LOCUS       NM_008653               4163 bp    mRNA    linear   ROD 25-MAR-2023
DEFINITION  Mus musculus myosin binding protein C, cardiac (Mybpc3), mRNA.
ACCESSION   NM_008653
VERSION     NM_008653.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4163)
  AUTHORS   Zou X, Ouyang H, Lin F, Zhang H, Yang Y, Pang D, Han R and Tang X.
  TITLE     MYBPC3 deficiency in cardiac fibroblasts drives their activation
            and contributes to fibrosis
  JOURNAL   Cell Death Dis 13 (11), 948 (2022)
   PUBMED   36357371
  REMARK    GeneRIF: MYBPC3 deficiency in cardiac fibroblasts drives their
            activation and contributes to fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4163)
  AUTHORS   Stathopoulou K, Schnittger J, Raabe J, Fleischer F, Mangels N,
            Piasecki A, Findlay J, Hartmann K, Krasemann S, Schlossarek S,
            Uebeler J, Wixler V, Blake DJ, Baillie GS, Carrier L, Ehler E and
            Cuello F.
  TITLE     CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes
  JOURNAL   FEBS J 289 (15), 4622-4645 (2022)
   PUBMED   35176204
REFERENCE   3  (bases 1 to 4163)
  AUTHORS   Hall EJ, Pal S, Glennon MS, Shridhar P, Satterfield SL, Weber B,
            Zhang Q, Salama G, Lal H and Becker JR.
  TITLE     Cardiac natriuretic peptide deficiency sensitizes the heart to
            stress-induced ventricular arrhythmias via impaired CREB signalling
  JOURNAL   Cardiovasc Res 118 (9), 2124-2138 (2022)
   PUBMED   34329394
REFERENCE   4  (bases 1 to 4163)
  AUTHORS   Pal S, Nixon BR, Glennon MS, Shridhar P, Satterfield SL, Su YR and
            Becker JR.
  TITLE     Replication Stress Response Modifies Sarcomeric Cardiomyopathy
            Remodeling
  JOURNAL   J Am Heart Assoc 10 (15), e021768 (2021)
   PUBMED   34323119
REFERENCE   5  (bases 1 to 4163)
  AUTHORS   Ku MC, Kober F, Lai YC, Pohlmann A, Qadri F, Bader M, Carrier L and
            Niendorf T.
  TITLE     Cardiovascular magnetic resonance detects microvascular dysfunction
            in a mouse model of hypertrophic cardiomyopathy
  JOURNAL   J Cardiovasc Magn Reson 23 (1), 63 (2021)
   PUBMED   34053450
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4163)
  AUTHORS   Fougerousse F, Delezoide AL, Fiszman MY, Schwartz K, Beckmann JS
            and Carrier L.
  TITLE     Cardiac myosin binding protein C gene is specifically expressed in
            heart during murine and human development
  JOURNAL   Circ Res 82 (1), 130-133 (1998)
   PUBMED   9440712
REFERENCE   7  (bases 1 to 4163)
  AUTHORS   Gautel M, Furst DO, Cocco A and Schiaffino S.
  TITLE     Isoform transitions of the myosin binding protein C family in
            developing human and mouse muscles: lack of isoform
            transcomplementation in cardiac muscle
  JOURNAL   Circ Res 82 (1), 124-129 (1998)
   PUBMED   9440711
REFERENCE   8  (bases 1 to 4163)
  AUTHORS   Schiaffino S and Reggiani C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
REFERENCE   9  (bases 1 to 4163)
  AUTHORS   Vikstrom KL and Leinwand LA.
  TITLE     Contractile protein mutations and heart disease
  JOURNAL   Curr Opin Cell Biol 8 (1), 97-105 (1996)
   PUBMED   8791411
  REMARK    Review article
REFERENCE   10 (bases 1 to 4163)
  AUTHORS   Kasahara H, Itoh M, Sugiyama T, Kido N, Hayashi H, Saito H, Tsukita
            S and Kato N.
  TITLE     Autoimmune myocarditis induced in mice by cardiac C-protein.
