LOCUS       NM_001081044            2948 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus myosin, light polypeptide kinase 2, skeletal muscle
            (Mylk2), mRNA.
ACCESSION   NM_001081044 XM_001005681
VERSION     NM_001081044.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2948)
  AUTHORS   Al Madhoun,A.S., Mehta,V., Li,G., Figeys,D., Wiper-Bergeron,N. and
            Skerjanc,I.S.
  TITLE     Skeletal myosin light chain kinase regulates skeletal myogenesis by
            phosphorylation of MEF2C
  JOURNAL   EMBO J 30 (12), 2477-2489 (2011)
   PUBMED   21556048
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2948)
  AUTHORS   Khiem,D., Cyster,J.G., Schwarz,J.J. and Black,B.L.
  TITLE     A p38 MAPK-MEF2C pathway regulates B-cell proliferation
  JOURNAL   Proc Natl Acad Sci U S A 105 (44), 17067-17072 (2008)
   PUBMED   18955699
REFERENCE   3  (bases 1 to 2948)
  AUTHORS   Moitra,J., Evenoski,C., Sammani,S., Wadgaonkar,R., Turner,J.R.,
            Ma,S.F. and Garcia,J.G.
  TITLE     A transgenic mouse with vascular endothelial over-expression of the
            non-muscle myosin light chain kinase-2 isoform is susceptible to
            inflammatory lung injury: role of sexual dimorphism and age
  JOURNAL   Transl Res 151 (3), 141-153 (2008)
   PUBMED   18279813
  REMARK    GeneRIF: These data reveal that nmMLCK2 overexpression in the
            endothelium exacerbates lung injury in vivo in a sexually dimorphic
            and age-dependent manner.
REFERENCE   4  (bases 1 to 2948)
  AUTHORS   Jevsek,M., Jaworski,A., Polo-Parada,L., Kim,N., Fan,J.,
            Landmesser,L.T. and Burden,S.J.
  TITLE     CD24 is expressed by myofiber synaptic nuclei and regulates
            synaptic transmission
  JOURNAL   Proc Natl Acad Sci U S A 103 (16), 6374-6379 (2006)
   PUBMED   16606832
REFERENCE   5  (bases 1 to 2948)
  AUTHORS   Zhi,G., Ryder,J.W., Huang,J., Ding,P., Chen,Y., Zhao,Y., Kamm,K.E.
            and Stull,J.T.
  TITLE     Myosin light chain kinase and myosin phosphorylation effect
            frequency-dependent potentiation of skeletal muscle contraction
  JOURNAL   Proc Natl Acad Sci U S A 102 (48), 17519-17524 (2005)
   PUBMED   16299103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833801.9.
            
            On Dec 20, 2007 this sequence version replaced NM_001081044.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AL833801.9         49024-49271
            249-723             AL833801.9         49712-50186
            724-1019            AL833801.9         51117-51412
            1020-1125           AL833801.9         52802-52907
            1126-1219           AL833801.9         53329-53422
            1220-1329           AL833801.9         55006-55115
            1330-1471           AL833801.9         55197-55338
            1472-1542           AL833801.9         56821-56891
            1543-1671           AL833801.9         56997-57125
            1672-1824           AL833801.9         57958-58110
            1825-1957           AL833801.9         58193-58325
            1958-2948           AL833801.9         59747-60737
FEATURES             Location/Qualifiers
     source          1..2948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..2948
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /note="myosin, light polypeptide kinase 2, skeletal
                     muscle"
                     /db_xref="GeneID:228785"
                     /db_xref="MGI:MGI:2139434"
     exon            1..248
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            249..723
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            724..1019
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1125
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1219
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1329
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1471
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1542
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1671
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1824
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1957
