LOCUS       NM_177369               6149 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus myosin, heavy polypeptide 8, skeletal muscle,
            perinatal (Myh8), mRNA.
ACCESSION   NM_177369 XM_354617 XM_618891 XM_618892
VERSION     NM_177369.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6149)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6149)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6149)
  AUTHORS   Dos Santos,M., Shah,A.M., Zhang,Y., Bezprozvannaya,S., Chen,K.,
            Xu,L., Lin,W., McAnally,J.R., Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     Opposing gene regulatory programs governing myofiber development
            and maturation revealed at single nucleus resolution
  JOURNAL   Nat Commun 14 (1), 4333 (2023)
   PUBMED   37468485
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6149)
  AUTHORS   Wurmser,M., Madani,R., Chaverot,N., Backer,S., Borok,M., Dos
            Santos,M., Comai,G., Tajbakhsh,S., Relaix,F., Santolini,M.,
            Sambasivan,R., Jiang,R. and Maire,P.
  TITLE     Overlapping functions of SIX homeoproteins during embryonic
            myogenesis
  JOURNAL   PLoS Genet 19 (6), e1010781 (2023)
   PUBMED   37267426
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6149)
  AUTHORS   Dennehey,B.K., Leinwand,L.A. and Krauter,K.S.
  TITLE     Diversity in transcriptional start site selection and alternative
            splicing affects the 5'-UTR of mouse striated muscle myosin
            transcripts
  JOURNAL   J Muscle Res Cell Motil 27 (8), 559-575 (2006)
   PUBMED   16819597
REFERENCE   6  (bases 1 to 6149)
  AUTHORS   Miner,J.H., Miller,J.B. and Wold,B.J.
  TITLE     Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic
            mouse heart
  JOURNAL   Development 114 (4), 853-860 (1992)
   PUBMED   1618148
REFERENCE   7  (bases 1 to 6149)
  AUTHORS   Smith,T.H. and Miller,J.B.
  TITLE     Distinct myogenic programs of embryonic and fetal mouse muscle
            cells: expression of the perinatal myosin heavy chain isoform in
            vitro
  JOURNAL   Dev Biol 149 (1), 16-26 (1992)
   PUBMED   1728586
REFERENCE   8  (bases 1 to 6149)
  AUTHORS   Cox,R.D., Weydert,A., Barlow,D. and Buckingham,M.E.
  TITLE     Three linked myosin heavy chain genes clustered within 370 kb of
            each other show independent transcriptional and
            post-transcriptional regulation during differentiation of a mouse
            muscle cell line
  JOURNAL   Dev Biol 143 (1), 36-43 (1991)
   PUBMED   1985022
REFERENCE   9  (bases 1 to 6149)
  AUTHORS   Lyons,G.E., Ontell,M., Cox,R., Sassoon,D. and Buckingham,M.
  TITLE     The expression of myosin genes in developing skeletal muscle in the
            mouse embryo
  JOURNAL   J Cell Biol 111 (4), 1465-1476 (1990)
   PUBMED   2211821
REFERENCE   10 (bases 1 to 6149)
  AUTHORS   Weydert,A., Daubas,P., Lazaridis,I., Barton,P., Garner,I.,
            Leader,D.P., Bonhomme,F., Catalan,J., Simon,D., Guenet,J.L. et al.
  TITLE     Genes for skeletal muscle myosin heavy chains are clustered and are
            not located on the same mouse chromosome as a cardiac myosin heavy
            chain gene
  JOURNAL   Proc Natl Acad Sci U S A 82 (21), 7183-7187 (1985)
   PUBMED   3864153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596129.27.
            
            On or before Jul 27, 2005 this sequence version replaced
            XM_618891.1, XM_618892.1, XM_354617.3, NM_177369.2.
