LOCUS       NM_024263               2280 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus matrix-remodelling associated 8 (Mxra8), mRNA.
ACCESSION   NM_024263
VERSION     NM_024263.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2280)
  AUTHORS   Holmes,A.C., Lucas,C.J., Brisse,M.E., Ware,B.C., Hickman,H.D.,
            Morrison,T.E. and Diamond,M.S.
  TITLE     Ly6C+ monocytes in the skin promote systemic alphavirus
            dissemination
  JOURNAL   Cell Rep 43 (3), 113876 (2024)
   PUBMED   38446669
REFERENCE   2  (bases 1 to 2280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2280)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2280)
  AUTHORS   Ng,W.H., Ling,Z.L., Kueh,A.J., Herold,M.J., West,N.P., King,N.J.C.,
            Mahalingam,S. and Liu,X.
  TITLE     Role of MXRA8 in Ross River Virus Disease Pathogenesis
  JOURNAL   mBio 14 (2), e0058823 (2023)
   PUBMED   37036079
  REMARK    GeneRIF: Role of MXRA8 in Ross River Virus Disease Pathogenesis.
REFERENCE   5  (bases 1 to 2280)
  AUTHORS   Han,J., Cho,H.J., Park,D. and Han,S.
  TITLE     DICAM in the Extracellular Vesicles from Astrocytes Attenuates
            Microglia Activation and Neuroinflammation
  JOURNAL   Cells 11 (19), 2977 (2022)
   PUBMED   36230938
  REMARK    GeneRIF: DICAM in the Extracellular Vesicles from Astrocytes
            Attenuates Microglia Activation and Neuroinflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2280)
  AUTHORS   Adams,A.C., Astapova,I., Fisher,F.M., Badman,M.K., Kurgansky,K.E.,
            Flier,J.S., Hollenberg,A.N. and Maratos-Flier,E.
  TITLE     Thyroid hormone regulates hepatic expression of fibroblast growth
            factor 21 in a PPARalpha-dependent manner
  JOURNAL   J Biol Chem 285 (19), 14078-14082 (2010)
   PUBMED   20236931
REFERENCE   7  (bases 1 to 2280)
  AUTHORS   Jung,Y.K., Jin,J.S., Jeong,J.H., Kim,H.N., Park,N.R. and Choi,J.Y.
  TITLE     DICAM, a novel dual immunoglobulin domain containing cell adhesion
            molecule interacts with alphavbeta3 integrin
  JOURNAL   J Cell Physiol 216 (3), 603-614 (2008)
   PUBMED   18366072
  REMARK    GeneRIF: Results indicate that DICAM, a novel dual Ig domain
            containing adhesion molecule, mediates cell adhesion via
            alphavbeta3 integrin.
REFERENCE   8  (bases 1 to 2280)
  AUTHORS   Jung,Y.K., Jeong,J.H., Ryoo,H.M., Kim,H.N., Kim,Y.J., Park,E.K.,
            Si,H.J., Kim,S.Y., Takigawa,M., Lee,B.H., Park,R.W., Kim,I.S. and
            Choi,J.Y.
  TITLE     Gene expression profile of human chondrocyte HCS-2/8 cell line by
            EST sequencing analysis
  JOURNAL   Gene 330, 85-92 (2004)
   PUBMED   15087127
REFERENCE   9  (bases 1 to 2280)
  AUTHORS   Yonezawa,T., Ohtsuka,A., Yoshitaka,T., Hirano,S., Nomoto,H.,
            Yamamoto,K. and Ninomiya,Y.
  TITLE     Limitrin, a novel immunoglobulin superfamily protein localized to
            glia limitans formed by astrocyte endfeet
  JOURNAL   Glia 44 (3), 190-204 (2003)
   PUBMED   14603461
  REMARK    GeneRIF: new member of the transmembrane-type immunoglobulin
            superfamily and designated limitrin, localizing selectively to glia
            limitans in mouse brain
REFERENCE   10 (bases 1 to 2280)
  AUTHORS   Bachmanov,A.A., Li,X., Reed,D.R., Ohmen,J.D., Li,S., Chen,Z.,
            Tordoff,M.G., de Jong,P.J., Wu,C., West,D.B., Chatterjee,A.,
            Ross,D.A. and Beauchamp,G.K.
  TITLE     Positional cloning of the mouse saccharin preference (Sac) locus
  JOURNAL   Chem Senses 26 (7), 925-933 (2001)
   PUBMED   11555487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670236.9, AK004732.1 and BQ033722.1.
