LOCUS       NM_019660               1485 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus MYC binding protein (Mycbp), mRNA.
ACCESSION   NM_019660
VERSION     NM_019660.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1485)
  AUTHORS   Lin,C., Yao,E., Wang,K., Nozawa,Y., Shimizu,H., Johnson,J.R.,
            Chen,J.N., Krogan,N.J. and Chuang,P.T.
  TITLE     Regulation of Sufu activity by p66beta and Mycbp provides new
            insight into vertebrate Hedgehog signaling
  JOURNAL   Genes Dev 28 (22), 2547-2563 (2014)
   PUBMED   25403183
REFERENCE   2  (bases 1 to 1485)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   3  (bases 1 to 1485)
  AUTHORS   Nakagawa,M., Takizawa,N., Narita,M., Ichisaka,T. and Yamanaka,S.
  TITLE     Promotion of direct reprogramming by transformation-deficient Myc
  JOURNAL   Proc Natl Acad Sci U S A 107 (32), 14152-14157 (2010)
   PUBMED   20660764
  REMARK    GeneRIF: L-Myc, as well as c-Myc mutants (W136E and dN2), all of
            which have little transformation activity, promoted human iPSC
            generation more efficiently and specifically compared with WT
            c-Myc.
REFERENCE   4  (bases 1 to 1485)
  AUTHORS   Liu,T., Cheng,W., Liu,T., Guo,L., Huang,Q., Jiang,L., Du,X., Xu,F.,
            Liu,Z. and Lai,D.
  TITLE     Human amniotic epithelial cell feeder layers maintain mouse
            embryonic stem cell pluripotency via epigenetic regulation of the
            c-Myc promoter
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 42 (2), 109-115 (2010)
   PUBMED   20119621
  REMARK    GeneRIF: These data suggested that hAECs can alter mouse ESC gene
            expression via epigenetic modification of c-Myc, providing a
            possible mechanism for the hAEC-induced maintenance of ESCs in an
            undifferentiated state.
REFERENCE   5  (bases 1 to 1485)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 1485)
  AUTHORS   Welstead,G.G., Brambrink,T. and Jaenisch,R.
  TITLE     Generating iPS cells from MEFS through forced expression of Sox-2,
            Oct-4, c-Myc, and Klf4
  JOURNAL   J Vis Exp (14), 734 (2008)
   PUBMED   19066578
  REMARK    GeneRIF: The advantage of this system over the traditional
            retroviral infection is the ability to turn the genes on and off so
            that the kinetics of reprogramming and gene expression requirements
            can be analyzed in detail.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1485)
  AUTHORS   Liu,J., Puscheck,E.E., Wang,F., Trostinskaia,A., Barisic,D.,
            Maniere,G., Wygle,D., Zhong,W., Rings,E.H. and Rappolee,D.A.
  TITLE     Serine-threonine kinases and transcription factors active in signal
            transduction are detected at high levels of phosphorylation during
            mitosis in preimplantation embryos and trophoblast stem cells
  JOURNAL   Reproduction 128 (5), 643-654 (2004)
   PUBMED   15509711
REFERENCE   8  (bases 1 to 1485)
  AUTHORS   Furusawa,M., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Molecular cloning of the mouse AMY-1 gene and identification of the
            synergistic activation of the AMY-1 promoter by GATA-1 and Sp1
  JOURNAL   Genomics 81 (2), 221-233 (2003)
   PUBMED   12620400
REFERENCE   9  (bases 1 to 1485)
  AUTHORS   Yukitake,H., Furusawa,M., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     AAT-1, a novel testis-specific AMY-1-binding protein, forms a
            quaternary complex with AMY-1, A-kinase anchor protein 84, and a
            regulatory subunit of cAMP-dependent protein kinase and is
            phosphorylated by its kinase
  JOURNAL   J Biol Chem 277 (47), 45480-45492 (2002)
   PUBMED   12223483
  REMARK    GeneRIF: identified a novel AMY-1-binding protein, AAT-1, and
            determied its expression profiles, genes, and cellular
            localization; results showed that AAT-1 was specifically expressed
            in the testis throughout spermatogenesis and was also present in
            mature sperm
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK145773.1.