            
            Summary: This gene encodes a myosin heavy chain. The encoded
            protein forms a hexamer with two heavy chains, two alkali light
            chains, and two regulatory light chain components. This complex
            functions in muscle contraction. This gene is located in a cluster
            of related genes on chromosome 11. [provided by RefSeq, Jun 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AL596129.27        179650-179760
            112-155             AL596129.27        179944-179987
            156-394             AL596129.27        181354-181592
            395-538             AL596129.27        182416-182559
            539-695             AL596129.27        182645-182801
            696-723             AL596129.27        185778-185805
            724-832             AL596129.27        185904-186012
            833-925             AL596129.27        186103-186195
            926-989             AL596129.27        186328-186391
            990-1088            AL596129.27        186959-187057
            1089-1192           AL596129.27        187151-187254
            1193-1331           AL596129.27        187409-187547
            1332-1450           AL596129.27        188697-188815
            1451-1600           AL596129.27        188902-189051
            1601-1771           AL596129.27        190725-190895
            1772-2081           AL596129.27        192053-192362
            2082-2149           AL596129.27        192469-192536
            2150-2237           AL596129.27        194705-194792
            2238-2355           AL596129.27        194876-194993
            2356-2479           AL596129.27        195162-195285
            2480-2616           AL596129.27        195368-195504
            2617-2872           AL596129.27        196883-197138
            2873-3115           AL596129.27        199618-199860
            3116-3292           AL596129.27        199972-200148
            3293-3438           AL596129.27        200228-200373
            3439-3529           AL596129.27        200455-200545
            3530-3919           AL596129.27        200871-201260
            3920-4046           AL596129.27        201797-201923
            4047-4165           AL596129.27        202239-202357
            4166-4362           AL596129.27        202481-202677
            4363-4546           AL596129.27        203927-204110
            4547-4712           AL596129.27        204185-204350
            4713-4837           AL596129.27        204439-204563
            4838-5146           AL596129.27        206144-206452
            5147-5350           AL596129.27        206850-207053
            5351-5476           AL596129.27        208148-208273
            5477-5647           AL596129.27        208361-208531
            5648-5752           AL596129.27        208680-208784
            5753-5848           AL596129.27        209403-209498
            5849-6149           AL596129.27        210860-211160
FEATURES             Location/Qualifiers
     source          1..6149
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 40.59 cM"
     gene            1..6149
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /note="myosin, heavy polypeptide 8, skeletal muscle,
                     perinatal"
                     /db_xref="GeneID:17885"
                     /db_xref="MGI:MGI:1339712"
     exon            1..111
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            112..155
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            156..394
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..5998
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /note="myHC-perinatal; myosin heavy chain 8; myosin heavy
                     chain, skeletal muscle, perinatal; Beta-MHC antisense"
                     /codon_start=1
                     /product="myosin-8"
                     /protein_id="NP_796343.2"
                     /db_xref="CCDS:CCDS24857.1"
                     /db_xref="GeneID:17885"
                     /db_xref="MGI:MGI:1339712"
                     /translation="MSAGSDAEMAIFGEAAPYLRKSEKERIEAQNKPFDAKTSVFVAE
                     PKESYVKSVIQSKDGGKVTVKTESGATLTVKEDQVFPMNPPKYDKIEDMAMMTHLHEP
                     GVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSI
