LOCUS       NM_001085378            6132 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus myosin, heavy chain 7B, cardiac muscle, beta (Myh7b),
            mRNA.
ACCESSION   NM_001085378 XM_001481279 XM_001481334
VERSION     NM_001085378.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6132)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6132)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6132)
  AUTHORS   Peter,A.K., Rossi,A.C., Buvoli,M., Ozeroff,C.D., Crocini,C.,
            Perry,A.R., Buvoli,A.E., Lee,L.A. and Leinwand,L.A.
  TITLE     Expression of Normally Repressed Myosin Heavy Chain 7b in the
            Mammalian Heart Induces Dilated Cardiomyopathy
  JOURNAL   J Am Heart Assoc 8 (15), e013318 (2019)
   PUBMED   31364453
REFERENCE   4  (bases 1 to 6132)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6132)
  AUTHORS   Lewandowski,S.L., Janardhan,H.P., Smee,K.M., Bachman,M., Sun,Z.,
            Lazar,M.A. and Trivedi,C.M.
  TITLE     Histone deacetylase 3 modulates Tbx5 activity to regulate early
            cardiogenesis
  JOURNAL   Hum Mol Genet 23 (14), 3801-3809 (2014)
   PUBMED   24565863
REFERENCE   6  (bases 1 to 6132)
  AUTHORS   Yeung,F., Chung,E., Guess,M.G., Bell,M.L. and Leinwand,L.A.
  TITLE     Myh7b/miR-499 gene expression is transcriptionally regulated by
            MRFs and Eos
  JOURNAL   Nucleic Acids Res 40 (15), 7303-7318 (2012)
   PUBMED   22638570
  REMARK    GeneRIF: MyoD and Eos form an active transcriptional complex on the
            chromatin to regulate the expression of the endogenous
            Myh7b/miR-499 gene in muscle cells.
REFERENCE   7  (bases 1 to 6132)
  AUTHORS   Bell,M.L., Buvoli,M. and Leinwand,L.A.
  TITLE     Uncoupling of expression of an intronic microRNA and its myosin
            host gene by exon skipping
  JOURNAL   Mol Cell Biol 30 (8), 1937-1945 (2010)
   PUBMED   20154144
REFERENCE   8  (bases 1 to 6132)
  AUTHORS   Rossi,A.C., Mammucari,C., Argentini,C., Reggiani,C. and
            Schiaffino,S.
  TITLE     Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b
            and MYH15 are expressed in extraocular muscles and muscle spindles
  JOURNAL   J Physiol 588 (Pt 2), 353-364 (2010)
   PUBMED   19948655
  REMARK    GeneRIF: Myh7b, the ortholog of slow myosin 2 (SM2) of frogs and
            birds, is detected as mRNA in heart, slow muscles and extraocular
            muscles. MYH7b protein is detected only in a minor fiber population
            in extraocular muscles, corresponding to slow-tonic fibers.
REFERENCE   9  (bases 1 to 6132)
  AUTHORS   van Rooij,E., Quiat,D., Johnson,B.A., Sutherland,L.B., Qi,X.,
            Richardson,J.A., Kelm,R.J. Jr. and Olson,E.N.
  TITLE     A family of microRNAs encoded by myosin genes governs myosin
            expression and muscle performance
  JOURNAL   Dev Cell 17 (5), 662-673 (2009)
   PUBMED   19922871
REFERENCE   10 (bases 1 to 6132)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL844852.11.
            
            On Jun 26, 2013 this sequence version replaced NM_001085378.1.
