LOCUS       NM_001099635            5992 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus myosin, heavy polypeptide 3, skeletal muscle,
            embryonic (Myh3), mRNA.
ACCESSION   NM_001099635 XM_354614
VERSION     NM_001099635.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5992)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5992)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5992)
  AUTHORS   Kim,K.H., Oprescu,S.N., Snyder,M.M., Kim,A., Jia,Z., Yue,F. and
            Kuang,S.
  TITLE     PRMT5 mediates FoxO1 methylation and subcellular localization to
            regulate lipophagy in myogenic progenitors
  JOURNAL   Cell Rep 42 (11), 113329 (2023)
   PUBMED   37883229
REFERENCE   4  (bases 1 to 5992)
  AUTHORS   Cai,S., Wang,X., Xu,R., Liang,Z., Zhu,Q., Chen,M., Lin,Z., Li,C.,
            Duo,T., Tong,X., Li,E., He,Z., Liu,X., Chen,Y. and Mo,D.
  TITLE     KLF4 regulates skeletal muscle development and regeneration by
            directly targeting P57 and Myomixer
  JOURNAL   Cell Death Dis 14 (9), 612 (2023)
   PUBMED   37723138
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5992)
  AUTHORS   Bharadwaj,A., Sharma,J., Singh,J., Kumari,M., Dargar,T., Kalita,B.
            and Mathew,S.J.
  TITLE     Musculoskeletal defects associated with myosin heavy
            chain-embryonic loss of function are mediated by the YAP signaling
            pathway
  JOURNAL   EMBO Mol Med 15 (9), e17187 (2023)
   PUBMED   37492882
  REMARK    GeneRIF: Musculoskeletal defects associated with myosin heavy
            chain-embryonic loss of function are mediated by the YAP signaling
            pathway.
REFERENCE   6  (bases 1 to 5992)
  AUTHORS   Remmers,E.F., Goldmuntz,E.A., Cash,J.M., Crofford,L.J.,
            Misiewicz-Poltorak,B., Zha,H. and Wilder,R.L.
  TITLE     Genetic map of nine polymorphic loci comprising a single linkage
            group on rat chromosome 10: evidence for linkage conservation with
            human chromosome 17 and mouse chromosome 11
  JOURNAL   Genomics 14 (3), 618-623 (1992)
   PUBMED   1358809
REFERENCE   7  (bases 1 to 5992)
  AUTHORS   Miner,J.H., Miller,J.B. and Wold,B.J.
  TITLE     Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic
            mouse heart
  JOURNAL   Development 114 (4), 853-860 (1992)
   PUBMED   1618148
REFERENCE   8  (bases 1 to 5992)
  AUTHORS   Smith,T.H. and Miller,J.B.
  TITLE     Distinct myogenic programs of embryonic and fetal mouse muscle
            cells: expression of the perinatal myosin heavy chain isoform in
            vitro
  JOURNAL   Dev Biol 149 (1), 16-26 (1992)
   PUBMED   1728586
REFERENCE   9  (bases 1 to 5992)
  AUTHORS   Sanchez,A., Jones,W.K., Gulick,J., Doetschman,T. and Robbins,J.
  TITLE     Myosin heavy chain gene expression in mouse embryoid bodies. An in
            vitro developmental study
  JOURNAL   J Biol Chem 266 (33), 22419-22426 (1991)
   PUBMED   1939265
REFERENCE   10 (bases 1 to 5992)
  AUTHORS   Robbins,J., Gulick,J., Sanchez,A., Howles,P. and Doetschman,T.
  TITLE     Mouse embryonic stem cells express the cardiac myosin heavy chain
            genes during development in vitro
  JOURNAL   J Biol Chem 265 (20), 11905-11909 (1990)
   PUBMED   1694848
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645988.6 and AL596129.27.
            
            On Jul 25, 2007 this sequence version replaced XM_354614.6.
