LOCUS       NM_139300               7858 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus myosin, light polypeptide kinase (Mylk), transcript
            variant 2, mRNA.
ACCESSION   NM_139300 XM_358955
VERSION     NM_139300.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7858)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7858)
  AUTHORS   Liu,Z.L., Li,Y., Lin,Y.J., Shi,M.M., Fu,M.X., Li,Z.Q., Ning,D.S.,
            Zeng,X.M., Liu,X., Cui,Q.H., Peng,Y.M., Zhou,X.M., Hu,Y.R.,
            Liu,J.S., Liu,Y.J., Wang,M., Zhang,C.X., Kong,W., Ou,Z.J. and
            Ou,J.S.
  TITLE     Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK
            signaling axis in mice
  JOURNAL   Nat Commun 15 (1), 5985 (2024)
   PUBMED   39013850
  REMARK    GeneRIF: Aging aggravates aortic aneurysm and dissection via
            miR-1204-MYLK signaling axis in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7858)
  AUTHORS   Huycke,T.R., Hakkinen,T.J., Miyazaki,H., Srivastava,V., Barruet,E.,
            McGinnis,C.S., Kalantari,A., Cornwall-Scoones,J., Vaka,D., Zhu,Q.,
            Jo,H., Oria,R., Weaver,V.M., DeGrado,W.F., Thomson,M.,
            Garikipati,K., Boffelli,D., Klein,O.D. and Gartner,Z.J.
  TITLE     Patterning and folding of intestinal villi by active mesenchymal
            dewetting
  JOURNAL   Cell 187 (12), 3072-3089 (2024)
   PUBMED   38781967
REFERENCE   4  (bases 1 to 7858)
  AUTHORS   Wang,L., He,X., Hu,G., Liu,J., Kang,X., Yu,L., Dong,K., Zhao,J.,
            Zhang,A., Zhang,W., Brands,M.W., Su,H., Zheng,Z. and Zhou,J.
  TITLE     A novel mouse model carrying a gene trap insertion into the Hmgxb4
            gene locus to examine Hmgxb4 expression in vivo
  JOURNAL   Physiol Rep 12 (8), e16014 (2024)
   PUBMED   38644513
REFERENCE   5  (bases 1 to 7858)
  AUTHORS   Drolia,R., Bryant,D.B., Tenguria,S., Jules-Culver,Z.A., Thind,J.,
            Amelunke,B., Liu,D., Gallina,N.L.F., Mishra,K.K., Samaddar,M.,
            Sawale,M.R., Mishra,D.K., Cox,A.D. and Bhunia,A.K.
  TITLE     Listeria adhesion protein orchestrates caveolae-mediated apical
            junctional remodeling of epithelial barrier for Listeria
            monocytogenes translocation
  JOURNAL   mBio 15 (3), e0282123 (2024)
   PUBMED   38376160
REFERENCE   6  (bases 1 to 7858)
  AUTHORS   Hoggatt,A.M., Kriegel,A.M., Smith,A.F. and Herring,B.P.
  TITLE     Hepatocyte nuclear factor-3 homologue 1 (HFH-1) represses
            transcription of smooth muscle-specific genes
  JOURNAL   J Biol Chem 275 (40), 31162-31170 (2000)
   PUBMED   10896677
REFERENCE   7  (bases 1 to 7858)
  AUTHORS   Kabir,N., Yamamura,H., Niki,I., Iida,Y., Uzzaman,M., Sarkar,D.,
            Hayasaka,S., Takagishi,Y., Inouye,M. and Hidaka,H.
  TITLE     Immunocytochemical detection and spatial distribution of myosin
            light-chain kinase in preimplantation mouse embryos
  JOURNAL   J Exp Zool 278 (3), 147-155 (1997)
   PUBMED   9181694
REFERENCE   8  (bases 1 to 7858)
  AUTHORS   Herring,B.P. and Smith,A.F.
  TITLE     Telokin expression is mediated by a smooth muscle cell-specific
            promoter
  JOURNAL   Am J Physiol 270 (6 Pt 1), C1656-C1665 (1996)
   PUBMED   8764148
REFERENCE   9  (bases 1 to 7858)
  AUTHORS   Kabir,N., Yamamura,H., Takagishi,Y., Inouye,M., Oda,S. and
            Hidaka,H.
  TITLE     Regulation of preimplantation development of mouse embryos: effects
            of inhibition of myosin light-chain kinase, a
            Ca2+/calmodulin-dependent enzyme
  JOURNAL   J Exp Zool 274 (2), 101-110 (1996)
   PUBMED   8742690
REFERENCE   10 (bases 1 to 7858)
  AUTHORS   Gallagher,P.J., Garcia,J.G. and Herring,B.P.