            
            Summary: This gene encodes a myosin heavy chain. The encoded
            protein forms a hexamer comprised of two heavy chains, two alkali
            light chains, and two regulatory light chain components. This
            complex functions in muscle contraction. [provided by RefSeq, Jun
            2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL844852.11        175795-175813
            20-181              AL844852.11        176139-176300
            182-288             AL844852.11        177700-177806
            289-432             AL844852.11        177985-178128
            433-589             AL844852.11        178591-178747
            590-617             AL844852.11        179020-179047
            618-714             AL844852.11        179953-180049
            715-738             AL844852.11        182076-182099
            739-831             AL844852.11        182200-182292
            832-895             AL844852.11        182414-182477
            896-994             AL844852.11        183286-183384
            995-1098            AL844852.11        184642-184745
            1099-1237           AL844852.11        184939-185077
            1238-1356           AL844852.11        185333-185451
            1357-1506           AL844852.11        185544-185693
            1507-1677           AL844852.11        185818-185988
            1678-1857           AL844852.11        186720-186899
            1858-1990           AL844852.11        186986-187118
            1991-2067           AL844852.11        187197-187273
            2068-2155           AL844852.11        187755-187842
            2156-2273           AL844852.11        187996-188113
            2274-2397           AL844852.11        190192-190315
            2398-2534           AL844852.11        190403-190539
            2535-2790           AL844852.11        190889-191144
            2791-3033           AL844852.11        192124-192366
            3034-3210           AL844852.11        193045-193221
            3211-3356           AL844852.11        193306-193451
            3357-3447           AL844852.11        193671-193761
            3448-3837           AL844852.11        193843-194232
            3838-3964           AL844852.11        194810-194936
            3965-4083           AL844852.11        195027-195145
            4084-4280           AL844852.11        195233-195429
            4281-4630           AL844852.11        195563-195912
            4631-4755           AL844852.11        196031-196155
            4756-4871           AL844852.11        196266-196381
            4872-5268           AL844852.11        196700-197096
            5269-5394           AL844852.11        197179-197304
            5395-5565           AL844852.11        197400-197570
            5566-5670           AL844852.11        197717-197821
            5671-5766           AL844852.11        197905-198000
            5767-5904           AL844852.11        198415-198552
            5905-6132           AL844852.11        198632-198859
FEATURES             Location/Qualifiers
     source          1..6132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.26 cM"
     gene            1..6132
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /note="myosin, heavy chain 7B, cardiac muscle, beta"
                     /db_xref="GeneID:668940"
                     /db_xref="MGI:MGI:3710243"
     exon            1..19
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            20..181
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..5916
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /codon_start=1
                     /product="myosin-7B"
                     /protein_id="NP_001078847.1"
                     /db_xref="CCDS:CCDS50768.1"
                     /db_xref="GeneID:668940"
                     /db_xref="MGI:MGI:3710243"
                     /translation="MMDMSELGESACYLRQGYQEMMKVHTVPWDGKKRVWVPDEQDAY
                     VEAEVKTEATGGKVTVETKDQKVLTVRETEMQPMNPPRFDLLEDMAMMTHLNEAAVLH
                     NLRQRYARWMIYTYSGLFCVTINPYKWLPVYTAAVVAAYKGKRRSEAPPHIYAVADNA
                     YNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGT
                     LEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDSYLLEKSRV
                     IFQLPGERGYHVYYQILSGKKPELQDMLLLSMNPYDYHFCSQGVTTVDNMDDGEELIA
