LOCUS       NM_001198914            3777 bp    mRNA    linear   ROD 04-OCT-2023
DEFINITION  Mus musculus myeloblastosis oncogene (Myb), transcript variant 1,
            mRNA.
ACCESSION   NM_001198914
VERSION     NM_001198914.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3777)
  AUTHORS   Varadinkova S, Oralova V, Clarke M, Frampton J, Knopfova L, Lesot
            H, Bartos P and Matalova E.
  TITLE     Expression dynamics of metalloproteinases during mandibular bone
            formation: association with Myb transcription factor
  JOURNAL   Front Cell Dev Biol 11, 1168866 (2023)
   PUBMED   37701782
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3777)
  AUTHORS   Li Q, Jiao J, Heng Y, Lu Q, Zheng Y, Li H, Cai J, Mei M and Bao S.
  TITLE     Prmt5 promotes ciliated cell specification of airway epithelial
            progenitors via transcriptional inhibition of Tp63
  JOURNAL   J Biol Chem 299 (8), 104964 (2023)
   PUBMED   37364687
REFERENCE   3  (bases 1 to 3777)
  AUTHORS   Clarke ML, Lemma RB, Walton DS, Volpe G, Noyvert B, Gabrielsen OS
            and Frampton J.
  TITLE     MYB insufficiency disrupts proteostasis in hematopoietic stem
            cells, leading to age-related neoplasia
  JOURNAL   Blood 141 (15), 1858-1870 (2023)
   PUBMED   36603185
  REMARK    GeneRIF: MYB insufficiency disrupts proteostasis in hematopoietic
            stem cells, leading to age-related neoplasia.
REFERENCE   4  (bases 1 to 3777)
  AUTHORS   Anand S, Khan MA, Zubair H, Sudan SK, Vikramdeo KS, Deshmukh SK,
            Azim S, Srivastava SK, Singh S and Singh AP.
  TITLE     MYB sustains hypoxic survival of pancreatic cancer cells by
            facilitating metabolic reprogramming
  JOURNAL   EMBO Rep 24 (3), e55643 (2023)
   PUBMED   36592158
  REMARK    GeneRIF: MYB sustains hypoxic survival of pancreatic cancer cells
            by facilitating metabolic reprogramming.
REFERENCE   5  (bases 1 to 3777)
  AUTHORS   Tsui C, Kretschmer L, Rapelius S, Gabriel SS, Chisanga D, Knopper
            K, Utzschneider DT, Nussing S, Liao Y, Mason T, Torres SV, Wilcox
            SA, Kanev K, Jarosch S, Leube J, Nutt SL, Zehn D, Parish IA,
            Kastenmuller W, Shi W, Buchholz VR and Kallies A.
  TITLE     MYB orchestrates T cell exhaustion and response to checkpoint
            inhibition
  JOURNAL   Nature 609 (7926), 354-360 (2022)
   PUBMED   35978192
REFERENCE   6  (bases 1 to 3777)
  AUTHORS   Shimizu A, Sakai Y, Ohno K, Masaki S, Kuwano R, Takahashi Y,
            Miyashita N and Watanabe T.
  TITLE     A molecular genetic linkage map of mouse chromosome 10, including
            the Myb, S100b, Pah, Sl, and Ifg genes
  JOURNAL   Biochem Genet 30 (9-10), 529-535 (1992)
   PUBMED   1359872
REFERENCE   7  (bases 1 to 3777)
  AUTHORS   Blackshear PJ, Tuttle JS, Oakey RJ, Seldin MF, Chery M, Philippe C
            and Stumpo DJ.
  TITLE     Chromosomal mapping of the human (MACS) and mouse (Macs) genes
            encoding the MARCKS protein
  JOURNAL   Genomics 14 (1), 168-174 (1992)
   PUBMED   1427822
REFERENCE   8  (bases 1 to 3777)
  AUTHORS   Moen CJ, Snoek M, Hart AA and Demant P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   9  (bases 1 to 3777)
  AUTHORS   Buckley MF and Goding JW.
  TITLE     Plasma cell membrane glycoprotein gene Pca-1 (alkaline
            phosphodiesterase I) is linked to the proto-oncogene Myb on mouse
            chromosome 10
  JOURNAL   Immunogenetics 36 (3), 199-201 (1992)
   PUBMED   1351877
REFERENCE   10 (bases 1 to 3777)
  AUTHORS   Le Roy H, Simon-Chazottes D, Montagutelli X and Guenet JL.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M12848.1, AK132250.1, CN693253.1 and AC153556.5.
