LOCUS       NM_026064               1779 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus myosin, light chain 12A, regulatory, non-sarcomeric
            (Myl12a), transcript variant 1, mRNA.
ACCESSION   NM_026064 XM_622765
VERSION     NM_026064.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1779)
  AUTHORS   Huycke,T.R., Hakkinen,T.J., Miyazaki,H., Srivastava,V., Barruet,E.,
            McGinnis,C.S., Kalantari,A., Cornwall-Scoones,J., Vaka,D., Zhu,Q.,
            Jo,H., Oria,R., Weaver,V.M., DeGrado,W.F., Thomson,M.,
            Garikipati,K., Boffelli,D., Klein,O.D. and Gartner,Z.J.
  TITLE     Patterning and folding of intestinal villi by active mesenchymal
            dewetting
  JOURNAL   Cell 187 (12), 3072-3089 (2024)
   PUBMED   38781967
REFERENCE   2  (bases 1 to 1779)
  AUTHORS   Tang,Y.C., Ponsin,K., Graham-Paquin,A.L., Luthold,C., Homsy,K.,
            Schindler,M., Tran,V., Cote,J.F., Bordeleau,F., Khadra,A. and
            Bouchard,M.
  TITLE     Coordination of non-professional efferocytosis and actomyosin
            contractility during epithelial tissue morphogenesis
  JOURNAL   Cell Rep 42 (3), 112202 (2023)
   PUBMED   36871220
REFERENCE   3  (bases 1 to 1779)
  AUTHORS   Alcantara,M.C., Suzuki,K., Acebedo,A.R., Sakamoto,Y., Nishita,M.,
            Minami,Y., Kikuchi,A. and Yamada,G.
  TITLE     Stage-dependent function of Wnt5a during male external genitalia
            development
  JOURNAL   Congenit Anom (Kyoto) 61 (6), 212-219 (2021)
   PUBMED   34255394
REFERENCE   4  (bases 1 to 1779)
  AUTHORS   Sun,J., Qiao,Y.N., Tao,T., Zhao,W., Wei,L.S., Li,Y.Q., Wang,W.,
            Wang,Y., Zhou,Y.W., Zheng,Y.Y., Chen,X., Pan,H.C., Zhang,X.N. and
            Zhu,M.S.
  TITLE     Distinct Roles of Smooth Muscle and Non-muscle Myosin Light
            Chain-Mediated Smooth Muscle Contraction
  JOURNAL   Front Physiol 11, 593966 (2020)
   PUBMED   33424621
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1779)
  AUTHORS   Young,R.E., Jones,M.K., Hines,E.A., Li,R., Luo,Y., Shi,W.,
            Verheyden,J.M. and Sun,X.
  TITLE     Smooth Muscle Differentiation Is Essential for Airway Size,
            Tracheal Cartilage Segmentation, but Dispensable for Epithelial
            Branching
  JOURNAL   Dev Cell 53 (1), 73-85 (2020)
   PUBMED   32142630
REFERENCE   6  (bases 1 to 1779)
  AUTHORS   Park,I., Han,C., Jin,S., Lee,B., Choi,H., Kwon,J.T., Kim,D.,
            Kim,J., Lifirsu,E., Park,W.J., Park,Z.Y., Kim,D.H. and Cho,C.
  TITLE     Myosin regulatory light chains are required to maintain the
            stability of myosin II and cellular integrity
  JOURNAL   Biochem J 434 (1), 171-180 (2011)
   PUBMED   21126233
REFERENCE   7  (bases 1 to 1779)
  AUTHORS   Bajaj,G., Zhang,Y., Schimerlik,M.I., Hau,A.M., Yang,J., Filtz,T.M.,
            Kioussi,C. and Ishmael,J.E.
  TITLE     N-methyl-D-aspartate receptor subunits are non-myosin targets of
            myosin regulatory light chain
  JOURNAL   J Biol Chem 284 (2), 1252-1266 (2009)
   PUBMED   18945678
REFERENCE   8  (bases 1 to 1779)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (bases 1 to 1779)
  AUTHORS   Amparan,D., Avram,D., Thomas,C.G., Lindahl,M.G., Yang,J., Bajaj,G.
            and Ishmael,J.E.
  TITLE     Direct interaction of myosin regulatory light chain with the NMDA
            receptor
  JOURNAL   J Neurochem 92 (2), 349-361 (2005)
   PUBMED   15663482
REFERENCE   10 (bases 1 to 1779)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY319676.1, BY258797.1, AK045160.1 and CAAA01075437.1.
