LOCUS       NM_001161775            6543 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus myosin, heavy polypeptide 11, smooth muscle (Myh11),
            transcript variant 2, mRNA.
ACCESSION   NM_001161775
VERSION     NM_001161775.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6543)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6543)
  AUTHORS   Wang,L., He,X., Hu,G., Liu,J., Kang,X., Yu,L., Dong,K., Zhao,J.,
            Zhang,A., Zhang,W., Brands,M.W., Su,H., Zheng,Z. and Zhou,J.
  TITLE     A novel mouse model carrying a gene trap insertion into the Hmgxb4
            gene locus to examine Hmgxb4 expression in vivo
  JOURNAL   Physiol Rep 12 (8), e16014 (2024)
   PUBMED   38644513
REFERENCE   3  (bases 1 to 6543)
  AUTHORS   Chen,J., Zhang,X., DeLaughter,D.M., Trembley,M.A., Saifee,S.,
            Xiao,F., Chen,J., Zhou,P., Seidman,C.E., Seidman,J.G. and Pu,W.T.
  TITLE     Molecular and Spatial Signatures of Mouse Embryonic Endothelial
            Cells at Single-Cell Resolution
  JOURNAL   Circ Res 134 (5), 529-546 (2024)
   PUBMED   38348657
REFERENCE   4  (bases 1 to 6543)
  AUTHORS   Xu,Z., Wang,W., Yang,T., Li,L., Ma,X., Chen,J., Wang,J., Huang,Y.,
            Gould,J., Lu,H., Du,W., Sahu,S.K., Yang,F., Li,Z., Hu,Q., Hua,C.,
            Hu,S., Liu,Y., Cai,J., You,L., Zhang,Y., Li,Y., Zeng,W., Chen,A.,
            Wang,B., Liu,L., Chen,F., Ma,K., Xu,X. and Wei,X.
  TITLE     STOmicsDB: a comprehensive database for spatial transcriptomics
            data sharing, analysis and visualization
  JOURNAL   Nucleic Acids Res 52 (D1), D1053-D1061 (2024)
   PUBMED   37953328
REFERENCE   5  (bases 1 to 6543)
  AUTHORS   Russell,N.X., Burra,K., Shah,R.M., Bottasso-Arias,N.,
            Mohanakrishnan,M., Snowball,J., Ediga,H.H., Madala,S.K. and
            Sinner,D.
  TITLE     Wnt signaling regulates ion channel expression to promote smooth
            muscle and cartilage formation in developing mouse trachea
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L788-L802 (2023)
   PUBMED   37873566
REFERENCE   6  (bases 1 to 6543)
  AUTHORS   Suzuki,T., Kim,H.S., Kurabayashi,M., Hamada,H., Fujii,H.,
            Aikawa,M., Watanabe,M., Watanabe,N., Sakomura,Y., Yazaki,Y. and
            Nagai,R.
  TITLE     Preferential differentiation of P19 mouse embryonal carcinoma cells
            into smooth muscle cells. Use of retinoic acid and antisense
            against the central nervous system-specific POU transcription
            factor Brn-2
  JOURNAL   Circ Res 78 (3), 395-404 (1996)
   PUBMED   8593698
REFERENCE   7  (bases 1 to 6543)
  AUTHORS   Doggett,N.A. and Callen,D.F.
  TITLE     Report and abstracts of the third international workshop on human
            chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 165-184 (1995)
   PUBMED   7842732
REFERENCE   8  (bases 1 to 6543)
  AUTHORS   Miano,J.M., Cserjesi,P., Ligon,K.L., Periasamy,M. and Olson,E.N.
  TITLE     Smooth muscle myosin heavy chain exclusively marks the smooth
            muscle lineage during mouse embryogenesis
  JOURNAL   Circ Res 75 (5), 803-812 (1994)
   PUBMED   7923625
REFERENCE   9  (bases 1 to 6543)
  AUTHORS   Deng,Z., Liu,P., Marlton,P., Claxton,D.F., Lane,S., Callen,D.F.,
            Collins,F.S. and Siciliano,M.J.
  TITLE     Smooth muscle myosin heavy chain locus (MYH11) maps to
            16p13.13-p13.12 and establishes a new region of conserved synteny
            between human 16p and mouse 16
  JOURNAL   Genomics 18 (1), 156-159 (1993)
   PUBMED   8276405
REFERENCE   10 (bases 1 to 6543)
  AUTHORS   Matsuoka,R., Yoshida,M.C., Furutani,Y., Imamura,S., Kanda,N.,
            Yanagisawa,M., Masaki,T. and Takao,A.
