFYFKLYCFLDTDSMPKDSVEFAFMFEQAHEAVIHGHHPAPEESLQVLAALRLQYL
                     QGDYTPHTSIPPLEEVYSVQRLRARISQSTKTFTPYERLEKRRTSFLEGTLRRSFRTG
                     SVVRQKAEEEQMLDMWIKEEVCSARTSIIDKWKKLQGMNQEQAMAKYMALIKEWPGYG
                     STLFDVECKEGGFPQELWLGVSADAVSVYKRGEGKPLEVFQYEHILSFGAPLANTYKI
                     VVDERELLFETSEVVDVAKLMKAYISMIVKKRYSTTRSVSSQGSSR"
     exon            482..580
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            581..739
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            740..927
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1062
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1187
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1201
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1286
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1390
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1520
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1639
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1786
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1887
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1954
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2047
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2116
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2199
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2308
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2389
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2514
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2629
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2736
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2964
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3013
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3904
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..4028
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4272
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4368
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            4369..4462
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            4463..4518
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..4661
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            4662..4856
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..5014
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            5015..5138
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            5139..5436
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            5437..5644
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            5645..5781
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            5782..5902
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            5903..6355
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            6356..6547
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     exon            6548..8098
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8079..8084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /note="hexamer: AATAAA"
     polyA_site      8098
                     /gene="Myo10"
                     /gene_synonym="D15Ertd600e; mKIAA0799; myosin-X"
                     /note="major polyA site"
ORIGIN      
        1 ggtaagcgag accggagagc tggtgagagc cggccgcgcc tggggcggga gagctcaccg
       61 ttgttggttt gctggtgatc cgaagtcgtc caccccaccc ccgctgggac cgagcgcccc
