LOCUS       NM_146189               3624 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus myosin binding protein C, fast-type (Mybpc2), mRNA.
ACCESSION   NM_146189 NM_178067
VERSION     NM_146189.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3624)
  AUTHORS   Hessel,A.L., Kuehn,M.N., Han,S.W., Ma,W., Irving,T.C., Momb,B.A.,
            Song,T., Sadayappan,S., Linke,W.A. and Palmer,B.M.
  TITLE     Fast myosin binding protein C knockout in skeletal muscle alters
            length-dependent activation and myofilament structure
  JOURNAL   Commun Biol 7 (1), 648 (2024)
   PUBMED   38802450
  REMARK    GeneRIF: Fast myosin binding protein C knockout in skeletal muscle
            alters length-dependent activation and myofilament structure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3624)
  AUTHORS   Fukushima,T., Hasegawa,Y., Kuse,S., Fujioka,T., Nikawa,T.,
            Masubuchi,S. and Sakakibara,I.
  TITLE     PHF2 regulates sarcomeric gene transcription in myogenesis
  JOURNAL   PLoS One 19 (5), e0301690 (2024)
   PUBMED   38701072
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3624)
  AUTHORS   Dos Santos,M., Shah,A.M., Zhang,Y., Bezprozvannaya,S., Chen,K.,
            Xu,L., Lin,W., McAnally,J.R., Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     Opposing gene regulatory programs governing myofiber development
            and maturation revealed at single nucleus resolution
  JOURNAL   Nat Commun 14 (1), 4333 (2023)
   PUBMED   37468485
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3624)
  AUTHORS   Perazza,L.R., Wei,G. and Thompson,L.V.
  TITLE     Fast and slow skeletal myosin binding protein-C and aging
  JOURNAL   Geroscience 45 (2), 915-929 (2023)
   PUBMED   36409445
  REMARK    GeneRIF: Fast and slow skeletal myosin binding protein-C and aging.
REFERENCE   5  (bases 1 to 3624)
  AUTHORS   Song,T., McNamara,J.W., Ma,W., Landim-Vieira,M., Lee,K.H.,
            Martin,L.A., Heiny,J.A., Lorenz,J.N., Craig,R., Pinto,J.R.,
            Irving,T. and Sadayappan,S.
  TITLE     Fast skeletal myosin-binding protein-C regulates fast skeletal
            muscle contraction
  JOURNAL   Proc Natl Acad Sci U S A 118 (17) (2021)
   PUBMED   33888578
  REMARK    GeneRIF: Fast skeletal myosin-binding protein-C regulates fast
            skeletal muscle contraction.
REFERENCE   6  (bases 1 to 3624)
  AUTHORS   Cohen,S., Brault,J.J., Gygi,S.P., Glass,D.J., Valenzuela,D.M.,
            Gartner,C., Latres,E. and Goldberg,A.L.
  TITLE     During muscle atrophy, thick, but not thin, filament components are
            degraded by MuRF1-dependent ubiquitylation
  JOURNAL   J Cell Biol 185 (6), 1083-1095 (2009)
   PUBMED   19506036
REFERENCE   7  (bases 1 to 3624)
  AUTHORS   Kurasawa,M., Sato,N., Matsuda,A., Koshida,S., Totsuka,T. and
            Obinata,T.
  TITLE     Differential expression of C-protein isoforms in developing and
            degenerating mouse striated muscles
  JOURNAL   Muscle Nerve 22 (2), 196-207 (1999)
   PUBMED   10024132
REFERENCE   8  (bases 1 to 3624)
  AUTHORS   Gautel,M., Furst,D.O., Cocco,A. and Schiaffino,S.
  TITLE     Isoform transitions of the myosin binding protein C family in
            developing human and mouse muscles: lack of isoform
            transcomplementation in cardiac muscle
  JOURNAL   Circ Res 82 (1), 124-129 (1998)
   PUBMED   9440711
REFERENCE   9  (bases 1 to 3624)
  AUTHORS   Duriez,P.J. and Shah,G.M.
  TITLE     Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to
            study cell death
  JOURNAL   Biochem Cell Biol 75 (4), 337-349 (1997)
   PUBMED   9493956
  REMARK    Review article
REFERENCE   10 (bases 1 to 3624)
  AUTHORS   Schiaffino,S. and Reggiani,C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK787764.1, AK029282.1 and AK132563.1.
