LOCUS       NM_023402                939 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus myosin, light chain 12B, regulatory (Myl12b), mRNA.
ACCESSION   NM_023402
VERSION     NM_023402.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Sun,J., Qiao,Y.N., Tao,T., Zhao,W., Wei,L.S., Li,Y.Q., Wang,W.,
            Wang,Y., Zhou,Y.W., Zheng,Y.Y., Chen,X., Pan,H.C., Zhang,X.N. and
            Zhu,M.S.
  TITLE     Distinct Roles of Smooth Muscle and Non-muscle Myosin Light
            Chain-Mediated Smooth Muscle Contraction
  JOURNAL   Front Physiol 11, 593966 (2020)
   PUBMED   33424621
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Lin,C., Yao,E., Zhang,K., Jiang,X., Croll,S., Thompson-Peer,K. and
            Chuang,P.T.
  TITLE     YAP is essential for mechanical force production and epithelial
            cell proliferation during lung branching morphogenesis
  JOURNAL   Elife 6, e21130 (2017)
   PUBMED   28323616
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Wu,F., Dong,X.J., Li,Y.Y., Zhao,Y., Xu,Q.L. and Su,L.
  TITLE     Identification of phosphorylated MYL12B as a potential plasma
            biomarker for septic acute kidney injury using a quantitative
            proteomic approach
  JOURNAL   Int J Clin Exp Pathol 8 (11), 14409-14416 (2015)
   PUBMED   26823757
  REMARK    GeneRIF: Phosphorylated MYL12B may be employed as a potential
            plasma biomarker for the early diagnosis of sepsis induced acute
            kidney injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Osipovich,A.B., Singh,A. and Ruley,H.E.
  TITLE     Post-entrapment genome engineering: first exon size does not affect
            the expression of fusion transcripts generated by gene entrapment
  JOURNAL   Genome Res 15 (3), 428-435 (2005)
   PUBMED   15741512
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Klezovitch,O., Fernandez,T.E., Tapscott,S.J. and Vasioukhin,V.
  TITLE     Loss of cell polarity causes severe brain dysplasia in Lgl1
            knockout mice
  JOURNAL   Genes Dev 18 (5), 559-571 (2004)
   PUBMED   15037549
REFERENCE   8  (bases 1 to 939)
  AUTHORS   Srivastava,D., Thomas,T., Lin,Q., Kirby,M.L., Brown,D. and
            Olson,E.N.
  TITLE     Regulation of cardiac mesodermal and neural crest development by
            the bHLH transcription factor, dHAND
  JOURNAL   Nat Genet 16 (2), 154-160 (1997)
   PUBMED   9171826
  REMARK    Erratum:[Nat Genet 1997 Aug;16(4):410]
REFERENCE   9  (bases 1 to 939)
  AUTHORS   Kuo,C.T., Morrisey,E.E., Anandappa,R., Sigrist,K., Lu,M.M.,
            Parmacek,M.S., Soudais,C. and Leiden,J.M.
  TITLE     GATA4 transcription factor is required for ventral morphogenesis
            and heart tube formation
  JOURNAL   Genes Dev 11 (8), 1048-1060 (1997)
   PUBMED   9136932
REFERENCE   10 (bases 1 to 939)
  AUTHORS   Kubalak,S.W., Miller-Hance,W.C., O'Brien,T.X., Dyson,E. and
            Chien,K.R.
  TITLE     Chamber specification of atrial myosin light chain-2 expression
            precedes septation during murine cardiogenesis
  JOURNAL   J Biol Chem 269 (24), 16961-16970 (1994)
   PUBMED   8207020
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK002885.1.
            
            On Apr 5, 2007 this sequence version replaced NM_023402.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002885.1, AK146115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               AK002885.1         3-941
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 41.87 cM"
     gene            1..939
                     /gene="Myl12b"
                     /gene_synonym="1500001M02Rik; Mylc2b; RLC-B"
                     /note="myosin, light chain 12B, regulatory"
                     /db_xref="GeneID:67938"
                     /db_xref="MGI:MGI:107494"
     exon            1..44
                     /gene="Myl12b"
                     /gene_synonym="1500001M02Rik; Mylc2b; RLC-B"
                     /inference="alignment:Splign:2.1.0"
     exon            45..243
                     /gene="Myl12b"
                     /gene_synonym="1500001M02Rik; Mylc2b; RLC-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..578
                     /gene="Myl12b"
                     /gene_synonym="1500001M02Rik; Mylc2b; RLC-B"
                     /note="myosin light chain, regulatory B; MLC20; myosin
                     regulatory light chain MRLC2; myosin regulatory light
                     chain 20 kDa"
                     /codon_start=1
                     /product="myosin regulatory light chain 12B"
                     /protein_id="NP_075891.1"
                     /db_xref="CCDS:CCDS28954.1"
                     /db_xref="GeneID:67938"
                     /db_xref="MGI:MGI:107494"
                     /translation="MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQN
                     RDGFIDKEDLHDMLASLGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDV
                     IRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFT
                     RILKHGAKDKDD"
     exon            244..405
                     /gene="Myl12b"
                     /gene_synonym="1500001M02Rik; Mylc2b; RLC-B"
                     /inference="alignment:Splign:2.1.0"
     exon            406..939
                     /gene="Myl12b"
                     /gene_synonym="1500001M02Rik; Mylc2b; RLC-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      842..847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myl12b"
                     /gene_synonym="1500001M02Rik; Mylc2b; RLC-B"
                     /note="hexamer: AATGAA"
     polyA_site      871
                     /gene="Myl12b"
                     /gene_synonym="1500001M02Rik; Mylc2b; RLC-B"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcgccg gtcggatcct ctcgggtgtg cagcatcagg tcagatttaa accgccacca
       61 tgtcgagcaa aaaagcgaag accaagacca ccaagaagcg ccctcagcgc gcaacctcca
      121 atgtgttcgc catgtttgac cagtcccaga tccaggagtt caaagaggcc tttaacatga
      181 ttgaccagaa ccgggatggc ttcattgaca aggaggacct gcacgacatg ctggcgtctc
      241 tggggaagaa tcccactgat gcctacctgg acgccatgat gaacgaggcc ccgggcccca
      301 tcaatttcac catgttcctc accatgtttg gggagaagct aaacggcact gaccccgagg
      361 acgtcatcag aaacgccttc gcttgctttg atgaggaagc cacaggcacc atccaggagg
      421 attacctgag ggagctgctg accaccatgg gcgaccgctt cacagacgag gaagtggatg
      481 agctgtacag agaggccccc attgacaaaa aggggaactt caactacatt gagttcacac
      541 gcatcctgaa gcacggcgcg aaagacaaag atgactgaag agctgcggcg gctgacacgc
      601 ctcttgcgtt tgcttgctca cttcctgtct cagacacaca caccccatag gacctactgc
      661 gtgccactta gtttctcagt cacttcccct cccccatagg gcctactgtg tgccacttag
      721 ttgagagctt tttttttaaa tgtatttatt ccaggccctt tctgtcactt agcatgtgca
      781 taatcagact ggaacggggg acaatgttgt aaattgtact gaaaacgaga tgcaaataaa
      841 aaatgaacca ctgtgaaagc ccaggacaat atatccggat ttctggtttt gctggatttt
      901 ttttttttta catttttata taataaaaat gttattttg
//