            
            [WARNING] On Jan 22, 2024 this sequence was replaced by
            NM_001198914.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088079.1, SRR10662773.1794856.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               M12848.1           1-143
            144-1469            AK132250.1         9-1334
            1470-1613           CN693253.1         291-434
            1614-1826           AC153556.5         89614-89826
            1827-2735           M12848.1           1468-2376
            2736-3777           AC153556.5         108824-109865
FEATURES             Location/Qualifiers
     source          1..3777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.75 cM"
     gene            1..3777
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /note="myeloblastosis oncogene"
                     /db_xref="GeneID:17863"
                     /db_xref="MGI:MGI:97249"
     exon            1..289
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..2534
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myeloblastosis proto-oncogene product; myb proto-oncogene
                     protein; transcriptional activator Myb; gag-myb protein;
                     tumor-specific myb protein; proto-oncogene c-Myb"
                     /codon_start=1
                     /product="transcriptional activator Myb isoform 1"
                     /protein_id="NP_001185843.1"
                     /db_xref="CCDS:CCDS78800.1"
                     /db_xref="GeneID:17863"
                     /db_xref="MGI:MGI:97249"
                     /translation="MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWT
                     REEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQR
                     VIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHK
                     RLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNN
                     HLMGFGHASPPSQLSPSGQSSVNSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPA
                     AAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTCSYPGWHSTSIVD
                     QTRPHGDSAPVSCLGEHHATPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEF
                     AETLQFIDSDSSWCDLSSFEFSEEAAAFSPSQQPTGKAFQLQQREGHGTRSAGEPSLR
                     VTRRVLSEASLGPDSPQARHSKVPLVVLRKRRGQASPLAAGEPSPSLFADVISSTLKR
                     SPVKSLPFSPSQFLNTSSNHESSGLDAPTLPSTPLIGHKLTPCRDQTVKTQKENSIFR
                     TPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHAVEDLQDVIKQESDES
                     GIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSNHWAENSLSTQLFSQASPVADAPN
                     ILTSSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPCSGAWEPASCGKTEDQMTASGP
                     ARKYVNAFSARTLVM"
     exon            290..407
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            408..479
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            480..572
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            573..793
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1028
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1109
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1214
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1469
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1826
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1957
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2072
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2198
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2309
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2417
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..3777
                     /gene="Myb"
                     /gene_synonym="c-myb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagtgtcc aaacctcttt gtttgatggc atctgtttac agagttacac tttaatatca
       61 acctgtttcc tcctcctcct tctcctcctt ctcctcctcc tcctcggtga cctccttctc
      121 ctcccctttc tccggagaaa cttcgccccg gcggtgcgga gcgccgctgc gcagccgggg
      181 gaggacgcag gcaaggcgga gggcagcggg aggcggcaac cggtgcggtc cccggggctc
      241 ttggcggagc cccggcccgc ctcgccatgg cccggagacc ccgacacagc atctacagta
      301 gcgatgaaga tgatgaagac attgagatgt gtgaccatga ctacgatggg ctgctgccca
      361 aatctggaaa gcgtcacttg gggaaaacta ggtggacaag ggaagaggat gagaagctga
