LOCUS       NM_008709               2596 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus v-myc avian myelocytomatosis viral related oncogene,
            neuroblastoma derived (Mycn), mRNA.
ACCESSION   NM_008709
VERSION     NM_008709.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2596)
  AUTHORS   Cheung,B.B., Mittra,R., Murray,J., Wang,Q., Seneviratne,J.A.,
            Raipuria,M., Wong,I.P.L., Restuccia,D., Gifford,A., Salib,A.,
            Sutton,S., Huang,L., Ferdowsi,P.V., Tsang,J., Sekyere,E., Mayoh,C.,
            Luo,L., Brown,D.L., Stow,J.L., Zhu,S., Young,R.J., Solomon,B.J.,
            Chappaz,S., Kile,B., Kueh,A., Herold,M.J., Hilton,D.J., Liu,T.,
            Norris,M.D., Haber,M., Carter,D.R., Parker,M.W. and Marshall,G.M.
  TITLE     Golgi-localized Ring Finger Protein 121 is necessary for
            MYCN-driven neuroblastoma tumorigenesis
  JOURNAL   Commun Biol 7 (1), 1322 (2024)
   PUBMED   39402275
  REMARK    GeneRIF: Golgi-localized Ring Finger Protein 121 is necessary for
            MYCN-driven neuroblastoma tumorigenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2596)
  AUTHORS   Guan,J., Li,M., Wang,Y., Zhang,Y., Que,Y., Lu,S., Wang,J., Zhu,J.,
            Huang,J., Zhen,Z., Sun,F., Song,M. and Zhang,Y.
  TITLE     MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified
            neuroblastoma
  JOURNAL   Cell Death Dis 15 (2), 124 (2024)
   PUBMED   38336749
  REMARK    GeneRIF: MTHFD1 regulates the NADPH redox homeostasis in
            MYCN-amplified neuroblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2596)
  AUTHORS   Gao,W., Guo,N., Yan,H., Zhao,S., Sun,Y. and Chen,Z.
  TITLE     Mycn ameliorates cardiac hypertrophy-induced heart failure in mice
            by mediating the USP2/JUP/Akt/beta-catenin cascade
  JOURNAL   BMC Cardiovasc Disord 24 (1), 82 (2024)
   PUBMED   38297207
  REMARK    GeneRIF: Mycn ameliorates cardiac hypertrophy-induced heart failure
            in mice by mediating the USP2/JUP/Akt/beta-catenin cascade.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2596)
  AUTHORS   Weiss,A.C., Blank,E., Bohnenpoll,T., Kleppa,M.J., Rivera-Reyes,R.,
            Taketo,M.M., Trowe,M.O. and Kispert,A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   5  (bases 1 to 2596)
  AUTHORS   Sendra,M., de Dios Hourcade,J., Temino,S., Sarabia,A.J.,
            Ocana,O.H., Dominguez,J.N. and Torres,M.
  TITLE     Cre recombinase microinjection for single-cell tracing and
            localised gene targeting
  JOURNAL   Development 150 (3) (2023)
   PUBMED   36734327
REFERENCE   6  (bases 1 to 2596)
  AUTHORS   Charron,J., Malynn,B.A., Fisher,P., Stewart,V., Jeannotte,L.,
            Goff,S.P., Robertson,E.J. and Alt,F.W.
  TITLE     Embryonic lethality in mice homozygous for a targeted disruption of
            the N-myc gene
  JOURNAL   Genes Dev 6 (12A), 2248-2257 (1992)
   PUBMED   1459450
REFERENCE   7  (bases 1 to 2596)
  AUTHORS   Stanton,B.R., Perkins,A.S., Tessarollo,L., Sassoon,D.A. and
            Parada,L.F.
  TITLE     Loss of N-myc function results in embryonic lethality and failure
            of the epithelial component of the embryo to develop
  JOURNAL   Genes Dev 6 (12A), 2235-2247 (1992)
   PUBMED   1459449
REFERENCE   8  (bases 1 to 2596)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   9  (bases 1 to 2596)
  AUTHORS   Mukherjee,B., Morgenbesser,S.D. and DePinho,R.A.
  TITLE     Myc family oncoproteins function through a common pathway to
            transform normal cells in culture: cross-interference by Max and
            trans-acting dominant mutants
  JOURNAL   Genes Dev 6 (8), 1480-1492 (1992)
   PUBMED   1644290
REFERENCE   10 (bases 1 to 2596)
  AUTHORS   Moens,C.B., Auerbach,A.B., Conlon,R.A., Joyner,A.L. and Rossant,J.
  TITLE     A targeted mutation reveals a role for N-myc in branching
            morphogenesis in the embryonic mouse lung
  JOURNAL   Genes Dev 6 (5), 691-704 (1992)
   PUBMED   1577267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146696.1 and BY644089.1.
