LOCUS       NM_016754                755 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus myosin light chain, phosphorylatable, fast skeletal
            muscle (Mylpf), transcript variant 1, mRNA.
ACCESSION   NM_016754 XM_914902
VERSION     NM_016754.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 755)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 755)
  AUTHORS   Zhang,X., Wang,Z., Xu,Q., Chen,Y., Liu,W., Zhong,T., Li,H.,
            Quan,C., Zhang,L. and Cui,C.P.
  TITLE     Splicing factor Srsf5 deletion disrupts alternative splicing and
            causes noncompaction of ventricular myocardium
  JOURNAL   iScience 24 (10), 103097 (2021)
   PUBMED   34622152
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 755)
  AUTHORS   Gerber,S.D., Beauchamp,P., Zhuang,L., Villiger,P.M. and Trueb,B.
  TITLE     Functional domains of the FgfrL1 receptor
  JOURNAL   Dev Biol 461 (1), 43-54 (2020)
   PUBMED   31923383
REFERENCE   4  (bases 1 to 755)
  AUTHORS   Zoupa,M., Xavier,G.M., Bryan,S., Theologidis,I., Arno,M. and
            Cobourne,M.T.
  TITLE     Gene expression profiling in the developing secondary palate in the
            absence of Tbx1 function
  JOURNAL   BMC Genomics 19 (1), 429 (2018)
   PUBMED   29866044
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 755)
  AUTHORS   Janssen,L., Dupont,L., Bekhouche,M., Noel,A., Leduc,C., Voz,M.,
            Peers,B., Cataldo,D., Apte,S.S., Dubail,J. and Colige,A.
  TITLE     ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and
            regulates placental angiogenesis
  JOURNAL   Angiogenesis 19 (1), 53-65 (2016)
   PUBMED   26446156
REFERENCE   6  (bases 1 to 755)
  AUTHORS   Faerman,A. and Shani,M.
  TITLE     The expression of the regulatory myosin light chain 2 gene during
            mouse embryogenesis
  JOURNAL   Development 118 (3), 919-929 (1993)
   PUBMED   8076526
REFERENCE   7  (bases 1 to 755)
  AUTHORS   Lee,K.J., Ross,R.S., Rockman,H.A., Harris,A.N., O'Brien,T.X., van
            Bilsen,M., Shubeita,H.E., Kandolf,R., Brem,G., Price,J. et al.
  TITLE     Myosin light chain-2 luciferase transgenic mice reveal distinct
            regulatory programs for cardiac and skeletal muscle-specific
            expression of a single contractile protein gene
  JOURNAL   J Biol Chem 267 (22), 15875-15885 (1992)
   PUBMED   1379240
REFERENCE   8  (bases 1 to 755)
  AUTHORS   Czosnek,H., Barker,P.E., Ruddle,F.H. and Robert,B.
  TITLE     Chromosomal distribution of genes coding for fast twitch skeletal
            muscle myosin light chains
  JOURNAL   Somat Cell Mol Genet 11 (6), 533-540 (1985)
   PUBMED   3865381
REFERENCE   9  (bases 1 to 755)
  AUTHORS   Czosnek,H., Nudel,U., Shani,M., Barker,P.E., Pravtcheva,D.D.,
            Ruddle,F.H. and Yaffe,D.
  TITLE     The genes coding for the muscle contractile proteins, myosin heavy
            chain, myosin light chain 2, and skeletal muscle actin are located
            on three different mouse chromosomes
  JOURNAL   EMBO J 1 (11), 1299-1305 (1982)
   PUBMED   6897916
REFERENCE   10 (bases 1 to 755)
  AUTHORS   Katcoff,D., Nudel,U., Zevin-Sonkin,D., Carmon,Y., Shani,M.,
            Lehrach,H., Frischauf,A.M. and Yaffe,D.
  TITLE     Construction of recombinant plasmids containing rat muscle actin
            and myosin light chain DNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 77 (2), 960-964 (1980)
   PUBMED   6928693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122537.4.
