LOCUS       NM_175418               3924 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus myosin binding protein C, slow-type (Mybpc1),
            transcript variant 2, mRNA.
ACCESSION   NM_175418
VERSION     NM_175418.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3924)
  AUTHORS   Perazza LR, Wei G and Thompson LV.
  TITLE     Fast and slow skeletal myosin binding protein-C and aging
  JOURNAL   Geroscience 45 (2), 915-929 (2023)
   PUBMED   36409445
  REMARK    GeneRIF: Fast and slow skeletal myosin binding protein-C and aging.
REFERENCE   2  (bases 1 to 3924)
  AUTHORS   Weiss AC, Blank E, Bohnenpoll T, Kleppa MJ, Rivera-Reyes R, Taketo
            MM, Trowe MO and Kispert A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   3  (bases 1 to 3924)
  AUTHORS   Geist Hauserman J, Stavusis J, Joca HC, Robinett JC, Hanft L,
            Vandermeulen J, Zhao R, Stains JP, Konstantopoulos K, McDonald KS,
            Ward C and Kontrogianni-Konstantopoulos A.
  TITLE     Sarcomeric deficits underlie MYBPC1-associated myopathy with
            myogenic tremor
  JOURNAL   JCI Insight 6 (19), e147612 (2021)
   PUBMED   34437302
  REMARK    GeneRIF: Sarcomeric deficits underlie MYBPC1-associated myopathy
            with myogenic tremor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3924)
  AUTHORS   Firulli BA, George RM, Harkin J, Toolan KP, Gao H, Liu Y, Zhang W,
            Field LJ, Liu Y, Shou W, Payne RM, Rubart-von der Lohe M and
            Firulli AB.
  TITLE     HAND1 loss-of-function within the embryonic myocardium reveals
            survivable congenital cardiac defects and adult heart failure
  JOURNAL   Cardiovasc Res 116 (3), 605-618 (2020)
   PUBMED   31286141
REFERENCE   5  (bases 1 to 3924)
  AUTHORS   Chen JQ, Mori H, Cardiff RD, Trott JF, Hovey RC, Hubbard NE,
            Engelberg JA, Tepper CG, Willis BJ, Khan IH, Ravindran RK, Chan SR,
            Schreiber RD and Borowsky AD.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3924)
  AUTHORS   Jin C, Chen J, Meng Q, Carreira V, Tam NN, Geh E, Karyala S, Ho SM,
            Zhou X, Medvedovic M and Xia Y.
  TITLE     Deciphering gene expression program of MAP3K1 in mouse eyelid
            morphogenesis
  JOURNAL   Dev Biol 374 (1), 96-107 (2013)
   PUBMED   23201579
REFERENCE   7  (bases 1 to 3924)
  AUTHORS   Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor
            D, Tang DT, Grimmond SM and Little MH.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3924)
  AUTHORS   Kurasawa M, Sato N, Matsuda A, Koshida S, Totsuka T and Obinata T.
  TITLE     Differential expression of C-protein isoforms in developing and
            degenerating mouse striated muscles
  JOURNAL   Muscle Nerve 22 (2), 196-207 (1999)
   PUBMED   10024132
REFERENCE   9  (bases 1 to 3924)
  AUTHORS   Gautel M, Furst DO, Cocco A and Schiaffino S.
  TITLE     Isoform transitions of the myosin binding protein C family in
            developing human and mouse muscles: lack of isoform
            transcomplementation in cardiac muscle
  JOURNAL   Circ Res 82 (1), 124-129 (1998)
   PUBMED   9440711
REFERENCE   10 (bases 1 to 3924)
  AUTHORS   Schiaffino S and Reggiani C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY135230.1, BC062158.1 and BB669565.1.
            
            On Nov 14, 2011 this sequence version replaced NM_175418.4.
