LOCUS       NM_010859                909 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus myosin, light polypeptide 3 (Myl3), transcript variant
            1, mRNA.
ACCESSION   NM_010859 XM_979450
VERSION     NM_010859.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 909)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 909)
  AUTHORS   Cao,H., Yang,P., Liu,J., Shao,Y., Li,H., Lai,P., Wang,H., Liu,A.,
            Guo,B., Tang,Y., Bai,X. and Li,K.
  TITLE     MYL3 protects chondrocytes from senescence by inhibiting
            clathrin-mediated endocytosis and activating of Notch signaling
  JOURNAL   Nat Commun 14 (1), 6190 (2023)
   PUBMED   37794006
  REMARK    GeneRIF: MYL3 protects chondrocytes from senescence by inhibiting
            clathrin-mediated endocytosis and activating of Notch signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 909)
  AUTHORS   Gerber,S.D., Beauchamp,P., Zhuang,L., Villiger,P.M. and Trueb,B.
  TITLE     Functional domains of the FgfrL1 receptor
  JOURNAL   Dev Biol 461 (1), 43-54 (2020)
   PUBMED   31923383
REFERENCE   4  (bases 1 to 909)
  AUTHORS   Agarwal,M., Sharma,A., Kumar,P., Kumar,A., Bharadwaj,A., Saini,M.,
            Kardon,G. and Mathew,S.J.
  TITLE     Myosin heavy chain-embryonic regulates skeletal muscle
            differentiation during mammalian development
  JOURNAL   Development 147 (7) (2020)
   PUBMED   32094117
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 909)
  AUTHORS   Gao,R., Liang,X., Cheedipudi,S., Cordero,J., Jiang,X., Zhang,Q.,
            Caputo,L., Gunther,S., Kuenne,C., Ren,Y., Bhattacharya,S., Yuan,X.,
            Barreto,G., Chen,Y., Braun,T., Evans,S.M., Sun,Y. and Dobreva,G.
  TITLE     Pioneering function of Isl1 in the epigenetic control of
            cardiomyocyte cell fate
  JOURNAL   Cell Res 29 (6), 486-501 (2019)
   PUBMED   31024170
REFERENCE   6  (bases 1 to 909)
  AUTHORS   Houzelstein,D., Lyons,G.E., Chamberlain,J. and Buckingham,M.E.
  TITLE     Localization of dystrophin gene transcripts during mouse
            embryogenesis
  JOURNAL   J Cell Biol 119 (4), 811-821 (1992)
   PUBMED   1429837
REFERENCE   7  (bases 1 to 909)
  AUTHORS   Keller,A., Ott,M.O., Lamande,N., Lucas,M., Gros,F., Buckingham,M.
            and Lazar,M.
  TITLE     Activation of the gene encoding the glycolytic enzyme beta-enolase
            during early myogenesis precedes an increased expression during
            fetal muscle development
  JOURNAL   Mech Dev 38 (1), 41-54 (1992)
   PUBMED   1525038
REFERENCE   8  (bases 1 to 909)
  AUTHORS   Lyons,G.E., Buckingham,M.E., Tweedie,S. and Edwards,Y.H.
  TITLE     Carbonic anhydrase III, an early mesodermal marker, is expressed in
            embryonic mouse skeletal muscle and notochord
  JOURNAL   Development 111 (1), 233-244 (1991)
   PUBMED   1901785
REFERENCE   9  (bases 1 to 909)
  AUTHORS   Lyons,G.E., Schiaffino,S., Sassoon,D., Barton,P. and Buckingham,M.
  TITLE     Developmental regulation of myosin gene expression in mouse cardiac
            muscle
  JOURNAL   J Cell Biol 111 (6 Pt 1), 2427-2436 (1990)
   PUBMED   2277065
REFERENCE   10 (bases 1 to 909)
  AUTHORS   Lyons,G.E., Ontell,M., Cox,R., Sassoon,D. and Buckingham,M.
  TITLE     The expression of myosin genes in developing skeletal muscle in the
            mouse embryo
  JOURNAL   J Cell Biol 111 (4), 1465-1476 (1990)
   PUBMED   2211821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146943.1, AK002312.1 and AV015350.1.
            
            On Jun 19, 2018 this sequence version replaced NM_010859.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061222.1, AK146943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK146943.1         2-4
            4-901               AK002312.1         3-900
            902-909             AV015350.1         254-261
FEATURES             Location/Qualifiers
     source          1..909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.69 cM"
     gene            1..909
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /note="myosin, light polypeptide 3"
                     /db_xref="GeneID:17897"
                     /db_xref="MGI:MGI:97268"
     exon            1..223
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..682
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /note="myosin, light polypeptide 3, alkali; ventricular,
                     skeletal, slow; myosin light chain, alkali, cardiac
                     ventricles"
                     /codon_start=1
                     /product="myosin light chain 3"
                     /protein_id="NP_034989.1"
                     /db_xref="CCDS:CCDS23571.1"
                     /db_xref="GeneID:17897"
                     /db_xref="MGI:MGI:97268"
                     /translation="MAPKKPEPKKDDAKAAAPKAAPAPAAAPAAAPAAAPEPERPKEA
                     EFDASKIKIEFTPEQIEEFKEAFLLFDRTPKGEMKITYGQCGDVLRALGQNPTQAEVL
                     RVLGKPKQEELNSKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGA
                     ELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMAS"
     exon            224..251
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..401
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..575
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..653
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..691
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..909
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      881..886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /note="hexamer: AATAAA"
     polyA_site      901
                     /gene="Myl3"
                     /gene_synonym="MLC1s; MLC1SB; MLC1v; Mylc; VLC1"
                     /note="major polyA site"
ORIGIN      
        1 agtaggactc acctatctta ctctcttctc ctttccttct tccctcctct ttgtgattac
       61 agctccaatg gcccccaaaa agccagagcc caagaaggat gatgccaaag cggctgcccc
      121 caaagcagct ccagctcctg cggctgcacc tgcagctgca cctgcggctg caccagagcc
      181 tgagcgcccc aaggaagccg agtttgatgc ctccaagatt aagatcgagt tcacacctga
      241 acagattgaa gagttcaagg aggccttcct gctgttcgac cgcacaccca agggcgagat
      301 gaagatcaca tacgggcagt gtggggatgt cctgcgggct ctgggtcaga atcctaccca
      361 ggcagaggtg ctccgtgtcc tggggaagcc aaaacaggaa gagctcaatt ccaagatgat
      421 ggattttgag acgttcctgc ctatgctcca gcacatctcc aagaacaagg acactggcac
      481 gtacgaggac ttcgtggagg ggctgcgggt cttcgacaag gagggcaacg gcacggtcat
      541 gggtgcagag ctccgacacg tgctggccac gctgggtgag agactgacag aagatgaggt
      601 agagaaactg atggctggtc aagaggactc caacggctgc atcaactatg aagcgtttgt
      661 gaagcatatc atggcgagct gagcctctca ggaagcccag ggcaggccaa gcatctccca
      721 accatgatgc tgacaccatg tctggagctt cgggaaggag tggttcggac tcctgcaggt
      781 tgtcctggat cactctgtgt gtggtagtct ttcctggccc ctgctgggat gggcttacct
      841 acctgtgctt gcctttctgt atccaccctg tggccttatg aataaatggt ttccttcctt
      901 ccttccttc
//
