LOCUS       NM_010851               1965 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus myeloid differentiation primary response gene 88
            (Myd88), mRNA.
ACCESSION   NM_010851
VERSION     NM_010851.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1965)
  AUTHORS   Lohrberg,M., Mortensen,L.S., Thomas,C., Fries,F., van der Meer,F.,
            Gotz,A., Landt,C., Rhee,H.J., Rhee,J., Gomez-Varela,D., Schmidt,M.,
            Mobius,W., Ruhwedel,T., Pardo,L.A., Remling,L., Kramann,N.,
            Wrzos,C., Bahn,E., Stadelmann,C. and Barrantes-Freer,A.
  TITLE     Astroglial modulation of synaptic function in the non-demyelinated
            cerebellar cortex is dependent on MyD88 signaling in a model of
            toxic demyelination
  JOURNAL   J Neuroinflammation 22 (1), 47 (2025)
   PUBMED   39988657
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1965)
  AUTHORS   De Ponti,F.F., Bujko,A., Liu,Z., Collins,P.J., Schuermans,S.,
            Maueroder,C., Amstelveen,S., Thone,T., Martens,L., McKendrick,J.G.,
            Louwe,P.A., Sanchez Cruz,A., Saelens,W., Matchett,K.P.,
            Waller,K.J., Zwicker,C., Buglar-Lamb,A., Vanneste,B.,
            Parmentier,F., Binte Abdul Latib,M., Remmerie,A., Kertesz,L.,
            Kremer,A., Verbeke,J., Ipsen,D.H., Pfister,D.R., Liu,Z.,
            Guilliams,M., Henderson,N.C., Ravichandran,K., Marques,P.E. and
            Scott,C.L.
  TITLE     Spatially restricted and ontogenically distinct hepatic macrophages
            are required for tissue repair
  JOURNAL   Immunity 58 (2), 362-380 (2025)
   PUBMED   39862865
REFERENCE   3  (bases 1 to 1965)
  AUTHORS   Danielson,M., Nicolai,C.J., Vo,T.T., Wolf,N.K. and Burke,T.P.
  TITLE     Cytosolic bacterial pathogens activate TLR pathways in tumors that
            synergistically enhance STING agonist cancer therapies
  JOURNAL   iScience 27 (12), 111385 (2024)
   PUBMED   39669426
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1965)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1965)
  AUTHORS   Xie,Y., Chi,Y., Tao,X., Yu,P., Liu,Q., Zhang,M., Yang,N., Liu,S.
            and Zhu,W.
  TITLE     Rabies Virus Regulates Inflammatory Response in BV-2 Cells through
            Activation of Myd88 and NF-kappaB Signaling Pathways via TLR7
  JOURNAL   Int J Mol Sci 25 (17), 9144 (2024)
   PUBMED   39273091
  REMARK    GeneRIF: Rabies Virus Regulates Inflammatory Response in BV-2 Cells
            through Activation of Myd88 and NF-kappaB Signaling Pathways via
            TLR7.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1965)
  AUTHORS   Bonnert,T.P., Garka,K.E., Parnet,P., Sonoda,G., Testa,J.R. and
            Sims,J.E.
  TITLE     The cloning and characterization of human MyD88: a member of an
            IL-1 receptor related family
  JOURNAL   FEBS Lett 402 (1), 81-84 (1997)
   PUBMED   9013863
REFERENCE   7  (bases 1 to 1965)
  AUTHORS   Hardiman,G., Rock,F.L., Balasubramanian,S., Kastelein,R.A. and
            Bazan,J.F.
  TITLE     Molecular characterization and modular analysis of human MyD88
  JOURNAL   Oncogene 13 (11), 2467-2475 (1996)
   PUBMED   8957090
REFERENCE   8  (bases 1 to 1965)
  AUTHORS   Harroch,S., Gothelf,Y., Revel,M. and Chebath,J.
  TITLE     5' upstream sequences of MyD88, an IL-6 primary response gene in M1
            cells: detection of functional IRF-1 and Stat factors binding sites
  JOURNAL   Nucleic Acids Res 23 (17), 3539-3546 (1995)
   PUBMED   7567467
REFERENCE   9  (bases 1 to 1965)
  AUTHORS   Lord,K.A., Hoffman-Liebermann,B. and Liebermann,D.A.
  TITLE     Nucleotide sequence and expression of a cDNA encoding MyD88, a
            novel myeloid differentiation primary response gene induced by IL6
  JOURNAL   Oncogene 5 (7), 1095-1097 (1990)
   PUBMED   2374694
REFERENCE   10 (bases 1 to 1965)
  AUTHORS   Idell,S., James,K.K., Levin,E.G., Schwartz,B.S., Manchanda,N.,
            Maunder,R.J., Martin,T.R., McLarty,J. and Fair,D.S.
  TITLE     Local abnormalities in coagulation and fibrinolytic pathways
            predispose to alveolar fibrin deposition in the adult respiratory
            distress syndrome
  JOURNAL   J Clin Invest 84 (2), 695-705 (1989)
   PUBMED   2788176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005591.1 and BC058787.1.
