LOCUS       NM_026831               1287 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus myosin binding protein H-like (Mybphl), mRNA.
ACCESSION   NM_026831 XM_131077
VERSION     NM_026831.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1287)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1287)
  AUTHORS   Barefield,D.Y., Yamakawa,S., Tahtah,I., Sell,J.J., Broman,M.,
            Laforest,B., Harris,S., Alvarez-Arce,A., Araujo,K.N.,
            Puckelwartz,M.J., Wasserstrom,J.A., Fishman,G.I. and McNally,E.M.
  TITLE     Partial and complete loss of myosin binding protein H-like cause
            cardiac conduction defects
  JOURNAL   J Mol Cell Cardiol 169, 28-40 (2022)
   PUBMED   35533732
  REMARK    GeneRIF: Partial and complete loss of myosin binding protein H-like
            cause cardiac conduction defects.
REFERENCE   3  (bases 1 to 1287)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1287)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   5  (bases 1 to 1287)
  AUTHORS   Barefield,D.Y., Puckelwartz,M.J., Kim,E.Y., Wilsbacher,L.D.,
            Vo,A.H., Waters,E.A., Earley,J.U., Hadhazy,M.,
            Dellefave-Castillo,L., Pesce,L.L. and McNally,E.M.
  TITLE     Experimental Modeling Supports a Role for MyBP-HL as a Novel
            Myofilament Component in Arrhythmia and Dilated Cardiomyopathy
  JOURNAL   Circulation 136 (16), 1477-1491 (2017)
   PUBMED   28778945
  REMARK    GeneRIF: Report reduced ventricular function and conduction system
            defects in Mybphl knockout mice.
REFERENCE   6  (bases 1 to 1287)
  AUTHORS   Geyer,S.H., Reissig,L., Rose,J., Wilson,R., Prin,F., Szumska,D.,
            Ramirez-Solis,R., Tudor,C., White,J., Mohun,T.J. and Weninger,W.J.
  TITLE     A staging system for correct phenotype interpretation of mouse
            embryos harvested on embryonic day 14 (E14.5)
  JOURNAL   J Anat 230 (5), 710-719 (2017)
   PUBMED   28185240
REFERENCE   7  (bases 1 to 1287)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1287)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   9  (bases 1 to 1287)
  AUTHORS   Lewandowski,S.L., Janardhan,H.P., Smee,K.M., Bachman,M., Sun,Z.,
            Lazar,M.A. and Trivedi,C.M.
  TITLE     Histone deacetylase 3 modulates Tbx5 activity to regulate early
            cardiogenesis
  JOURNAL   Hum Mol Genet 23 (14), 3801-3809 (2014)
   PUBMED   24565863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY704393.1, AK004148.1 and BC089625.1.
            
            On Sep 15, 2005 this sequence version replaced XM_131077.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089625.1, AK004148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-781               BY704393.1         2-782
            782-1275            AK004148.1         783-1276
            1276-1287           BC089625.1         1264-1275
FEATURES             Location/Qualifiers
     source          1..1287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.98 cM"
     gene            1..1287
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /note="myosin binding protein H-like"
                     /db_xref="GeneID:68753"
                     /db_xref="MGI:MGI:1916003"
     exon            1..234
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1154
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /codon_start=1
                     /product="myosin-binding protein H-like"
                     /protein_id="NP_081107.1"
                     /db_xref="CCDS:CCDS17757.1"
                     /db_xref="GeneID:68753"
                     /db_xref="MGI:MGI:1916003"
                     /translation="METATTLEIASCSQRQVEAAADPADAKGPRTSHQQEAGSPSLQL
                     LPSIEEHPKIWLPRALKQTYIRKAGETVNLLIPIQGKPKPQTTWTHNGCALDSSRVSV
                     RNGEHDSILFIREAQRTDSGCYQLCVQLGGLQATATINILVIEKPGPPQSIKLVDVWG
                     ANATLEWTPPQDTGNTALLGYTVQKADKKSGLWFTVLERYHRTSCVVSNLIVGNSYAF
                     RVFAENQCGLSDTAPVTADLAHIQKAATVYKAKGFAQRDLSEAPKFTQPLADCTTVTG
                     YDTQLFCCVRASPRPKIIWLKNKMDLQGNPKYRALSQLGICSLEIRKPSPFDGGIYTC
                     KAINALGEASVDCRVDVKAPH"
     exon            235..323
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            324..519
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            520..659
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            660..819
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            820..956
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1143
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1187
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1276
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1257..1262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1276
                     /gene="Mybphl"
                     /gene_synonym="1110037P11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgaccccag ggagaccagc ctggacagca ggtgcacagc ccctccctca ccagcaacaa
       61 agaaaatttt cagctagacc ccaggcatgg agacagccac cacactggag atagcctcat
      121 gctcccagcg gcaggtagaa gcagctgctg acccagcgga tgctaaagga ccccggactt
      181 cacatcaaca ggaggcaggc agcccttctc tgcagctcct gccctctatt gaagagcacc
      241 ccaagatctg gctacctcgg gccctgaagc agacttacat ccggaaggct ggggagacag
      301 tgaatctact aatcccgatc cagggtaagc ccaaacctca aaccacctgg actcacaatg
      361 gctgtgccct ggacagcagc cgtgtcagcg tgcggaatgg ggagcatgac tctattcttt
      421 tcatcagaga ggcccaacgc actgactcag gatgctacca actctgtgtg cagctcggtg
      481 ggctgcaggc cactgccacc atcaatatcc tggtgatcga gaagccaggc cctcctcaga
      541 gtattaagtt ggtggacgtt tggggcgcca atgctactct ggaatggaca cctccacaag
      601 atacgggcaa tacagctctc ctgggataca cggtgcagaa ggctgacaaa aaatctgggc
      661 tctggttcac agtcctggag cgttaccacc gaaccagctg cgttgtctcc aatctcattg
      721 ttggcaactc ctatgccttc cgggtctttg cggagaacca gtgtgggctc agcgacacag
      781 cccctgtcac agctgacctt gcccacatcc agaaagcagc tactgtttac aaggccaagg
      841 ggtttgccca gcgggacctc tcagaagctc ccaagtttac ccagccgctg gcagactgca
      901 ctacagtcac tggctatgat acccagctct tctgctgtgt gcgtgcctct cccaggccca
      961 agatcatctg gctaaagaac aagatggacc tccaaggcaa ccccaagtac agagccctca
     1021 gtcagctggg gatctgctcc ctagaaatcc gcaagcctag ccccttcgat ggaggcatct
     1081 acacctgcaa ggccatcaat gctctggggg aggcatccgt ggactgtcgg gtggatgtta
     1141 aagctcctca ttaaggctgt cctaagaaga caggatatct gaggaagggc ctcctgggag
     1201 cctgactctg acaagactgt gtcctcaagg agcattagct ggcttggcct agactaaata
     1261 aatgtataca tcctcaaaaa aaaaaaa
//