  TITLE     Expression of a novel myosin light chain kinase in embryonic
            tissues and cultured cells
  JOURNAL   J Biol Chem 270 (49), 29090-29095 (1995)
   PUBMED   7493932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010574.8, AC154813.2 and AC110166.17.
            
            On Jun 14, 2022 this sequence version replaced NM_139300.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               CT010574.8         146661-146785
            126-293             AC154813.2         114136-114303       c
            294-501             AC154813.2         68967-69174         c
            502-550             AC154813.2         56501-56549         c
            551-701             AC154813.2         55566-55716         c
            702-867             AC154813.2         54076-54241         c
            868-886             AC154813.2         51802-51820         c
            887-1401            AC154813.2         50170-50684         c
            1402-1608           AC154813.2         49441-49647         c
            1609-1743           AC154813.2         34793-34927         c
            1744-1896           AC154813.2         30225-30377         c
            1897-2034           AC154813.2         17454-17591         c
            2035-2232           AC154813.2         15577-15774         c
            2233-2482           AC154813.2         14706-14955         c
            2483-2554           AC154813.2         8615-8686           c
            2555-3642           AC154813.2         7078-8165           c
            3643-3759           AC110166.17        91366-91482         c
            3760-3846           AC110166.17        82304-82390         c
            3847-3897           AC110166.17        68487-68537         c
            3898-4025           AC110166.17        67610-67737         c
            4026-4179           AC110166.17        64780-64933         c
            4180-4482           AC110166.17        57470-57772         c
            4483-4515           AC110166.17        50042-50074         c
            4516-4609           AC110166.17        49849-49942         c
            4610-4813           AC110166.17        49294-49497         c
            4814-5031           AC110166.17        44214-44431         c
            5032-5155           AC110166.17        42021-42144         c
            5156-5308           AC110166.17        34723-34875         c
            5309-5432           AC110166.17        32311-32434         c
            5433-5562           AC110166.17        26113-26242         c
            5563-5694           AC110166.17        24460-24591         c
            5695-7858           AC110166.17        18880-21043         c
FEATURES             Location/Qualifiers
     source          1..7858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 24.49 cM"
     gene            1..7858
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /note="myosin, light polypeptide kinase"
                     /db_xref="GeneID:107589"
                     /db_xref="MGI:MGI:894806"
     exon            1..125
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            126..293
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            294..501
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            502..550
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            551..701
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            702..867
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            868..886
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1401
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1608
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1743
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1896
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2034
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2232