            
            On Dec 11, 2007 this sequence version replaced NM_008709.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005453.1, AK146696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2590              AK146696.1         2-2591
            2591-2596           BY644089.1         351-356
FEATURES             Location/Qualifiers
     source          1..2596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 6.14 cM"
     gene            1..2596
                     /gene="Mycn"
                     /gene_synonym="bHLHe37; c-nmyc; N-myc; Nmyc; Nmyc-1;
                     Nmyc1"
                     /note="v-myc avian myelocytomatosis viral related
                     oncogene, neuroblastoma derived"
                     /db_xref="GeneID:18109"
                     /db_xref="MGI:MGI:97357"
     exon            1..201
                     /gene="Mycn"
                     /gene_synonym="bHLHe37; c-nmyc; N-myc; Nmyc; Nmyc-1;
                     Nmyc1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..1078
                     /gene="Mycn"
                     /gene_synonym="bHLHe37; c-nmyc; N-myc; Nmyc; Nmyc-1;
                     Nmyc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..2596
                     /gene="Mycn"
                     /gene_synonym="bHLHe37; c-nmyc; N-myc; Nmyc; Nmyc-1;
                     Nmyc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2572..2577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mycn"
                     /gene_synonym="bHLHe37; c-nmyc; N-myc; Nmyc; Nmyc-1;
                     Nmyc1"
                     /note="hexamer: AATAAA"
     polyA_site      2592
                     /gene="Mycn"
                     /gene_synonym="bHLHe37; c-nmyc; N-myc; Nmyc; Nmyc-1;
                     Nmyc1"
                     /note="major polyA site"
ORIGIN      
        1 agtgacagtc atctgtctgg acgcgctggg tggatgcggg gggctcctgg gaactgggtt
       61 ggagccgaac gagcgctagc caggcgtaag cgcgcacaca ctgcagccgc cggaggacaa
      121 ccccctcccg ccgccgctcc ctcagcccac ccggagaccc cagccccgag tcgcctccgg
      181 atccccggca gtctgcggga gagttggagg ttggcgcgac tctgctgctc tccacgggaa
      241 ggaagcactc ccccatatta aaaagagcgg agatattaaa agagaggcga acccatgccc
      301 agctgcaccg cgtccaccat gccggggatg atctgcaaga acccagacct cgagtttgac
      361 tcactgcagc cctgcttcta cccggacgaa gatgacttct acttcggcgg tcccgactcg
      421 accccaccgg gggaggacat ctggaagaag tttgagctgc tgcccacgcc cccgttgtcg
      481 cccagccgcg ccttcccaga gcacagcccg gagccttcga attgggctac ggagatgctg
      541 ctgccggagg ccgacctgtg gggcaacccg gccgaggagg atgcgttcgg tctcgggggc
      601 ctgggtggcc tcactcctaa tccggtcatc cttcaggact gcatgtggag cggcttctct
      661 gcccgcgaga agctagagcg cgcagtgaac gaaaaactac agcacggcca cgggcccccg
      721 ggcgtcagct cagcctgctc ggctcccgga gtgggtgcca gcagccccgg gggccgtgcc
      781 cttggtgggt cgtcgagtgc tagccacacc ggggccaccc tgcctaccga cctctcccac
      841 ccggctgccg aatgtgtgga ccccgccgtg gtcttcccct tcccggtgaa caagcgagag
      901 tcggcgtcgg tgcccgctgc ccccactagc gccccggcga ccagcgctgc ggtcactagt
      961 gtgtctgttc cagctactgc cccggtggct gctcctgctc gtgcaggcgg ccgtcctgcc
     1021 agcagtgggg aggccaaggc cctcagcacc tccggagagg ataccttgag cgactcagat
     1081 gatgaggatg acgaggagga agatgaagag gaggaaatcg atgtggtcac cgtagagaag
     1141 agacgttcct cctctaacaa caaggcggta accactttca cgatcactgt gcgtcccaag
     1201 acctccgctc tgggcctggg gcgagcacag cctggcgagc tgatcctcaa gcgctgtgtt
     1261 cccatccatc agcagcacaa ctatgctgca ccctcaccct acgtggagag cgaggacgcg
     1321 cccccgcaga aaaagatcaa gagcgaggct tctccacgcc ccctcaaaag tgttgttcca
     1381 gcaaaagcga agagcctgag cccccgaaac tcagactcgg aggacagcga gcgccgccgc
     1441 aaccacaaca tcctggagcg tcaacgccgg aacgacctgc gctccagctt cctgacgctc
     1501 agggaccatg tgcctgagct ggtgaagaac gagaaggccg ccaaggtggt catcttgaaa
     1561 aaggccaccg agtacgtgca cgccctacag gccaacgagc accagctcct gctggaaaag
     1621 gagaaactgc aggcgaggca gcagcagttg ctaaagaaga tcgaacacgc tcggacttgc
     1681 taaacgtttc ccacacggac agtcactgcc actttgcaca ttttgatttt tttttttttt
     1741 taaacaaaca ttgtgttgac attaagaatg ttggtttact ttcaaattgg tcccctgtcg
     1801 agtctggatc tgggtagggg gcaggacacg gggttctgcc atgaccttgg aaaaaaaact
     1861 gacttatggg atgctgggtg gcttgttttc ctcctccata tcacctggtg acagccgtgg
     1921 aagttcggga cactaaggag cttcaggagg ctgtgaagtc accttgttcc ggtccaagat
     1981 tccaaacaga gtcattcctt ctttttacaa tggtgcttaa gttccagcaa atgccacaga
     2041 agggggggtt gccatttgat gcccctggga acacttgtgt aaataccatt gatacacccg
     2101 ccttttgtat acgtcctggg taatgagagg tggctcttgc ggccagtatt agactggaag
     2161 ttcacaccta agtactgtaa gaatacctca atgtttgagg ggcatgtttt gtatacaaat
     2221 atattgttaa tctgttatgt actgtactaa ttcctacacg gcctgtatac tttagtatga
     2281 cgctgataca taactaaatt tgatacttat attttcgtat gaaaatgagt tgtggaagtt
     2341 ttgagtagat attactttat cactttttga actaagaaac ttttgtaaag aaattttact
     2401 atatatatat attccttttt ttcctagcct gtttcttcct tgtttactgt atttgttcat
     2461 gtttggtgca tagaactggg taaaatggca aagttctgtg tttaatttct tcaaaatgta
     2521 tatatttagt gctgcacctt agagcacttt gaaatacctc atgtttatga aaataaatag
     2581 caattaaatg atgcaa
//