            
            On Apr 5, 2007 this sequence version replaced NM_019660.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077762.1, AK077995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1485              AK145773.1         2-1486
FEATURES             Location/Qualifiers
     source          1..1485
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.42 cM"
     gene            1..1485
                     /gene="Mycbp"
                     /gene_synonym="5730488M09Rik; Amy-1"
                     /note="MYC binding protein"
                     /db_xref="GeneID:56309"
                     /db_xref="MGI:MGI:1891750"
     exon            1..75
                     /gene="Mycbp"
                     /gene_synonym="5730488M09Rik; Amy-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..372
                     /gene="Mycbp"
                     /gene_synonym="5730488M09Rik; Amy-1"
                     /note="associate of Myc 1; c-myc binding protein"
                     /codon_start=1
                     /product="C-Myc-binding protein"
                     /protein_id="NP_062634.2"
                     /db_xref="CCDS:CCDS18621.1"
                     /db_xref="GeneID:56309"
                     /db_xref="MGI:MGI:1891750"
                     /translation="MAHYKAADSKREQFRRYLEKSGVLDTLTKVLVALYEEPEKPTSA
                     LDFLKHHLGAATPENPEIELLRLELAEMKEKYEATVEENKKLKAKLVQYEPPQEEKRA
                     E"
     exon            76..148
                     /gene="Mycbp"
                     /gene_synonym="5730488M09Rik; Amy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..197
                     /gene="Mycbp"
                     /gene_synonym="5730488M09Rik; Amy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..327
                     /gene="Mycbp"
                     /gene_synonym="5730488M09Rik; Amy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..1485
                     /gene="Mycbp"
                     /gene_synonym="5730488M09Rik; Amy-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      530..535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mycbp"
                     /gene_synonym="5730488M09Rik; Amy-1"
                     /note="hexamer: AATAAA"
     polyA_site      547
                     /gene="Mycbp"
                     /gene_synonym="5730488M09Rik; Amy-1"
                     /note="major polyA site"
ORIGIN      
        1 gaggcttgga gcccgcctgc ccgtgtctcc ggcgccagct acgccgctgt ggctgtcact
       61 atggcccatt acaaagccgc cgactcgaag cgcgagcagt tccggaggta cttggagaag
      121 tcgggggtgc tggacacgct gacgaaagtg ttggtagcct tatatgaaga accagagaag
      181 cccaccagtg ctctggattt tttaaagcat cacttaggag ctgctacccc ggaaaaccca
      241 gaaatagagc tgcttcgcct agaattggca gaaatgaaag agaaatatga agctactgta
      301 gaagaaaata aaaaactgaa agcaaagctt gttcagtatg aaccacctca ggaggagaag
      361 cgtgctgaat aggattcttc tcagttgaaa agacactgaa aactggtttt gtatcacttg
      421 aatagcttgt atagtatatg atctttcctg aaaagatgct ataaactttt aatatgttaa
      481 atccactcat cacactttaa tgttataaac acatatacat agaatcacca ataaaaactc
      541 aatataactt tctttgggtc ttaaagcagg agaatccaaa gtagatcttg aagaaaagct
      601 aaagagccac ataacttttt accttaaaag acattttatt tattatccag ttaggaatga
      661 tggtactggt tgtattttag ctaggagatc tagcatggag ctgttccttg gtccagggct
      721 tgagcatagt aggcacactc attcttgaca gcatctatgt cctgtggaca gctggacata
      781 tctgtgatgt acaatgcctt tgcatgggtt cccgtgcatc ttctgctctt ttatagaaat
      841 ctagtacaaa ttactcttct ttgccaccac tttgccttag atcactgtgt gtgccagtat
      901 ggactctgac accacgtttt ctttctatgc aatcctgccc atctgataat gctgccttgc
      961 tgtgtgtgct ttagtgcgtt ctggttgcac attagtctgt gtcgttttca gtttgtgtaa
     1021 tgctgcagct accttgattg taatttacat agcctccaaa agaactacac tcttaccctg
     1081 cctgccttcc ttccttcttt agttgagcac agaagagaga taaaattctg agttcataca
     1141 caaactggga tgggaaagga gatgaaccat tatgtcacag atcattatag tatgtaatta
     1201 tacagtgatt tctttcccct caaacatatt tttttgagcc ttgaattcat tttatcttta
     1261 ttatccctgt gaagtaggta gggtagtgaa gggaaggttg ggtgttgagt ttttaggcca
     1321 aagactgaca tacagatttg ttgctaactg tagaaacctg ggcaggtcag ttaatggttt
     1381 ggagattcac tatcctcatc tgtaccatga aaacatttgc tgcctacctc acagggttgt
     1441 tgtgaggtca aatgagagaa tgtatatgaa agatttgtaa atggt
//