      421 agaagctggt ggaacagaac ggaacagacg actggaaagt cattgccaat tatctgccca
      481 accggacaga tgtgcagtgc caacaccggt ggcagaaagt gctgaaccct gaactcatca
      541 aaggtccctg gaccaaagaa gaagatcaga gagtcataga gcttgtccag aaatatggtc
      601 cgaagcgttg gtctgttatt gccaagcact taaaagggag aattggaaag cagtgtcggg
      661 agaggtggca caaccatttg aatccagaag ttaagaaaac ctcctggaca gaagaggagg
      721 acagaatcat ttaccaggca cacaagcgtc tggggaacag atgggcagag atcgcaaagc
      781 tgctgcccgg acggactgat aatgctatca agaaccactg gaattccacc atgcgtcgca
      841 aggtggaaca ggaaggctac ctgcaggagc cttccaaagc cagccagacg ccagtggcca
      901 cgagcttcca gaagaacaat catttgatgg ggtttgggca tgcctcacct ccatctcagc
      961 tctctccaag tggccagtcc tccgtcaaca gcgaatatcc ctattaccac atcgccgaag
     1021 cacaaaacat ctccagtcac gttccctatc ctgtcgcatt gcatgttaat atagtcaacg
     1081 tccctcagcc ggctgcggca gccatccaga gacactataa cgacgaagac cctgagaagg
     1141 aaaagcgaat aaaggagctg gagttgctcc tgatgtcaac agagaacgag ctgaagggac
     1201 agcaggcatt accaacacag aaccacactt gcagctaccc cgggtggcac agcacctcca
     1261 ttgtggacca gaccagacct catggggata gtgcacctgt ttcctgtttg ggagaacacc
     1321 atgccacccc atctctgcct gcagatcccg gctccctacc tgaagaaagt gcctcaccag
     1381 caaggtgcat gatcgtccac cagggcacca ttctggacaa tgttaagaac ctcttagaat
     1441 ttgcagaaac actccagttt atagattctg attcttcgtg gtgtgatctc agcagttttg
     1501 aattctctga agaagcggca gctttttcac ctagccagca gcccacaggc aaagccttcc
     1561 agcttcagca aagagagggc catgggacta gatctgcagg agagcctagc ctgagggtga
     1621 ccaggcgagt gctgagcgag gcatccctcg gcccagactc accccaagcg aggcacagca
     1681 aggttccgct ggtcgtccta cgaaaaaggc ggggccaggc cagcccccta gccgctggag
     1741 agcctagccc ctccctcttt gctgacgtca tcagctcaac tctcaagcgt tcccctgtca
     1801 aaagcctacc cttctctccc tcgcagttct tgaacacttc cagcaaccat gaaagctcgg
     1861 gcttagatgc acctacctta ccctccactc ctctcattgg tcacaaactg acaccatgtc
     1921 gagaccagac tgtgaaaacc cagaaggaaa attccatctt tagaactcca gctatcaaaa
     1981 ggtcaatcct cgaaagctct cctcgaactc ccacaccatt caaacatgcc cttgcagctc
     2041 aagaaattaa atacggtccc ctgaagatgc tacctcagac cccctcccat gcagtggagg
     2101 acctacaaga tgtgattaag caggaatcgg atgaatctgg aattgtggct gagtttcaag
     2161 agagtggacc accgttactg aaaaaaatca agcaggaggt ggagtcgcca actgagaaat
     2221 cgggaaactt cttctgctca aaccactggg cagagaacag cctgagcacc cagctgttct
     2281 cgcaggcgtc tcctgtggca gatgccccaa atattcttac aagctctgtt ttaatgacac
     2341 ctgtatcaga agatgaagac aatgtcctca aagcctttac cgtacctaag aacaggcccc
     2401 tggtgggtcc cttgcagcca tgcagtggtg cctgggagcc agcatcctgt gggaagacag
     2461 aggaccagat gacggcctcc ggtccggctc ggaaatacgt gaacgcgttc tcagctcgaa
     2521 ctctggtcat gtgagacatt tccagaaaag cattatggtt ttcagaacac ttaaaagttg
     2581 actttcgaca catggctcct cagcgtggag cgctccatgg ctgagagaag agcctgattt
     2641 tgttgtggta caacagttga gagcagcacc aagtgcattt ttagttgctt gagatctcac
     2701 ttgatttcac acaactaaaa aggatttttt tttttaaaaa taataataat gaataacagt
     2761 cttacctaaa ttattaggta atgaattgtg accatttgtt aatatcataa tcagattttt
     2821 taaaaaaaat aaaatgattt atttgtattt tagaggatac aacagatcag tatttttgac
     2881 tgtggtgaat ttaaaaaaaa aatttacaca aagaaatatc ccagtattcc atgtatctca
     2941 gtcactaaac atacacagag agatttttaa aaaccaggag aagcattatt ttgaatgtta
     3001 gctaaatccc aagtaatact taatgcaacc ctctaggagc tcatttgtgg ctaataatct
     3061 tggaaatatc tttattatac taaaccattt catgaggaga attttgttgt cagcttgctt
     3121 gaaaagttat tactgtatga aatagtttta ttgaaaaaat tatattttta ttcagtaatt
     3181 taattttgta aatgccaaat ggagaaatgt gttcgctgct atggttttag cctgtagtca
     3241 tgctgctagc tagtgtcagg gggcaataga gcttagatgg aaaaaagaga aagagactcg
     3301 gtgttagata acggactatg cactagtatt ccagactttt ttatttttat atatatgtac
     3361 cttttccttt tgtaattgga aaacttattt gggagaattt tgcatttgtt gtacattttt
     3421 gttttttagg attttttttt tttgttgtta ttgtcgattt ataaaagcat tgcacttctt
     3481 tttctttttt tgggagattt gtgttgttta tgtcatatgt tttgttttga gttcagcctg
     3541 aatgttcatc cgtttgggcg tttttctgac ttggaagaac attctctgta ggtttctaag
     3601 tgtacagagc cggaactgcc tcgtggttcc tgggcttcag ggaagacaaa tatggaagtc
     3661 aacagccagt ttctgccttg agagcatttg caagaatgct ggccttgaat tctgaaatga
     3721 cagtgtatct actgccttgt agcaaaataa agctatcctc ttattttaca tacttcc
//
