LOCUS       NM_021713               1480 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus melanocyte proliferating gene 1 (Myg1), mRNA.
ACCESSION   NM_021713
VERSION     NM_021713.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Grover,R., Burse,S.A., Shankrit,S., Aggarwal,A., Kirty,K.,
            Narta,K., Srivastav,R., Ray,A.K., Malik,G., Vats,A., Motiani,R.K.,
            Thukral,L., Roy,S.S., Bhattacharya,S., Sharma,R., Natarajan,K.,
            Mukerji,M., Pandey,R., Gokhale,R.S. and Natarajan,V.T.
  TITLE     Myg1 exonuclease couples the nuclear and mitochondrial
            translational programs through RNA processing
  JOURNAL   Nucleic Acids Res 47 (11), 5852-5866 (2019)
   PUBMED   31081026
  REMARK    GeneRIF: analysis of the widely conserved dually localized protein
            Myg1 shows that it has a role as a 3'-5' RNA exonuclease
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Philips,M.A., Abramov,U., Lillevali,K., Luuk,H., Kurrikoff,K.,
            Raud,S., Plaas,M., Innos,J., Puussaar,T., Koks,S. and Vasar,E.
  TITLE     Myg1-deficient mice display alterations in stress-induced responses
            and reduction of sex-dependent behavioural differences
  JOURNAL   Behav Brain Res 207 (1), 182-195 (2010)
   PUBMED   19818808
  REMARK    GeneRIF: Myg1 knockout decreases several behavioural differences
            (anxiety- and stress-related responses) between male and female
            animals, indicating that Myg1 contributes to the expression of
            sex-dependent behavioural differences in mice.
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Philips,M.A., Vikesa,J., Luuk,H., Jonson,L., Lillevali,K.,
            Rehfeld,J.F., Vasar,E., Koks,S. and Nielsen,F.C.
  TITLE     Characterization of MYG1 gene and protein: subcellular distribution
            and function
  JOURNAL   Biol Cell 101 (6), 361-373 (2009)
   PUBMED   19014353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ180315.1, AF289484.1 and BU851558.1.
            
            On Mar 14, 2007 this sequence version replaced NM_021713.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF289484.1, BC028501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 CJ180315.1         1-9
            10-1192             AF289484.1         2-1184
            1193-1480           BU851558.1         128-415
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.49 cM"
     gene            1..1480
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /note="melanocyte proliferating gene 1"
                     /db_xref="GeneID:60315"
                     /db_xref="MGI:MGI:1929864"
     exon            1..245
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1175
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /note="protein Gamm1; UPF0160 protein MYG1, mitochondrial;
                     MYG1 exonuclease"
                     /codon_start=1
                     /product="MYG1 exonuclease precursor"
                     /protein_id="NP_068359.1"
                     /db_xref="CCDS:CCDS27879.1"
                     /db_xref="GeneID:60315"
                     /db_xref="MGI:MGI:1929864"
                     /translation="MGRRFLRGILTLPLRSVLQAQHRMLGSEQDPPAKRPRNNLMAPP
                     RIGTHNGTFHCDEALACALLRLLPEYANAEIVRTRDPEKLASCDIVVDVGGEYNPQSH
                     RYDHHQRTFTETMSSLCPGKPWQTKLSSAGLVYLHFGRKLLAQLLGTSEEDSVVDTIY
                     DKMYENFVEEVDAVDNGISQWAEGEPRYAMTTTLSARVARLNPTWNQPNQDTEAGFRR
                     AMDLVQEEFLQRLNFYQHSWLPARALVEEALAQRFKVDSSGEIVELAKGGCPWKEHLY
                     HLESELSPKVAITFVIYTDQAGQWRVQCVPKEPHSFQSRLPLPEPWRGLRDKALDQVS
                     GIPGCIFVHASGFIGGHHTREGALNMARATLAQRPAPVPLANAVVQ"
     exon            246..358
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..518
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..671
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..794
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..976
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1480
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1171..1176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /note="hexamer: AATAAA"
     polyA_site      1192
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /note="major polyA site"
ORIGIN      
        1 ttccgggtcg accttccctt ggagggaact atatgggtag acgtttcctg cgtggtatct
       61 taacattgcc gctccggtca gttctccaag cccagcaccg catgcttggc tcagagcagg
      121 atccgcccgc taaaagacct cgcaacaacc tcatggcacc gccccgaatc gggacgcaca
      181 acggcacctt ccactgcgat gaagctctgg cttgcgcgtt gctccgcctc ctgcccgagt
      241 acgcgaacgc agagattgtg cggactcggg atcctgaaaa gttggcttcg tgtgacatcg
      301 tggtggatgt gggcggtgag tacaaccccc agagtcaccg ttatgatcat caccagagga
      361 cttttacaga aaccatgagt tcactgtgcc ctggaaagcc atggcagacc aagctgagca
      421 gtgcgggact tgtctatttg cacttcggac gtaagctcct ggcccagttg ctgggcacta
      481 gtgaagagga cagcgtggtg gataccatct atgacaagat gtatgagaac tttgtggaag
      541 aggtggatgc ggtggacaat gggatctctc agtgggcaga gggggagcct cggtatgcca
      601 tgaccaccac actgagtgcc cgggttgctc ggcttaatcc cacctggaac cagcccaacc
      661 aagacactga ggcagggttc aggcgagcaa tggacctggt acaagaggag tttctgcaaa
      721 gactaaactt ctaccagcac agctggctgc cagcccgggc cttagtagag gaggcactgg
      781 cccagagatt caaggtagat tcaagtgggg aaatagtgga actcgcaaaa ggtggatgcc
      841 cttggaagga gcatctatac cacctagaat ctgagctgtc ccccaaagtg gccattacct
      901 ttgttatcta cactgaccag gctggacagt ggcgagtcca gtgcgtaccc aaggagcctc
      961 actcattcca aagccggcta cccttgcccg agccatggag aggacttcgg gataaggccc
     1021 tggaccaagt cagtgggatc cctggttgca tcttcgtcca tgccagtggc ttcattggtg
     1081 ggcaccacac tcgagagggt gccctgaaca tggcccgtgc cacccttgcc cagcgcccag
     1141 cacctgtgcc tcttgcaaat gctgtagtcc aataaaacgt attcacctct aactgaccca
     1201 gtccctgatc caccaacctg gaattttctt agacttgtaa gtgctttgct tttcagttga
     1261 caaccatctc agttggctgg agagatagct cagcagtcaa catggttgtt gtgggagagg
     1321 actgggattc catccccagc acccacaaag cagctcataa ctgtaactcc agctccagga
     1381 gatccaacac ccccttcctg acctctgtgg gcactagaca cacatttgta catgcaggca
     1441 acacaaacgt gtaaaataat aaatccttaa gaaatagaaa
//
