LOCUS       NM_022879                599 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus myosin, light polypeptide 7, regulatory (Myl7), mRNA.
ACCESSION   NM_022879
VERSION     NM_022879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 599)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 599)
  AUTHORS   Teng,X., He,H., Yu,H., Zhang,X., Xing,J., Shen,J., Li,C., Wang,M.,
            Shao,L., Wang,Z., Yang,H., Zhang,Y. and Wu,Q.
  TITLE     LncRNAs in the Dlk1-Dio3 Domain Are Essential for Mid-Embryonic
            Heart Development
  JOURNAL   Int J Mol Sci 25 (15), 8184 (2024)
   PUBMED   39125754
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 599)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   4  (bases 1 to 599)
  AUTHORS   Schule,K.M., Weckerle,J., Probst,S., Wehmeyer,A.E., Zissel,L.,
            Schroder,C.M., Tekman,M., Kim,G.J., Schlagl,I.M., Sagar and
            Arnold,S.J.
  TITLE     Eomes restricts Brachyury functions at the onset of mouse
            gastrulation
  JOURNAL   Dev Cell 58 (18), 1627-1642 (2023)
   PUBMED   37633271
REFERENCE   5  (bases 1 to 599)
  AUTHORS   Liang,Q., Wang,S., Zhou,X., Li,Y., Xing,S., Sha,Y., Yang,F.,
            Huang,W., Liu,N., Li,Z., Chen,Y., Xu,Y., Zhu,P., Lan,F. and Sun,N.
  TITLE     Essential role of MESP1-RING1A complex in cardiac differentiation
  JOURNAL   Dev Cell 57 (22), 2533-2549 (2022)
   PUBMED   36413948
REFERENCE   6  (bases 1 to 599)
  AUTHORS   Dyson,E., Sucov,H.M., Kubalak,S.W., Schmid-Schonbein,G.W.,
            DeLano,F.A., Evans,R.M., Ross,J. Jr. and Chien,K.R.
  TITLE     Atrial-like phenotype is associated with embryonic ventricular
            failure in retinoid X receptor alpha -/- mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7386-7390 (1995)
   PUBMED   7638202
REFERENCE   7  (bases 1 to 599)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   8  (bases 1 to 599)
  AUTHORS   Kubalak,S.W., Miller-Hance,W.C., O'Brien,T.X., Dyson,E. and
            Chien,K.R.
  TITLE     Chamber specification of atrial myosin light chain-2 expression
            precedes septation during murine cardiogenesis
  JOURNAL   J Biol Chem 269 (24), 16961-16970 (1994)
   PUBMED   8207020
REFERENCE   9  (bases 1 to 599)
  AUTHORS   Faerman,A. and Shani,M.
  TITLE     The expression of the regulatory myosin light chain 2 gene during
            mouse embryogenesis
  JOURNAL   Development 118 (3), 919-929 (1993)
   PUBMED   8076526
REFERENCE   10 (bases 1 to 599)
  AUTHORS   Lowey,S. and Risby,D.
  TITLE     Light chains from fast and slow muscle myosins
  JOURNAL   Nature 234 (5324), 81-85 (1971)
   PUBMED   4942892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA461005.1, AK146716.1 and AJ348866.1.
            
            On Sep 14, 2006 this sequence version replaced NM_022879.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA461005.1, BC061100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CA461005.1         38-44
            8-586               AK146716.1         9-587
            587-599             AJ348866.1         497-509
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.88 cM"
     gene            1..599
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /note="myosin, light polypeptide 7, regulatory"
                     /db_xref="GeneID:17898"
                     /db_xref="MGI:MGI:107495"
     exon            1..22
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..547
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /note="MLC-2a; myosin light chain 2a; myosin regulatory
                     light chain 7; myosin light chain, regulatory A"
                     /codon_start=1
                     /product="myosin regulatory light chain 2, atrial isoform"
                     /protein_id="NP_075017.2"
                     /db_xref="CCDS:CCDS24408.1"
                     /db_xref="GeneID:17898"
                     /db_xref="MGI:MGI:107495"
                     /translation="MASRKAGTRGKAAATKQAQRGSSNVFSMFEQAQIQEFKEAFSCI
                     DQNRDGIICKSDLKETYSQLGRVSVPEEELDAMLQEGKGPINFTVFLTLFGEKLNGTD
                     PEEAILSAFRMFDPSGQGVVNKEEFKQLLMTQADKFSPAEVEQLFALTPMDLAGNIDY
                     KSLCYIITHGDEKEE"
     exon            23..136
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            137..212
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            213..317
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            318..396
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            397..445
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            446..590
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      566..571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /note="hexamer: AATAAA"
     polyA_site      590
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /note="major polyA site"
ORIGIN      
        1 agtcagaccg ccacagatca tggccagtag gaaggctggg acccgaggca aggctgcagc
       61 caccaagcag gcacaacgtg gctcttctaa tgtcttctca atgttcgaac aagcccagat
      121 tcaggaattc aaggaagcct tcagctgcat tgaccagaac agggatggga tcatctgcaa
      181 atcagacctg aaggagacct attcccagct cgggagggta agtgttccgg aggaagagct
      241 ggacgccatg ctgcaggaag ggaagggtcc catcaacttc accgtcttcc tcacactctt
      301 cggggagaag ctcaatggga cggaccccga ggaagccatc ctgagtgcct tccgcatgtt
      361 cgaccccagc ggccaggggg tggtgaacaa ggaagagttc aagcagcttc tcatgaccca
      421 ggcagacaag ttctctcctg ctgaggtaga gcaactgttt gcgctgacac ccatggacct
      481 ggccggcaac attgactaca agtctctctg ctacatcatc acccacgggg atgagaaaga
      541 ggagtagaca ggctgaggtc acctcaataa actctgtgcc tgaactagaa aaaaaaaaa
//