            
            Summary: Myosin is a major contractile protein which converts
            chemical energy into mechanical energy through the hydrolysis of
            ATP. Myosin is a hexameric protein composed of a pair of myosin
            heavy chains (MYH) and two pairs of nonidentical light chains. This
            gene is a member of the MYH family and encodes a protein with an IQ
            domain and a myosin head-like domain. [provided by RefSeq, Sep
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR10223970.13397.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164137, SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL645988.6         195829-195853
            26-36               AL645988.6         196668-196678
            37-248              AL645988.6         197520-197731
            249-392             AL645988.6         199811-199954
            393-549             AL645988.6         200380-200536
            550-577             AL645988.6         200928-200955
            578-686             AL645988.6         201279-201387
            687-779             AL645988.6         201604-201696
            780-843             AL645988.6         202324-202387
            844-942             AL645988.6         202472-202570
            943-1046            AL645988.6         203874-203977
            1047-1185           AL645988.6         204057-204195
            1186-1304           AL645988.6         204774-204892
            1305-1454           AL645988.6         204978-205127
            1455-1625           AL645988.6         206087-206257
            1626-1932           AL645988.6         206347-206653
            1933-2003           AL645988.6         206770-206840
            2004-2091           AL645988.6         207718-207805
            2092-2209           AL645988.6         207889-208006
            2210-2333           AL645988.6         208281-208404
            2334-2470           AL645988.6         208498-208634
            2471-2726           AL645988.6         209412-209667
            2727-2969           AL645988.6         209860-210102
            2970-3146           AL645988.6         210666-210842
            3147-3292           AL645988.6         210970-211115
            3293-3383           AL645988.6         211196-211286
            3384-3773           AL645988.6         212003-212392
            3774-3900           AL645988.6         212484-212610
            3901-4019           AL645988.6         213538-213656
            4020-4216           AL645988.6         213830-214026
            4217-4400           AL645988.6         214404-214587
            4401-4566           AL645988.6         215408-215573
            4567-4691           AL645988.6         216107-216231
            4692-4988           AL645988.6         216707-217003
            4989-5000           AL596129.27        2001-2012
            5001-5204           AL596129.27        2126-2329
            5205-5330           AL596129.27        2402-2527
            5331-5501           AL596129.27        3324-3494
            5502-5606           AL596129.27        3614-3718
            5607-5702           AL596129.27        3864-3959
            5703-5840           AL596129.27        4054-4191
            5841-5992           AL596129.27        4666-4817
FEATURES             Location/Qualifiers
     source          1..5992
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 40.59 cM"
     gene            1..5992
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /note="myosin, heavy polypeptide 3, skeletal muscle,
                     embryonic"
                     /db_xref="GeneID:17883"
                     /db_xref="MGI:MGI:1339709"
     exon            1..25
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            26..36
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            37..248
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            249..392
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            393..549
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            550..577
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            578..686
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            687..779
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            780..843
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            844..942
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1046
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1185
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1304
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1454
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1625
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1932
