LOCUS       NM_010848               3420 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus myeloblastosis oncogene (Myb), transcript variant 2,
            mRNA.
ACCESSION   NM_010848
VERSION     NM_010848.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3420)
  AUTHORS   Simats,A., Zhang,S., Messerer,D., Chong,F., Beskardes,S.,
            Chivukula,A.S., Cao,J., Besson-Girard,S., Montellano,F.A.,
            Morbach,C., Carofiglio,O., Ricci,A., Roth,S., Llovera,G., Singh,R.,
            Chen,Y., Filser,S., Plesnila,N., Braun,C., Spitzer,H., Gokce,O.,
            Dichgans,M., Heuschmann,P.U., Hatakeyama,K., Beltran,E., Clauss,S.,
            Bonev,B., Schulz,C. and Liesz,A.
  TITLE     Innate immune memory after brain injury drives inflammatory cardiac
            dysfunction
  JOURNAL   Cell 187 (17), 4637-4655 (2024)
   PUBMED   39043180
REFERENCE   2  (bases 1 to 3420)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3420)
  AUTHORS   Varadinkova,S., Oralova,V., Clarke,M., Frampton,J., Knopfova,L.,
            Lesot,H., Bartos,P. and Matalova,E.
  TITLE     Expression dynamics of metalloproteinases during mandibular bone
            formation: association with Myb transcription factor
  JOURNAL   Front Cell Dev Biol 11, 1168866 (2023)
   PUBMED   37701782
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3420)
  AUTHORS   Li,Q., Jiao,J., Heng,Y., Lu,Q., Zheng,Y., Li,H., Cai,J., Mei,M. and
            Bao,S.
  TITLE     Prmt5 promotes ciliated cell specification of airway epithelial
            progenitors via transcriptional inhibition of Tp63
  JOURNAL   J Biol Chem 299 (8), 104964 (2023)
   PUBMED   37364687
REFERENCE   5  (bases 1 to 3420)
  AUTHORS   Clarke,M.L., Lemma,R.B., Walton,D.S., Volpe,G., Noyvert,B.,
            Gabrielsen,O.S. and Frampton,J.
  TITLE     MYB insufficiency disrupts proteostasis in hematopoietic stem
            cells, leading to age-related neoplasia
  JOURNAL   Blood 141 (15), 1858-1870 (2023)
   PUBMED   36603185
  REMARK    GeneRIF: MYB insufficiency disrupts proteostasis in hematopoietic
            stem cells, leading to age-related neoplasia.
REFERENCE   6  (bases 1 to 3420)
  AUTHORS   Shimizu,A., Sakai,Y., Ohno,K., Masaki,S., Kuwano,R., Takahashi,Y.,
            Miyashita,N. and Watanabe,T.
  TITLE     A molecular genetic linkage map of mouse chromosome 10, including
            the Myb, S100b, Pah, Sl, and Ifg genes
  JOURNAL   Biochem Genet 30 (9-10), 529-535 (1992)
   PUBMED   1359872
REFERENCE   7  (bases 1 to 3420)
  AUTHORS   Blackshear,P.J., Tuttle,J.S., Oakey,R.J., Seldin,M.F., Chery,M.,
            Philippe,C. and Stumpo,D.J.
  TITLE     Chromosomal mapping of the human (MACS) and mouse (Macs) genes
            encoding the MARCKS protein
  JOURNAL   Genomics 14 (1), 168-174 (1992)
   PUBMED   1427822
REFERENCE   8  (bases 1 to 3420)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   9  (bases 1 to 3420)
  AUTHORS   Buckley,M.F. and Goding,J.W.
  TITLE     Plasma cell membrane glycoprotein gene Pca-1 (alkaline
            phosphodiesterase I) is linked to the proto-oncogene Myb on mouse
            chromosome 10
  JOURNAL   Immunogenetics 36 (3), 199-201 (1992)
   PUBMED   1351877
REFERENCE   10 (bases 1 to 3420)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153556.5, M12848.1, AK137965.1, AK132250.1, AK137794.1,
            AA170760.1 and BB543454.1.