      121 cggcggagct ccaagggagg caggcgcgtc gccagcccct tgccggccct cccccagctc
      181 gggaagaatg tgccaccagc tgttctcctc ccgggagcac ttcgcccaga agtgaggaac
      241 ttggaggaag gagagacaaa ggctgtggtt gggacagagg aggtccgaga cgcggacaaa
      301 aggtgcggag gagcagcagc gaccggggga tggcagagcg gcggctccgc gggctggagt
      361 cgccccgagg cgcaccgtga cacgcgtggc ttcccgggac ctgccgctgc gctgacttcc
      421 gcgactggag ccgtgccggg aaggtgcggg cgccggaaca atggacagct tctttcccga
      481 gggagcacgg gtctggctaa gagaaaatgg ccagcatttt ccgagtactg taaattcctg
      541 tgcagaaggc gtcgtggtct tccagacaga ctatgggcag gtgttcacct acaagcagag
      601 tacaatcacc aaccagaagg tgacagctat gcaccccctg cacgaggagg gcgtggacga
      661 catggcttcc ctggccgagc tccatggggg ctccatcatg tacaaccttt tccagcgcta
      721 caaaaggaac caaatctata cctacatcgg ctccatcatc gcgtcagtga acccctacca
      781 gcccatcgct ggcctgtacg agcgcgccac catggaggag tacagcaggt gccacctggg
      841 cgagcttcca ccgcacatct tcgccattgc caacgaatgc tatcgctgct tgtggaagcg
      901 ccatgacaac caatgtgtcc tcatcagcgg ggaaagcgga gctgggaaaa cggaaagcac
      961 caagctgatc ctcaagttcc tgtccgtcat cagccagcag actttggacc tgggcctgca
     1021 ggagaagaca tccagcgtcg agcaagccat ccttcaaagc agcccaatca tggaagcatt
     1081 tggcaatgcg aagacagtat acaacaacaa ctccagtcgc ttcgggaagt ttgttcagct
     1141 gaacatctgc cagcagggaa acattcaggg aggaagaatt gtagattatt tattagaaaa
     1201 aaaccgagta gtgaggcaga atcccgggga gaggaattat cacatattct atgcactgct
     1261 ggcagggctg gaccagggag agcgagaaga attttattta tctttgccag aaaactacca
     1321 ttacttgaat cagtctgggt gtacggaaga caagacgatc agcgaccagg aatccttcag
     1381 acaagttatc acggcaatgg aagtcatgca attcagcaag gaggaagttc gggaagtttt
     1441 gaggttgctg gcgggaattc tgcatctcgg caacatagag tttatcactg ctggaggggc
     1501 gcagattccc ttcaaaacag ctttgggtag gtctgcggac ttgcttgggc tggacccaac
     1561 gcagctcaca gatgcactga cccagagatc catgatcctc aggggagaag agatcctgac
     1621 gcctctcagt gtccagcagg ccgtagatag cagagactca ttggccatgg cactttatgc
     1681 tcgctgcttt gagtgggtga tcaagaagat caacagccgg atcaaaggca aagacgactt
     1741 caaatccatc ggcatccttg acatcttcgg atttgaaaac ttcgaggtta accactttga
     1801 gcagttcaat atcaactatg caaatgaaaa gcttcaggaa tacttcaaca aacacatttt
     1861 ttccttagaa caactagaat atagcaggga gggattggtg tgggaagata ttgactggat
     1921 agacaatgga gaatgtctag acctgatcga gaagaaactt ggcctcctcg ccttgatcaa
     1981 tgaagagagc cattttcctc aagccacaga cagcactttg ttggagaagc tacacagtca
     2041 gcatgctaat aaccactttt atgtgaaacc ccgcgttgca gtcaacaatt ttggcgtgaa
     2101 gcattatgca ggagaggtgc agtatgatgt ccgaggcatc ttggaaaaga acagagacac
     2161 attcagagat gaccttctca acctgctcag ggaaagcagg ttcgacttca tctatgacct
     2221 ctttgaacac gtctccagcc gcaacaacca ggacaccttg aaatgcggaa gcaaacaccg
     2281 gcggcccact gtcagctcgc agttcaagga ctccctgcac tccttaatgg caacactaag
     2341 ctcctcaaat cctttctttg tcagatgcat caagccaaac acacagaaga tgccagacca
     2401 gtttgatcag gtggtagtgc tcaaccagct gcgctactcg gggatgctgg agacggtgag
     2461 gattcggaaa gcagggtatg ccgtcagaag accctttcag gacttttaca aaaggtataa
     2521 agtgctgatg aggaacttgg ccctgcctga cgacatccga gggaagtgca ctgtgctcct
     2581 gcaggtctat gacgcttcta acagcgagtg gcagctgggg aagaccaagg tcttccttcg
     2641 agaatccttg gagcagaaac tggaaaagag gcgggaagag gagattgacc gtgcggccat
     2701 ggtgatccga gctcacatct taggctactt ggcacgaaag caatatagaa aggtcctctg