  TITLE     Human smooth muscle myosin heavy chain gene mapped to chromosomal
            region 16q12
  JOURNAL   Am J Med Genet 46 (1), 61-67 (1993)
   PUBMED   7684189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164291.2.
            
            On Mar 23, 2022 this sequence version replaced NM_001161775.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            3' coding region, compared to variant 1, that causes a frameshift.
            The resulting protein (isoform 2) has a longer and distinct
            C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173045.1, D85923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC164291.2         170268-170355       c
            89-449              AC164291.2         156544-156904       c
            450-606             AC164291.2         148101-148257       c
            607-634             AC164291.2         135477-135504       c
            635-737             AC164291.2         129514-129616       c
            738-830             AC164291.2         125719-125811       c
            831-894             AC164291.2         124493-124556       c
            895-993             AC164291.2         123797-123895       c
            994-1137            AC164291.2         118388-118531       c
            1138-1233           AC164291.2         115361-115456       c
            1234-1352           AC164291.2         113345-113463       c
            1353-1505           AC164291.2         112532-112684       c
            1506-1679           AC164291.2         111517-111690       c
            1680-1853           AC164291.2         109685-109858       c
            1854-1968           AC164291.2         107728-107842       c
            1969-2162           AC164291.2         105451-105644       c
            2163-2284           AC164291.2         102970-103091       c
            2285-2354           AC164291.2         102808-102877       c
            2355-2515           AC164291.2         102488-102648       c
            2516-2624           AC164291.2         100736-100844       c
            2625-2756           AC164291.2         99147-99278         c
            2757-2963           AC164291.2         98852-99058         c
            2964-3101           AC164291.2         97832-97969         c
            3102-3225           AC164291.2         96934-97057         c
            3226-3397           AC164291.2         94728-94899         c
            3398-3610           AC164291.2         91510-91722         c
            3611-3755           AC164291.2         90218-90362         c
            3756-3962           AC164291.2         88503-88709         c
            3963-4067           AC164291.2         87224-87328         c
            4068-4220           AC164291.2         86981-87133         c
            4221-4469           AC164291.2         86532-86780         c
            4470-4682           AC164291.2         84903-85115         c
            4683-4895           AC164291.2         84493-84705         c
            4896-5057           AC164291.2         84099-84260         c
            5058-5186           AC164291.2         83623-83751         c
            5187-5275           AC164291.2         83317-83405         c
            5276-5399           AC164291.2         82105-82228         c
            5400-5608           AC164291.2         81055-81263         c
            5609-5717           AC164291.2         79961-80069         c
            5718-5890           AC164291.2         79687-79859         c
            5891-6543           AC164291.2         73524-74176         c
FEATURES             Location/Qualifiers
     source          1..6543
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.71 cM"
     gene            1..6543
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /note="myosin, heavy polypeptide 11, smooth muscle"
                     /db_xref="GeneID:17880"
                     /db_xref="MGI:MGI:102643"
     exon            1..88
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            89..449
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..6023
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /note="isoform 2 is encoded by transcript variant 2;
                     myosin heavy chain 11, smooth muscle; myosin-11"
                     /codon_start=1
                     /product="myosin-11 isoform 2"
                     /protein_id="NP_001155247.1"
                     /db_xref="CCDS:CCDS88881.1"
                     /db_xref="GeneID:17880"
                     /db_xref="MGI:MGI:102643"