            Cloning of complementary DNA encoding murine cardiac C-protein and
            partial characterization of the antigenic peptides
  JOURNAL   J Clin Invest 94 (3), 1026-1036 (1994)
   PUBMED   8083344
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146886.1.
            
            [WARNING] On Jun 15, 2023 this sequence was replaced by
            NM_008653.3.
            
            On Mar 23, 2007 this sequence version replaced NM_008653.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146886.1, AK146661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4163              AK146886.1         2-4164
FEATURES             Location/Qualifiers
     source          1..4163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..4163
                     /gene="Mybpc3"
                     /note="myosin binding protein C, cardiac"
                     /db_xref="GeneID:17868"
                     /db_xref="MGI:MGI:102844"
     exon            1..74
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3862
                     /gene="Mybpc3"
                     /note="cardiac MyBP-C; cardiac C-protein"
                     /codon_start=1
                     /product="myosin-binding protein C, cardiac-type"
                     /protein_id="NP_032679.2"
                     /db_xref="CCDS:CCDS50631.1"
                     /db_xref="GeneID:17868"
                     /db_xref="MGI:MGI:102844"
                     /translation="MPGVTVLKMPEPGKKPVSAFNKKPRSAEVTAGSAAVFEAETERS
                     GVKVRWQRDGSDITANDKYGLAAEGKRHTLTVRDASPDDQGSYAVIAGSSKVKFDLKV
                     TEPAPPEKAESEVAPGAPKEVPAPATELEESVSSPEGSVSVTQDGSAAEHQGAPDDPI
                     GLFLMRPQDGEVTVGGSIVFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDS
                     YDRASKVYLFELHITDAQTTSAGGYRCEVSTKDKFDSCNFNLTVHEAIGSGDLDLRSA
                     FRRTSLAGAGRRTSDSHEDAGTLDFSSLLKKRDSFRRDSKLEAPAEEDVWEILRQAPP
                     SEYERIAFQHGVTDLRGMLKRLKGMKQDEKKSTAFQKKLEPAYQVNKGHKIRLTVELA
                     DPDAEVKWLKNGQEIQMSGSKYIFESVGAKRTLTISQCSLADDAAYQCVVGGEKCSTE
                     LFVKEPPVLITRSLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFK
                     KDGRKHHLIINEATLEDAGHYAVRTSGGQSLAELIVQEKKLEVYQSIADLAVGAKDQA
                     VFKCEVSDENVRGVWLKNGKELVPDNRIKVSHIGRVHKLTIDDVTPADEADYSFVPEG
                     FACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGSTPDTIVVVAGNKLRLDVPISGDPA
                     PTVVWQKTVTQGKKASTGPHPDAPEDAGADEEWVFDKKLLCETEGRVRVETTKDRSVF
                     TVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEP
                     PAYDGGQPVLGYILERKKKKSYRWMRLNFDLLRELSHEARRMIEGVAYEMRVYAVNAV
                     GMSRPSPASQPFMPIGPPGEPTHLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCQ
                     EGCSEWTPALQGLTERTSMLVKDLPTGARLLFRVRAHNVAGPGGPIVTKEPVTVQEIL
                     QRPRLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPT
                     DTILFIRAARRTHSGTYQVTVRIENMEDKATLILQIVDKPSPPQDIRIVETWGFNVAL
                     EWKPPQDDGNTEIWGYTVQKADKKTMEWFTVLEHYRRTHCVVSELIIGNGYYFRVFSH
                     NMVGSSDKAAATKEPVFIPRPGITYEPPKYKALDFSEAPSFTQPLANRSIIAGYNAIL
                     CCAVRGSPKPKISWFKNGLDLGEDARFRMFCKQGVLTLEIRKPCPYDGGVYVCRATNL
                     QGEAQCECRLEVRVPQ"
     exon            75..341
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            342..440
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..548
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            549..697
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..815
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..864