            
            On or before Feb 27, 2010 this sequence version replaced
            NM_178067.3, NM_146189.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029282.1, BC039184.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CK787764.1         15-29
            16-1974             AK029282.1         2-1960
            1975-2856           AK132563.1         1965-2846
            2857-3624           AK029282.1         2843-3610
FEATURES             Location/Qualifiers
     source          1..3624
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.83 cM"
     gene            1..3624
                     /gene="Mybpc2"
                     /note="myosin binding protein C, fast-type"
                     /db_xref="GeneID:233199"
                     /db_xref="MGI:MGI:1336170"
     exon            1..99
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..3491
                     /gene="Mybpc2"
                     /note="fast-type C-protein; fast MyBP-C"
                     /codon_start=1
                     /product="myosin-binding protein C, fast-type"
                     /protein_id="NP_666301.2"
                     /db_xref="CCDS:CCDS52233.1"
                     /db_xref="GeneID:233199"
                     /db_xref="MGI:MGI:1336170"
                     /translation="MPEAKPAAKKASKGKDAPKEAPAKQTPEEPPKEAPPEDQSPTAE
                     EPTGIFLKKPDSVSVETGKDAVILAKVNGKELPGKPTIKWFKGKWQELGSKSGARFIF
                     KESHDSTSNVYTVELHIGKVVLGDRGDYRLEIKAKDVCDSCSFNVDVEAPRQDSSGQS
                     LESFKRSGDGKSEDAGELDFSGLLKKREVVEEEKKKKKDDDDLGIPPEIWELLKGAKK
                     SEYEKIAFQYGITDLRGMLKRLKKAKVEVKKSAAFTKKLDPAYQVDRGNKIKLVVEIS
                     DPDLPLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYEVAVQDEKCFTEL
                     FVKEPPVLIVTPLEDQQVFVGDRVEMSVEVSEEGAQVMWMKDGVEMTREDSYKARYRF
                     KKDGKRHILIYSDVAQEDGGRYQVITNGGQCEAELIVEEKQLEVLQDIADLTVKAAEQ
                     AVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPD
                     GYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSDNSIVVVAGNKLRLDVAITGE
                     PPPTATWLRGDEVFTATEGRTHIEQRPDCSSFVIESAERSDEGRYTIKVTNPVGEDVA
                     SIFLRVVDVPDPPEAVRVTSVGEDWAILVWEPPKYDGGQPVTGYLMERKKKGSQRWMK
                     INFEVFTDTTYESTKMIEGVLYEMRVFAVNAIGVSQPSMNTKPFMPIAPTSAPQHLTV
                     EDVTDTTTTLKWRPPDRIGAGGIDGYLVEYCLEGSEEWVPANKEPVERCGFTVKDLPT
                     GARILFRVVGVNIAGRSEPATLLQPVTIREIVEQPKIRLPRHLRQTYIRKVGEALNLV
                     IPFQGKPRPQVVWTKGGAPLDTSRVNVRTSDFDTVFFVRQAARSDSGEYELSVQIENM
                     KDTATIRIRVVEKAGPAENVMVKEVWGTNALVEWQPPKDDGNSEITGYFVQKADKKTM
                     EWFNVYEHNRHTSCTVSDLIVGNEYYFRIFSENICGLSDSPGVSKNTARILKTGITLK
                     PLEYKEHDFRTAPKFLTPLMDRVVVAGYTAALNCAVRGHPKPKVVWMKNKMEIHEDPK
                     FLITNYQGILTLNIRRPSPFDAGTYSCRAFNELGEALAECKLDVRVPQ"
     exon            100..177
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            178..264
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            265..413
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..531
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..580
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..640
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..834
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..967
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1092
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1198
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1371
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1537
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1644
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1674
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1814
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1974
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2079
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2268
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2403
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2571
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2660
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2856
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2996
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3156
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3293
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3480
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3624
                     /gene="Mybpc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3583..3588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mybpc2"
                     /note="hexamer: GATAAA"
     polyA_site      3603
