LOCUS       NM_016749               1856 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus myosin binding protein H (Mybph), transcript variant
            1, mRNA.
ACCESSION   NM_016749
VERSION     NM_016749.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Hayashi,S., Manabe,I., Suzuki,Y., Relaix,F. and Oishi,Y.
  TITLE     Klf5 regulates muscle differentiation by directly targeting
            muscle-specific genes in cooperation with MyoD in mice
  JOURNAL   Elife 5, e17462 (2016)
   PUBMED   27743478
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Gomez-Del Arco,P., Perdiguero,E., Yunes-Leites,P.S., Acin-Perez,R.,
            Zeini,M., Garcia-Gomez,A., Sreenivasan,K., Jimenez-Alcazar,M.,
            Segales,J., Lopez-Maderuelo,D., Ornes,B., Jimenez-Borreguero,L.J.,
            D'Amato,G., Enshell-Seijffers,D., Morgan,B., Georgopoulos,K.,
            Islam,A.B., Braun,T., de la Pompa,J.L., Kim,J., Enriquez,J.A.,
            Ballestar,E., Munoz-Canoves,P. and Redondo,J.M.
  TITLE     The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle
            Identity and Metabolic Homeostasis
  JOURNAL   Cell Metab 23 (5), 881-892 (2016)
   PUBMED   27166947
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Diehl,A.G., Zareparsi,S., Qian,M., Khanna,R., Angeles,R. and
            Gage,P.J.
  TITLE     Extraocular muscle morphogenesis and gene expression are regulated
            by Pitx2 gene dose
  JOURNAL   Invest Ophthalmol Vis Sci 47 (5), 1785-1793 (2006)
   PUBMED   16638982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA673795.1, U68267.1 and CB587371.1.
            
            On Dec 16, 2004 this sequence version replaced NM_016749.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68267.1, BC116684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AA673795.1         14-222
            210-800             U68267.1           204-794
            801-1532            CB587371.1         48-779
            1533-1538           CB587371.1         781-786
            1539-1545           CB587371.1         788-794
            1546-1856           U68267.1           1540-1850
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C3H"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.15 cM"
     gene            1..1856
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /note="myosin binding protein H"
                     /db_xref="GeneID:53311"
                     /db_xref="MGI:MGI:1858196"
     exon            1..279
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1508
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /note="H-protein"
                     /codon_start=1
                     /product="myosin-binding protein H"
                     /protein_id="NP_058029.2"
                     /db_xref="CCDS:CCDS35713.1"
                     /db_xref="GeneID:53311"
                     /db_xref="MGI:MGI:1858196"
                     /translation="MTGKATSEASVSTPEETAPEPAKVPTTEPSGEVAASESTGQEQA
                     PEPQKPQAQDPAAPAASAMPAATKPEPPSEDVPSAPLRLTLEDVSHSSLTVSWEPPEK
                     LGKLGLQGYVLEFCREGASEWVPVNPRPVMVTQQTVRNLALGDKFFLRVTAVSSAGAG
                     PPAVLDQPVHIQEITEAPKIRVPRHLRQTYIRQVGESVNLQIPFQGKPKPQVSWTHNG
                     HALDNQRVNVRSGDQDSILFIRSAQRADSGRYELTVHLEGLEAKASIDILVIEKPGPP
                     SSIKLLDVWGCNAALEWTPPQDTGNTELLGYTVQKADKRTGQWFTVLERYHPTTCTIS
                     DLIIGNSYSFRVFSENLCGLSDLATTTKELAHIHKADITAKPREFIERDFSEAPSFTQ
                     PLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKMDIQGDPKYRAVSEQGVCTLEIRKP
                     SPFDSGVYTCKAINVLGEASVDCRLEVKASATH"
     exon            280..414
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     exon            415..582
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     exon            583..671
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     exon            672..867
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1007
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1167
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1304
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1491
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1544
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1829
                     /gene="Mybph"
                     /gene_synonym="MyBP-H"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgaccctt aaacactcca gcttgacaca cccccccaca cacaccagct aaaaaaatga
       61 caggaaaagc cacctctgag gcttctgtct ctactccaga ggagacagca cctgagcctg
      121 ccaaggtgcc cactacagag ccttctggag aggtggcagc atcagagtcc accgggcaag
      181 agcaggctcc agagccacag aagcctcagg cacaggatcc tgcagctcct gcagcttctg
      241 ccatgcccgc agccactaag cctgaacctc cgagtgaaga tgtccccagt gccccactgc
      301 ggctgacctt ggaggatgtg agccacagct ccttgactgt gagctgggag ccccccgaga
      361 agctgggcaa actggggctt caaggctatg tgttggagtt ctgtcgagag ggagcctcag
      421 aatgggtgcc tgtgaatccc cggcccgtga tggtgaccca gcagacggtt cgaaacctgg
      481 ccctgggaga caagttcttc ctgcgtgtga ctgcagtaag ctcagcaggg gcaggccctc
      541 cagccgttct ggaccagcct gtccacatcc aagagatcac tgaagccccc aagatccgtg
      601 ttccccgaca ccttcgtcag acctacatcc gccaggtggg agagtcagtc aacctgcaaa
      661 tccccttcca ggggaagccc aagccacagg tctcttggac ccacaatggc cacgctctgg
      721 acaaccagag agttaatgtg cgcagcgggg accaggactc catcctcttc attcgctctg
      781 ctcagcgcgc agactcaggc cgctatgagc tcaccgtgca tctggaaggc ttggaagcca
      841 aggccagcat tgacatcctg gtgattgaga agcccgggcc cccgagcagc atcaagctac
      901 tggatgtctg gggttgcaat gctgccctcg agtggacacc accccaggac acaggcaaca
      961 cagagctcct gggctacaca gtacagaagg cagacaaaag gacagggcaa tggttcacag
     1021 tgttggagcg ctatcacccc accacctgca ccatctcaga cctcatcatt ggcaactcgt
     1081 actcttttcg ggtcttctca gaaaacctgt gtggcctcag tgacttagcc accaccacca
     1141 aggagctggc tcacatccac aaggcagata ttactgccaa acctagagag tttattgagc
     1201 gagacttctc agaagcgccc tcgttcaccc agcccctggc tgaccatacc tccactcctg
     1261 gctatagcac gcagcttttc tgcagcgtcc gagcatcacc taagcccaag atcatctgga
     1321 tgaaaaacaa gatggacatc cagggtgacc ccaagtaccg tgccgtctcc gagcaagggg
     1381 tctgcaccct ggagatccgg aagcccagcc cctttgattc tggggtctac acttgcaagg
     1441 ccatcaacgt gctaggggag gcctctgtgg attgtcggct ggaggttaaa gcttctgcca
     1501 cacactaaag agcaacagag gcagagactg ggacaaggag acagcttggt cacataccag
     1561 gacgcagaag gacactatcc accaagtcct gcagacctga ggatcaggac cccaggaatc
     1621 cccaagacca taggaacagc gaatggggcg gggtctctag tacctgcagg ccccctccat
     1681 cagacgctgg gtccagaccc aggatcaggc ctggcaggcc ccaggccata ccttctgggt
     1741 tcaagagggc ccagaagggg cagagactgg caccctcttc agagttgtac actgtatgag
     1801 aagtattcaa ataaaggtgt gtggtgttaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