     2761 tggtgtggtg accatacaga agaattacag agctttcctt gcgaggaaga aatttttgca
     2821 cctgaaaaag gcagccatcg tgttccagaa gcaactgcga ggacagctgg cacgcagggt
     2881 ttacaggcag ctgttggctg agaaacggga gctggaggaa aagaagaggc gggaggaaga
     2941 gaagaagaga gaggaagagg aaagagaaag agagcgagcg caaagagaag ctgacctcct
     3001 ccgtgcccat caggaggcag agacaaggag gcagcaagaa ctggaagcct tgcagaagag
     3061 ccagagggaa gcggacttga ccagggagct ggaaaagcaa agggagaaca agcaggtgga
     3121 ggagatcctc cgcctggaga aggaaatcga ggatctgcag cgcatgaagg agcggcagga
     3181 gctgtcgttg accgaggcct ccctgcagaa gctgcagcag ctgcgggatg aggagttgcg
     3241 caggctggag gatgaggcct gccgcgccgc ccaggagttc ttggagtcgc tcaacttcga
     3301 cgagatcgac gagtgcgtcc gcaacatcga gcgctccctg tcggtaggga gcgagatttc
     3361 gggcgaagag ctcagtgagc ttgccgagag tgccagcgga gagaagccaa acttcaactt
     3421 cagccagccc taccccgcgg aggaggaggt ggacgagggc ttcgaggcgg atgacgacgc
     3481 cttcaaggac tcgcccaacc ccagcgagca cggccactcc gaccagcgaa cgagtggcat
     3541 ccggacgagc gacgactcat ccgaggagga cccttacatg aactacacgg tggtgcccac
     3601 cagccccagt gccgacagta cggtgcttct tgctgcgtcc atgcaggact ccgctagcct
     3661 gcacaactcc tcgagtgggg agtccaccta ctgcatgccg cagaacaacg gcgacctgcc
     3721 ctcccccgac ggcgactatg actatgacca ggacgattac gaggatggcg ccatcacgtc
     3781 aggcagcagc gtgactttct ccaactccta tggaagccag tggtcccccg actacaggta
     3841 ttccgtggga acctacaaca gttccggagc gtaccggttc agctcagaag gggcgcagtc
     3901 ctcctttgaa gacagcgagg aggacttcga ctccaggttt gatacagatg atgaactttc
     3961 ctaccggcga gactctgtgt atagctgcgt cacactgccc tatttccaca gttttctgta
     4021 catgaaaggt ggcttaatga actcctggaa gcgccgctgg tgtgtcctga aggacgagac
     4081 cttcctgtgg ttccgctcca agcaggaagc cctcaagcaa ggctggctgc acaagaaagg
     4141 cgggggctcc tccacgctgt cccggaggaa ctggaagaag cgctggtttg tccttcgcca
     4201 gtcgaagctg atgtactttg aaaacgatag cgaggagaag ctcaagggca ccgtggaagt
     4261 ccgcaccgcc aaggagatca tagacaacac aagcaaagag aacgggatcg acatcatcct
     4321 ggccgacagg accttccatc tcatcgcgga gtcccccgaa gatgccagcc aatggttcag
     4381 cgtgctgagt caggtccact cgtccacaga ccaggagatc agagaaatgc atgatgagca
     4441 ggcaaacccc cagaatgctg tgggcacact ggatgtcggg ctgattgatt ctgtatgcgc
     4501 ctctgacagc cctgatagac ccaactcatt tgtgatcatc acagccaacc gggtgctgca
     4561 ctgtaacgcg gacaccccag aggagatgca ccactggata accctgctgc agagatccaa
     4621 gggggacacc agggtggagg gccaggagtt catcgtcaga gggtggctgc ataaggaagt
     4681 gaagaacagt ccgaagatgt cctccctgaa actgaagaaa cggtggttcg tgctgacgca
     4741 caattccctg gactactaca agagctcaga gaagaacgct ctgaaactgg gcactctggt
     4801 cctcaacagc ctgtgctccg ttgtgccccc agacgagaag atattcaaag agacaggcta
     4861 ctggaatgtc accgtgtatg ggcgcaaaca ctgttaccga ctctacacga aactactgaa
     4921 cgaggcgact aggtggtcca gcgccatcca gaatgtgact gacaccaagg ctccaatcga
     4981 cacgcccacc cagcagctga tccaagatat taaggagaac tgcctcaact ctgacgtggt
     5041 ggagcagatt tacaagcgga acccgatcct tcgctacacg catcacccgc tgcactcccc
     5101 gctcctgcct cttccctatg gggacataaa tctcaacctg ctgaaagaca aaggctacac
     5161 gacccttcag gacgaagcca tcaagatatt caattctctc caacaactgg agtccatgtc
     5221 cgaccccatc cctatcatcc agggcatcct gcagaccggg cacgacctgc ggcctctgcg
     5281 ggatgaactg tattgtcagc tcatcaaaca gaccaacaag gtgccccatc ccggcagcgt
     5341 gggcaacctt tacagctggc agatcctgac ctgcctcagc tgcaccttcc tgccgagccg
     5401 cgggatcctc aaatacctca agttccacct gaaaaggata cgggaacagt tcccaggaac