            
            On Jul 19, 2006 this sequence version replaced NM_010848.2.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            3' coding region, compared to variant 1, and encodes a shorter
            isoform (2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M12848.1, AK132250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AC153556.5         73811-74099
            290-1028            M12848.1           288-1026
            1029-1952           AK137965.1         895-1818
            1953-2923           AK132250.1         1818-2788
            2924-3136           AK137794.1         1870-2082
            3137-3411           AA170760.1         206-480
            3412-3420           BB543454.1         299-307
FEATURES             Location/Qualifiers
     source          1..3420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.75 cM"
     gene            1..3420
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /note="myeloblastosis oncogene"
                     /db_xref="GeneID:17863"
                     /db_xref="MGI:MGI:97249"
     exon            1..289
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..2177
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /note="isoform 2 is encoded by transcript variant 2;
                     myeloblastosis proto-oncogene product; myb proto-oncogene
                     protein; transcriptional activator Myb; gag-myb protein;
                     tumor-specific myb protein; proto-oncogene c-Myb"
                     /codon_start=1
                     /product="transcriptional activator Myb isoform 2"
                     /protein_id="NP_034978.3"
                     /db_xref="CCDS:CCDS35861.1"
                     /db_xref="GeneID:17863"
                     /db_xref="MGI:MGI:97249"
                     /translation="MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWT
                     REEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQR
                     VIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHK
                     RLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNN
                     HLMGFGHASPPSQLSPSGQSSVNSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPA
                     AAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTCSYPGWHSTSIVD
                     QTRPHGDSAPVSCLGEHHATPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEF
                     AETLQFIDSFLNTSSNHESSGLDAPTLPSTPLIGHKLTPCRDQTVKTQKENSIFRTPA
                     IKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHAVEDLQDVIKQESDESGIV
                     AEFQESGPPLLKKIKQEVESPTEKSGNFFCSNHWAENSLSTQLFSQASPVADAPNILT
                     SSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPCSGAWEPASCGKTEDQMTASGPARK
                     YVNAFSARTLVM"
     exon            290..407
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            408..479
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            480..572
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            573..793
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1028
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1109
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1214
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1469
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1600
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1715
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1841
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1952
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2060
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..3420
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3389..3394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /note="hexamer: AATAAA"
     polyA_site      3415
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /note="major polyA site"
ORIGIN      
        1 gggagtgtcc aaacctcttt gtttgatggc atctgtttac agagttacac tttaatatca
       61 acctgtttcc tcctcctcct tctcctcctt ctcctcctcc tcctcggtga cctccttctc
      121 ctcccctttc tccggagaaa cttcgccccg gcggtgcgga gcgccgctgc gcagccgggg