                     TDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMG
                     VSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTL
                     DTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREG
                     IDWVFIDFGLDLQPCIDLIEKPLGILSILEEECMFPKASDASFRAKLYDNHSGKSPNF
                     QQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATL
                     YENYAGSCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVP
                     NENKTPGVMDSFLVLHQLRCNGVLEGIRICRQGFPNRLLYADFRQRYRILNPSAIPDD
                     TFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFKAGLLGILEELRDQRLAKVLTLLQAR
                     SRGRLMRLEYQRMLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEEL
                     AALRAELRGLRGALATAEAKRQELEETQVSVTQEKNDLALQLQAEQDNLADAEERCHL
                     LIKSKVQLEAKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAE
                     KEKQATENKVKNLTEEMAALDEAVVRLTKEKKALQEAHQQALGDLQAEEDRVSALAKA
                     KIRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQETVTDTTQDKQQLEEKLK
                     KKDSELSQLNLRVEDEQLVGVQLQKKIKELQARAEELEEELEAERAARARVEKQRAEA
                     ARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAVLRHEATVAALRRKQA
                     DSAAELSEQVDSLQRIRQKLEKEKSELRMEVDDLGASVETLARGKASAEKLCRTYEDQ
                     LSEAKIKVEELQRQLADASTQRGRLQTENGELGRLLEEKESMISQLSRGKTSAAQSLE
                     ELRRQLEEESKAKGALAHAVQALRHDCDLLREQHEEESEAQAELQRLLSKANAEVAQW
                     RSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT
                     LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQREARGLGTELFRLRHS
                     HEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKAKKALEGEKSELQAALE
                     EAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECTNLRRNHQRAVESLQASLDA
                     ETRARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAATRLLQAQLKEEQAGRDEEQ
                     RLAAELREQGQALERRAALLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ
                     NTGLLNQKKKLEVDLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSA
                     HLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE
                     ALKGVRKHERRVKELVYQTEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQASTNL
                     AKYRKAQHELDDAEERADMAETQANKLRARSRDALGPKHKE"
     exon            182..288
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            289..432
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            433..589
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            590..617
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            618..714
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            715..738
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            739..831
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            832..895
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            896..994
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1098
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1237
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1356
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1506
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1677
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1857
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1990
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2067
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2155
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2273
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2397
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2534
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2790
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..3033
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3210
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3356
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3447
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3837
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..3964
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4083
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4280
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4281..4630
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4631..4755
