LOCUS       NM_008652               3702 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus myeloblastosis oncogene-like 2 (Mybl2), mRNA.
ACCESSION   NM_008652
VERSION     NM_008652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3702)
  AUTHORS   Young,C.A., Burt,E. and Munnamalai,V.
  TITLE     A cochlear progenitor pool influences patterning of the mammalian
            sensory epithelium via MYBL2
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39254648
  REMARK    GeneRIF: A cochlear progenitor pool influences patterning of the
            mammalian sensory epithelium via MYBL2.
REFERENCE   2  (bases 1 to 3702)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3702)
  AUTHORS   Brahim,S., Negulescu,A.M., Geneste,C., Schott,T., Lin,S.,
            Morel,L.O., Rama,N., Gadot,N., Treilleux,I., Mehlen,P. and
            Meurette,O.
  TITLE     Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor
            initiation in breast cancer
  JOURNAL   Cell Death Dis 14 (2), 171 (2023)
   PUBMED   36854682
  REMARK    GeneRIF: Notch3 regulates Mybl2 via HeyL to limit proliferation and
            tumor initiation in breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3702)
  AUTHORS   Xia,Y., Inoue,K., Du,Y., Baker,S.J., Reddy,E.P., Greenblatt,M.B.
            and Zhao,B.
  TITLE     TGFbeta reprograms TNF stimulation of macrophages towards a
            non-canonical pathway driving inflammatory osteoclastogenesis
  JOURNAL   Nat Commun 13 (1), 3920 (2022)
   PUBMED   35798734
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3702)
  AUTHORS   Zhang,J., Liu,W., Li,G., Xu,C., Nie,X., Qin,D., Wang,Q., Lu,X.,
            Liu,J. and Li,L.
  TITLE     BCAS2 is involved in alternative splicing and mouse oocyte
            development
  JOURNAL   FASEB J 36 (2), e22128 (2022)
   PUBMED   34972250
REFERENCE   6  (bases 1 to 3702)
  AUTHORS   Latham,K.E., Litvin,J., Orth,J.M., Patel,B., Mettus,R. and
            Reddy,E.P.
  TITLE     Temporal patterns of A-myb and B-myb gene expression during testis
            development
  JOURNAL   Oncogene 13 (6), 1161-1168 (1996)
   PUBMED   8808690
REFERENCE   7  (bases 1 to 3702)
  AUTHORS   Sitzmann,J., Noben-Trauth,K., Kamano,H. and Klempnauer,K.H.
  TITLE     Expression of B-Myb during mouse embryogenesis
  JOURNAL   Oncogene 12 (9), 1889-1894 (1996)
   PUBMED   8649849
REFERENCE   8  (bases 1 to 3702)
  AUTHORS   Kamano,H., Burk,B., Noben-Trauth,K. and Klempnauer,K.H.
  TITLE     Differential splicing of the mouse B-myb gene
  JOURNAL   Oncogene 11 (12), 2575-2582 (1995)
   PUBMED   8545114
REFERENCE   9  (bases 1 to 3702)
  AUTHORS   Lam,E.W. and Watson,R.J.
  TITLE     An E2F-binding site mediates cell-cycle regulated repression of
            mouse B-myb transcription
  JOURNAL   EMBO J 12 (7), 2705-2713 (1993)
   PUBMED   8334989
REFERENCE   10 (bases 1 to 3702)
  AUTHORS   Lam,E.W., Robinson,C. and Watson,R.J.
  TITLE     Characterization and cell cycle-regulated expression of mouse B-myb
  JOURNAL   Oncogene 7 (9), 1885-1890 (1992)
   PUBMED   1501895
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK028497.1.