            
            On Oct 31, 2007 this sequence version replaced NM_024263.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040488.1, BC026438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AL670236.9         146270-146386
            118-1145            AK004732.1         1-1028
            1146-1146           AL670236.9         149184-149184
            1147-2254           AK004732.1         1030-2137
            2255-2280           BQ033722.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..2280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.58 cM"
     gene            1..2280
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /note="matrix-remodelling associated 8"
                     /db_xref="GeneID:74761"
                     /db_xref="MGI:MGI:1922011"
     exon            1..211
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1491
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /note="matrix-remodeling-associated protein 8; dual Ig
                     domain containing cell adhesion molecule;
                     adipocyte-specific protein 3; limitrin"
                     /codon_start=1
                     /product="matrix remodeling-associated protein 8
                     precursor"
                     /protein_id="NP_077225.4"
                     /db_xref="CCDS:CCDS19044.1"
                     /db_xref="GeneID:74761"
                     /db_xref="MGI:MGI:1922011"
                     /translation="MELLSRVLLWKLLLLQSSAVLSSGPSGTAAASSSLVSESVVSLA
                     AGTQAVLRCQSPRMVWTQDRLHDRQRVVHWDLSGGPGSQRRRLVDMYSAGEQRVYEPR
                     DRDRLLLSPSAFHDGNFSLLIRAVDRGDEGVYTCNLHHHYCHLDESLAVRLEVTEDPL
                     LSRAYWDGEKEVLVVAHGAPALMTCINRAHVWTDRHLEEAQQVVHWDRQLPGVSHDRA
                     DRLLDLYASGERRAYGPPFLRDRVSVNTNAFARGDFSLRIDELERADEGIYSCHLHHH
                     YCGLHERRVFHLQVTEPAFEPPARASPGNGSGHSSAPSPDPTLTRGHSIINVIVPEDH
                     THFFQQLGYVLATLLLFILLLITVVLATRYRHSGGCKTSDKKAGKSKGKDVNMVEFAV
                     ATRDQAPYRTEDIQLDYKNNILKERAELAHSPLPAKDVDLDKEFRKEYCK"
     exon            212..232
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     exon            233..535
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     exon            536..637
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     exon            638..1108
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1267
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1307
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1384
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1465
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..2263
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /note="hexamer: AATAAA"
     polyA_site      2255
                     /gene="Mxra8"
                     /gene_synonym="1200013A08Rik; 1700095D18Rik; Asp3; Dicam"
                     /note="major polyA site"
ORIGIN      
        1 agtcaagatg ggggaggcca agcagttgag cagcgcagtg ggcggggccc agacccggcc
       61 cagggctccg tgatgtcagc gggtgctggc agggagaggg ggtcggctgt ttttctggag
      121 agttagagct gagtaagaca aagcacgtcc cccgcaggcg ccatggagct gctgtcccgc
      181 gtcctgctgt ggaaactgct gcttcttcag agctctgcag tcctgtcctc agggccttca
      241 gggaccgcag cagccagcag ctctctggtg tctgagtctg tggtgagctt ggcagccgga
      301 acccaggctg tgctacgctg ccagagcccc cgcatggtgt ggacccaaga ccggctgcat
      361 gatcgccagc gcgtggtcca ctgggacctc agcgggggcc cgggcagcca acggcgccga
      421 cttgtggata tgtattcggc gggtgaacag cgcgtgtacg agccgcgcga tcgcgaccgc
      481 ctcctgctgt cgccttctgc tttccacgac ggcaacttct cgctgctcat tcgcgctgtg
      541 gacagaggcg atgaaggggt gtacacctgc aacctgcacc atcactactg ccacctcgat
      601 gagagcctgg ctgtgcgcct cgaggttaca gaggatcccc tattaagtcg cgcatactgg
      661 gacggtgaga aggaagtgtt ggtggtggcc catggcgcgc cggcactgat gacctgcatc
      721 aaccgtgcgc acgtgtggac tgaccgccat ttagaggagg cgcagcaggt ggtccattgg
      781 gaccgacagc tacctggggt gtcacacgac cgcgccgacc gcctgcttga cctgtatgca
      841 tctggcgagc gccgcgccta tgggccaccc ttcctgcgtg atcgcgtgtc agtgaacacc
      901 aacgcttttg cacgcggtga cttctcccta cgcatcgatg agctggagcg agctgatgag
      961 ggcatctatt cctgccacct gcaccatcac tactgtggcc tccacgagcg ccgagtcttc
     1021 cacctacagg tcacagagcc tgcctttgag ccaccagctc gtgcttctcc tggcaatggg
     1081 tctggtcaca gcagtgctcc tagcccagat cccaccctga cccgaggcca cagcatcatc
     1141 aatgtcattg tcccagagga ccacacacat ttcttccagc aactgggcta tgtgttggcc
     1201 acgctgctgc tcttcatctt gctgctcatc actgtagtcc tggctacacg atatcgtcac
     1261 agcggaggat gcaagacgtc ggacaaaaaa gctgggaagt caaaggggaa ggatgtgaac
     1321 atggtggagt ttgctgtagc cacaagggat caggctccat ataggactga ggacatccag
     1381 ctagattaca aaaacaacat cctgaaggag agggctgagc tggcccatag tcctctgcct
     1441 gccaaggatg tggatctgga taaagagttc aggaaggagt actgcaaata aatggaccct
     1501 gagcttctgg ctgggccagc agctctgtat caaaggacat ctccctgacc ctcctgcggt
     1561 attcctggct cttctcagcg gctggtccga cttacctaga aacttggcag agcagctgcc
     1621 tgtactttgc ccttcctaga atcgccaccc ctcatcttgg tgagcaactg tgggttccct
     1681 agagactctg gtatagtacg attgctgccc ttcacctgtg cccactgatg gttgtacccc
     1741 caacttaaac acaacaaaga tcccttgtta atatccacca aatgcaaagt ccctcgtggc
     1801 ctcttactgc tagggtcagg aagacactta aaaattccag ttaagactcc ctagccacca
     1861 gttaaacaca ttagccattg tcctgggggg tcttcctgag ctgcattgtg cctgtgtact
     1921 gttcagagcc ctgctgttat aggttctgac tcatgggccc gccttgctgc tttgggcaac
     1981 ttgaggctag cccagggccc tttctctgct tctgattcct ttctgccgaa tgcctcccaa
     2041 gagctacacc agcagttact gggtaccgta tgactcttgg ccttgacatc cctccctagg
     2101 ctggagtctg gggttggggc cccatttgtc ctctgttttg gctgaagatg gggcgaagat
     2161 ttggctgagt ggcctatgct gtcacatcaa acagctatca tttactccta cttgggaagt
     2221 tttcatgtga caataaaaga tacatctgat ttttagtctt ggaaaaaaaa aaaaaaaaaa
//
