LOCUS       NP_001277326             691 aa            linear   ROD 02-APR-2024
DEFINITION  myb-related protein A isoform 2 [Mus musculus].
ACCESSION   NP_001277326 XP_006495525
VERSION     NP_001277326.1
DBSOURCE    REFSEQ: accession NM_001290397.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 691)
  AUTHORS   Xu,J., Wang,B. and Zhang,D.
  TITLE     LncRNA ENSMUST00000171502 Induced by HIF-1alpha Ameliorates
            Ischemic Acute Kidney Injury via Targeting the miR-130b-3p/Mybl-1
            Axis
  JOURNAL   Cells 11 (23), 3747 (2022)
   PUBMED   36497007
  REMARK    GeneRIF: LncRNA ENSMUST00000171502 Induced by HIF-1alpha
            Ameliorates Ischemic Acute Kidney Injury via Targeting the
            miR-130b-3p/Mybl-1 Axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 691)
  AUTHORS   Yu,T., Biasini,A., Cecchini,K., Saflund,M., Mou,H., Arif,A.,
            Eghbali,A., de Rooij,D., Weng,Z., Zamore,P.D. and Ozata,D.M.
  TITLE     A-MYB/TCFL5 regulatory architecture ensures the production of
            pachytene piRNAs in placental mammals
  JOURNAL   RNA 29 (1), 30-43 (2022)
   PUBMED   36241367
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 691)
  AUTHORS   Maezawa,S., Sakashita,A., Yukawa,M., Chen,X., Takahashi,K.,
            Alavattam,K.G., Nakata,I., Weirauch,M.T., Barski,A. and
            Namekawa,S.H.
  TITLE     Super-enhancer switching drives a burst in gene expression at the
            mitosis-to-meiosis transition
  JOURNAL   Nat Struct Mol Biol 27 (10), 978-988 (2020)
   PUBMED   32895557
  REMARK    GeneRIF: Super-enhancer switching drives a burst in gene expression
            at the mitosis-to-meiosis transition.
REFERENCE   4  (residues 1 to 691)
  AUTHORS   Liang,M., Wang,H., He,C., Zhang,K. and Hu,K.
  TITLE     LncRNA-Gm2044 is transcriptionally activated by A-MYB and regulates
            Sycp1 expression as a miR-335-3p sponge in mouse
            spermatocyte-derived GC-2spd(ts) cells
  JOURNAL   Differentiation 114, 49-57 (2020)
   PUBMED   32585553
  REMARK    GeneRIF: LncRNA-Gm2044 is transcriptionally activated by A-MYB and
            regulates Sycp1 expression as a miR-335-3p sponge in mouse
            spermatocyte-derived GC-2spd(ts) cells.
REFERENCE   5  (residues 1 to 691)
  AUTHORS   Ozata,D.M., Yu,T., Mou,H., Gainetdinov,I., Colpan,C., Cecchini,K.,
            Kaymaz,Y., Wu,P.H., Fan,K., Kucukural,A., Weng,Z. and Zamore,P.D.
  TITLE     Evolutionarily conserved pachytene piRNA loci are highly divergent
            among modern humans
  JOURNAL   Nat Ecol Evol 4 (1), 156-168 (2020)
   PUBMED   31900453
REFERENCE   6  (residues 1 to 691)
  AUTHORS   Toscani,A., Mettus,R.V., Coupland,R., Simpkins,H., Litvin,J.,
            Orth,J., Hatton,K.S. and Reddy,E.P.
  TITLE     Arrest of spermatogenesis and defective breast development in mice
            lacking A-myb
  JOURNAL   Nature 386 (6626), 713-717 (1997)
   PUBMED   9109487
REFERENCE   7  (residues 1 to 691)
  AUTHORS   Latham,K.E., Litvin,J., Orth,J.M., Patel,B., Mettus,R. and
            Reddy,E.P.
  TITLE     Temporal patterns of A-myb and B-myb gene expression during testis
            development
  JOURNAL   Oncogene 13 (6), 1161-1168 (1996)
   PUBMED   8808690
REFERENCE   8  (residues 1 to 691)
  AUTHORS   Sitzmann,J., Noben-Trauth,K. and Klempnauer,K.H.