            
            On Jun 19, 2018 this sequence version replaced NM_010851.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058787.1, AK152596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1883              BC005591.1         23-1905
            1884-1965           BC058787.1         1841-1922
FEATURES             Location/Qualifiers
     source          1..1965
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..1965
                     /gene="Myd88"
                     /note="myeloid differentiation primary response gene 88"
                     /db_xref="GeneID:17874"
                     /db_xref="MGI:MGI:108005"
     exon            1..387
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..950
                     /gene="Myd88"
                     /note="myeloid differentiation primary response protein
                     88"
                     /codon_start=1
                     /product="myeloid differentiation primary response protein
                     MyD88"
                     /protein_id="NP_034981.1"
                     /db_xref="CCDS:CCDS23612.1"
                     /db_xref="GeneID:17874"
                     /db_xref="MGI:MGI:108005"
                     /translation="MSAGDPRVGSGSLDSFMFSIPLVALNVGVRRRLSLFLNPRTPVA
                     ADWTLLAEEMGFEYLEIRELETRPDPTRSLLDAWQGRSGASVGRLLELLALLDREDIL
                     KELKSRIEEDCQKYLGKQQNQESEKPLQVARVESSVPQTKELGGITTLDDPLGQTPEL
                     FDAFICYCPNDIEFVQEMIRQLEQTDYRLKLCVSDRDVLPGTCVWSIASELIEKRCRR
                     MVVVVSDDYLQSKECDFQTKFALSLSPGVQQKRLIPIKYKAMKKDFPSILRFITICDY
                     TNPCTKSWFWTRLAKALSLP"
     exon            388..522
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     exon            523..703
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     exon            704..795
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     exon            796..971
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1937
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1852..1857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myd88"
                     /note="hexamer: AATAAA"
     polyA_site      1880
                     /gene="Myd88"
     regulatory      1907..1912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myd88"
                     /note="hexamer: AATAAA"
     polyA_site      1928
                     /gene="Myd88"
                     /note="major polyA site"
ORIGIN      
        1 agtaggaaac tccacaggcg agcgtactgg acggcaccgg gggcccaggg ttgcctgcca
       61 tgtctgcggg agacccccgc gtgggatccg ggtccctgga ctccttcatg ttctccatac
      121 ccttggtcgc gcttaacgtg ggagtgaggc gccgcctatc gctgttcttg aaccctcgga
      181 cgcccgtggc ggccgactgg accttgctgg cggaggagat gggcttcgag tacttggaga
      241 tccgagagct ggaaacgcgc cctgacccca ctcgcagttt gttggatgcc tggcaggggc
      301 gctctggcgc gtctgtcggc aggctgctag agctgctggc cttgttagac cgtgaggata
      361 tactgaagga gctgaagtcg cgcatcgagg aggactgcca gaaatactta ggtaagcagc
      421 agaaccagga gtccgagaag cctttacagg tggccagagt ggaaagcagt gtcccacaaa
      481 caaaggaact gggaggcatc accacccttg atgaccccct aggacaaacg ccggaacttt
      541 tcgatgcctt tatctgctac tgccccaacg atatcgagtt tgtgcaggag atgatccggc
      601 aactagaaca gacagactat cggcttaagt tgtgtgtgtc cgaccgtgac gtcctgccgg
      661 gcacctgtgt ctggtccatt gccagcgagc taattgagaa aaggtgtcgc cgcatggtgg
      721 tggttgtttc tgacgattat ctacagagca aggaatgtga cttccagacc aagtttgcac
      781 tcagcctgtc tccaggtgtc caacagaagc gactgattcc tattaaatac aaggcgatga
      841 agaaggactt tcccagtatc ctgcggttca tcactatatg cgactatacc aacccttgca
      901 ccaagtcctg gttctggacc cgccttgcca aggctttgtc cctgccctga agatgaccct
      961 gggagcccta gggcagaggg gaagatgaga ctgatgcgga gccagattct ctgatgccgt
     1021 cctgtctaca tctttgactc ccctgggctc aacccgtgtt caatgatgac tggcctgagc
     1081 aactaggact gcctttcctc ccagccaccc atgcctgtgc acgcacctca gtacacacat
     1141 gcctcctcgc acacacaggc atctgcatat gtgtgtttcc tttgggacag ctcccaagga
     1201 tagctgagtg gaagagttct atcatcaagg gggcctggcc atctccctgg acaaaagtgg
     1261 ggtgcctttg ctacaggtag tggcacgggc ctatagtttc agcatttggg aggtagaggc
     1321 aggagaatca ggagttcaag cttatccttg gcaacacacc tagtttaagg tcagcctggg
     1381 ctacatgaga gcctacctcc cccatcccct acccccagaa aagaaggaaa atctgggggc
     1441 actgtggatt tctcctctct tttctctacc tgttgaaagc aaagtctagg aaggccccaa
     1501 acatgatagc atttgggccc ttagtaagct gaagataaaa aggagaagct gtttggcttc
     1561 gccccacaaa gcagctgcag gctcagctgt tttctcccca gcagcgaggt ttgcatcttc
     1621 ttattccttt cacgttctct accatagagg caatgtcatg gtccctctca gggtacaccc
     1681 cagggccctg agtccccaag aaagtgagtc tcccctcagt gtctggggga ggaatgaggc
     1741 ctctgtgcac ggtctcatgg ggcatttcac tgcttgatgt tgagcatttt aaagcaacct
     1801 gggtcaagtg taaacctcct ccacctgtgt tagaggtttc atgggaatgt caataaagaa
     1861 aagaagggct cgtgtttgta ctttgtactt ctgtgtgtga atttataata aaaagtattc
     1921 tattttgaga aagtgtaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