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4756..4871
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4872..5268
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5269..5394
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5395..5565
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5566..5670
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5671..5766
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5767..5904
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5905..6132
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6008..6013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /note="hexamer: AATAAA"
     polyA_site      6032
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /note="major polyA site"
     regulatory      6113..6118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
                     /note="hexamer: AATAAA"
     polyA_site      6132
                     /gene="Myh7b"
                     /gene_synonym="Myh14"
ORIGIN      
        1 gtcctcaccg tggtgccaga gcccgctgcc taggactgct ttgagttgct gccccggttt
       61 tcaggtcctc cttttgcacc tctcgccacc atgatggata tgagtgaact tggagaatca
      121 gcctgctacc tccgccaggg ctaccaggaa atgatgaagg tgcacactgt cccatgggat
      181 ggtaagaaac gggtctgggt gcctgatgag caggatgcct atgtggaggc tgaggtcaag
      241 actgaagcta ctggaggcaa agtcactgtg gagaccaaag accagaaggt gctgacagtg
      301 cgtgaaacgg agatgcaacc catgaaccca ccccgtttcg acttactgga ggacatggcc
      361 atgatgacgc acctcaacga ggctgcagtg ctgcataacc tgcggcagcg ctatgctcgc
      421 tggatgatct acacatactc gggcctcttc tgtgtcacca ttaacccata caaatggctc
      481 ccggtctaca cagctgctgt ggtggctgcc tacaagggca agcgtcgctc cgaggcccca
      541 cctcatatat atgcagtggc agataatgcc tacaacgaca tgctccgcaa ccgagagaat
      601 cagtccatgc tgatcaccgg agagtcgggg gccggtaaga cggttaacac caagcgggtc
      661 attcagtact ttgccatcgt cgctgccctg ggagacgggc cgggcaagaa ggcacaattt
      721 ctggcgacaa agacaggggg cacccttgag gatcaaatca tcgaggctaa ccctgccatg
      781 gaggcttttg gcaacgccaa gactctgagg aacgacaact cctcccgttt tggcaagttc
      841 atccgcatcc actttggtcc cactgggaag ctggcctctg cggacattga tagctatctc
      901 ctggagaagt cgcgagtgat cttccagctg cccggtgagc gtggttacca tgtctactac
      961 cagatcctct cagggaagaa gccggagctg caggacatgc tgctcctgtc catgaatccc
     1021 tacgactacc acttctgcag ccagggggtc accactgtgg acaacatgga tgacggcgag
     1081 gaacttatcg ccactgatca tgcaatggat atcctgggct tcagtgtgga tgagaagtgt
     1141 gcctgctata agatcgtggg tgctctcctg cactttggca acatgaagtt caaacagaag
     1201 cagagagagg aacaggctga ggcagacggc actgagagtg cggacaaggc tgcctacttg
     1261 atgggtgtca gcagcgggga cctcctcaaa ggtctcctgc atccccgggt tcgtgtggga
     1321 aatgagtatg ttaccaaggg ccagagtgtg gagcaggtgg tatttgccgt gggggccctg
     1381 gccaaggcta cctacgaccg gttgttccga tggctggttt ctcgaatcaa tcagaccctg
     1441 gacacaaagc tccctcgaca gttctttatc ggggtcctgg acatcgctgg ttttgagatt
     1501 tttgagttta acagcttcga gcagctgtgc atcaacttca ccaacgagaa gctgcagcag
     1561 ttcttcaacc agcacatgtt cgtgctggag caggaggagt acaagcggga gggcatcgac
     1621 tgggtcttca tcgacttcgg ccttgacctg cagccttgta tcgacctcat cgagaagcct
     1681 ctgggcatcc tgtccatcct ggaggaggag tgcatgttcc ccaaggcttc agacgcaagc
     1741 ttcagggcca agctctatga caatcattct gggaagtcac ctaatttcca gcagcctcgc
     1801 ccagacaaga aacgcaagta ccaggctcac ttcgaggtgg tccactacgc aggcgtggtt
     1861 ccttatagca tcgtgggctg gctggagaaa aacaaggatc ccctcaatga gacggtggtc
     1921 cccatcttcc aaaagtcaca gaataggctc ttggccaccc tctatgagaa ctatgcaggt
     1981 tcttgctcca ccgagccccc caagtctggg gtgaaagaga agcgcaagaa agcagcatca
     2041 tttcagaccg tgtctcagct tcacaaggag aacctcaaca agctcatgac caacctgcgg
     2101 gccacacagc cccatttcgt ccgctgtatc gtccccaacg agaacaagac tccaggggtc
     2161 atggattcct tcttggtgtt acaccaacta cgctgcaacg gggtcttgga gggaatccgg
     2221 atctgccgcc aagggttccc caacagactg ctgtatgctg acttcaggca gcggtaccga
     2281 atcctgaacc ccagtgccat cccagacgac acctttgtgg acagcagaaa ggccacagag
     2341 aagctgctgg gctccctgga catcgaccac actcagtatc agtttggcca caccaaggtg
     2401 ttcttcaagg ctgggcttct aggcatcctg gaggagctgc gggaccagcg tctggctaag
     2461 gtgttgacac tgctgcaggc tcggagccgg ggccgcctca tgcggctgga gtaccagcgc
     2521 atgctagggg gaagggatgc cctgttcacc atacagtgga acatccgggc ctttaatgcc
     2581 gtcaagaact ggtcctggat gaagctcttc ttcaagatga agccactgct gcgctcagca
     2641 caggcggagg aggagctggc ggcactgcgg gcagagctgc gggggctgcg aggggccctg