                     SDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEESGKMQGT
                     LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRV
                     TFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMA
                     TDSAIDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQC
                     LNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQL
                     DTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG
                     IEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNF
                     QKPKPTKGKAEAHFSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLF
                     STYASAEADGGAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETK
                     TPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFID
                     SKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGY
                     LMRVEYQKMLLRRESIFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMK
                     EEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN
                     KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH
                     ATENKVKNLTEEMAGLDENIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKL
                     EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEF
                     EISNLISKIEDEQAVEIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL
                     EEISERLEEAGGATSAQVEMNKKRETEFQKLRRDLEEATLQHEATAAALRKKHADSVA
                     ELGEQIDNLQRVKQKLEKEKSELKMEIDDLSSNAEAIAKAKGNLEKMCRTLEDQVSEL
                     KSKEEEQQRLINELTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKR
                     QLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY
                     ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVE
                     RTNAACAALDKKQRNFDKVLSEWRQKYEETQAELESCQKESRTLSTELFKVKNAYEES
                     LDHLETLRRENKNLQQEISDLTEQIAEGGKHIHELEKIKKQVEQEKCEIQAALEEAEA
                     SLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHVRVVETMQSTLDAEIRS
                     RNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKDTQLHLDDALRGQE
                     DLKEQLAIVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL
                     INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER
                     MKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKG
                     LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLAKFR
                     KLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE"
     exon            395..538
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            539..695
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            696..723
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            724..832
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            833..925
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            926..989
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1088
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1192
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1331
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1450
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1600
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1771
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2081
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2149
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2237
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2355
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2479
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2616
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2872
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3115
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3292
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3438
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3529
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3919
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4046
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4165
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4362
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            4363..4546
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            4547..4712
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            4713..4837