            
            On Jun 9, 2003 this sequence version replaced NM_008652.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028497.1, BC050842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.0 cM"
     gene            1..3702
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /note="myeloblastosis oncogene-like 2"
                     /db_xref="GeneID:17865"
                     /db_xref="MGI:MGI:101785"
     exon            1..214
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2309
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /note="myb-like protein 2"
                     /codon_start=1
                     /product="myb-related protein B"
                     /protein_id="NP_032678.1"
                     /db_xref="CCDS:CCDS17006.1"
                     /db_xref="GeneID:17865"
                     /db_xref="MGI:MGI:101785"
                     /translation="MSRRTRCEDLDELHYQDVDSDLLEQRDNRCKVKWTHEEDEQLRA
                     LVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYG
                     TKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEI
                     AKMLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRDCKPVYLLLELEDKEQHQGVQPVD
                     GQGSLVSSWPLVPSIVKEESSEEEIAIAATSAKELGHEPVPADLGEVRTPEPPESLKR
                     EYQEFSSPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEP
                     STEGSVVSSPVQPQTSQQQQEEALQSSQQAATPGPSVTEYRLDGHTISDLSRSSRGEL
                     IPISPSTEFGGSGIGTPPSVLKRQKKRRVALSPVTENSASLSFLDSCNSLTPKSTPVK
                     TLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKYPSSEV
                     LPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGMELIIEDD
                     MRPEKQKRKPGLRRSPIKKVRKSLALDIMDEDGKLMSSTMPKPLSLPTSVTPSSCGFT
                     SPGSKEGNSLLNQGFLQAKPEKVVAAQKTRSHIPTPAPMTHAWKTVACGGTKDQLFMQ
                     EKARQLLSRLKSSHTSRTLILS"
     exon            215..308
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            309..380
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            381..473
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            474..694
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            695..854
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1145
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1568
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1708
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1811
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1925
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2030
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2180
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..3702
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3702
                     /gene="Mybl2"
                     /gene_synonym="B-Myb; Bmyb"
                     /note="putative"
ORIGIN      
        1 aaagtggttc tgtgcgctcc ctaggcagct gcagttcctg ggaacgtgcg accagacctg
       61 cagacacgct gacgcctgag agcaccgcct ggggcccgga gcggctcgag cagcctgagt
      121 cctgaccccg gcccggctcc cgctccgggc tcggccggcg ggcgtaaggg tgcggcgggg
      181 tccgggccgg ggggatgtct cggcggacgc gctgcgagga tctggatgag ttacactacc
      241 aggacgtgga ctcagacctc ctggagcaga gagacaacag atgtaaggtt aaatggaccc
      301 acgaggagga cgagcagttg agggccctgg tgaggcagtt tggacagcaa gactggaagt
      361 tcttggccag tcactttcct aaccgcacag accagcaatg ccagtaccgg tggctgaggg
      421 ttttgaatcc cgaccttgtt aagggaccat ggaccaaaga ggaagatcaa aaggtcattg
      481 agttggtcaa gaagtatggc accaaacagt ggacgctgat agccaagcac ctgaagggcc
      541 ggctggggaa gcagtgccgt gagcgctggc acaaccacct caaccccgag gtgaagaagt
      601 catgctggac cgaggaggaa gacaggataa tctgtgaggc ccataaagtc ctgggtaacc
      661 gctgggctga gatcgccaag atgctaccag ggaggacgga caatgctgtg aagaatcact
