LOCUS       NM_010849               2399 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus myelocytomatosis oncogene (Myc), transcript variant 1,
            mRNA.
ACCESSION   NM_010849
VERSION     NM_010849.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Warren,R., Klinkhammer,K., Lyu,H., Knopp,J., Yuan,T., Yao,C.,
            Stripp,B. and De Langhe,S.P.
  TITLE     Cell competition drives bronchiolization and pulmonary fibrosis
  JOURNAL   Nat Commun 15 (1), 10624 (2024)
   PUBMED   39639058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Nakagawa,R., Llorian,M., Varsani-Brown,S., Chakravarty,P.,
            Camarillo,J.M., Barry,D., George,R., Blackledge,N.P., Duddy,G.,
            Kelleher,N.L., Klose,R.J., Turner,M. and Calado,D.P.
  TITLE     Epi-microRNA mediated metabolic reprogramming counteracts hypoxia
            to preserve affinity maturation
  JOURNAL   Nat Commun 15 (1), 10516 (2024)
   PUBMED   39627218
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Spotts,G.D., Patel,S.V., Xiao,Q. and Hann,S.R.
  TITLE     Identification of downstream-initiated c-Myc proteins which are
            dominant-negative inhibitors of transactivation by full-length
            c-Myc proteins
  JOURNAL   Mol Cell Biol 17 (3), 1459-1468 (1997)
   PUBMED   9032273
REFERENCE   4  (bases 1 to 2399)
  AUTHORS   Mueller,R.E., Baggio,L., Kozak,C.A. and Ball,J.K.
  TITLE     A common integration locus in type B retrovirus-induced thymic
            lymphomas
  JOURNAL   Virology 191 (2), 628-637 (1992)
   PUBMED   1333116
REFERENCE   5  (bases 1 to 2399)
  AUTHORS   Roberts,S., Purton,T. and Bentley,D.L.
  TITLE     A protein-binding site in the c-myc promoter functions as a
            terminator of RNA polymerase II transcription
  JOURNAL   Genes Dev 6 (8), 1562-1574 (1992)
   PUBMED   1644297
REFERENCE   6  (bases 1 to 2399)
  AUTHORS   Hann,S.R., Sloan-Brown,K. and Spotts,G.D.
  TITLE     Translational activation of the non-AUG-initiated c-myc 1 protein
            at high cell densities due to methionine deprivation
  JOURNAL   Genes Dev 6 (7), 1229-1240 (1992)
   PUBMED   1628829
REFERENCE   7  (bases 1 to 2399)
  AUTHORS   Hirning-Folz,U., Winking,H. and Hameister,H.
  TITLE     Aberrant Myc expression in the murine trisomy 15 syndrome is
            correlated with prolonged proliferation in spongiotrophoblast cells
            of the placenta
  JOURNAL   Cytogenet Cell Genet 61 (4), 289-294 (1992)
   PUBMED   1283123
REFERENCE   8  (bases 1 to 2399)
  AUTHORS   Hann,S.R., King,M.W., Bentley,D.L., Anderson,C.W. and Eisenman,R.N.
  TITLE     A non-AUG translational initiation in c-myc exon 1 generates an
            N-terminally distinct protein whose synthesis is disrupted in
            Burkitt's lymphomas
  JOURNAL   Cell 52 (2), 185-195 (1988)
   PUBMED   3277717
REFERENCE   9  (bases 1 to 2399)
  AUTHORS   Stanton,L.W., Fahrlander,P.D., Tesser,P.M. and Marcu,K.B.
  TITLE     Nucleotide sequence comparison of normal and translocated murine
            c-myc genes
  JOURNAL   Nature 310 (5976), 423-425 (1984)
   PUBMED   6462227
REFERENCE   10 (bases 1 to 2399)
  AUTHORS   Stanton,L.W., Yang,J.Q., Eckhardt,L.A., Harris,L.J., Birshtein,B.K.
            and Marcu,K.B.
  TITLE     Products of a reciprocal chromosome translocation involving the
            c-myc gene in a murine plasmacytoma
  JOURNAL   Proc Natl Acad Sci U S A 81 (3), 829-833 (1984)
   PUBMED   6322170
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE853266.1, BB858498.1,
            BC138931.1 and BE456204.1.
            
            On May 25, 2006 this sequence version replaced NM_010849.3.
