LOCUS       NM_021285               1003 bp    mRNA    linear   ROD 11-APR-2023
DEFINITION  Mus musculus myosin, light polypeptide 1 (Myl1), transcript variant
            1f, mRNA.
ACCESSION   NM_021285
VERSION     NM_021285.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1003)
  AUTHORS   Gineste C, Youhanna S, Vorrink SU, Henriksson S, Hernandez A, Cheng
            AJ, Chaillou T, Buttgereit A, Schneidereit D, Friedrich O, Hultenby
            K, Bruton JD, Ivarsson N, Sandblad L, Lauschke VM and Westerblad H.
  TITLE     Enzymatically dissociated muscle fibers display rapid
            dedifferentiation and impaired mitochondrial calcium control
  JOURNAL   iScience 25 (12), 105654 (2022)
   PUBMED   36479146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1003)
  AUTHORS   Akkuratova N, Faure L, Kameneva P, Kastriti ME and Adameyko I.
  TITLE     Developmental heterogeneity of embryonic neuroendocrine chromaffin
            cells and their maturation dynamics
  JOURNAL   Front Endocrinol (Lausanne) 13, 1020000 (2022)
   PUBMED   36237181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1003)
  AUTHORS   Gambarotto L, Metti S, Chrisam M, Cerqua C, Sabatelli P, Armani A,
            Zanon C, Spizzotin M, Castagnaro S, Strappazzon F, Grumati P,
            Cescon M, Braghetta P, Trevisson E, Cecconi F and Bonaldo P.
  TITLE     Ambra1 deficiency impairs mitophagy in skeletal muscle
  JOURNAL   J Cachexia Sarcopenia Muscle 13 (4), 2211-2224 (2022)
   PUBMED   35593053
REFERENCE   4  (bases 1 to 1003)
  AUTHORS   Antony R, Aby K, Gao H, Eichholz M, Srinivasan R and Li Y.
  TITLE     UCHL1 Regulates Lipid and Perilipin 2 Level in Skeletal Muscle
  JOURNAL   Front Physiol 13, 855193 (2022)
   PUBMED   35464088
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1003)
  AUTHORS   Lafuse WP, Brown D and Zwilling BS.
  TITLE     Assignment of the microtubule-associated protein 2 gene to mouse
            chromosome 1
  JOURNAL   Mamm Genome 3 (1), 48-51 (1992)
   PUBMED   1581633
REFERENCE   6  (bases 1 to 1003)
  AUTHORS   Yelick PC, Kozak C, Kwon YK, Seldin MF and Hecht NB.
  TITLE     The mouse transition protein 1 gene contains a B1 repetitive
            element and is located on chromosome 1
  JOURNAL   Genomics 11 (3), 687-694 (1991)
   PUBMED   1685480
REFERENCE   7  (bases 1 to 1003)
  AUTHORS   Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding MD,
            Plachov D, Balling R and Gruss P.
  TITLE     Pax: a murine multigene family of paired box-containing genes
  JOURNAL   Genomics 11 (2), 424-434 (1991)
   PUBMED   1685142
REFERENCE   8  (bases 1 to 1003)
  AUTHORS   Cohen A, Barton PJ, Robert B, Garner I, Alonso S and Buckingham ME.
  TITLE     Promoter analysis of myosin alkali light chain genes expressed in
            mouse striated muscle
  JOURNAL   Nucleic Acids Res 16 (21), 10037-10052 (1988)
   PUBMED   3194193
REFERENCE   9  (bases 1 to 1003)
  AUTHORS   Robert,B., Daubas,P., Akimenko,M.A., Cohen,A., Garner,I.,
            Guenet,J.L. and Buckingham,M.
  TITLE     A single locus in the mouse encodes both myosin light chains 1 and
            3, a second locus corresponds to a related pseudogene
  JOURNAL   Cell 39 (1), 129-140 (1984)
   PUBMED   6091905
REFERENCE   10 (bases 1 to 1003)
  AUTHORS   Robert,B., Weydert,A., Caravatti,M., Minty,A., Cohen,A., Daubas,P.,
            Gros,F. and Buckingham,M.
  TITLE     cDNA recombinant plasmid complementary to mRNAs for light chains 1
            and 3 of mouse skeletal muscle myosin
  JOURNAL   Proc Natl Acad Sci U S A 79 (8), 2437-2441 (1982)
   PUBMED   6283523
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from W87050.1, AK003182.1 and
            W48198.1.
            
            [WARNING] On Apr 28, 2023 this sequence was replaced by
            NM_021285.4.
            
            On Jan 13, 2008 this sequence version replaced NM_021285.2.
            