      721 ggaactccac tatcaaaagg aaagtcgaca cgggaggttt cccagccgag tccagggact
      781 gcaagcctgt ctacttgctc ctggagctgg aggacaagga acagcaccag ggtgtccagc
      841 cggtggacgg ccagggaagt ctcgtgagca gctggccgct ggtgccctct attgtgaagg
      901 aggagagcag cgaggaggag attgccatag ctgctacttc tgctaaagaa ctcggacatg
      961 agcctgtccc tgctgatctg ggagaagtgc gcaccccaga gcccccagaa tctctcaagc
     1021 gtgaatacca ggagttctcc tccccggaaa cgagcctgcc ctacaagtgg gtggtagagg
     1081 cggcaaacct cctcatcccg gctgtggggt ccagcctctc tgaagctctg gacttgattg
     1141 agtcggaccc tgatgcttgg tgcgacctga gtaaatttga ccttcctgaa gaaccctcta
     1201 cggagggcag tgtcgtcagc agcccagtgc agccccagac gtcgcagcag cagcaggagg
     1261 aggcactgca gtcatcccag caggctgcca cgccggggcc cagtgtgact gagtaccgcc
     1321 ttgatggcca cactatttca gacctgagcc ggagcagtcg gggggagctg atccccattt
     1381 ctcctagcac tgagtttggg ggctcaggca ttggcacacc tccctcagtg ctcaagcgac
     1441 agaagaaacg gcgtgtggcc ctgtcgcctg tcacagagaa cagtgccagc ctgtccttcc
     1501 tggactcttg taacagcctc accccgaaga gcacgcctgt caaaaccctc cccttctctc
     1561 cttcccagtt tctgaacttc tggaacaaac aggataccct ggagctggag agcccctcac
     1621 tgacatccac tccagtgtgt agccaaaagg tggtcgtcac cacgcccctg cacagggata
     1681 agacacccct gcaccagaag tatccatcat cagaagtact cccagatcag aagtactcca
     1741 tggacaacac tccccacacg ccaaccccgt tcaagaatgc cctggagaag tacggaccgc
     1801 tgaagcccct gccgcagact ccgcacctgg aggaggactt gaaggaggtg ctccgttctg
     1861 aggccggcat ggagctcatc attgaggatg acatgaggcc cgagaagcag aagagaaagc
     1921 ctgggctgcg gcgaagccct atcaagaagg tccgcaagtc tctggctctc gacattatgg
     1981 atgaagatgg gaagctgatg tcctctacca tgcccaaacc cctgtccttg ccaaccagtg
     2041 tcacacccag ctcctgtggc ttcacctcgc caggtagcaa agagggtaac agcctgctca
     2101 accagggttt cctacaggcc aaacccgaga aggtggtggc cgcccagaag actcggagcc
     2161 acattccaac ccctgcccct atgacccatg cctggaagac ggtggcctgt gggggcacca
     2221 aagaccagct cttcatgcag gagaaagccc ggcagctcct gagccgcctg aagtccagcc
     2281 acacatctcg gaccctcatt ctgtcctgag ggacttgaat ggcaagagcc ggctctcatg
     2341 tttacagggg tagggtgtgg ggtaaggtta aagtcacatt aagtgaccag cttcaggatg
     2401 tcttctgcca gcccctcaaa ctacttaggt ggcagaagtc acgtggtaat accccttccc
     2461 tgagtctagc tttgggaagt tcctggtgct aatagaacaa ggtcccactc ctgggcctgc
     2521 ctgtcctcta cccaatgcta gaaggaaccc tatcagggtc tcccaggctc tcatccagtc
     2581 tggcctcatc tcagactcct gcttaggatg ggggtgtggc taggggtgcg cctttcctcg
     2641 tctcctgttg gtacactgtc cccacaataa aatgccattc tccctctgcc gccccgactc
     2701 tgccctctga gtcctgaagt gcctcgatgg ccttttcctg acatgtagac ctttgtcact
     2761 gggtacagct ttgccctgtg agtatctctg caaagctccc aagaactatg tatgagtgga
     2821 tgaagatggg ttctgagaac ttgttggagc gctgcattca ccttggcctt aatgcatcag
     2881 agtcataacg cacttggctt gggccatctt ccaaggagcg gctgccttaa gttgagccag
     2941 cccttaggta agaccattaa tagagggctg gcagaccttt caactctagc caatgtgcag
     3001 aaggctgccc agcccctgga ttctgtatca tgagttggtg gcagcagttg cctcggctgt
     3061 tacctcccta ggaatcagtg ggtagagtgt ggcccatagc tggtgatcag tctcaaactt
     3121 gaaaagggag atgctgagcc taaagtctag atcaggaagt gttttcagta gccttgcctg
     3181 ggtgtccttg ggttggggat catatgggag ccctatactt agtcctgttt gtaagggaga
     3241 tgaggcaaac cctctccaac agggcaagag acaacatctg aagacatgac caagttagca
     3301 caccagagtc tagacacttt cctgctctta tgcaaaggat gcaggaggtg gactctacta
     3361 tcccactctg cctcatccta cagcctcctg agccccatgc tcactgagct gcatctgcct
     3421 cacccctact tgttttctca gtatgactaa ggcaacttag agtagctaca ctcattggtg
     3481 tgtggtctgt gctaggaaag gcgtgggtag ggtggggtga ggctgtcaag cagaggatag
     3541 aggctgctgg tgcccacctg gctttcctgc cgtctaggat ctctccatgg gtgctgccac
     3601 ctgcattatt agggtggctc ttttaaacct ggaatttcct cgcagacaca cccaaatgtg
     3661 tcttctggtc agccaagttg acaataaaga gtaacacatt gt
//