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..5146
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            5147..5350
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            5351..5476
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            5477..5647
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            5648..5752
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            5753..5848
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     exon            5849..6149
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6119..6124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /note="hexamer: AATAAA"
     polyA_site      6149
                     /gene="Myh8"
                     /gene_synonym="4832426G23Rik; MHCp; MyHC-pn; Myhs-p;
                     Myhsp"
                     /note="major polyA site"
ORIGIN      
        1 tgttgccaag tgtttggccc tgacaaagag gagggagctg cagcatcagc acttctgttc
       61 ctatataagc agggctgccc ctcacaccct atctccgcca agagcccaga gtgaaggaca
      121 ggcgtgactc tacgttttca tccagagctc catagctgaa acctcggcta aataagtagc
      181 agccatgagt gcgggttcgg acgcggagat ggctattttt ggcgaagctg ctccttacct
      241 ccgaaaatcg gagaaggaga ggattgaggc ccaaaataag ccttttgacg caaaaacatc
      301 tgtctttgtg gcggagccca aggagtctta tgtgaaaagc gttatacaaa gcaaggatgg
      361 agggaaagtg accgtgaaga cggaaagtgg agcaactctc accgtcaagg aagatcaagt
      421 cttccccatg aaccctccca aatatgacaa gatcgaggac atggccatga tgacccacct
      481 ccatgagccc ggagtgctgt acaacctcaa agagcgttat gcagcctgga tgatctatac
      541 ctactcaggc ctcttctgtg tcaccgtcaa cccctacaag tggctgccgg tgtacaaccc
      601 tgaggtggtg gcagcctacc gaggcaaaaa gcgccaggag gccccacccc acatcttctc
      661 catctctgac aacgcctacc agttcatgct gacggatcgt gagaaccagt ccatcctgat
      721 caccggagaa tccggggccg ggaagactgt gaacacgaag cgtgtcatcc agtactttgc
      781 aacaattgca gtcactgggg acaagaagaa ggaggagtct ggcaaaatgc aggggaccct
      841 ggaagatcaa atcatcagtg ctaaccccct gctggaggcc tttgggaacg ccaagaccgt
      901 gaggaatgac aactcatctc gctttggcaa gttcatcaga atccacttcg gtaccacggg
      961 gaaactggca tcagctgata ttgaaaccta tcttctagag aagtctagag tcactttcca
     1021 gctaaaagct gaaagaagtt accacatttt ttatcagatc acctccaata agaagccaga
     1081 gctaattgaa atgctcctga tcaccaccaa cccgtatgac tacgcctttg tcagtcaggg
     1141 ggagatcacg gtgcccagca ttgatgacca agaagagttg atggccacag atagtgccat
     1201 tgatatcctt ggcttttcac ctgaagagaa agtgtccatc tataaactca caggggctgt
     1261 gatgcattat gggaacatga agttcaagca aaagcagcgg gaggagcagg ctgagccaga
     1321 tggcactgaa gtggctgaca aggctgccta tctccagtgt ctgaactctg ctgatctgct
     1381 caaagccctc tgctatccca gggtcaaggt tggcaatgaa tatgtcacca aaggccagac
     1441 ggttcaacaa gtgtataatg cggtgggtgc cctggccaag gctgtctatg agaagatgtt
     1501 cctgtggatg gtcacccgca tcaaccagca gctggacacc aagcagcccc ggcagtactt
     1561 catcggggtc ttggacatcg ctggctttga gatctttgat ttcaacagcc tggagcagct
     1621 gtgcatcaac ttcaccaatg agaaactgca acagtttttc aaccaccaca tgttcgtgct
     1681 ggagcaggag gagtacaaga aggaaggcat cgagtggacc ttcatcgact tcgggatgga
     1741 cctggcggcc tgcatcgagc tcattgagaa gccactgggc atcttctcca tcctggaaga
     1801 agagtgcatg ttccctaagg cgacagacac ctccttcaag aacaagctgt acgaccaaca
     1861 tctgggaaaa tccaacaact tccagaagcc caagcctacc aaaggcaagg ccgaggccca
     1921 cttctccctg gtgcactatg cgggcactgt ggattacaac atcaccggct ggctggacaa
     1981 gaacaaggac cccctgaatg acaccgtggt ggggctgtac cagaagtcag caatgaaaac
     2041 tctggccagc ctcttttcca catacgctag tgctgaagca gatggtggtg caaagaaagg
     2101 agctaagaag aagggctctt ctttccaaac tgtgtcagcc cttttcaggg aaaacttaaa
     2161 taaactgatg accaatctga gaagtacaca ccctcacttc gtacggtgta tcattcccaa
     2221 tgaaacgaag actcccggtg ccatggagca cgaactggtc ctgcaccagc tgaggtgtaa
     2281 cggggtgctg gagggcatcc gcatctgcag gaaggggttc cccagccgga tcctgtatgg
     2341 ggactttaag cagagataca aggttttaaa tgcaagtgct attccagagg gacagttcat
     2401 cgacagcaag aaggcctctg agaagcttct gggctctatt gatatcgatc acactcagta
     2461 taaatttgga cacaccaagg ttttcttcaa agctggtctc ctgggtctcc tggaagaaat
     2521 gagagatgaa aagctggccc agattataac aagaacccag gcggtctgta ggggatacct
     2581 aatgagagtg gagtatcaga agatgctgct gagaagagaa tccatcttct gtatccagta
     2641 caacgtccgc gccttcatga acgtcaagca ctggccctgg atgaaactct tcttcaagat