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2948
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2885..2890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2930
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
                     /note="major polyA site"
     polyA_site      2948
                     /gene="Mylk2"
                     /gene_synonym="9830004H17Rik"
ORIGIN      
        1 agctgcagca gactgccggc caccaggttg cccctctcta tccagggaca tctctcctct
       61 cagttgactg gccttggtct tctctcacca cagctggaaa agaaggggca atctgacaac
      121 ctgatacact cctctcctct ttctgcagct agaaagactt gagttagaca agcagacgca
      181 cacgcctacc tacctcatga ctacagaaaa cggagcagtt gagctgggaa gccagagcct
      241 gtcaacagaa cagacaccta aagccgctgc aggtgatgga ccttcagctt cagaaaaaga
      301 acccagcgcc ccagccacag agaaagacct gagcccccct aacgcgaaga aagacccggg
      361 cgcgccagat ccaaagaaca atccagatcc accctccctg aagaaagatc ccgccaaagc
      421 ccctggccca gagaaaaagg gtgacccggt cccagcttca gccagcagcc agggcccttc
      481 aggagaggga gatggaggtg ggggacctgc tgaaggcagt gaggggcctc ctgcagcctt
      541 gcccctgccc actgctacag ccgaggccag catccagaag ctggacccca cgcaagcacc
      601 ctcaggcaac cagggatccg gagaagccaa ggcaggcaag aaggcagcag aatgccgcga
      661 agcaggaaga aggggctcac ctgcctttct ccacagccct agctgcccgg ctatcatctc
      721 ctgctctgag aagacactgg ctgtgaagcc cctaagcgag acaacagacc tcgtctttac
      781 aggggtgtct gtgacccctg acccccaaga tcctggtcca gtcaaagcag gagggacaaa
      841 cgccctggca gagaagaaga aggaagaggc agagaaagcc tcaggccagg ccgggcaggc
      901 taaggtgcaa ggggacaccc cccagaggat cgggttccag gctgttccct cagagagagt
      961 ggaggtgggg caggccctct gtctcactgc cagggaggaa gactgcttcc aaatcctgga
     1021 tgattgtcca ccgcccccag cccccttccc acacaggatc gtggagctga ggaccggaaa
     1081 tgtcaacagt gaattcagca tgaactcaaa ggaggcactg ggaggtggca aatttggagc
     1141 tgtgtgcacc tgcacggaga gagccacagg cctcaagctg gcagccaagg tcatcaagaa
     1201 acagacaccc aaggacaagg aaatggtgtt gctggagatc gaggtcatga accagctgaa
     1261 ccatcgcaac ctgatccagc tgtacgcagc cattgagacc tctcacgaga tcatcctgtt
     1321 catggaatac atcgagggcg gcgagctctt tgagaggatt gtggatgaag actaccatct
     1381 gacggaggtg gacaccatgg tgttcgtcag gcagatctgc gacgggatcc tcttcatgca
     1441 caagatgagg gtcctgcatc tggacctcaa gccagagaac atcctgtgtg tgaataccac
     1501 tgggcacttg gtgaagataa ttgactttgg cttggcgagg aggtataacc ccaatgagaa
     1561 actgaaggtg aattttggga ccccggagtt cctgtcaccg gaggtggtga actacgacca
     1621 aatctctgac aagacagaca tgtggagcct tggggtgatc acctacatgc tactgagtgg
     1681 cctctctccc ttcctgggag acgatgacac ggagacctta aacaatgtcc tgtctgccaa
     1741 ctggtacttt gatgaggaga cctttgaagc tgtgtcagat gaggccaaag actttgtctc
     1801 caatcttctc acgaaggacc agagtgccag aatgagtgct gagcagtgcc tcgcccaccc
     1861 ctggctcaac aacctggcag aaaaagccaa acgctgcaac cgtcgcctca agtcccagat
     1921 cctgcttaag aaatacctca tgaagaggcg ttggaagaaa aacttcattg ctgtcagcgc
     1981 agccaatcgc ttcaagaaga tcagtagctc gggggcactg atggctctgg gggtctgaac
     2041 cccaggagca gctaagcctg gatgcagcta cgcggtggtc aaggctgaaa ccacacagct
     2101 cagaaggcca gagacagcca gctggccaga tctctagagc aggctggtca ggacaaagct
     2161 gcatcaggcc cggaggcttg gggctccgca ggtccttagg cgataccgct tcccctatgt
     2221 gaacatggag tggggcctgg aatccatctc gctaccgcct cctcagcggg gctgtggcct
     2281 gtcagcccca cccagactcc aaggacggcc agaccattcc ctagtctctc cctagcttcc
     2341 ccctttgaac tgctgcccta gagcctcttc tctgccccac cttgggcatc cttgcctgga
     2401 gcgggaaggc gggggttcag caggtgggct gctatggtgg tgggtggaga gcttccagca
     2461 ggggtcagaa tgcagtccag ctgccggggg agacagagca ggctttgtgt gagaggacct
     2521 ctgtggcctg cttcacactc cccacagata gagcctcgca cacaccatct ggcctcctgg
     2581 cccccacctt ctgtttttgt gaccaccaac acacaggaac tctgagagag aaagccagcc
     2641 cgggcctgga gtggtggtgg tggtggtggt ggtggtggtg gtggtggtgg tggtggtggc
     2701 ggggagagac ctgggaggca tgagactacc ccaccaagtt tacttgggga ctgagtcttc
     2761 ccagcctgac tactctgtgc ccatcccagg agcagtcaca accccaaata acaggatgaa
     2821 ctggcccacg aggagtatga agccatcggg cagaccccaa cctgctctca gcttgtgcct
     2881 tgtaaataaa aacacaggtt ggaggcagcc tccttccctt tgcacgtgca cacacgtgtg
     2941 tgtgataa
//