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2003
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2091
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2209
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2333
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2470
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2726
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2969
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3146
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3292
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3383
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3773
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3900
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4019
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4216
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..4400
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4566
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            4567..4691
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            4692..5000
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5204
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            5205..5330
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            5331..5501
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            5502..5606
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..5702
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            5703..5840
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     exon            5841..5992
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5966..5971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /note="hexamer: AATAAA"
     polyA_site      5987
                     /gene="Myh3"
                     /gene_synonym="MyHC-emb; Myhs-e; Myhse"
                     /note="major polyA site"
ORIGIN      
        1 atgcttctct ctgtcacagt cagaggtgtg actcagccga caccatgagt agcgacaccg
       61 agatggaagt gtttggcata gctgcacctt tcctccgcaa gtcggaaaag gagaggatcg
      121 aagctcagaa ccagcccttt gatgccaaaa cctactgctt tgtggttgac tcaaaggaag
      181 aatatgtcaa ggggaaaatt aagagtagcc aggatgggaa agtcactgtg gagacagaag
      241 acagcaggac cctggtggtt aagccagagg acgtgtatgc catgaaccca cccaagtttg
      301 acaagattga ggacatggcc atgctgaccc acctgaacga gcccgctgtg ctgtacaacc
      361 tcaaggaccg atacacgtcc tggatgatct acacctattc aggcctcttc tgtgtcactg
      421 tcaaccccta caaatggctg ccagtgtaca accccgaggt ggtggacggc taccgaggca
      481 aaaaacgcca ggaggctccg ccccacatct tctccatctc cgacaacgcc taccagttca
      541 tgctgactga tcgtgagaac cagtctatcc tgatcaccgg agaatccggg gccgggaaga
      601 cggtgaacac caagcgggtc atccagtact ttgcaacaat tgcagccact ggggaccttg
      661 ccaagaagaa ggactccaaa atgaagggga cgctggagga tcaaattatc agcgctaacc
      721 ccctgctgga ggcctttggg aacgccaaga ccgtgaggaa cgacaactcg tctcgctttg
      781 gcaagttcat ccgcatccat tttggcacca ctgggaagct ggcttctgca gatattgaaa
      841 cttatctgct ggaaaagtcc agagtcacct tccagctgaa ggctgagaga agctaccaca
      901 tcttctacca gattctctcc aacaagaaac ctgagctgat tgagctgctg ctgattacga
      961 ccaaccctta tgactacccg ttcatcagcc agggcgaaat cctggtggcc agcatcgacg
     1021 atgcggagga gctgttagct acggatagtg ccatcgacat cctgggcttc accccggagg
     1081 agaaatctgg actttataaa ctgacagggg ctgtgatgca ttatgggaac atgaagttca
     1141 agcagaagca gcgggaggag caggccgagc cagatggcac tgaagtggct gacaaaacag
     1201 cctacttgat gggcctgaat tcctcagacc tcctcaaggc cttgtgcttt cccagagtga
     1261 aagtcgggaa tgaatacgtt acaaaagggc agactgtgga ccaggttcac catgctgtga
     1321 acgctctctc caagtccgtg tacgagaagc tgttcttgtg gatggtcact cgtattaacc
     1381 agcagctgga tacaaagcta ccaagacagc acttcattgg cgttttggac attgcgggtt
     1441 ttgaaatttt tgagtataac agcctggagc agctgtgcat caacttcacc aacgagaaac
     1501 tgcaacagtt tttcaaccac cacatgttcg tgctggaaca ggaggaatac aagaaggagg
     1561 gcatcgagtg gaccttcatc gacttcggga tggacctggc agcctgcatc gagctcatcg
     1621 agaagccgat gggcatcttc tccatcctgg aagaggagtg catgttcccc aaggcgacag
     1681 acacctcctt caagaacaag ctgtatgacc agcacctggg aaagtccaac aacttccaga
     1741 aacctaaggt ggtcaaaggc aaggctgaag cccacttctc cctggtgcac tatgcgggca
     1801 ccgtggacta cagtgtctca ggctggctgg agaagaacaa ggaccccctg aatgagaccg
     1861 tggtgggact gtaccagaag tcctccaaca gactcctggc acatctctat gccaccttcg
     1921 ctacaacaga tgcggacggt gggaagaaga aagtcgctaa gaagaaaggc tcttccttcc
     1981 aaaccgtctc tgcactgttc agggaaaact tgaacaagct gatgtccaat ttaagaacca
     2041 cacacccaca ctttgtacgc tgtataatac ccaacgaaac caagacccca ggggccatgg
     2101 aacacagcct tgtcctgcac cagctcaggt gtaacggggt gctggaaggc atccggatct
     2161 gcaggaaggg cttccccaac aggatcctgt atggagactt taaacagaga taccgagtgc