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2482
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2554
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..3642
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3759
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3846
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            3847..3897
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..4025
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4179
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            4180..4482
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4515
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            4516..4609
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            4610..4813
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            4814..5031
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            5032..5155
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            5156..5308
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            5309..5432
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            5433..5562
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            5563..5694
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     exon            5695..7858
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7824..7829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /note="hexamer: AATAAA"
     polyA_site      7858
                     /gene="Mylk"
                     /gene_synonym="9530072E15Rik; A930019C19Rik; KRP; Mlck;
                     MLCK108; MLCK210; nmMlck; smMLCK"
                     /note="major polyA site"
ORIGIN      
        1 agtactgctg ctgttgacca ttctgcctca ggatcctgga gagctgtaga ggggaactcg
       61 tgtctctgcc tgggtttcca agagagcctt tatgtgaaag catgtctggc cagttacctg
      121 ggaagaccat gggggacgtg aaactgtttg cctcgtcaca catgtctaaa acctcccaca
      181 gtgtggatcc ctcgaaggtc agctccatgc ctctcaccga ggccccagct ttcattctgc
      241 cccctcggaa cctctgcgtc aaagaaggag ccacagccaa gttcgaaggg agggtccggg
      301 gctacccaga gccccaggtg acatggcaca gaaaagggca agccatcacc aatggtggcc
      361 gcttcctgct ggactgtgga gtgcggggga cttttagtct tgtcatccac actgtccgcg
      421 aggaggacaa gggcaaatac acctgtgaag ctagcaatgg cagtggcgcc cgccaggtga
      481 ccgtggagct gactgtggaa gggaattcta tgaagaagcg tgatcagcct gttctttcta
      541 aagcctcagg atttccaggg gagactcgtc ctagcatctg gggtgagtgc ccaccaaagt
      601 ttgccaccaa gctgggcaga gctgtggtca aagaagggca gatggggcga ttctcctgca
      661 agatcactgg ccggcctcca ccacaggtca cctggctcaa gggaaatgtc ccgttgcagc
      721 caagtgcccg tgtgtcaatg tcagagaaga atggcatgca gatcctggag atccgtgggg
      781 tcactcggga tgacctgggc gtgtacacct gcatggtggt gaatgggtca gggaaagcct
      841 ccatgtcggc ggagctctcc atcccaggtt tggacaatgc cgctaggttg gctgtgagag
      901 gaaccaaagc ccccagtcca gacatcagga aggaggtgac caatggagtc tccaaagacc
      961 cagagactgt ggctgaaagt aagaactgtc caagtcccca gaggagtggc tcctcagccc
     1021 gggccaccaa cagtcacctc aagtccccgc aggagcccaa gccaaagctg tgtgaggatg
     1081 ctcccagaaa ggtcccgcag tcctccatcc tgcagaagtc caccagcacc atcactctgc
     1141 aggccttgaa agtccagcca gaagcgagag taccagccat agggtccttc tctcctgggg
     1201 aagacaggaa gagtctggct gcccctcagc aagccacact ccctaccaga cagtctagcc
     1261 tgggaggttc cgttgggaac aagtttgtta ccgggaacat ccccagagag agccaaaggg
     1321 agtcaacatt ccccagattt gagagtcagc cccaaagcca ggaagtcact gaaggtcaga
     1381 cagtcaagtt catctgcgag gtttcaggta taccaaagcc tgacgtgggc tggttcctgg
     1441 aaggcatccc cgtgaggaga cgggaaggca tcactgaggt ttatgaagat ggtgtatccc
     1501 atcacctgtg cctgctgaga gcccggacga gagacagtgg gaggtacagc tgcacagcat
     1561 ccaatagcct tggccaggtg tcctgcagct ggagcctgct ggtggaccgg ccgaacttgg
     1621 cacagacagc cccttcattc tctagtgttc tgaaggacag tgttgtcatt gagggccagg
     1681 attttgtgct acggtgctca gtgcagggga ctccagcacc ccgggtcacg tggctgctca