     2701 gctacggctg aggctaagcg gcaggagctg gaggagactc aagtcagtgt cactcaggag
     2761 aagaacgacc tggccctgca gctgcaggca gagcaggaca acctcgcaga tgcagaggag
     2821 cgctgccact tgctgatcaa gtccaaggtg cagctggagg cgaaggtgaa ggagctgagc
     2881 gagcggctgg aggacgagga ggaagtgaac gcggacctgg ccgcccgcag gcgcaagctg
     2941 gaggacgagt gcacggagct caagaaagac atcgatgacc tggagctgac gctggccaag
     3001 gccgagaaag agaaacaagc cacagagaac aaggtgaaga acctgacaga agagatggcg
     3061 gcactggatg aagccgtggt ccgcctgact aaggagaaga aggcattgca ggaggctcac
     3121 cagcaggctc tgggtgacct gcaggctgag gaggaccgtg tgagcgcact ggccaaggcc
     3181 aagatccggt tggaacagca agtggaggat ctggagtgct ccctggagca agagaagaag
     3241 ctgcgcatgg acacagaacg cgccaagcgc aaacttgaag gagacttgaa gctgacgcag
     3301 gagacggtga cagacacaac acaagacaag cagcagttgg aggagaagtt gaagaagaag
     3361 gattcggagc tgagtcagct gaacctgcgg gtggaggatg agcagctcgt gggggtgcag
     3421 ctgcagaaga agatcaagga gctgcaggct agggccgagg agctggagga ggagctggag
     3481 gcggagcgag cagcccgcgc ccgcgtggaa aagcagcgag ccgaggcagc gcgggagctg
     3541 gaggagctga gcgagaggct ggaggaggct ggcggagctt ccgcggggca gcgtgagggt
     3601 tgccgcaagc gtgaggctga gttgggccgg ctgcggcggg agctggagga ggcagttctg
     3661 aggcacgagg ccactgtggc tgccctgcgc cgcaagcagg ccgatagcgc tgcagagctg
     3721 agcgagcagg tggacagcct gcagcgcatc cggcagaaac tggaaaagga gaagagcgag
     3781 ctgcgcatgg aggtggacga tctgggcgcc agcgtggaaa ctctggcccg tggcaaggcc
     3841 agtgcggaaa agctgtgtcg gacctatgag gaccagctga gcgaggccaa aatcaaagtg
     3901 gaggagctgc agcgacagct ggccgacgcc agcacccagc gggggcggtt acaaacggag
     3961 aatggggagc tgggccgcct gctggaggag aaggagtcca tgatcagcca gctgagccgc
     4021 gggaagacct cagcagcgca gagtctggag gaacttcggc ggcagctgga ggaagaaagc
     4081 aaggccaagg gtgcgctggc tcatgcagtg caggccctgc ggcacgactg cgacctcctc
     4141 cgagagcagc acgaggaaga gtctgaggct caggctgagc tgcagcggct gctgtccaaa
     4201 gccaacgcgg aggtggccca gtggcggagc aagtatgaag cagatgccat ccaaaggacg
     4261 gaggagctgg aggaggccaa gaagaagctg gccctgcggc tgcaagaggc agaagaaggc
     4321 gtagaggccg caaatgccaa atgctcctca ctggagaagg ccaagctgcg gctgcagaca
     4381 gagtcggagg atgtgacctt ggagctggag cgggccacct cggccgccgc agccctggat
     4441 aagaagcagc ggcacttgga gcgggcgctg gaggagcgga ggcggcagga ggaggagatg
     4501 cagcgggaac tcgaggcggc acagagggag gctcgaggtc tggggacaga gctctttcga
     4561 ctgcgacata gccacgagga agcgcttgag gctctggaga cactcaagcg ggagaacaag
     4621 aatctgcagg aggagatcag tgaccttaca gaccaggtca gcctcagcgg gaagagcatc
     4681 caggaactgg agaaggccaa gaaggcgctg gaaggggaga agagtgagct gcaagctgca
     4741 ctggaggagg ctgagggggc actggagttg gaagagacaa agactctacg gatccagttg
     4801 gagttgtccc aggtcaaggc agaggtggac cggaagctgg cggagaagga cgaggagtgt
     4861 actaacctga ggcgcaacca ccagcgggct gtggaatccc tgcaggcctc cctggatgca
     4921 gagacaaggg cccgcaatga agcactgcgc ctcaagaaga agatggaggg ggacctcaac
     4981 gacctggagc tacagctggg ccacgcaacc cgccaggcca tggaggcaca ggcagccacg
     5041 aggctgctgc aggctcaact caaggaggaa caagcagggc gagatgagga gcagaggctg
     5101 gctgccgagc tccgtgagca gggtcaagcc ctcgagcgca gggctgcact gctggcggct
     5161 gagctggaag agcttcgggc tgccctggaa cagggcgagc gcagccggag gctggctgag
     5221 caggagctgc tggaggccac cgagcgcctc aacctactgc attcgcagaa cacaggcctc
     5281 ctgaaccaga aaaagaagct ggaggtggac ttggcccagc tgagtgggga agtggaggag
     5341 gctgcgcagg agaggcgtga agctgaggag aaggccaaaa aggccatcac tgatgcagcc
     5401 atgatggccg aggagctgaa aaaggaacag gacacgagcg cacacctgga acggatgaag
     5461 aagaccctgg aacagaccgt gcgggagctg caggcacgcc ttgaggaagc cgagcaggcc
     5521 gcacttcggg gtgggaagaa gcaagtgcag aagctggagg ccaaggtgcg ggagctggag
     5581 gccgagctgg atgcagagca gaaaaagcat gccgaggccc tcaagggggt gcgtaaacac
     5641 gagcgccggg tcaaggagct cgtgtaccag actgaagagg acaggaagaa cctggctcgc
     5701 atgcaggacc tggtggacaa gctgcagagc aaggtcaaga gctacaagcg tcagtttgag
     5761 gaggcggagc agcaggccag taccaacctg gctaagtacc gcaaggccca gcacgagctg
     5821 gatgatgccg aggaacgggc agacatggca gagacccagg ccaacaagct gcgggcaagg
     5881 tccagggatg ccctgggccc caagcacaag gagtgacacc caggctctga ggagggatac
     5941 cccacccctg cgatcctgtt gtctctttcc atctgccact ccaccctccc tgagcccctg
     6001 aaccccaaat aaacaccctg tctgcagcag tagccactgt ccttatttct tggggctaga
     6061 ggagctggga acagaacatc atggacaaag tcaggtccac atcagtcttt aaaataaagt
     6121 tctttaatag tc
//