                     /translation="MAQKGQLSDDEKFLFVDKNFMNSPMAQADWVAKKLVWVPSEKQG
                     FEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVL
                     HNLRERYFSGLIYTYSGLFCVVVNPYKYLPIYSEKIVDMYKGKKRHEMPPHIYAIADT
                     AYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITGELEKQL
                     LQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAR
                     DERTFHIFYYLLAGAKEKMKSDLLLESFNSYTFLSNGFVPIPAAQDDEMFQETLEAMS
                     IMGFNEEEQLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGINVTDF
                     TRAILTPRIKVGRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQ
                     GASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNF
                     IDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKP
                     KQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDR
                     IVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPN
                     HEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGF
                     MDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCR
                     GYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQA
                     KEEEMQKIKERQQKAETELKELEQKHTQLAEEKTLLQEQLQAETELYAEAEEMRVRLA
                     AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE
                     KVTAEAKIKKLEDDILVMDDQNSKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKS
                     KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK
                     EEELQAALARLDEEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE
                     ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHTQA
                     VEELTEQLEQFKRAKANLDKSKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEVQLQ
                     DLQSKCSDGERARAELSDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLGSQLQDT
                     QELLQEETRQKLNVSTKLRQLEDERNSLQDQLDEEMEAKQNLERHVSTLNIQLSDSKK
                     KLQDFASTIEVMEEGKKRLQKEMEGLSQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL
                     DNQRQLVSNLEKKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE
                     ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE
                     DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK
                     QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELDDARASR
                     DEIFATSKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNT
                     LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELATERSTAQKNE
                     SARQQLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIAQLEEQVEQEAREKQAATK
                     SLKQKDKKLKEVLLQVEDERKMAEQYKEQAEKGNTKVKQLKRQLEEAEEESQRINANR
                     RKLQRELDEATESNEAMGREVNALKSKLRRGNEASFVPSRRAGGRRVIENTDGSEEEM
                     DARDSDFNGTKASE"
     exon            450..606
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            607..634
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            635..737
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            738..830
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            831..894
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            895..993
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1137
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1233
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1352
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1505
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1679
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1853
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1968
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2162
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2284
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2354
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2515
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2624
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2756
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2963
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3101
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3225
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3397
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3610
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3755
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3962
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..4067
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..4220
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4221..4469