     1741 atggacagcc catccagttt gctcactcca tctgtgaggc aggcgtggct gagctccaca
     1801 tccaggatgc cctgccagag gaccgtggca cctacacctg cctggctgag aatgccatgg
     1861 ggcaggtgtc ctgcagcgcc actgtcaccg tccaagagaa gaaaggtgaa ggagagaggg
     1921 aacaccgtct gtccccagct cgcagcaagc ccatcgcacc catcttcctg cagggcctct
     1981 ccgacctcaa agtcatggat ggaagccagg tcactatgac agtccaggtg tcagggaacc
     2041 cacctccgga agtcatctgg cttcacgacg ggaatgagat tcaggagtcc gaggacttcc
     2101 acttcgagca gaagggtggc tggcacagcc tgtgtatcca ggaggtgttc ccggaggaca
     2161 cgggcacgta cacctgtgag gcctggaaca gtgccgggga ggtccgcacc cgggccgtcc
     2221 tcaccgtgca agagcctcat gatggcaccc agccctggtt catcagcaag cctcgttcgg
     2281 tgacagccac cctgggccag agtgtcctca tctcctgcgc catagctgga gacccctttc
     2341 ccaccgtgca ctggctccgg gatggcagag ccctctccaa ggacagtggc cactttgagc
     2401 tgctccagaa tgaggacgtg ttcaccctgg ttctaaagaa cgtgcagccc tggcatgccg
     2461 gccagtatga gattctgctc aagaaccggg ttggcgagtg tagttgccaa gtgtcactga
     2521 tgcttcacaa cagcccttcc agagccccac cacgggggcg ggagcctgcc agctgcgagg
     2581 gcctctgtgg tggtggagga gttggtgctc atggtgatgg tgaccgtcat gggaccctga
     2641 ggccctgctg gccagcaaga gggcaaggtt ggcctgagga ggaagacgga gaagacgtga
     2701 gggggctgtt gaagagacgg gtggagacca ggctgcacac agaagaggcc atccgccagc
     2761 aggaggtggg gcagctggat tttcgagacc tcctgggaaa gaaggtgagc accaagaccg
     2821 tctcagaaga cgacctgaag gacatcccag ccgagcagat ggatttccgc gccaaccttc
     2881 agcggcaagt gaagccaaag accatatccg aggaagagag gaaggtgcat agccctcagc
     2941 aggttgactt ccggtctgtc ctcgccaaga aggggacccc taagaccccc gttcctgaga
     3001 aggcacctcc aaaagctgcc accccagact ttcgctctgt gctaggtggc aagaagaagt
     3061 caccctcgga gaatgggggc aacagcgctg aggtcttgaa tgtcaaggct ggggaaagcc
     3121 ccacacctgc aggcgatgcg caggccatcg gggccctgaa acccgtaggc aatgccaagc
     3181 ctgctgagac cccgaaacct ataggtaatg ccaagcctac cgagaccctg aagcctgtgg
     3241 gcaacaccaa gcctgccgag accctgaaac ccatagccaa cgcacagcct tcagggtccc
     3301 tgaaacctgt aaccaacgca caacctgctg agccccagaa gcctgtgggc aatgccaagt
     3361 ctgctgagac ctcgaaacca gctgggaaag aagaagtcaa ggaggtaaag aatgatgtga
     3421 actgtaagaa agggcaggtc ggagccacgg gcaatgaaaa gcgacccgag agccaaggct
     3481 cggccccagt tttcaaggaa aagctacaag atgtccatgt ggcagagggg gagaagctgc
     3541 tactccaatg ccaggtgatc tctgatcccc ccgccactgt cacctggtcg ctgaatggga
     3601 agacactcaa gaccacaaaa ttcatcgtcc tcgcccaaga aggctcacgt ttctctgtct
     3661 ccatcgagaa ggcactgcct gaggaccgag gtttgtacaa gtgtgtagcc aagaacagcg
     3721 ctggccaggc agagtgttcc tgccaagtca ctgtggacga tgctcagacc agtgagaaca
     3781 ccaaggcccc ggagatgaaa tcccggagac ccaagagctc tcttccccct gtgctaggaa
     3841 cagagagcga cgcaactgtg aaaaagaaac ctgcccccaa gacacccaca aaagcagcta
     3901 tgccccctca aatcatccag ttccccgagg accagaaggt gcgcgcagga gaacctgtgg
     3961 agctgtttgg gaaagtggct ggcacccagc ccatcacctg caagtggatg aagttccgaa
     4021 agcagatcca ggagagcgag catatcaagg tggagaatgg cgagagcggc agcaagctca
     4081 ccatcctggc cgcgcggcag gagcactgtg gctgctacac actggtggtg gagaacaagc
     4141 tgggcagcag gcaggcccaa gtcaacctca cggtcgtgga taagccagac cccccggctg
     4201 gcacaccttg tgcttctgac attcggagtt cctcactgac cctgtcctgg tatggctcct
     4261 catatgatgg gggcagtgct gtacagtcct acaatgtgga gatctgggac acagaggaca
     4321 aggtgtggaa agagctagcc acgtgccgca gcacctcttt taatgtccaa gacctgctgc
     4381 ctgaccgcga gtacaaattc cgagtgcgtg cagtcaacgt ctatggaacc agcgagccaa
     4441 gccaagagtc cgagctcaca gctgtgggag agaaacctga agagccaaag gatgaagtgg
     4501 aagtgtccga tgatgacgaa aaggaacctg aggttgatta ccggacggtg actgttaaca
     4561 ctgaacagaa agtgtctgat gtgtatgaca ttgaagagcg actaggatct gggaagtttg
     4621 gacaagtctt ccgacttgtg gaaaagaaaa ctggaaaaat ctgggcaggg aaatttttca
     4681 aggcctattc cgccaaggag aaagacaaca tccgtcagga gatcagcatc atgaactgcc
     4741 tccaccaccc caagctggtc cagtgtgtgg atgccttcga agaaaaggcc aacattgtca