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            865..894
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            895..948
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            949..951
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..963
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1127
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1260
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1263
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1388
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1494
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1661
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1827
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1934
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..1964
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2104
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2185
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2345
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2450
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2639
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2774
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2942
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3031
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3227
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3367
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3527
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3664
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3851
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..3889
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..4163
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4137..4142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mybpc3"
                     /note="putative"
     polyA_site      4163
                     /gene="Mybpc3"
                     /note="putative"
ORIGIN      
        1 agtccctcct tgggtggcct gcttgatgcc tggtgtgact gttctcaaga tgccggagcc
       61 agggaagaaa ccagtgtcag ccttcaacaa gaagccaagg tcagcggagg tgaccgctgg
      121 cagtgctgcc gtgttcgagg ctgagacgga gcggtcaggc gtgaaggtgc ggtggcagcg
      181 ggatggcagc gacatcaccg ccaatgacaa gtatggtttg gcagcagagg gcaagcgaca
      241 cacactgaca gtgcgggatg cgagccctga tgaccagggt tcctacgcgg tcattgcagg
      301 ctcctcaaag gtcaagtttg acctcaaggt cacagagcca gcccctccag agaaggcaga
      361 atctgaagtt gctccaggag cccccaaaga agtccctgct ccagccactg agttggaaga
      421 aagtgtctca agtcctgaag ggtcagtctc ggtaacccag gatggctcag ctgcagagca
      481 tcagggagcc cctgatgacc ctattggcct ctttctgatg cgaccacagg atggtgaggt
      541 gaccgtgggc ggcagcattg tcttctcagc ccgagtggct ggggccagcc tcctgaaacc
      601 gcctgtggtc aagtggttca agggcaagtg ggtggacctg agcagcaaag tgggccagca
      661 cctgcagctg catgacagct atgacagagc cagcaaggtc tacttgtttg agttgcacat
      721 cacagatgct cagaccactt ctgctggggg ctaccgctgt gaggtgtcta ccaaggacaa
      781 atttgacagc tgtaacttca acctcactgt ccatgaggcc attggttctg gagacctgga
      841 cctcagatca gctttccgac gcacgagcct ggcgggagca ggtcggagaa ccagtgacag
      901 ccatgaagat gctgggactc tggactttag ttccctgctg aagaagagag acagtttccg
      961 gagggactca aagctggagg cacctgctga agaagacgtg tgggagatcc tgagacaggc
     1021 accgccgtca gaatatgagc gcatcgcctt ccagcacgga gtcacagacc ttcgaggcat
     1081 gctgaagagg ctcaagggca tgaagcagga tgaaaagaag agcacagcct ttcagaagaa
     1141 gctggagcct gcctaccagg taaacaaggg ccacaagatt cggcttactg tggaactggc
     1201 tgatccggac gccgaagtca agtggcttaa gaatggacag gagatccaga tgagtggcag
     1261 caagtacatc ttcgagtccg tcggtgccaa gcgcaccctg accatcagcc agtgctcact