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4682
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4683..4895
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4896..5057
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5186
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5187..5275
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5399
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5608
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5609..5717
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5718..5890
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5891..6543
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6522..6527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /note="hexamer: AATAAA"
     polyA_site      6543
                     /gene="Myh11"
                     /gene_synonym="SM1; SM2; smMHC"
                     /note="major polyA site"
ORIGIN      
        1 agatttggac catcccagcc tgggatcagt gccagatccg agctctccat ccggtgtcct
       61 cctgctaatc cacccccgga gtagatctgg gaccaccaga catcatggcg cagaaagggc
      121 agctcagcga tgatgagaag ttcctctttg tggataaaaa cttcatgaac agcccaatgg
      181 ctcaggccga ctgggtagcc aagaagctgg tgtgggtccc ttcagagaag cagggcttcg
      241 aagcagccag catcaaggag gagaagggcg atgaggtggt cgtggagttg gtggaaaatg
      301 gaaagaaggt cacagttggc aaagatgaca tccaaaaaat gaacccaccc aagttctcta
      361 aggtggagga catggcagag ctgacgtgcc tcaatgaggc ctctgtgctg cacaacctga
      421 gggagcgata cttctcaggc ctcatctata cctactctgg cctcttctgt gtggtggtca
      481 acccctacaa gtacctaccc atctactcag aaaagatcgt ggatatgtac aagggcaaga
      541 agaggcatga gatgccgcct cacatctatg ccattgccga cacagcctac agaagcatgc
      601 tacaagatcg tgaagaccag tccattctgt gcacaggtga gtctggagcc ggaaagacag
      661 agaacacaaa gaaagtcata cagtacttgg ctgtggtggc atcctcccac aagggcaaga
      721 aagacagcag catcacgggg gagctggaaa agcagcttct acaggcaaac ccaatcctgg
      781 aggctttcgg caatgcgaaa accgtcaaga acgacaactc ctctcgcttt ggcaagttca
      841 ttcgcatcaa cttcgatgtc actggttaca ttgtaggtgc caatattgaa acatatcttc
      901 tggaaaagtc tagggctatt cgacaggcta gggatgagag aacatttcac atcttctact
      961 acctgctcgc cggagccaag gaaaagatga aaagtgacct gcttttggag agcttcaaca
     1021 gctacacatt tttatccaat ggctttgtgc ccatcccagc tgcacaagat gatgagatgt
     1081 tccaggagac actggaagcc atgtctatca tgggcttcaa tgaagaggaa cagctagcca
     1141 tcttgaaggt agtatcatct gtccttcagc ttggaaacat tgtcttcaag aaggagcgaa
     1201 acacagacca ggcatccatg cctgataaca cagcggctca gaaagtttgc cacctcgtgg
     1261 ggattaatgt gacagatttc actagagcca tcctgacccc acgtatcaaa gttggacggg
     1321 atgtggtgca gaaggctcag accaaagaac aggctgactt tgccatcgag gccttagcca
     1381 aggccaccta tgagcgcctt ttccgatgga ttctcagccg tgtaaacaag gccttggaca
     1441 agacccatcg gcagggggcc tccttcctgg gcattctgga tattgctggg tttgaaatct
     1501 ttgaggtaaa ctccttcgag cagctgtgca tcaactacac caacgagaag ctgcagcagc
     1561 tgttcaacca cacgatgttc atcctggagc aggaagagta ccagcgagag ggcatcgagt
     1621 ggaacttcat cgacttcggc ctggacctgc agccttgtat tgagctgatt gagcggccga
     1681 acaaccctcc cggtgtgctg gccctgctgg atgaagaatg ctggttcccc aaagctacag
     1741 acaagtcttt tgtggagaag ctatgctcag agcagggaaa tcaccccaaa tttcagaagc
     1801 ccaagcagct aaaggacaaa acagagttct ccatcatcca ctatgctggg aaggtggact
     1861 acaatgcaag tgcctggctg accaagaaca tggacccgct aaatgacaat gtgacatcac
     1921 tcctcaatgc ctcctctgac aagtttgtgg ctgacctgtg gaaggatgtg gaccgcattg
     1981 tggggctgga ccagatggcc aagatgactg agagctcact gcccagtgcc tccaagacca
     2041 aaaagggcat gttccgcacc gtgggccagc tctacaaaga gcagttgggg aaactgatga
     2101 ctacactgcg caataccacg cctaactttg tgcgctgcat catccccaac catgagaaga
     2161 ggtctggcaa gctggatgca tttctagtgc tggaacagct gcgctgcaac ggtgtgttgg
     2221 aaggcatccg catctgccgt cagggcttcc ccaacaggat tgtcttccaa gagttccggc
     2281 aacgctatga gatcctggca gcgaacgcca tccccaaagg cttcatggat ggaaagcaag
     2341 cctgcattct catgatcaaa gccctcgaac ttgaccctaa cctgtacagg attgggcaga
     2401 gcaaaatctt cttccgaacg ggggtcctgg cccacctaga ggaggaacga gacctgaaaa
     2461 ttactgatgt catcatggcc ttccaggcaa tgtgtcgtgg ctaccttgcc agaaaggcct
     2521 tcaccaagag gcagcaacag ctgacagcca tgaaggtgat ccagaggaac tgcgctgcct
     2581 accttaagct ccgcaactgg caatggtggc ggctcttcac caaagtaaag ccattgctcc
     2641 aggtgacacg gcaggaggag gagatgcagg ccaaggagga ggagatgcaa aagatcaagg
     2701 agcggcagca gaaggcagag actgagttga aggagctgga gcagaagcac actcagctgg
     2761 ctgaggagaa gactctgctg caggagcagt tgcaggcaga gacagagctg tatgctgagg
     2821 ctgaggagat gcgggtccgg ttggcagcca agaagcagga actggaggag atcctacatg