      181 gaggacgcag gcaaggcgga gggcagcggg aggcggcaac cggtgcggtc cccggggctc
      241 ttggcggagc cccggcccgc ctcgccatgg cccggagacc ccgacacagc atctacagta
      301 gcgatgaaga tgatgaagac attgagatgt gtgaccatga ctacgatggg ctgctgccca
      361 aatctggaaa gcgtcacttg gggaaaacta ggtggacaag ggaagaggat gagaagctga
      421 agaagctggt ggaacagaac ggaacagacg actggaaagt cattgccaat tatctgccca
      481 accggacaga tgtgcagtgc caacaccggt ggcagaaagt gctgaaccct gaactcatca
      541 aaggtccctg gaccaaagaa gaagatcaga gagtcataga gcttgtccag aaatatggtc
      601 cgaagcgttg gtctgttatt gccaagcact taaaagggag aattggaaag cagtgtcggg
      661 agaggtggca caaccatttg aatccagaag ttaagaaaac ctcctggaca gaagaggagg
      721 acagaatcat ttaccaggca cacaagcgtc tggggaacag atgggcagag atcgcaaagc
      781 tgctgcccgg acggactgat aatgctatca agaaccactg gaattccacc atgcgtcgca
      841 aggtggaaca ggaaggctac ctgcaggagc cttccaaagc cagccagacg ccagtggcca
      901 cgagcttcca gaagaacaat catttgatgg ggtttgggca tgcctcacct ccatctcagc
      961 tctctccaag tggccagtcc tccgtcaaca gcgaatatcc ctattaccac atcgccgaag
     1021 cacaaaacat ctccagtcac gttccctatc ctgtcgcatt gcatgttaat atagtcaacg
     1081 tccctcagcc ggctgcggca gccatccaga gacactataa cgacgaagac cctgagaagg
     1141 aaaagcgaat aaaggagctg gagttgctcc tgatgtcaac agagaacgag ctgaagggac
     1201 agcaggcatt accaacacag aaccacactt gcagctaccc cgggtggcac agcacctcca
     1261 ttgtggacca gaccagacct catggggata gtgcacctgt ttcctgtttg ggagaacacc
     1321 atgccacccc atctctgcct gcagatcccg gctccctacc tgaagaaagt gcctcaccag
     1381 caaggtgcat gatcgtccac cagggcacca ttctggacaa tgttaagaac ctcttagaat
     1441 ttgcagaaac actccagttt atagattctt tcttgaacac ttccagcaac catgaaagct
     1501 cgggcttaga tgcacctacc ttaccctcca ctcctctcat tggtcacaaa ctgacaccat
     1561 gtcgagacca gactgtgaaa acccagaagg aaaattccat ctttagaact ccagctatca
     1621 aaaggtcaat cctcgaaagc tctcctcgaa ctcccacacc attcaaacat gcccttgcag
     1681 ctcaagaaat taaatacggt cccctgaaga tgctacctca gaccccctcc catgcagtgg
     1741 aggacctaca agatgtgatt aagcaggaat cggatgaatc tggaattgtg gctgagtttc
     1801 aagagagtgg accaccgtta ctgaaaaaaa tcaagcagga ggtggagtcg ccaactgaga
     1861 aatcgggaaa cttcttctgc tcaaaccact gggcagagaa cagcctgagc acccagctgt
     1921 tctcgcaggc gtctcctgtg gcagatgccc caaatattct tacaagctct gttttaatga
     1981 cacctgtatc agaagatgaa gacaatgtcc tcaaagcctt taccgtacct aagaacaggc
     2041 ccctggtggg tcccttgcag ccatgcagtg gtgcctggga gccagcatcc tgtgggaaga
     2101 cagaggacca gatgacggcc tccggtccgg ctcggaaata cgtgaacgcg ttctcagctc
     2161 gaactctggt catgtgagac atttccagaa aagcattatg gttttcagaa cacttaaaag
     2221 ttgactttcg acacatggct cctcagcgtg gagcgctcca tggctgagag aagagcctga
     2281 ttttgttgtg gtacaacagt tgagagcagc accaagtgca tttttagttg cttgagatct
     2341 cacttgattt cacacaacta aaaaggattt ttttttttaa aaataataat aatgaataac
     2401 agtcttacct aaattattag gtaatgaatt gtgaccattt gttaatatca taatcagatt
     2461 ttttaaaaaa aataaaatga tttatttgta ttttagagga tacaacagat cagtattttt
     2521 gactgtggtg aatttaaaaa aaaaatttac acaaagaaat atcccagtat tccatgtatc
     2581 tcagtcacta aacatacaca gagagatttt taaaaaccag gagaagcatt attttgaatg
     2641 ttagctaaat cccaagtaat acttaatgca accctctagg agctcatttg tggctaataa
     2701 tcttggaaat atctttatta tactaaacca tttcatgagg agaattttgt tgtcagcttg
     2761 cttgaaaagt tattactgta tgaaatagtt ttattgaaaa aattatattt ttattcagta
     2821 atttaatttt gtaaatgcca aatggagaaa tgtgttcgct gctatggttt tagcctgtag
     2881 tcatgctgct agctagtgtc agggggcaat agagcttaga tggaaaaaag agaaagagac
     2941 tcggtgttag ataacggact atgcactagt attccagact tttttatttt tatatatatg
     3001 taccttttcc ttttgtaatt ggaaaactta tttgggagaa ttttgcattt gttgtacatt
     3061 tttgtttttt aggatttttt ttttttgttg ttattgtcga tttataaaag cattgcactt
     3121 ctttttcttt ttttgggaga tttgtgttgt ttatgtcata tgttttgttt tgagttcagc
     3181 ctgaatgttc atccgtttgg gcgtttttct gacttggaag aacattctct gtaggtttct
     3241 aagtgtacag agccggaact gcctcgtggt tcctgggctt cagggaagac aaatatggaa
     3301 gtcaacagcc agtttctgcc ttgagagcat ttgcaagaat gctggccttg aattctgaaa
     3361 tgacagtgta tctactgcct tgtagcaaaa taaagctatc ctcttatttt acatacttcc
//