     1321 ggctgacgac gcagcctacc agtgtgtggt ggggggcgag aagtgcagca cggagctctt
     1381 tgtcaaagag cccccggtgc tgatcactcg gtccctggaa gaccagctgg tgatggtggg
     1441 tcagcgggtg gagtttgagt gtgaggtctc agaagaaggg gcccaagtca aatggctgaa
     1501 ggatggggtt gagctgacac gtgaggagac cttcaaatac cggttcaaga aagatgggcg
     1561 gaaacaccac ttgatcatca atgaagcaac cctggaggat gcaggacact atgcagtacg
     1621 cacaagtgga ggccagtcac tggctgagct cattgtgcaa gagaagaagt tggaggtata
     1681 ccaaagcatc gcggacctgg cagtgggagc caaggaccag gctgtgttta agtgtgaggt
     1741 ttcagatgag aatgtacgcg gcgtgtggct gaagaatggg aaggaactgg tgcctgacaa
     1801 ccgcataaag gtgtcccata taggccgggt ccacaaactg accattgacg atgtcacacc
     1861 tgctgatgag gctgactaca gctttgtccc tgaagggttt gcctgcaacc tgtctgccaa
     1921 gctccacttc atggaggtca agattgactt tgtgcctagg caggaacctc ccaagatcca
     1981 cttggattgt cccggcagca caccagacac cattgtggtt gttgctggga acaagttacg
     2041 cctggatgtc cctatttctg gagaccctgc tcccactgtg gtctggcaga agactgtaac
     2101 acaggggaag aaggcctcaa ctgggccaca ccctgatgcc ccagaagatg ctggtgctga
     2161 tgaggagtgg gtgtttgata agaagctgtt gtgtgagact gagggccggg tccgggtgga
     2221 gaccaccaaa gaccgcagcg tctttacagt cgaaggggca gagaaggaag atgaaggtgt
     2281 ctacacagtc acagtaaaga accccgtggg cgaggaccag gtcaacctca cagtcaaggt
     2341 catcgatgtc ccagatgctc ctgcggcccc taagatcagc aacgtgggcg aggactcctg
     2401 cactgtgcag tgggaaccgc ctgcctatga tggcgggcag ccggtcctgg gatacatcct
     2461 ggagcgcaag aagaaaaaga gctacaggtg gatgaggctc aactttgatc tgctgcggga
     2521 gctgagccac gaggcgaggc gcatgatcga gggtgtagcc tatgagatgc gagtctacgc
     2581 agtcaatgcc gtgggaatgt ccaggcccag ccctgcctct cagcccttca tgcctattgg
     2641 gccccctggc gaaccaaccc acttggctgt ggaggatgtg tcagacacca ctgtctcact
     2701 caagtggcgg cccccagagc gcgtgggggc cggtggcctg gacggataca gcgtggagta
     2761 ctgccaggag ggatgctccg agtggacacc tgctctgcag gggctgacag agcgcacatc
     2821 gatgctggtg aaggacctac ccactggggc acggctgctg ttccgagtac gggcacacaa
     2881 tgtggcaggt cctggaggcc ctatcgtcac caaggagcct gtgacagtgc aggagatact
     2941 gcaacgacca cggctccaac tgcccagaca cctgcgccag accatccaga agaaagttgg
     3001 ggagcctgtg aacctcctca tccctttcca gggcaaaccc cggcctcagg tgacctggac
     3061 caaagagggg cagcccctgg caggtgagga ggtgagcatc cggaacagcc ccacagacac
     3121 gatcttgttc atccgagctg cccgccgcac ccactcgggc acctaccagg tgacagttcg
     3181 cattgagaac atggaggaca aggcaacgct gatcctgcag attgtggaca agccaagtcc
     3241 tccccaggat atccggatcg ttgagacttg gggtttcaat gtggctctgg agtggaagcc
     3301 accccaagat gatggcaata cagagatctg gggttatact gtacagaaag ctgacaagaa
     3361 gaccatggag tggttcacgg ttttggaaca ctaccgacgc actcactgtg tggtatcaga
     3421 gcttatcatt ggcaatggct actacttccg ggtcttcagc cataacatgg tgggttccag
     3481 tgacaaagct gccgccacca aggagccagt ctttattcca agaccaggca tcacatatga
     3541 gccacccaaa tacaaggccc tggacttctc tgaggcccca agcttcaccc agcccttggc
     3601 aaatcgctcc atcattgcag gctataatgc catcctctgc tgtgctgtcc gaggtagtcc
     3661 taagcccaag atttcctggt tcaagaatgg cctggatctg ggagaagatg ctcgcttccg
     3721 catgttctgc aagcagggag tattgaccct ggagatcagg aaaccctgcc cctatgatgg
     3781 tggtgtctat gtctgcaggg ccaccaactt gcagggcgag gcacagtgtg agtgccgcct
     3841 ggaggtgcga gttcctcagt gaccaggatg gctccccaga gatggctagg tacaaatgga
     3901 tgccaggctg tgtaccagac cggaagggag ttggaggagc acccttttct gctactgcat
     3961 gtgtgtgtgc aactgtgcat cctggaagga ctggccagca gtgacaccag gcaggtctgc
     4021 tgggttctga agaaactgac cctaaggata atgttaatac tgggagcata aagtgtgtgg
     4081 gcttcagaag tggtgactgg ggacaggccc ttttggctgg ctcattgtgt aggagcaata
     4141 aaagatctgt gccattcctg ggg
//