     2881 agatggaggc ccgcctggag gaagaggaag accggggcca gcaactacag gctgagagga
     2941 agaagatggc tcagcagatg ctagacctgg aggagcaact ggaggaggaa gaggccgcca
     3001 gacagaaact acagctagag aaggtcacgg ctgaggccaa gatcaagaaa ctggaggatg
     3061 acatcttggt tatggatgat cagaacagta aactttcaaa agaacgaaaa ctccttgaag
     3121 agagggtcag cgacttgaca accaacctag cagaagagga agaaaaggct aaaaacctca
     3181 caaagctgaa gagcaagcat gagtctatga tctcagagct ggaggtgagg ctgaagaaag
     3241 aggagaagag ccggcaggag ctggagaaac tcaagaggaa actggagggt gatgccagtg
     3301 acttccatga gcagatcgct gacttgcagg cccagattgc agagctcaag atgcagctgg
     3361 caaagaaaga ggaagagcta caggcagctc tagccaggct tgatgaagag atcgcccaga
     3421 aaaacaatgc cctaaagaag attcgcgagc tagagggcca tatctcagac ctacaagagg
     3481 acctagactc agagcgggct gccaggaaca aggccgagaa gcagaagcga gacctggggg
     3541 aggagctgga ggcactcaag acggagctgg aggatacgct ggacagcaca gctacccagc
     3601 aggagctcag agccaagagg gaacaggagg tgacagtgct gaagaaggcc ctggatgagg
     3661 agacgcggtc ccatgaggcc caggtccagg agatgaggca gaagcacaca caggcagtgg
     3721 aggaactcac agagcagctg gagcagttca aaagggccaa ggcaaacctg gacaaaagca
     3781 agcagacact ggagaaggag aacgcggacc tggctgggga gctgcgtgtc ctgggccagg
     3841 cgaagcagga ggtggaacac aagaagaaga agctggaggt gcagctgcag gatctgcagt
     3901 ccaagtgcag tgatggggag cgtgcccggg ctgagctcag tgacaaggtc cacaagctac
     3961 agaatgaagt ggagagtgtc actggcatgc tcaatgaggc agagggcaaa gccatcaaac
     4021 tggccaaaga tgtggcttcc cttggatccc agcttcagga cacccaagag ctgctccaag
     4081 aagaaacccg gcagaagctc aatgtgtcta ccaagctgcg tcagttggaa gatgaaagga
     4141 acagcctgca ggaccagctg gatgaggaga tggaggctaa gcaaaacctg gagcgccatg
     4201 tctcaacact gaacattcag ctctcagact ctaagaagaa gctgcaggac tttgcaagta
     4261 ccatcgaggt catggaggag gggaagaaga ggttacagaa agagatggag ggcctcagcc
     4321 agcagtatga ggagaaggcg gctgcctatg acaaactgga gaaaaccaag aacaggctcc
     4381 agcaggagct ggatgacctg gtcgtggact tggacaacca gcggcaactg gtatccaatc
     4441 tggaaaagaa gcagaagaaa tttgaccagt tgttagctga ggagaagaac atctcctcca
     4501 agtatgcgga tgagagagac cgagctgaag cagaggccag ggaaaaggag acaaaggctt
     4561 tgtctctagc ccgggccctg gaggaagccc tggaagccaa agaagagctg gagaggacca
     4621 acaagatgct caaagctgag atggaagacc tggtcagctc caaggatgat gtaggcaaga
     4681 acgtgcatga actggagaag tccaagcgtg ccttggagac ccagatggaa gagatgaaaa
     4741 cccagctgga ggagttggag gatgagctgc aggccactga ggatgccaag ctgcggctag
     4801 aggtcaacat gcaggccctc aagggccagt ttgaacgcga tctccaggct cgggatgaac
     4861 agaatgagga gaagaggagg cagctacagc ggcagctgca cgagtatgag acagaactgg
     4921 aagatgaacg gaagcagaga gctctggcgg cggcagctaa gaagaagctg gaaggggacc
     4981 taaaagacct agagctccag gctgactcag ccatcaaagg gagggaggaa gccatcaagc
     5041 agcttcgaaa actgcaggct cagatgaagg acttccaaag agagctggat gatgcccgtg
     5101 cctccaggga tgagatcttt gccacctcaa aagagaatga gaagaaagcc aagagtctgg
     5161 aggcagacct catgcagctc caagaggacc tggcagcagc tgagagagct cgcaagcaag
     5221 ctgacctgga gaaggaggag ctggccgagg agctggctag cagcttgtca ggaaggaata
     5281 cactgcagga tgagaagcgc cgcctggagg caaggatcgc ccaactagag gaggagctgg
     5341 aggaagagca gggcaacatg gaggccatga gtgatagagt acgcaaggcc acactgcagg
     5401 ctgagcaact gagcaatgag ctggccacag aacgcagcac ggctcagaag aatgagagcg
     5461 cacggcaaca gctggagcgc cagaacaagg aactgcgaag caagttgcag gaggtagaag
     5521 gtgctgtcaa agccaagctc aagtccactg ttgcggcgct ggaggccaag attgcacagc
     5581 tggaggagca ggttgaacag gaggccagag agaaacaggc ggccaccaag tcgctgaagc
     5641 aaaaggacaa gaagctaaag gaggtcctgc tgcaggtgga ggatgagcgc aagatggcag
     5701 agcagtacaa ggagcaggca gagaaaggaa acaccaaggt caagcagctg aagaggcagc
     5761 tggaagaggc agaggaggag tcccagcgca tcaacgccaa ccgcaggaag ctgcagcggg
     5821 agctagatga ggccacagag agcaatgagg ccatgggccg tgaggtgaac gccctcaaga
     5881 gcaaactcag gagaggaaac gaggcttcat ttgttccttc cagaagggct gggggccgta
     5941 gagttattga aaacacagat ggttctgaag aagaaatgga cgctcgggac tcagacttca
     6001 atggaaccaa agccagtgaa taaattcagg attggacacc atgtcaggga aaacagaaca
     6061 ctaaacgaca gcagagccca gcagactgct tagcacttgt gtccattcgt tctcaagtca
     6121 cagaaatcac tccacccctc accaggagtc aaccacagcc ctgcacaaag ggtgtgaatt
     6181 caagttctta gatgggctat cagagaaaaa tccaaataag acgtacaggt caggagccac
     6241 agtcaccagc aactttgttt acatgaaatg aggaagttac atgaatgggt gccacagccc
     6301 ccaacccact cccaaccttt ccctgacctg cctgaccttc cagtttggga ggaaatcccg
     6361 tttgaaaatt cccttccctt tcctgcctgc cacacctcag acacacagtt cacttcgccc
     6421 aagtgacttt tttagtcatc tgaattaaaa aaagaaacac tgctcccaga gcgagcggag
     6481 cagagcaatc acacttattt gcacccatgg tcactttcac taataaaagg ttgtaagtca
     6541 cga
//