            
            Transcript Variant: This variant (2) has multiple differences in
            the coding region, compared to variant 1, one of which results in a
            translational frameshift. The resulting protein (isoform 2) has a
            distinct C-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               BY135230.1         2-139
            139-3919            BC062158.1         1-3781
            3920-3924           BB669565.1         409-413
FEATURES             Location/Qualifiers
     source          1..3924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.99 cM"
     gene            1..3924
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /note="myosin binding protein C, slow-type"
                     /db_xref="GeneID:109272"
                     /db_xref="MGI:MGI:1336213"
     exon            1..252
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..3602
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Slow-type C-protein; MyBP-C slow"
                     /codon_start=1
                     /product="myosin-binding protein C, slow-type isoform 2"
                     /protein_id="NP_780627.2"
                     /db_xref="CCDS:CCDS48666.1"
                     /db_xref="GeneID:109272"
                     /db_xref="MGI:MGI:1336213"
                     /translation="MPEPTKKEENEVSAPAPPPEEPNKEKEAGTAPAKEWSLGESPAG
                     GEEQDKQNANSQLSTLFVEKPQTGSVKVGANITFVAKVRAEDLLRKPTVKWFKGKWMD
                     LASKAGKHLQLKETFERQTRVYTFEMQIIKAKENYAGNYRCEVTYKDKFDSCSFDLEV
                     HESTGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPEIDVWELLKNA
                     NPNEYEKIAFQYGITDLRGMLKRLKRMRRVEKKSAAFAKILDPAYQVDKGGKVRFVVE
                     LADPKLEVKWFKNGQEIRPSTKYIFEHKGNERIMFINNCSLTDDSEYYVTAGDEKCST
                     ELFVREPPIMVTKQLEDMNAYCGERVEMEVEVSEDDANVKWFKNGEEIFPGPKSRYKI
                     KVEGKKHTLIIEGATKADSAEYSAMTTGGQSSAKLSVDLRPLKITTPLTDQTVKLGKE
                     VCLKCEISENVPGKWTKNGLPVQEGERLKVVHKGRIHKLVIANALIEDEGEYVFTPDA
                     YNVPLSAKVHVIDPPKIILDGLDADNTVTVIAGSKLRLEIPVTGEPPPKAIWSRADKA
                     IMEGSGRIRAESYPDSSTLVIDVAERDDSGVYNINLKNEAGEAHASIKIKVVDIPDPP
                     VAPNVTEVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEP
                     KKMIEGVAYEVRIFAVNAIGISKPSMPSKPFVPLAVTSPPTLLAVDSVTDSSVTMKWR
                     PPDQIGAAGLDGYVLEYCFEGTEDWIVANTDLIDKTKFTINGLPTDAKIFVRVKAINA
                     AGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTW
                     KKDGEEIDKNQINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKYVENASIDIQIVDR
                     PGPPQTVTIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTN
                     ATITELVIGNEYYFRVFAENMCGLSEDATMTKESAVIAKDGKIYKNPVYEDFNFTEAP
                     MFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLE
                     IRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVVAQ"
     exon            253..288
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            289..330
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            331..444
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            445..593
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            594..711
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            712..763
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            764..820
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            821..987
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1120
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1245
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1351
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1518
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1681
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1788
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1922
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2082
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2187
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2376
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2511
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2679
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2768
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2964
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3104
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3264
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3401
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3588
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3589..3631
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3922
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaacaga tgtgagaaag gtcccagagc tgtcaggttt cagcatcctt gtgccgaagt
       61 agggaggcgc caacatgatt gatggtcgga gcctgtataa aaccggtcca cctctaagca
