LOCUS       NP_780627               1124 aa            linear   ROD 04-AUG-2023
DEFINITION  myosin-binding protein C, slow-type isoform 2 [Mus musculus].
ACCESSION   NP_780627
VERSION     NP_780627.2
DBSOURCE    REFSEQ: accession NM_175418.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1124)
  AUTHORS   Perazza LR, Wei G and Thompson LV.
  TITLE     Fast and slow skeletal myosin binding protein-C and aging
  JOURNAL   Geroscience 45 (2), 915-929 (2023)
   PUBMED   36409445
  REMARK    GeneRIF: Fast and slow skeletal myosin binding protein-C and aging.
REFERENCE   2  (residues 1 to 1124)
  AUTHORS   Weiss AC, Blank E, Bohnenpoll T, Kleppa MJ, Rivera-Reyes R, Taketo
            MM, Trowe MO and Kispert A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   3  (residues 1 to 1124)
  AUTHORS   Geist Hauserman J, Stavusis J, Joca HC, Robinett JC, Hanft L,
            Vandermeulen J, Zhao R, Stains JP, Konstantopoulos K, McDonald KS,
            Ward C and Kontrogianni-Konstantopoulos A.
  TITLE     Sarcomeric deficits underlie MYBPC1-associated myopathy with
            myogenic tremor
  JOURNAL   JCI Insight 6 (19), e147612 (2021)
   PUBMED   34437302
  REMARK    GeneRIF: Sarcomeric deficits underlie MYBPC1-associated myopathy
            with myogenic tremor.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1124)
  AUTHORS   Firulli BA, George RM, Harkin J, Toolan KP, Gao H, Liu Y, Zhang W,
            Field LJ, Liu Y, Shou W, Payne RM, Rubart-von der Lohe M and
            Firulli AB.
  TITLE     HAND1 loss-of-function within the embryonic myocardium reveals
            survivable congenital cardiac defects and adult heart failure
  JOURNAL   Cardiovasc Res 116 (3), 605-618 (2020)
   PUBMED   31286141
REFERENCE   5  (residues 1 to 1124)
  AUTHORS   Chen JQ, Mori H, Cardiff RD, Trott JF, Hovey RC, Hubbard NE,
            Engelberg JA, Tepper CG, Willis BJ, Khan IH, Ravindran RK, Chan SR,
            Schreiber RD and Borowsky AD.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1124)
  AUTHORS   Jin C, Chen J, Meng Q, Carreira V, Tam NN, Geh E, Karyala S, Ho SM,
            Zhou X, Medvedovic M and Xia Y.
  TITLE     Deciphering gene expression program of MAP3K1 in mouse eyelid
            morphogenesis
  JOURNAL   Dev Biol 374 (1), 96-107 (2013)
   PUBMED   23201579
REFERENCE   7  (residues 1 to 1124)
  AUTHORS   Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor
            D, Tang DT, Grimmond SM and Little MH.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 1124)
  AUTHORS   Kurasawa M, Sato N, Matsuda A, Koshida S, Totsuka T and Obinata T.
  TITLE     Differential expression of C-protein isoforms in developing and
            degenerating mouse striated muscles
  JOURNAL   Muscle Nerve 22 (2), 196-207 (1999)
   PUBMED   10024132
REFERENCE   9  (residues 1 to 1124)
  AUTHORS   Gautel M, Furst DO, Cocco A and Schiaffino S.
  TITLE     Isoform transitions of the myosin binding protein C family in
            developing human and mouse muscles: lack of isoform
            transcomplementation in cardiac muscle
  JOURNAL   Circ Res 82 (1), 124-129 (1998)
   PUBMED   9440711
REFERENCE   10 (residues 1 to 1124)
  AUTHORS   Schiaffino S and Reggiani C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY135230.1, BC062158.1 and BB669565.1.
            
            On Dec 20, 2003 this sequence version replaced NP_780627.1.