            Summary: Myosin is a hexameric ATPase cellular motor protein. It is
            composed of two heavy chains, two non-phosphorylatable alkali light
            chains, and two phosphorylatable regulatory light chains. This gene
            encodes a myosin alkali light chain expressed in fast skeletal
            muscle. Multiple transcript variants encoding different isoforms
            have been identified for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1f) encodes a protein that is 38
            aa longer than isoform 3f. Transcript variants 1f and 3f differ in
            their first two exons.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003182.1, CX733518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                W87050.1           90-113
            25-985              AK003182.1         1-961
            986-1003            W48198.1           492-509
FEATURES             Location/Qualifiers
     source          1..1003
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 33.71 cM"
     gene            1..1003
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
                     /note="myosin, light polypeptide 1"
                     /db_xref="GeneID:17901"
                     /db_xref="MGI:MGI:97269"
     exon            1..265
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..718
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
                     /note="isoform 1f is encoded by transcript variant 1f;
                     myosin, light polypeptide 4, alkali; atrial, embryonic;
                     myosin, light polypeptide 1, alkali; atrial, embryonic; A1
                     catalytic; A2 catalytic; MLC1/MLC3; MLC1F/MLC3F; myosin
                     light chain A1/A2; myosin light chain alkali 1/2; myosin
                     light chain, alkali, fast skeletal muscle"
                     /codon_start=1
                     /product="myosin light chain 1/3, skeletal muscle isoform
                     isoform 1f"
                     /protein_id="NP_067260.1"
                     /db_xref="CCDS:CCDS15024.1"
                     /db_xref="GeneID:17901"
                     /db_xref="MGI:MGI:97269"
                     /translation="MAPKKDVKKPAAAPAPAPAPAPAPAKPKEEKIDLSAIKIEFSKE
                     QQEDFKEAFLLFDRTGECKITLSQVGDVLRALGTNPTNAEVKKVLGNPSNEEMNAKKI
                     EFEQFLPMMQAISNNKDQGGYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEE
                     EVEALLAGQEDSNGCINYEAFVKHIMSV"
     exon            266..293
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
                     /inference="alignment:Splign:2.1.0"
     exon            294..437
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
                     /inference="alignment:Splign:2.1.0"
     exon            438..611
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
                     /inference="alignment:Splign:2.1.0"
     exon            612..689
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
                     /inference="alignment:Splign:2.1.0"
     exon            690..732
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
                     /inference="alignment:Splign:2.1.0"
     exon            733..995
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      966..971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
     polyA_site      995
                     /gene="Myl1"
                     /gene_synonym="MLC1f; MLC3f; Mylf"
ORIGIN      
        1 atatgcatgc ccttatacca tttaacactc tgggtccacc ctccagacgc tgggctgcgg
       61 gtcaagcgag tcacactgct cttccaagtg tcactctgac aggttcttct ggaggagatc
      121 cttcttttgt taacccatcc ttttaatcaa aatggcacca aagaaagacg tgaagaagcc
      181 cgctgctgcg cctgccccag ccccggcccc ggcccctgcc ccagccaaac ctaaggaaga
      241 aaaaatcgat ctgtctgcta ttaagatcga gttctctaag gagcaacagg aggacttcaa
      301 ggaggcattt ctcctgtttg acagaacagg tgaatgcaag atcaccttaa gtcaggtggg
      361 agacgtcctc cgggctctgg gcaccaatcc caccaatgca gaggtcaaga aggttcttgg
      421 gaaccccagc aatgaagaga tgaatgctaa gaaaatcgag tttgaacagt ttctgcccat
      481 gatgcaagct atctccaaca acaaggacca gggaggttat gaagatttcg ttgagggtct
      541 gcgtgtcttc gacaaggagg gcaatggcac cgtcatgggt gctgaactcc gccatgtcct
      601 cgccactctg ggagagaaga tgaaggagga agaggtagaa gcgttgctgg caggccagga
      661 ggactccaat ggctgcatca actatgaagc ttttgtcaaa cacatcatgt ctgtctaaac
      721 ggagttttca agcacgcaat gttggggaag actggccagt tcaagaacac ctatggctaa
      781 ctgtcaacac cagcttacca ccatgcagaa gatcaaacaa tctagaccat tctagatgga
      841 aggattccct gaatttttat aagccttgag ttttcatgac aaacatgcct acagttgata
      901 atctcaagtc cacacaccac cgttatcatc tacttgggtc cacaacattc ttaaaatact
      961 acatcaataa acttggtcag tctggaatac tcaaaaaaaa aaa
//