     4801 tggttctgga gatcgtgtcc gggggtgagc tgtttgagcg tatcattgac gaggacttcg
     4861 agctgacgga gcgggagtgt atcaagtaca tgaggcagat ctcggaaggg gtggagtaca
     4921 tccacaagca gggcattgtg cacctggacc tcaagcccga gaacatcatg tgtgtcaaca
     4981 agacaggcac caggatcaag ctcattgact tcggcctggc acggagactc gagaacgctg
     5041 ggtctctgaa ggtcctcttt gggaccccag agtttgtggc tcctgaagtg atcaactatg
     5101 agcccatcgg ctacgccaca gacatgtgga gcatcggggt catctgctat attctggtca
     5161 gcggactttc tcccttcatg ggtgacaatg ataacgagac cttagccaac gtcacttcag
     5221 ccacctggga cttcgatgac gaggcattcg atgagatctc cgatgacgca aaggatttca
     5281 tcagtaactt gctgaagaaa gatatgaaaa accgtctgga ctgcacccag tgccttcagc
     5341 acccatggct gatgaaagac accaagaaca tggaggccaa gaagctgtcc aaggaccgga
     5401 tgaagaaata catggcaaga aggaagtggc agaaaacggg caatgctgtg agagccatcg
     5461 ggagactgtc ctctatggca atgatctcag ggctcagtgg caggaaatct tcaacagggt
     5521 caccaaccag cccaatcaat gcggagaaac tagagtctga agacgatgtc tcccaagctt
     5581 tcctggaggc tgttgctgag gaaaagcccc atgtgaaacc ttatttctct aagaccatcc
     5641 gtgatctgga agtcgtggag ggaagcgctg ctagatttga ctgcaagatt gaaggatacc
     5701 cagaccctga ggtggtctgg ttcaaggatg accaatcaat cagggagtcc cgccacttcc
     5761 agatagacta cgacgaagac ggcaactgct cgctcatcat cagcgacgtc tgtggggatg
     5821 atgacgccaa gtacacctgc aaggctgtca acagcctcgg agaagccacc tgcactgcgg
     5881 agctcatcgt ggagaccatg gaggaagggg aaggggagga ggggggagag gaggaggagg
     5941 aggaggagga gtgaagccaa gccaaacaga agcagttcct aagtcatttt aaaaaggact
     6001 aattccttaa agctcaaaaa aaaaaaaaaa aaaatcaaaa aaaccaaagc tagaaaaggc
     6061 acctggtgtg gtagatgatc tagttaggct atttggaggc tgattcgtca gcgacggcgg
     6121 ctgatgcctg ggagatatac tgatgggcat tactttgaat tagatagcac cttaaacact
     6181 agtgcagcta gattccattt gggagagatc accagcaact cgtctaattg atttgatttt
     6241 agagagaaaa tagctaaaag aaatactcac ttagaaaagg tcaaacattt cccagtttaa
     6301 cgcaccctga aaaataaagt tgtcatcagc cccttccgcc ccgccccccg cccccccctc
     6361 cccaagcctc ctgctgtagc tcaacccaga tcccctggag atagaatgtc cagccccctc
     6421 ccacccaatc cagagaaccc gccttgtccc atcctgcggt gtctcattct ggaagcggtt
     6481 gagccaagct gactcaggag acacattgcc ttccaactct gcactttcaa gctctgcgtt
     6541 tctctccccg ctccaactgc tgggtttcct ggctctaatc cttgcctgag ttacagcaag
     6601 gaggacattt atcatgtttc ttccatcctg aaaccaagtt ccccggcttg tggatgactc
     6661 tggctgcctt gggggggtga gaggtacagg aaggggggtg tctcctctcc tctaaaatcc
     6721 ttaggaaact aaacttactc ctctgtgcag gagtctggca gctccagaca tttgcatgag
     6781 aattcatgaa ggagaaaaaa aaatccttgc taatgagctt ttccccccct tcaaccagga
     6841 ttcctatttg tgctgtgagc caacgtcagc ctgcacgtgc ggtagagtct tgcacccaga
     6901 cttaaaagcc cagtttgctg aagtgctggc tttattgggc actatgaaac tgatgtcagc
     6961 aactgtagga ctggggtgct ttggaatctc cttctaggca gtctgagttt aatccatctt
     7021 cattggcaac actcttcaaa gagcttgtcc tgccttctgg ggtccccctt gatctttctt
     7081 cctgaatgtg catcacgctt tgtagccccc ccacccccaa ccttgacctg ctcagtacac
     7141 tcagacttgc atctttagca gtttggttgt ttttttgttt ttttttttaa actttctttc
     7201 acttcattgg cacttaattg tttttcctta taagactttt tggaggtcat caacaaagac
     7261 cataaactga tatcctagtg tgcttcctct gtgtgtgcgt gtgcgtgtgt gtgtgtgtgt
     7321 ctaacattcc aaatactttt tttcttttcc actgtttgta aagggcaaca aattaatatt
     7381 tcaaaggttg ttttaatagt tccttacaac ccgaccttaa actacttctg tgcagtccca
     7441 cacagtgccg acattagaga gatgacattg ctttgtcttc tcagccgcca tccttcctga
     7501 gctgtttgct gctgcattgc cacttcttcc cctgtttcgc ttctcttaag cagtttcaat
     7561 atctttcatt atagtcacaa tattgccacg gtttattata ataagggggt tttaatttga
     7621 tttagagcat tcaaagtgtt tttcatcact ttgtgtttat actataatcc ttgagtgtat
     7681 gttgtgtgta tgtgtgcatg ggtggttatg cgtgtgttca tagggtaatg ccttcttggg
     7741 actgtgttac tgttctctca gtttattatg ccatccaaat ggtggacgag aacgctatga
     7801 ctgtagttag ctcacaattt ttaaataaag gataccacag tgcatggtgt ttgttcaa
//
