LOCUS       NM_080837                913 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus myeloid derived growth factor (Mydgf), mRNA.
ACCESSION   NM_080837
VERSION     NM_080837.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Han,G., Hao,Y., Li,R., Liu,W., Liu,J., Nie,Y., Bai,L. and Wang,Y.
  TITLE     [Loss of Myeloid-Derived Growth Factor Leads to Increased Fibrosis
            in Mice After Myocardial Infarction]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (4), 886-892 (2024)
   PUBMED   39170023
  REMARK    GeneRIF: [Loss of Myeloid-Derived Growth Factor Leads to Increased
            Fibrosis in Mice After Myocardial Infarction].
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 913)
  AUTHORS   Grosse-Segerath,L., Follert,P., Behnke,K., Ettich,J., Buschmann,T.,
            Kirschner,P., Hartwig,S., Lehr,S., Korf-Klingebiel,M., Eberhard,D.,
            Lehwald-Tywuschik,N., Al-Hasani,H., Knoefel,W.T., Heinrich,S.,
            Levkau,B., Wollert,K.C., Scheller,J. and Lammert,E.
  TITLE     Identification of myeloid-derived growth factor as a
            mechanically-induced, growth-promoting angiocrine signal for human
            hepatocytes
  JOURNAL   Nat Commun 15 (1), 1076 (2024)
   PUBMED   38316785
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 913)
  AUTHORS   Xu,J., Ma,H., Shi,L., Zhou,H., Cheng,Y., Tong,J., Meng,B., Xu,X.,
            He,K., Ding,S., Zhang,J., Yue,L. and Xiang,G.
  TITLE     Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL
            Transcytosis to Protect Against Atherogenesis
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (11), e443-e467 (2023)
   PUBMED   37767706
  REMARK    GeneRIF: Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL
            Transcytosis to Protect Against Atherogenesis.
REFERENCE   5  (bases 1 to 913)
  AUTHORS   Ding,Y., Xu,X., Meng,B., Wang,L., Zhu,B., Guo,B., Zhang,J.,
            Xiang,L., Dong,J., Liu,M. and Xiang,G.
  TITLE     Myeloid-derived growth factor alleviates non-alcoholic fatty liver
            disease alleviates in a manner involving IKKbeta/NF-kappaB
            signaling
  JOURNAL   Cell Death Dis 14 (6), 376 (2023)
   PUBMED   37365185
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 913)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   7  (bases 1 to 913)
  AUTHORS   Hughes,D.S., Keynes,R.J. and Tannahill,D.
  TITLE     Extensive molecular differences between anterior- and
            posterior-half-sclerotomes underlie somite polarity and spinal
            nerve segmentation
  JOURNAL   BMC Dev Biol 9, 30 (2009)
   PUBMED   19463158
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 913)
  AUTHORS   Wang,P., Mariman,E., Keijer,J., Bouwman,F., Noben,J.P., Robben,J.
            and Renes,J.
  TITLE     Profiling of the secreted proteins during 3T3-L1 adipocyte
            differentiation leads to the identification of novel adipokines
  JOURNAL   Cell Mol Life Sci 61 (18), 2405-2417 (2004)
   PUBMED   15378209
REFERENCE   9  (bases 1 to 913)
  AUTHORS   Rothfuchs,A.G., Gigliotti,D., Palmblad,K., Andersson,U., Wigzell,H.
            and Rottenberg,M.E.
  TITLE     IFN-alpha beta-dependent, IFN-gamma secretion by bone
            marrow-derived macrophages controls an intracellular bacterial
            infection
  JOURNAL   J Immunol 167 (11), 6453-6461 (2001)
   PUBMED   11714812
REFERENCE   10 (bases 1 to 913)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004074.1, AK008289.1 and W71193.1.
            
            On Nov 22, 2004 this sequence version replaced NM_080837.1.
            
            Summary: The protein encoded by this gene was previously thought to
            support proliferation of lymphoid cells and was identified in error
            as interleukin 25. This activity has not been reproducible,
            however, and the function of this protein is currently unknown.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148083.1, SRR1660811.391021.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-906               AK004074.1         1-906
            907-910             AK008289.1         893-896
            911-913             W71193.1           1-3                 c
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.2 cM"
     gene            1..913
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /note="myeloid derived growth factor"
                     /db_xref="GeneID:28106"
                     /db_xref="MGI:MGI:2156020"
     exon            1..182
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..530
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /note="UPF0556 protein C19orf10 homolog"
                     /codon_start=1
                     /product="myeloid-derived growth factor precursor"
                     /protein_id="NP_543027.1"
                     /db_xref="CCDS:CCDS28898.1"
                     /db_xref="GeneID:28106"
                     /db_xref="MGI:MGI:2156020"
                     /translation="MAAPSGGFWTAVVLAAAALKLAAAVSEPTTVPFDVRPGGVVHSF
                     SQDVGPGNKFTCTFTYASQGGTNEQWQMSLGTSEDSQHFTCTIWRPQGKSYLYFTQFK
                     AELRGAEIEYAMAYSKAAFERESDVPLKSEEFEVTKTAVSHRPGAFKAELSKLVIVAK
                     AARSEL"
     exon            183..233
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /inference="alignment:Splign:2.1.0"
     exon            234..295
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /inference="alignment:Splign:2.1.0"
     exon            296..377
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /inference="alignment:Splign:2.1.0"
     exon            378..450
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /inference="alignment:Splign:2.1.0"
     exon            451..913
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      868..873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /note="hexamer: AATAAG"
     polyA_site      913
                     /gene="Mydgf"
                     /gene_synonym="D17Wsu104e; Il25; Ly6elg"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcctgc gcattgcccc ggaagcaaga tggcagcccc cagcggaggc ttctggactg
       61 cggtggtcct ggcggccgca gcgctgaaat tggccgccgc tgtgtccgag cccaccaccg
      121 tgccatttga cgtgaggccc ggaggggtcg tgcattcgtt ctcccaggac gtaggacccg
      181 ggaacaagtt tacatgtaca ttcacctacg cttcccaagg agggaccaac gagcaatggc
      241 agatgagcct ggggacaagt gaagacagcc agcactttac ctgtaccatc tggaggcccc
      301 aggggaaatc ctacctctac ttcacacagt tcaaggctga gttgcgaggt gctgagatcg
      361 agtatgccat ggcctactcc aaagccgcat ttgagagaga gagtgatgtc cccctgaaaa
      421 gtgaggagtt tgaagtgacc aagacagcag tgtctcacag gcctggggcc ttcaaagctg
      481 agctctccaa gctggtgatc gtagccaagg cggcacgctc ggagctgtga ccctcgcctg
      541 tcaagggcct tcatgtccac gttcctcagg cacactgacc gggactactt gtctagggca
      601 ctggttccca taggagctgc cctgccctgc acaggtcaca ctgtgtcact ccgcagaact
      661 ctctgagccc ggtcacctgt tttgccaggg aagatgcagg gcatgtgcgg gggtgggatg
      721 gaaggacttc ctggctttcc tgaagtcaag atgtggtgtg gtttcccctc tgagccacag
      781 atgagtgtcc ccatcccagg accactttct aaccccatcc agggcagctc cactcagaag
      841 gatgggaaag gatagaaaaa ataaataaat aagtagccac cttagtggtg gctctgtggg
      901 gtcaggactc aga
//