     2221 tgaacgccag tgccatccca gaaggccagt tcattgacag caagaaagct tgcgagaaac
     2281 tcttggcttc cattgacatc gaccacacac agtacaaatt tggacacacc aaggtgttct
     2341 ttaaggctgg cttgctagga accctggaag agatgcggga tgagcgtttg gccaaactga
     2401 tcactcggac acaagccgtg tgcagagggt ttctcatgcg tgtggaattc cagaagatga
     2461 tgcagaggag ggagtccatc ttctgcatcc agtacaacat ccgtgccttc atgaacgtca
     2521 agcactggcc ctggatgaaa ctcttcttca agatcaagcc cctgctgaag agcgcggaga
     2581 ctgagaagga gatggccacc atgaaggagg agttccagaa aaccaaggat gagctggcta
     2641 agtcggaggc aaagaggaag gagctagagg agaagctcgt cactttggta caggagaaga
     2701 atgacctgca acttcaagta caggctgaga gtgaaaattt gttggatgct gaggaacgat
     2761 gcgaccagct gatcaaagcc aagttccagc tggaagccaa aatcaaagag gtgacagaga
     2821 gagccgagga cgaggaggag atcaacgcgg agctcacggc caagaagagg aagctggagg
     2881 acgagtgctc ggagctgaag aaggacatcg atgaccttga gctgacactg gccaaggttg
     2941 agaaggagaa gcacgccaca gagaacaagg tcaaaaacct taccgaagaa ctggcaggcc
     3001 tggatgaaac tattgcaaag ctaacacggg agaagaaggc cctccaagag gcccaccagc
     3061 agaccctgga cgacctccag gctgaagaag acaaggtcaa ttctctgagc aagctcaaga
     3121 gcaagctgga gcagcaagtg gatgatctgg agagctccct cgaacaagaa aagaagctgc
     3181 gtgtggacct agaaaggaac aaaaggaagc tggagggaga cctgaagctt gcccaagagt
     3241 ccatattaga tctggagaac gacaagcaac agctagacga gaggctcaag aagaaggact
     3301 ttgaatatag tcagctgcaa agcaaagtgg aagatgagca gaccttgagc ctccagcttc
     3361 agaagaaaat caaggagcta caggctcgca tcgaggagct ggaggaagag atagaggcag
     3421 agagggccac ccgggccaag acagagaagc agcgcagcga ctatgcacgc gagctggagg
     3481 agctgagtga gcggctggag gaggcgggcg gtgtcacctc cacccagatc gaactgaaca
     3541 agaagcgtga ggctgagttc ttgaagctgc gcagggacct ggaggaggcc accctgcagc
     3601 acgaggccac ggtggccacg ctgcggaaga agcacgcgga cagcgcggcc gagctggcgg
     3661 agcagatcga caacctgcag cgggtgaagc agaagctgga gaaggagaag agcgagttca
     3721 agctggagat tgacgacctc tccagcagcg tagagagcgt gtccaaatcc aaggccaatc
     3781 tggagaagat ctgccgaact ctagaggatc agttaagtga ggccaggggc aagaatgagg
     3841 agatgcagag gagcctaagt gagctgacca cacagaagtc ccggctgcag acagaggcgg
     3901 gtgagctgag tcgtcaacta gaagaaaagg aaagcattgt atctcagctc tccaggagca
     3961 agcaggcctt tacccaacag atagaggagc tcaagaggca actggaggaa gagaacaagg
     4021 ccaagaacgc gctggcccac gccctgcagt cctcccgcca tgactgtgac ctgctgcggg
     4081 aacagtacga ggaggagcag gaaggcaaag ccgagctgca gagggcactg tccaaggcca
     4141 acagcgaggt ggcccagtgg aggaccaagt atgaaacgga tgccatccag cgcacggagg
     4201 agctggagga ggccaaaaaa aagcttgcgc agcgccttca ggattcggag gagcaggtag
     4261 aggctgtaaa tgccaaatgt gcttccttgg aaaagaccaa gcagaggctg caaggggagg
     4321 tggaggacct gatggtggat gtggaaagag ccaactccct ggctgccgct ctggacaaga
     4381 agcagaggaa ctttgacaag gtgctagctg agtggaagac gaagtgtgag gagagccaag
     4441 ccgagctgga ggcagctctc aaggaatccc ggtccttgag cactgagctc ttcaaactga
     4501 agaatgccta tgaagaagcc ttggatcaac ttgaaaccgt gaaacgggag aataagaact
     4561 tagaacaaga gatagcagat ctcactgaac agattgccga gaacggtaaa agcatccatg
     4621 agctagagaa atccagaaaa cagatggagc tggagaaggc tgacatccag atggcgctgg
     4681 aggaagcaga ggcagctctt gagcacgaag aagccaagat tctccggatc cagcttgaac
     4741 tgacccaggt gaaatcagag attgatagga agattgcaga gaaggatgaa gagatcgagc
     4801 agctgaagag gaactaccag aggacagtgg agaccatgca aggcgccctg gacgctgagg
     4861 tgcgcagcag gaatgaggcc atccgcctga agaagaagat ggagggcgac ctcaatgaga
     4921 tcgagatcca gctgagccac gccaaccgcc aggccgcaga gaccatcaag cacctccgga
     4981 gcgtccaggg acagctgaag gacacccagc tgcacctgga tgacgctctc cggggccagg
     5041 aggacctgaa ggagcagctg gccatcgtgg aacgcagagc caacctcctg caggctgagg
     5101 tggaggagct gcgggccacg ctggagcaga cggagagggc ccggaagctg gcagagcagg
     5161 agctgttgga ttcgaatgag agggtccagc tgctgcacac ccagaacaca agcctcatcc
     5221 acaccaagaa gaagttggag actgacctca cgcagctcca gagtgaggtg gaggatgcct
     5281 gcagggacgc aaggaatgca gaggagaagg ccaaaaaggc catcactgac gccgccatga
     5341 tggcggagga gctgaagaag gagcaggaca ccagcgccca cctggagagg atgaagaaga
     5401 acctggagca gacggtgaag gacctgcagc accgtctgga tgaggctgag cagctggcgc
     5461 tgaagggcgg caagaagcag attcagaaac tggagacacg gatcagagag ctggagtttg
     5521 agctggaagg ggagcagaag aggaacacag agtctgtgaa gggcctgagg aagtatgagc
     5581 ggcgtgttaa ggagctcaca tatcagagtg aggaggacag gaagaatgtg ttgagattgc
     5641 aggatctggt ggataaactc caagtgaaag tcaagtccta caagaggcag gctgaggagg
     5701 ctgatgaaca agccaatgct catctcacca agttcaggaa agcccagcat gagctagagg
     5761 aggccgagga acgggctgat atcgcagaat cgcaagtcaa taaactgcgg gcaaagaccc
     5821 gtgacttcac ctctagccgg atggtggtcc atgaaagcga ggagtgagca agacctcctg
     5881 gtgcagggca gaagatatgc agaatgtata ttttcgtggc tcctgacaat tctacttaat
     5941 ttccacgtat cacttttcca catgcaataa agtttgcctt gtttcaagtt gg
//
