LOCUS       NP_068359                380 aa            linear   ROD 27-APR-2025
DEFINITION  MYG1 exonuclease precursor [Mus musculus].
ACCESSION   NP_068359
VERSION     NP_068359.1
DBSOURCE    REFSEQ: accession NM_021713.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 380)
  AUTHORS   Grover,R., Burse,S.A., Shankrit,S., Aggarwal,A., Kirty,K.,
            Narta,K., Srivastav,R., Ray,A.K., Malik,G., Vats,A., Motiani,R.K.,
            Thukral,L., Roy,S.S., Bhattacharya,S., Sharma,R., Natarajan,K.,
            Mukerji,M., Pandey,R., Gokhale,R.S. and Natarajan,V.T.
  TITLE     Myg1 exonuclease couples the nuclear and mitochondrial
            translational programs through RNA processing
  JOURNAL   Nucleic Acids Res 47 (11), 5852-5866 (2019)
   PUBMED   31081026
  REMARK    GeneRIF: analysis of the widely conserved dually localized protein
            Myg1 shows that it has a role as a 3'-5' RNA exonuclease
REFERENCE   2  (residues 1 to 380)
  AUTHORS   Philips,M.A., Abramov,U., Lillevali,K., Luuk,H., Kurrikoff,K.,
            Raud,S., Plaas,M., Innos,J., Puussaar,T., Koks,S. and Vasar,E.
  TITLE     Myg1-deficient mice display alterations in stress-induced responses
            and reduction of sex-dependent behavioural differences
  JOURNAL   Behav Brain Res 207 (1), 182-195 (2010)
   PUBMED   19818808
  REMARK    GeneRIF: Myg1 knockout decreases several behavioural differences
            (anxiety- and stress-related responses) between male and female
            animals, indicating that Myg1 contributes to the expression of
            sex-dependent behavioural differences in mice.
REFERENCE   3  (residues 1 to 380)
  AUTHORS   Philips,M.A., Vikesa,J., Luuk,H., Jonson,L., Lillevali,K.,
            Rehfeld,J.F., Vasar,E., Koks,S. and Nielsen,F.C.
  TITLE     Characterization of MYG1 gene and protein: subcellular distribution
            and function
  JOURNAL   Biol Cell 101 (6), 361-373 (2009)
   PUBMED   19014353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ180315.1, AF289484.1 and BU851558.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF289484.1, BC028501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.49 cM"
     Protein         1..380
                     /product="MYG1 exonuclease precursor"
                     /note="protein Gamm1; UPF0160 protein MYG1, mitochondrial;
                     MYG1 exonuclease"
                     /calculated_mol_wt=37450
     transit_peptide 1..46
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q9JK81.1)"
                     /calculated_mol_wt=5290
     Region          45..365
                     /region_name="UPF0160"
                     /note="Uncharacterized protein family (UPF0160);
                     pfam03690"
                     /db_xref="CDD:461014"
     mat_peptide     47..380
                     /product="MYG1 exonuclease. /id=PRO_0000213484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK81.1)"
                     /calculated_mol_wt=37450
     Site            266
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9HB07; propagated from
                     UniProtKB/Swiss-Prot (Q9JK81.1)"
     Site            272
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q9JK81.1)"
     CDS             1..380
                     /gene="Myg1"
                     /gene_synonym="0610023A07Rik; 2810433J21Rik;
                     5830429P19Rik; Gamm1"
                     /coded_by="NM_021713.2:33..1175"
                     /db_xref="CCDS:CCDS27879.1"
                     /db_xref="GeneID:60315"
                     /db_xref="MGI:MGI:1929864"
ORIGIN      
        1 mgrrflrgil tlplrsvlqa qhrmlgseqd ppakrprnnl mapprigthn gtfhcdeala
       61 callrllpey anaeivrtrd peklascdiv vdvggeynpq shrydhhqrt ftetmsslcp
      121 gkpwqtklss aglvylhfgr kllaqllgts eedsvvdtiy dkmyenfvee vdavdngisq
      181 waegepryam tttlsarvar lnptwnqpnq dteagfrram dlvqeeflqr lnfyqhswlp
      241 aralveeala qrfkvdssge ivelakggcp wkehlyhles elspkvaitf viytdqagqw
      301 rvqcvpkeph sfqsrlplpe pwrglrdkal dqvsgipgci fvhasgfigg hhtregalnm
      361 aratlaqrpa pvplanavvq
//