     2701 caaacccctg ctgaagagcg cagagaccga gaaggagatg gccaccatga aggaggagtt
     2761 ccagaaaacc aaggatgagc tggccaagtc ggaggcaaag cggaaggagc tggaggagaa
     2821 gatggtcact cttctcaaag agaaaaatga cctgcaactc caggttcaat ctgaagcaga
     2881 cagcttggcc gatgctgagg aaaggtgtga acaattgatc aaaaacaaaa tccagctgga
     2941 ggccaaaatc aaagaggtga ccgagagggc cgaggacgag gaggagatca acgcggagct
     3001 cacggccaag aagaggaagc tggaggacga gtgctcagag ctgaagaagg acatcgatga
     3061 ccttgagctg acactggcca aggttgagaa ggagaagcac gccacggaga acaaggtgaa
     3121 aaacctgaca gaggagatgg caggcctgga tgaaaatatc gccaagctga ccaaggagaa
     3181 gaaggccctc caggaggccc accagcagac cctggatgac ctgcaggcag aggaggacaa
     3241 agtcaacacc ctgaccaaag ccaaaaccaa gctggaacag caagtggatg accttgaggg
     3301 atcgctagag caagaaaaga agctgaggat ggacttagaa agagccaaga ggaaactgga
     3361 gggggacctg aaactggccc aagagtccac aatggacata gaaaacgata aacagcagct
     3421 tgatgagaaa ctcaaaaaga aggagtttga aatcagcaac ctgataagca aaattgaaga
     3481 tgagcaagct gtggagatcc agctgcagaa gaagatcaaa gagttgcagg cccgcatcga
     3541 ggagctggag gaggaaatcg aggcagagcg ggcctccagg gccaaagcag agaagcagcg
     3601 ctctgacctc tcccgggaac tggaggagat cagcgagagg ctggaagaag ccggcggggc
     3661 cacctctgct caggtggaga tgaacaagaa gcgggaaact gagtttcaga aacttcgccg
     3721 ggacctggag gaggccacgc tgcagcacga agccacagca gccgctcttc ggaagaagca
     3781 cgcggacagt gtggctgagc tcggggagca gatcgacaac ctgcagcggg tgaagcagaa
     3841 gctggagaag gagaagagcg agctgaagat ggagatcgat gaccttagca gtaatgcaga
     3901 ggccatcgcc aaagccaagg gaaatctgga gaagatgtgc cgcactctgg aggaccaggt
     3961 gagtgaactg aagagcaagg aggaggagca gcagcggctc atcaacgagc tgacagcgca
     4021 gagagcacgc ctgcagacag aagcaggtga gtactccaga cagctggatg agaaagatgc
     4081 tttagtctct cagttgtcaa ggagcaagca ggcatccacg cagcagattg aggagctgaa
     4141 gcgtcagctc gaggaagaaa ccaaggccaa gaacgcgctg gcccacgccc tgcagtcctc
     4201 ccgccacgac tgtgatctgc tgcgggaaca gtatgaagag gagcaggaag gcaaagccga
     4261 gctgcagagg gcactgtcca aggccaacag cgaggtggcc cagtggagga ccaaatatga
     4321 gaccgatgcc atccagcgca cagaggagct ggaggaggcc aagaagaagc tggctcagcg
     4381 tctgcaggcg gccgaggagc acgtagaagc cgtgaacgcc aagtgcgctt ccctggagaa
     4441 gacgaagcag cggctgcaga acgaggtgga ggacctcatg attgatgtgg agaggaccaa
     4501 cgcggcctgc gccgccctgg acaagaagca gagaaacttc gacaaggttc tatcagaatg
     4561 gagacagaag tatgaggaaa ctcaggctga gcttgagtcc tgccagaagg agtcccgaac
     4621 tctcagcacg gagctgttca aggtgaagaa cgcctacgag gagtctctgg accacctgga
     4681 gacgctgagg agagagaaca agaatctgca acaggagatc tctgacctga ctgagcagat
     4741 tgcagaggga gggaagcaca tccatgagct ggagaaaatc aagaagcaag tggaacagga
     4801 gaagtgtgag atacaggctg ccttagagga agcagaggca tctctggagc acgaggaggg
     4861 aaagatcctg cgcatccagc tggagctgaa ccaagtcaag tctgagatcg acaggaagat
     4921 tgctgagaag gatgaggaga tcgaccagct gaagaggaac cacgttagag tcgtggagac
     4981 catgcagagc acgctggatg ccgagatcag gagcaggaat gatgctctga gagtcaagaa
     5041 gaagatggag ggagacctga acgagatgga gatccagctg aaccacgcca accgcttggc
     5101 tgctgaaagt ttgaggaact acaggaacac acagggcatc ctcaaggaca cccagctgca
     5161 tctggatgac gctctccggg gccaggagga tctgaaggag cagctggcca tcgtggagcg
     5221 cagagccaac ctgctgcagg ctgagattga ggagctgcgg gccacgctgg agcagacgga
     5281 gaggagcagg aagattgcag agcaggagct gctggacgcc agtgagcgcg tgcagctcct
     5341 ccacacccag aacacgagcc tcatcaacac caagaagaag ctggaaaatg atgtttcaca
     5401 gctgcagagt gaagtggaag aagtgattca agagtcacgc aatgcagaag agaaggctaa
     5461 gaaagccatt actgatgccg ccatgatggc ggaggagctg aagaaggagc aggacaccag
     5521 cgcccacctg gagcggatga agaagaacat ggaacagacg gtgaaggacc tgcagcaccg
     5581 tctggacgag gctgagcagc tggcgctgaa gggcggcaag aagcagatcc agaaactgga
     5641 ggccagggta cgtgaacttg aaggagaggt cgaaaatgaa cagaaacgca atgctgaggc
     5701 tgttaaaggg ttaaggaagc atgaaagaag agtaaaggaa cttacctacc agactgagga
     5761 agaccgcaag aatgtgctcc ggctgcagga cctggtggac aaattacagg cgaaggtgaa
     5821 atcctacaag agacaggctg aggaggctga ggaacaatcc aatgccaacc tggccaagtt
     5881 ccgcaagctg cagcacgagc tggaggaagc cgaggagcgg gctgacatcg ccgagtccca
     5941 ggtcaacaag ctgcgggtga agagccggga ggttcacacc aaaatcagcg cagagtaaac
     6001 acatcttgca gaggaaggag gctgccaagg ggctgaagga aagcacagga ggggctgctt
     6061 tgggtcgctt gctgggtcac ttgcctctct gggtttactt ttctcctact gctgactaaa
     6121 taaaaactac aaggcattgg taaatcaaa
//