            
            Transcript Variant: This variant (2) has multiple differences in
            the coding region, compared to variant 1, one of which results in a
            translational frameshift. The resulting protein (isoform 2) has a
            distinct C-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.99 cM"
     Protein         1..1124
                     /product="myosin-binding protein C, slow-type isoform 2"
                     /note="Slow-type C-protein; MyBP-C slow"
                     /calculated_mol_wt=126066
     Region          60..160
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          76..80
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409554"
     Region          92..96
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409554"
     Region          126..130
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409554"
     Region          140..145
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409554"
     Region          153..156
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409554"
     Region          210..243
                     /region_name="THB"
                     /note="Tri-helix bundle domain; pfam18362"
                     /db_xref="CDD:465725"
     Region          257..338
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          271..275
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409559"
     Region          283..287
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409559"
     Region          308..312
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409559"
     Region          322..327
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409559"
     Region          331..334
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409559"
     Region          345..429
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          360..364
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409559"
     Region          372..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409559"
     Region          399..403
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409559"
     Region          413..418
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409559"
     Region          422..425
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409559"
     Region          435..505
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          451..455
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409570"
     Region          484..491
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409570"
     Region          532..617
                     /region_name="Ig_C5_MyBP-C"
                     /note="C5 immunoglobulin (Ig) domain of cardiac myosin
                     binding protein C (MyBP-C); cd05894"
                     /db_xref="CDD:409475"
     Region          535..539
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409475"
     Region          543..550
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409475"
     Region          556..563
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409475"
     Region          564..566
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409475"
     Region          574..580
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409475"
     Region          581..588
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409475"
     Region          596..604
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409475"
     Region          607..617
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409475"
     Region          621..710
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(621,687,702)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(703..704,706..707)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          720..804
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          831..897
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          840..844
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409406"
     Region          853..857
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409406"
     Region          877..881
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409406"
     Region          891..896
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409406"
     Region          915..998
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(915,980,995)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          1030..1119
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          1047..1051
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1060..1064
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1085..1089
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1099..1104
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..1124
                     /gene="Mybpc1"
                     /gene_synonym="8030451F13Rik"
                     /coded_by="NM_175418.5:228..3602"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS48666.1"
                     /db_xref="GeneID:109272"
                     /db_xref="MGI:MGI:1336213"
ORIGIN      
        1 mpeptkkeen evsapapppe epnkekeagt apakewslge spaggeeqdk qnansqlstl
       61 fvekpqtgsv kvganitfva kvraedllrk ptvkwfkgkw mdlaskagkh lqlketferq
      121 trvytfemqi ikakenyagn yrcevtykdk fdscsfdlev hestgttpni dirsafkrsg
      181 egqedageld fsgllkrrev kqqeeepeid vwellknanp neyekiafqy gitdlrgmlk
      241 rlkrmrrvek ksaafakild payqvdkggk vrfvveladp klevkwfkng qeirpstkyi
      301 fehkgnerim finncsltdd seyyvtagde kcstelfvre ppimvtkqle dmnaycgerv
      361 emevevsedd anvkwfknge eifpgpksry kikvegkkht liiegatkad saeysamttg
      421 gqssaklsvd lrplkittpl tdqtvklgke vclkceisen vpgkwtkngl pvqegerlkv
      481 vhkgrihklv ianaliedeg eyvftpdayn vplsakvhvi dppkiildgl dadntvtvia
      541 gsklrleipv tgepppkaiw sradkaimeg sgriraesyp dsstlvidva erddsgvyni
      601 nlkneageah asikikvvdi pdppvapnvt evgddwcimn weppaydggs pilgyfierk
      661 kkqssrwmrl nfdlckettf epkkmiegva yevrifavna igiskpsmps kpfvplavts
      721 pptllavdsv tdssvtmkwr ppdqigaagl dgyvleycfe gtedwivant dlidktkfti
      781 nglptdakif vrvkainaag asepkyysqp ilvkeiiepp kiriprhlkq tyirrvgeav
      841 nlvipfqgkp rpeltwkkdg eeidknqini rnsetdtiif irkaershsg kydlqvkvdk
      901 yvenasidiq ivdrpgppqt vtiedvwgen valtwtppkd dgnaaitgyt iqkadkksme
      961 wftviehyhr tnatitelvi gneyyfrvfa enmcglseda tmtkesavia kdgkiyknpv
     1021 yedfnfteap mftqplvnty aiagynatln csvrgnpkpk itwmknkvai vddpryrmfs
     1081 nqgvctleir kpspydggty cckavndlgt veiecklevk vvaq
//