  TITLE     Expression of mouse c-myb during embryonic development
  JOURNAL   Oncogene 11 (11), 2273-2279 (1995)
   PUBMED   8570177
REFERENCE   9  (residues 1 to 691)
  AUTHORS   Trauth,K., Mutschler,B., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Klempnauer,K.H.
  TITLE     Mouse A-myb encodes a trans-activator and is expressed in
            mitotically active cells of the developing central nervous system,
            adult testis and B lymphocytes
  JOURNAL   EMBO J 13 (24), 5994-6005 (1994)
   PUBMED   7813437
REFERENCE   10 (residues 1 to 691)
  AUTHORS   Mettus,R.V., Litvin,J., Wali,A., Toscani,A., Latham,K., Hatton,K.
            and Reddy,E.P.
  TITLE     Murine A-myb: evidence for differential splicing and
            tissue-specific expression
  JOURNAL   Oncogene 9 (10), 3077-3086 (1994)
   PUBMED   8084617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158790.5 and AC103620.12.
            
            On Mar 13, 2014 this sequence version replaced XP_006495525.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. The encoded
            protein (isoform 2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript from the same strain was
            available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments and orthologous
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849380
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.08 cM"
     Protein         1..691
                     /product="myb-related protein A isoform 2"
                     /note="myb-related protein A; myb-like protein 1"
                     /calculated_mol_wt=78599
     Region          1..22
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51960.2)"
     Region          38..98
                     /region_name="Myb_DNA-bind_6"
                     /note="Myb-like DNA-binding domain; pfam13921"
                     /db_xref="CDD:372817"
     Site            order(38,68..69,71..72,74..76,78..80)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     Region          84..>192
                     /region_name="PLN03091"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:215570"
     Region          230..294
                     /region_name="Transcriptional activation domain.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51960.2)"
     Region          240..285
                     /region_name="LMSTEN"
                     /note="LMSTEN motif; pfam07988"
                     /db_xref="CDD:462332"
     Region          297..552
                     /region_name="Negative regulatory domain.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51960.2)"
     Site            393
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P10243; propagated from
                     UniProtKB/Swiss-Prot (P51960.2)"
     Region          485..641
                     /region_name="Cmyb_C"
                     /note="C-myb, C-terminal; pfam09316"
                     /db_xref="CDD:462753"
     CDS             1..691
                     /gene="Mybl1"
                     /gene_synonym="A-myb; G1-419-6; repro9"
                     /coded_by="NM_001290397.1:256..2331"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS69861.1"
                     /db_xref="GeneID:17864"
                     /db_xref="MGI:MGI:99925"
ORIGIN      
        1 makrsrsede dddlqyadhd yevpqqkglk klwnrvkwtr deddklkklv eqhgtddwtl
       61 iashlqnrsd fqcqhrwqkv lnpelikgpw tkeedqrvie lvqkygpkrw sliakhlkgr
      121 igkqcrerwh nhlnpevkks swteeedrii yeahkrlgnr waeiakllpg rtdnsiknhw
      181 nstmrrkveq egylqdgiks ersssklqhk pcatmdhlqt qnqfyipvqi pgyqyvspdg
      241 ncvehvqtsa fiqqpfvded pdkekkikel elllmsaene vrrkrlppqp gsfsswsgsf
      301 lmddsmsntl nnleehttef ysmdenqtvs aqqnsptkfl aveanavlss lqtipefaet
      361 leliesdpva wsdvtsfdls daaaspvkst pvklmriqhn egamecqfnv slvlegkkns
      421 rnggdseaip ltspnvvkfs tpptilrkkk rirvgqsags elgdgslsev gnaalkhtpv
      481 ktlpfspsqf fntcpgneql nienpsftst picgqkvlit tplqkeatpk dqkenvgfrt
      541 ptirrsilgt tprtptpfkn alaaqekkyg plkivsqpla fleedirevl keetgtdifl
      601 keedepayks ckqehsasvk kvrkslales wdkeepgtql ltedisdmqs ncewetvvyg
      661 ktedqlimte qarrylstyt atsstsrali l
//