            
            Summary: The protein encoded by this gene is a multifunctional,
            nuclear phosphoprotein that plays a role in cell cycle progression,
            apoptosis and cellular transformation. It functions as a
            transcription factor that regulates transcription of specific
            target genes. Mutations, overexpression, rearrangement and
            translocation of this gene have been associated with a variety of
            hematopoietic tumors, leukemias and lymphomas, including Burkitt
            lymphoma, in human. There is evidence to show that alternative
            translation initiations from an upstream, in-frame non-AUG (CUG)
            and a downstream AUG start site result in the production of two
            isoforms with distinct N-termini, in human and mouse. Under
            conditions of stress, such as high cell densities and methionine
            deprivation, there is a specific and dramatic increase in the
            synthesis of the non-AUG initiated protein, suggesting its
            importance in times of adversity. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes two isoforms due to the use of alternative
            translation initiation codons. The longer isoform (a, also known as
            c-Myc 1) is derived from a non-AUG (CUG) start codon, while a
            shorter isoform (b, also known as c-Myc 2) is derived from a
            downstream AUG start codon. The longer isoform (a) is represented
            in this RefSeq.
            
            CCDS Note: This CCDS ID represents the longest c-Myc isoform, also
            known as c-Myc 1. Evidence in the literature, including in PMIDs
            1628829, 3277717 and 9032273, shows that the transcript can produce
            multiple isoforms due to the use of alternative translation
            initiation codons. This transcript variant is supported by several
            transcripts, including the long mRNAs X01023.1, AK145084.1 and
            BC138932.1. This isoform initiates translation at a non-AUG (CUG)
            start codon that is well-conserved. Alternative translation
            initiation at a downstream AUG start codon also produces a shorter
            isoform, known as c-Myc 2. The shorter isoform is represented by
            CCDS 49615.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145084.1, X01023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 1628829
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               BE853266.1         1-343               c
            344-537             BB858498.1         139-332
            538-2026            BC138931.1         1-1489
            2027-2399           BE456204.1         1-373               c
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 26.19 cM"
     gene            1..2399
                     /gene="Myc"
                     /gene_synonym="bHLHe39; Myc2; Niard; Nird"
                     /note="myelocytomatosis oncogene"
                     /db_xref="GeneID:17869"
                     /db_xref="MGI:MGI:97250"
     exon            1..611
                     /gene="Myc"
                     /gene_synonym="bHLHe39; Myc2; Niard; Nird"
                     /inference="alignment:Splign:2.1.0"
     CDS             582..1946
                     /gene="Myc"
                     /gene_synonym="bHLHe39; Myc2; Niard; Nird"
                     /note="isoform a is encoded by transcript variant 1;
                     non-AUG (CUG) translation initiation codon; c-myc
                     proto-oncogene; transcription factor p64"
                     /codon_start=1
                     /product="myc proto-oncogene protein isoform a"
                     /protein_id="NP_034979.3"
                     /db_xref="CCDS:CCDS27504.1"
                     /db_xref="GeneID:17869"
                     /db_xref="MGI:MGI:97250"
                     /translation="MDFLWALETPQTATTMPLNVNFTNRNYDLDYDSVQPYFICDEEE
                     NFYHQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDD
                     DGGGGNFSTADQLEMMTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKL
                     VSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDS
                     SSPKSCTSSDSTAFSPSSDSLLSSESSPRASPEPLVLHEETPPTTSSDSEEEQEDEEE
                     IDVVSVEKRQTPAKRSESGSSPSRGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDY
                     PAAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHNVLERQRRNELKRSFFAL
                     RDQIPELENNEKAPKVVILKKATAYILSIQADEHKLTSEKDLLRKRREQLKHKLEQLR
                     NSGA"
     exon            612..1383
                     /gene="Myc"
                     /gene_synonym="bHLHe39; Myc2; Niard; Nird"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..2399
                     /gene="Myc"
                     /gene_synonym="bHLHe39; Myc2; Niard; Nird"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2377..2382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myc"
                     /gene_synonym="bHLHe39; Myc2; Niard; Nird"
                     /note="hexamer: AATAAA"
     polyA_site      2398
                     /gene="Myc"
                     /gene_synonym="bHLHe39; Myc2; Niard; Nird"
                     /note="major polyA site"
ORIGIN      
        1 cccgcccacc cgccctttat attccggggg tctgcgcggc cgaggacccc tgggctgcgc
       61 tgctctcagc tgccgggtcc gactcgcctc actcagctcc cctcctgcct cctgaagggc
      121 agggcttcgc cgacgcttgg cgggaaaaag aagggagggg agggatcctg agtcgcagta
      181 taaaagaagc ttttcgggcg tttttttctg actcgctgta gtaattccag cgagagacag
      241 agggagtgag cggacggttg gaagagccgt gtgtgcagag ccgcgctccg gggcgaccta
      301 agaaggcagc tctggagtga gaggggcttt gcctccgagc ctgccgccca ctctccccaa
      361 ccctgcgact gacccaacat cagcggccgc aaccctcgcc gccgctggga aactttgccc
      421 attgcagcgg gcagacactt ctcactggaa cttacaatct gcgagccagg acaggactcc
      481 ccaggctccg gggagggaat ttttgtctat ttggggacag tgttctctgc ctctgcccgc
      541 gatcagctct cctgaaaaga gctcctcgag ctgtttgaag gctggatttc ctttgggcgt
      601 tggaaacccc gcagacagcc acgacgatgc ccctcaacgt gaacttcacc aacaggaact
      661 atgacctcga ctacgactcc gtacagccct atttcatctg cgacgaggaa gagaatttct
      721 atcaccagca acagcagagc gagctgcagc cgcccgcgcc cagtgaggat atctggaaga
      781 aattcgagct gcttcccacc ccgcccctgt ccccgagccg ccgctccggg ctctgctctc
      841 catcctatgt tgcggtcgct acgtccttct ccccaaggga agacgatgac ggcggcggtg
      901 gcaacttctc caccgccgat cagctggaga tgatgaccga gttacttgga ggagacatgg
      961 tgaaccagag cttcatctgc gatcctgacg acgagacctt catcaagaac atcatcatcc
     1021 aggactgtat gtggagcggt ttctcagccg ctgccaagct ggtctcggag aagctggcct
     1081 cctaccaggc tgcgcgcaaa gacagcacca gcctgagccc cgcccgcggg cacagcgtct
     1141 gctccacctc cagcctgtac ctgcaggacc tcaccgccgc cgcgtccgag tgcattgacc
     1201 cctcagtggt ctttccctac ccgctcaacg acagcagctc gcccaaatcc tgtacctcgt
     1261 ccgattccac ggccttctct ccttcctcgg actcgctgct gtcctccgag tcctccccac
     1321 gggccagccc tgagccccta gtgctgcatg aggagacacc gcccaccacc agcagcgact
     1381 ctgaagaaga gcaagaagat gaggaagaaa ttgatgtggt gtctgtggag aagaggcaaa
     1441 cccctgccaa gaggtcggag tcgggctcat ctccatcccg aggccacagc aaacctccgc
     1501 acagcccact ggtcctcaag aggtgccacg tctccactca ccagcacaac tacgccgcac
     1561 ccccctccac aaggaaggac tatccagctg ccaagagggc caagttggac agtggcaggg
     1621 tcctgaagca gatcagcaac aaccgcaagt gctccagccc caggtcctca gacacggagg
     1681 aaaacgacaa gaggcggaca cacaacgtct tggaacgtca gaggaggaac gagctgaagc
     1741 gcagcttttt tgccctgcgt gaccagatcc ctgaattgga aaacaacgaa aaggccccca
     1801 aggtagtgat cctcaaaaaa gccaccgcct acatcctgtc cattcaagca gacgagcaca
     1861 agctcacctc tgaaaaggac ttattgagga aacgacgaga acagttgaaa cacaaactcg
     1921 aacagcttcg aaactctggt gcataaactg acctaactcg aggaggagct ggaatctctc
     1981 gtgagagtaa ggagaacggt tccttctgac agaactgatg cgctggaatt aaaatgcatg
     2041 ctcaaagcct aacctcacaa ccttggctgg ggctttggga ctgtaagctt cagccataat
     2101 tttaactgcc tcaaacttaa atagtataaa agaacttttt tttatgcttc ccatcttttt
     2161 tctttttcct tttaacagat ttgtatttaa ttgttttttt aaaaaaatct taaaatctat
     2221 ccaattttcc catgtaaata gggccttgaa atgtaaataa ctttaataaa acgtttataa
     2281 cagttacaaa agattttaag acatgtacca taattttttt tatttaaaga cattttcatt
     2341 tttaaagttg atttttttct attgttttta gaaaaaaata aaataattgg aaaaaatac
//