            
            On Apr 28, 2007 this sequence version replaced NM_016754.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010483.1, BY709905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC122537.4         186677-186832
            157-249             AC122537.4         187930-188022
            250-325             AC122537.4         188234-188309
            326-430             AC122537.4         188487-188591
            431-509             AC122537.4         188679-188757
            510-558             AC122537.4         189004-189052
            559-755             AC122537.4         189160-189356
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.39 cM"
     gene            1..755
                     /gene="Mylpf"
                     /gene_synonym="2410014J02Rik; MLC-2; Mlc2; Myl11"
                     /note="myosin light chain, phosphorylatable, fast skeletal
                     muscle"
                     /db_xref="GeneID:17907"
                     /db_xref="MGI:MGI:97273"
     exon            1..156
                     /gene="Mylpf"
                     /gene_synonym="2410014J02Rik; MLC-2; Mlc2; Myl11"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..663
                     /gene="Mylpf"
                     /gene_synonym="2410014J02Rik; MLC-2; Mlc2; Myl11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin light chain 2; MLC2F; fast skeletal myosin light
                     chain 2; myosin light chain 11; myosin regulatory light
                     chain 11"
                     /codon_start=1
                     /product="myosin regulatory light chain 11 isoform 1"
                     /protein_id="NP_058034.1"
                     /db_xref="CCDS:CCDS40140.1"
                     /db_xref="GeneID:17907"
                     /db_xref="MGI:MGI:97273"
                     /translation="MAPKKAKRRAGAEGSSNVFSMFDQTQIQEFKEAFTVIDQNRDGI
                     IDKEDLRDTFAAMGRLNVKNEELDAMMKEASGPINFTVFLTMFGEKLKGADPEDVITG
                     AFKVLDPEGKGTIKKQFLEELLTTQCDRFSQEEIKNMWAAFPPDVGGNVDYKNICYVI
                     THGDAKDQE"
     exon            157..249
                     /gene="Mylpf"
                     /gene_synonym="2410014J02Rik; MLC-2; Mlc2; Myl11"
                     /inference="alignment:Splign:2.1.0"
     exon            250..325
                     /gene="Mylpf"
                     /gene_synonym="2410014J02Rik; MLC-2; Mlc2; Myl11"
                     /inference="alignment:Splign:2.1.0"
     exon            326..430
                     /gene="Mylpf"
                     /gene_synonym="2410014J02Rik; MLC-2; Mlc2; Myl11"
                     /inference="alignment:Splign:2.1.0"
     exon            431..509
                     /gene="Mylpf"
                     /gene_synonym="2410014J02Rik; MLC-2; Mlc2; Myl11"
                     /inference="alignment:Splign:2.1.0"
     exon            510..558
                     /gene="Mylpf"
                     /gene_synonym="2410014J02Rik; MLC-2; Mlc2; Myl11"
                     /inference="alignment:Splign:2.1.0"
     exon            559..755
                     /gene="Mylpf"
                     /gene_synonym="2410014J02Rik; MLC-2; Mlc2; Myl11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtatctggg gtgggtatcc acagggctaa ggttaccacg gtatgttaag ggctgccggg
       61 gcaggactat ataaccccag aagaactgct ccaagcagat tctcttcctt tttccatctg
      121 gagctactgc cttgccccca ggagatctaa gacatggcac ccaagaaggc caagagaagg
      181 gcaggagcgg aagggagctc caacgtcttc tccatgtttg accagactca gatccaggag
      241 ttcaaggagg cgttcactgt aattgatcag aacagggatg gcattatcga caaagaggat
      301 cttcgggaca cctttgcagc catgggccgt ctcaatgtga agaatgagga actcgacgct
      361 atgatgaagg aagccagtgg gcccatcaac ttcactgtct tcctgaccat gtttggggaa
      421 aagcttaagg gtgcggaccc ggaggatgtg atcactggag ccttcaaggt cctggaccca
      481 gaagggaagg gcaccatcaa aaagcagttc ttggaggagc tgcttaccac gcagtgcgac
      541 cgattttccc aggaggagat caagaacatg tgggcagcct tccccccaga cgtgggcggc
      601 aacgtggact acaagaacat ctgctacgtc atcacacatg gtgatgctaa ggaccaggaa
      661 taggggaccc aaggtctcag aagacctaga taggcttgta gccgctccat ctctcaccct
      721 ggccctcaat aaaactcaac tggtctttgt ttctt
//