                     /gene="Mybpc2"
                     /note="major polyA site"
ORIGIN      
        1 tggagaccca cctgtccctg ctagggcctg gttagagcca ctgcggtccc aagtcctggg
       61 agcaggagaa ggtcgccgac atgcctgagg ctaaaccagc ggccaaaaag gcctccaaag
      121 gcaaagatgc cccaaaggaa gcccctgcaa agcagactcc tgaagagccc cccaaagagg
      181 ccccacctga ggaccaatcc ccaactgcgg aggagcccac aggcatcttc ctgaaaaagc
      241 cggactctgt gtcagtggag actgggaaag acgcggtgat tctggccaag gtgaacggga
      301 aggagctccc aggcaagccg accatcaagt ggttcaaggg gaagtggcag gagctgggca
      361 gcaagagcgg agcccggttc atcttcaagg aatctcatga ctctaccagc aatgtgtaca
      421 ccgtggagct ccacattggg aaggtggtcc taggggaccg cggggattac cgtctagaga
      481 tcaaagccaa ggatgtctgc gacagctgct cgttcaacgt ggatgtggag gcaccccgtc
      541 aggactcatc cggtcagagc ctcgagagct tcaagcgttc gggtgacggg aagtcagaag
      601 atgcaggcga gctggatttc agtggcttgt tgaagaagag ggaagtagtt gaggaggaga
      661 agaagaagaa gaaagatgat gatgatctgg gtatacctcc ggagatttgg gagctcctga
      721 aaggggccaa gaagagcgag tacgagaaga tcgccttcca gtacggcatc actgacctcc
      781 gtggcatgct gaagcggctc aagaaggcca aggtggaggt caagaagagt gcagccttca
      841 ctaagaagtt ggacccagcc taccaagtag acaggggcaa caagatcaag ctggtggtgg
      901 agatcagtga cccagacctt cctctcaagt ggttcaagaa tggccaggag atcaaaccaa
      961 gcagcaagta tgtgtttgag aacgttggga agaaacgaat tcttaccatc aacaagtgca
     1021 cgctggcgga tgatgctgca tacgaggtgg cagtccaaga tgagaagtgt ttcactgaac
     1081 tctttgtcaa agagccccca gtcttgattg tcaccccact ggaggaccag caggtattcg
     1141 taggtgaccg agtggaaatg tcggtagagg tgtcagaaga gggtgcacag gttatgtgga
     1201 tgaaagatgg tgtggagatg actcgggagg attcctacaa ggcgcgctac cgcttcaaga
     1261 aggacgggaa acggcacatc ctcatctact ctgatgtggc ccaggaggat gggggccgct
     1321 accaggtcat aaccaatggt ggccagtgtg aggctgaact cattgtggaa gagaagcaac
     1381 tggaggtcct gcaggacatt gctgacctga cagtgaaggc tgcagagcag gctgtgttca
     1441 agtgtgaagt gtctgatgag aaggtgacag gcaaatggta caagaacggc gtggaggtac
     1501 gacccagcaa gaggatcacc atctcccatg tgggcagatt ccacaagctg gtgattgatg
     1561 acgtccgccc tgaggatgag ggagactaca cattcgtgcc cgatggctat gccctatccc
     1621 tctcagccaa gctcaacttt ttggaaatca aagtggagta tgtacctaag caagagcccc
     1681 cgaagatcca cctggactgc tcagggaaga cctcagataa ctcaattgtt gtggtggctg
     1741 gaaacaagct gcggctggat gtggccatca caggggaacc acctcccact gctacctggc
     1801 taaggggaga tgaggtgttc acagccacag aaggcaggac acacatcgag cagaggccag
     1861 actgcagcag ctttgtgatc gagagtgcgg agcggtcgga tgagggccgc tacaccatca
     1921 aagtcaccaa tcctgtgggc gaggacgtgg cctccatttt cctgcgggtt gtggatgttc
     1981 ctgatcctcc agaggctgtc cgtgtcacct cagttggaga agactgggcc attctggtct
     2041 gggagccacc caagtatgat ggaggacagc cagtgactgg gtacttgatg gagcggaaga
     2101 agaaaggctc ccagcgctgg atgaagatca actttgaggt cttcactgac accacctacg
     2161 agtccacaaa gatgatcgag ggcgtccttt atgagatgcg ggtcttcgct gtcaacgcca
     2221 ttggggtctc acagcccagc atgaacacca agcccttcat gcccattgct cccacgagtg
     2281 caccacaaca cctcaccgtg gaggatgtga cggacaccac caccacactt aagtggagac
     2341 ctccagatcg gattggtgct ggtggcattg atggctacct ggtggagtac tgcctggagg
     2401 gctctgagga atgggtacca gctaacaagg agccagtgga acgctgtggc ttcactgtca
     2461 aggatctccc aactggagcc aggatcctct tccgggttgt tggggtcaac atcgcagggc
     2521 gcagtgaacc agccaccctc cttcagccag tcactatcag ggagattgtg gagcaaccta
     2581 agatccgcct tccccgccat cttcgtcaga cttatatccg aaaagttggg gaggccctca
     2641 acctcgtcat ccccttccag ggcaagcccc ggcctcaggt ggtgtggacc aagggtgggg
     2701 ctcccttgga tacctcccgt gtgaatgtgc ggactagtga cttcgacaca gtgttcttcg
     2761 tgcgacaggc ggcccgctct gactccggag agtatgagct gagtgtgcag attgaaaaca
     2821 tgaaggacac tgctaccata cgcatccggg tcgtggaaaa ggcagggcca gcagagaatg
     2881 tgatggtgaa ggaggtgtgg ggcacaaatg ctctggtgga gtggcagccg cccaaggatg
     2941 acgggaacag tgagatcaca ggctactttg tccagaaggc tgacaaaaag accatggagt
     3001 ggttcaatgt ctacgaacac aatcgccaca ccagctgtac ggtgtctgac ctcattgtgg
     3061 gtaatgagta ctacttccgt atcttcagcg agaacatctg cggtctcagt gactcgccag
     3121 gtgtctccaa gaacacagct cgaattctca agacaggaat caccttaaaa ccactggagt
     3181 acaaggagca tgatttccgg acggctccca agttcctgac cccgctgatg gaccgggtcg
     3241 tggtggcggg atataccgca gctctcaact gtgccgtcag aggccaccct aagccaaagg
     3301 tggtgtggat gaagaacaag atggaaatcc atgaagatcc caaattcctc ataaccaact
     3361 accagggcat cctgacactg aacatccgcc gaccgtcacc ctttgatgca gggacctatt
     3421 cctgccgcgc cttcaatgag ctgggggaag ccctggctga atgcaaactg gatgtccgag
     3481 tgccacagtg acagctcatc acctgctaaa taagtcatca gaacccggac accagcgctg
     3541 caactcttgg gatggcagtc atctttccag aatgatcact gtgataaaga actgttgctc
     3601 aaattatcat gtgtccatct ttcc
//