            
            On Jul 20, 2005 this sequence version replaced NM_026064.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013776.1, AK018348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BY319676.1         2-59
            59-347              BY258797.1         62-350
            348-1272            AK045160.1         1-925
            1273-1779           CAAA01075437.1     18339-18845
FEATURES             Location/Qualifiers
     source          1..1779
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 41.87 cM"
     gene            1..1779
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /note="myosin, light chain 12A, regulatory,
                     non-sarcomeric"
                     /db_xref="GeneID:67268"
                     /db_xref="MGI:MGI:1914518"
     exon            1..426
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..625
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..960
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /note="isoform 1 is encoded by transcript variant 1; NMDA
                     receptor-interacting protein; brain specific myosin
                     regulatory light chain"
                     /codon_start=1
                     /product="myosin light chain, regulatory B-like isoform 1"
                     /protein_id="NP_080340.2"
                     /db_xref="CCDS:CCDS28955.1"
                     /db_xref="GeneID:67268"
                     /db_xref="MGI:MGI:1914518"
                     /translation="MSSKRAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQN
                     RDGFIDKEDLHDMLASMGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDV
                     IRNAFACFDEEAIGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFT
                     RILKHGAKDKDD"
     exon            626..787
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1779
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1278
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /note="major polyA site"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1429
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1775
                     /gene="Myl12a"
                     /gene_synonym="2900073G15Rik"
ORIGIN      
        1 gggggtcccc gcctctcgcc gcgctctgga atgcgggcag agggagagct ccgggccagg
       61 cgcaaccatc tgctgacagg ggggagggcg cagaatcaca attctaaaag agacgggaga
      121 aagaggaaga gccggtgatt agaccgagag accctccaca ggattcttta agccctactc
      181 cgcgtcccgg actccccgtc ggcgccccac gcctgccatc cgctctgtca ccttccccga
      241 ggcgccccct cccgtccggg ctggcgcacc gaggcgaagg agcatggccg ctaggcttcc
      301 ttccggttcg cgagcggagg ccggaagtgg ccgtactgcg gagtctggaa agttagaaag
      361 tctgggaggg cggcagcggc ggagcttcgc ggagacgctc actctcggtt ctcgcggctg
      421 agcagggatt taaccgccac catgtctagc aaaagggcaa agaccaagac caccaagaag
      481 cgccctcagc gcgcaacctc caatgtgttc gccatgtttg accagtccca gatccaggag
      541 ttcaaagaag cctttaacat gattgaccag aaccgggatg gcttcattga caaggaggac
      601 ctgcacgaca tgctggcgtc aatgggaaaa aacccaactg acgaatacct ggacgccatg
      661 atgaacgagg ccccgggccc catcaatttc accatgttcc tcaccatgtt tggggagaag
      721 ctgaacggca ctgaccccga ggacgtcatc agaaacgcct tcgcttgctt tgatgaggaa
      781 gccatcggca ccatccagga ggattacctg agggagctgc tgaccaccat gggcgaccgc
      841 ttcacagacg aggaggtgga tgagctgtac agagaggccc ccattgacaa aaaggggaac
      901 ttcaactaca ttgagttcac acgcatcctg aagcacggcg cgaaagacaa agatgactga
      961 agagctgcgg cggcttccag cccattgctc ccgttgccat tggggtattt ctgagatttt
     1021 ctcctggagc ccaatgcatg ccctagcttt actgcttttt gcctttcttg ttttatattt
     1081 attctcagcc attttgggcc acatgtacct tataatactg gaaatgggac cttctgtcat
     1141 tgtgatgaga aagtaagttc atttaactta caggcagtct tgtcccttgt aataactgca
     1201 gcccagaatc aatatatttt ttcagagaaa gttatccact caattttttc tgatttataa
     1261 ttaaactttc tgataaaatg cttagttgtt tagcgttatt tgccacttga cttttagttt
     1321 cacgtacgcc tttctctcta agcaccgtgg gccaagtgaa tgacagtcct gtcagggttt
     1381 ggtccgactg cttccagttg tgttattaaa gcaatcctgg ttttctctgc tcctgttcat
     1441 ttctccctcc agggaaatca gataaagccc gagttggggg ccctagactt tgtctttctt
     1501 ttggaagata gttcctgcag aattgtgacc ctgcattagc tctgccgcca gctggacgga
     1561 cctgctttac ctcgtccatg taaacttcct gccaccgaaa ctagcagccg ctgagcacac
     1621 taagttttct gtgttctatt ttaaaggttc tttggaatgc ttttaacaaa aaggacagat
     1681 ttcgctgtgt ttccagctgt tggaaatata gtattttttt ttgtatacag tttttcctta
     1741 ttataacaac ccctattaaa agacctgttt gtttataca
//