     5461 cgagatggag aagtacgccc tctttatcta cgaatccctt aagaaaacca aatgcagaga
     5521 gtttgtgcct tcccgagatg aaatcgaagc tctgatccac cggcaggaaa tgacgtccac
     5581 agtgtattgc catggcggag gctcctgcaa gatcaccatc aactcccaca ccacagccgg
     5641 ggaggtggtg gagaagctga tccgagggct cgccatggag gacagcagga acatgtttgc
     5701 cttgtttgag tacaacggac aggtggacaa ggccatcgaa agccggacca tcgtagctga
     5761 cgtcctggca aagtttgaaa agctagctgc cacgtcagaa gccggggacg cgccatggaa
     5821 attctacttc aaactttatt gcttcctgga caccgacagc atgccaaaag acagcgtgga
     5881 gtttgcgttt atgtttgaac aggcccacga agccgtcatc catggccacc acccagcccc
     5941 tgaggaaagc ctccaagtgc tggctgccct gagactgcag tatctgcagg gcgactatac
     6001 cccgcacacc tccatcccac ccctcgagga ggtttactct gtgcagagac tcagagctcg
     6061 cattagtcag tcgaccaaaa ccttcacccc gtacgagcgc ctcgagaaga gacggaccag
     6121 cttcctggag ggcacgctgc ggcggagctt ccggaccggg tcggtggttc ggcagaaggc
     6181 ggaggaggag cagatgctgg acatgtggat caaggaggaa gtctgctcgg ctcgcaccag
     6241 catcattgac aagtggaaga aactgcaggg gatgaaccag gaacaagcca tggccaagta
     6301 tatggccctg atcaaggagt ggcctggtta tggatcaaca ctctttgatg tggagtgcaa
     6361 agaaggcggc ttcccccagg agctctggct gggcgtcagc gcagacgccg tgtctgtcta
     6421 caagcgtgga gagggcaaac cgttagaagt cttccagtat gagcacatcc tctcgttcgg
     6481 ggcaccgctg gccaacacgt acaagatcgt agttgacgag cgggagctgc tctttgagac
     6541 gagtgaggtg gtggatgtgg ccaagctcat gaaagcgtat atcagcatga ttgtgaagaa
     6601 gcgctatagc accacacgct ctgtgagcag ccagggcagc tccaggtgaa gacgagccaa
     6661 gcccacgtgt cttgccgatg tgaacgtgcc actctttgcc tgggccagcg cctggtcctg
     6721 acccagcttt ggaaactcag ctgtccaggc ttctgataac cggtcgtcag agggaggagt
     6781 cccgggggct cccttcaccc gatcagcctc agagatcacg tattaagctg tcaaccttta
     6841 acagtctgca caatctctta agctttagtt aaaaatccta gatgagaact tgccttaaag
     6901 aaaaaaagaa aggggagaaa accacacggc caccaaagca gccagaagtg ccttaaactt
     6961 gcagagtgga ccctaatcga ccttaactgt gctactgagg gggagcgctt tcacctcccg
     7021 gtggggtttg cagagcttgg aggcggggca tggatccact gattgtgcac taacctcccc
     7081 agcctgattt cctgcaaatg aggggagctg agggggcggg gcgaggcagg gagacagcag
     7141 agggggacag tgtgttgtcg gagtgctgct ggcagccttc cttacgaaca tgtattaacg
     7201 tttttggggt ttttttgttt ttttgttttt tgtttttttg gttttttttt tgctttgttt
     7261 caactgtctg tgcttgcccg cgcatgcatg tgttcacaca ctcaacactt taatcattgt
     7321 cctgtgagca ttaaacacaa agggaaagag gatgtgcaat gttgtaaaca gtctgtatat
     7381 tttcctagtt cagagttcta gtctcgaggt ggctttatta acagacccgg atcctggacg
     7441 ttcctgtctt tgctgtattt tttggaaaga aacatttttt ttggactcgg tttcgtttta
     7501 catgtagcta gggcggcgac ctgtgactgc tgtattacta acaggtctac agcccagaga
     7561 gataactgta tttataaacc actcttaaac tgctggctcc agtgttttta gaatgatatg
     7621 aagtcatttt ggagtctttt tttcattcta aaagttaagt taaaaaattt tttttgtttt
     7681 gttttggtct tctttgaagg gtaacttgtg ttatcactct ggctagattg cagatataac
     7741 catgtcgaat gtgggggagg ggggagctgc tgcattccca aactctgtac ccctcaagca
     7801 aacctctaag ggacctccaa cacaaacgct gaggctttaa tggaattcac acgttgtttt
     7861 gtccctggtt cctacaggtg gcctgaacac agcacctgta agtaacagcg gttgtaacca
     7921 gaagaaaaaa gaatctggac ttggactttt atttttatat gggaaaaaaa tatataaagg
     7981 tgggccaaac gagtctgctc acaaagcaaa gttactttgg ccttatccct tacggacagt
     8041 tacgtggaag cagtgtctct tggctcacaa agtctgacaa taaaagatat taatatgc
//