      121 gctgcttgtc acactgaccc acaccatctc tctgctgccc ttggggtttc tgtcaaccgc
      181 tgctagaaag gagaaaacct tttggagagt aatcttttgt tgtggtcatg ccagaaccca
      241 ctaagaaaga ggaaaatgaa gtgtccgccc cagcccctcc cccggaagaa ccaaataaag
      301 agaaagaggc gggaaccgct ccagcaaaag aatggtctct tggtgagtca cctgctggcg
      361 gggaagagca ggacaaacag aatgccaact cccagctgtc caccctgttt gttgaaaaac
      421 ctcaaaccgg atcggtgaaa gttggtgcaa acatcacctt tgtagccaaa gttagggctg
      481 aagatcttct tagaaaaccc actgtcaaat ggttcaaggg gaaatggatg gatctggcca
      541 gcaaagccgg gaaacacctg cagctgaagg agaccttcga gaggcaaact cgggtataca
      601 cattcgagat gcagatcatc aaagccaaag agaactacgc agggaattat aggtgtgagg
      661 tcacctacaa ggataaattt gacagctgtt cgtttgatct tgaagtccat gagtctactg
      721 ggactactcc aaacattgac atcagatctg ccttcaaaag aagtggagaa ggtcaagagg
      781 atgcagggga acttgacttt agtggtctcc tgaaacgtag ggaggtgaag cagcaggaag
      841 aggagcctga gatagacgtg tgggagctgc tgaaaaatgc caaccccaac gaatacgaga
      901 agatcgcttt ccagtatggc atcaccgact tgcgtggcat gcttaagcgg ctcaagcgca
      961 tgcgcagggt ggaaaagaag agcgcagctt ttgcaaaaat tctcgatcct gcatatcagg
     1021 tggataaagg aggcaaagtg agatttgtcg tggagttggc agacccaaaa ctggaggtga
     1081 aatggtttaa aaatggccaa gagattcgac ccagcacaaa atacatcttt gagcacaaag
     1141 gaaacgagag aatcatgttt attaataact gttcgctgac agatgattcg gagtactatg
     1201 tgacagctgg agatgagaaa tgttctactg agctctttgt aagagagcct ccaatcatgg
     1261 tgactaagca gctggaagac atgaacgctt actgtgggga gagggtagag atggaagttg
     1321 aggtgtctga agatgacgcc aatgtaaaat ggtttaagaa tggtgaagag atcttccctg
     1381 gtccaaagtc aagatacaag attaaagttg aaggcaaaaa gcacacgttg atcatagaag
     1441 gggcaacaaa ggctgacagt gcggagtact cagccatgac aaccggggga caatcatctg
     1501 ccaaactcag cgttgacttg agacctctaa agatcacgac gcctctgacg gaccagacag
     1561 taaaacttgg gaaagaagta tgcttgaagt gtgaaatctc tgaaaatgta ccaggaaaat
     1621 ggacaaaaaa tggcctccct gttcaggagg gtgagcgtct gaaggttgtt cacaagggaa
     1681 gaatccacaa gttagtcata gccaatgctc tcattgaaga tgaaggtgaa tatgtattta
     1741 caccagatgc ctacaatgtt cctttgtctg ccaaagttca tgtcatcgac cctcccaaga
     1801 tcatcctgga tggcctggat gctgataaca cagtgacagt gatagctgga agcaagcttc
     1861 gcctggagat tcctgtcaca ggggaaccac ctcccaaagc catctggagc cgagcagata
     1921 aggctattat ggaaggcagt ggtcggatca gggcagaatc ctaccctgac agcagcacac
     1981 tggtcattga cgtggcagag agagacgact ctggtgtgta caacataaat ctgaaaaatg
     2041 aggctggaga agcacatgca agcatcaaga ttaaggttgt ggatatccct gatcctccag
     2101 tggcaccaaa tgtgacagaa gtgggagatg actggtgcat catgaactgg gagcctcctg
     2161 cctatgatgg agggtctcca atcttaggat actttattga gaggaaaaag aaacaaagct
     2221 ccaggtggat gagactgaat ttcgatctct gcaaagagac aacttttgag cccaagaaga
     2281 tgattgaagg cgtggcctac gaggtccgaa tctttgcggt caacgccatt ggcatctcca
     2341 agcccagtat gccctccaag ccctttgttc ctttggctgt gaccagccct cctactcttc
     2401 tggctgtcga ctccgtgact gactcgtctg tgacgatgaa gtggaggccc ccagatcaga
     2461 ttggcgcagc aggtttagat ggctatgtgc tagagtattg ctttgaagga actgaggact
     2521 ggatagttgc aaacacagac ctgatcgaca agaccaagtt caccatcaat ggtctgccca
     2581 cggatgcgaa gatctttgta cgtgtgaagg ctattaacgc ggctggggct agtgagccca
     2641 agtactattc tcagcccatc cttgtgaagg aaatcattga gccaccaaag attcgcatcc
     2701 caaggcatct gaagcaaact tacatccgca gagtcggaga agctgtcaat ctggtgattc
     2761 cttttcaggg taaaccaaga ccagagttga cctggaagaa ggacggtgaa gaaattgaca
     2821 agaatcaaat aaacattcgc aactcagaaa ctgataccat catattcatc cggaaagcag
     2881 agcggagcca ctcgggcaag tacgacctgc aggtcaaagt ggataaatac gtggaaaatg
     2941 cctctatcga catccagatt gttgaccgtc caggtccacc ccagactgtg actattgaag
     3001 atgtgtgggg agagaatgtt gccctaacat ggacaccacc aaaggacgat gggaatgctg
     3061 ccatcacagg gtacaccatc cagaaggccg acaagaaaag catggaatgg ttcaccgtca
     3121 ttgaacatta ccaccgaacc aacgccacca ttactgagct ggtcataggg aacgagtatt
     3181 acttccgggt ctttgctgaa aacatgtgcg gccttagcga ggatgcaact atgacgaagg
     3241 agagtgcagt gattgccaag gacggtaaga tctataaaaa tccagtgtac gaagacttca
     3301 atttcacaga ggcccccatg tttactcaac ctttggttaa cacctatgcc atcgctggtt
     3361 acaatgccac cctgaactgc agcgtccgag gaaatcccaa gcccaaaatc acctggatga
     3421 aaaacaaagt ggctattgtg gatgacccaa gatacagaat gttcagcaac caaggagtct
     3481 gtaccctgga gatccgcaag cctagtcctt atgacggagg cacgtactgc tgcaaagcag
     3541 tcaatgacct cgggacggtg gagattgaat gcaaactgga ggtgaaagtc gtagcacagt
     3601 aaggatgttt gaatgtatat tgtcacccaa ggtgggctgt ccttctgcag gctcctcctg
     3661 caaggcgtgc ctccaaacat aattgattcc tatttgcgag acttacaatc aagcaatccc
     3721 gaggaatact gagggcaggg cattgcttct agacacaccc actgctttga aatctgattg
     3781 aaaatggata gtactttctg gttttctccc aggcccccaa gtgtggtcac tttctttctt
     3841 tcctcctaac tttgaagaaa gtaaaaaaaa aatataataa ttgtttgcac agattgctta
     3901 attaaaaatt gcaaacaaag tcaa
//
