LOCUS       NM_026280               1725 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus matrix-remodelling associated 7 (Mxra7), transcript
            variant 1, mRNA.
ACCESSION   NM_026280 XM_126676
VERSION     NM_026280.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1725)
  AUTHORS   Shen,Y., Ning,J., Zhao,L., Liu,W., Wang,T., Yu,J. and Wang,Y.
  TITLE     Matrix remodeling associated 7 proteins promote cutaneous wound
            healing through vimentin in coordinating fibroblast functions
  JOURNAL   Inflamm Regen 43 (1), 5 (2023)
   PUBMED   36647132
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1725)
  AUTHORS   Zheng,Y.D., Sun,Z.J., Ma,K.P., Wang,Y.Q. and Lin,D.D.
  TITLE     [The Effect of Matrix Remodeling Associated 7 (MXRA7) Expression on
            the Biological Function of SHI-1 Cells]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 30 (3), 688-694 (2022)
   PUBMED   35680791
  REMARK    GeneRIF: [The Effect of Matrix Remodeling Associated 7 (MXRA7)
            Expression on the Biological Function of SHI-1 Cells].
REFERENCE   4  (bases 1 to 1725)
  AUTHORS   Zhou,Z., Shen,Y., Yin,J., Xi,F., Xu,R., Lin,D., Saijilafu, Chen,J.
            and Wang,Y.
  TITLE     Matrix remodeling associated 7 promotes differentiation of bone
            marrow mesenchymal stem cells toward osteoblasts
  JOURNAL   J Cell Physiol 234 (10), 18053-18064 (2019)
   PUBMED   30843215
  REMARK    GeneRIF: MXRA7 influences bone formation by regulating the balance
            between osteogenesis and adipogenesis in bone marrow mesenchymal
            stem cells.
            GeneRIF: MXRA7 influences bone formation via regulating the balance
            between osteogenesis and adipogenesis in bone marrow mesenchymal
            stem cells. Deficiency of MXRA7 in mice leads to shorter tibia.
REFERENCE   5  (bases 1 to 1725)
  AUTHORS   Ning,J., Shen,Y., Wang,T., Wang,M., Liu,W., Sun,Y., Zhang,F.,
            Chen,L. and Wang,Y.
  TITLE     Altered expression of matrix remodelling associated 7 (MXRA7) in
            psoriatic epidermis: Evidence for a protective role in the
            psoriasis imiquimod mouse model
  JOURNAL   Exp Dermatol 27 (9), 1038-1042 (2018)
   PUBMED   29781547
  REMARK    GeneRIF: These data demonstrated that MXRA7 gene might function as
            a negative modulator in psoriasis development when propsoriatic
            factors attack, presumably via expression alteration or
            redistribution of MXRA7 proteins in keratinocytes.
            GeneRIF: MXRA7 gene might function as a negative modulator in
            psoriasis development when propsoriatic factors attack, presumably
            via expression alteration or redistribution of MXRA7 proteins in
            keratinocytes.
REFERENCE   6  (bases 1 to 1725)
  AUTHORS   Jia,C., Zhang,F., Zhu,Y., Qi,X. and Wang,Y.
  TITLE     Public data mining plus domestic experimental study defined
            involvement of the old-yet-uncharacterized gene matrix-remodeling
            associated 7 (MXRA7) in physiopathology of the eye
  JOURNAL   Gene 632, 43-49 (2017)
   PUBMED   28847716
  REMARK    GeneRIF: MXRA7 is under-expressed during corneal infection and
            neovascularization.
REFERENCE   7  (bases 1 to 1725)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   8  (bases 1 to 1725)
  AUTHORS   Abe,K., Yamamoto,R., Franke,V., Cao,M., Suzuki,Y., Suzuki,M.G.,
            Vlahovicek,K., Svoboda,P., Schultz,R.M. and Aoki,F.
  TITLE     The first murine zygotic transcription is promiscuous and uncoupled
            from splicing and 3' processing
  JOURNAL   EMBO J 34 (11), 1523-1537 (2015)
   PUBMED   25896510
REFERENCE   9  (bases 1 to 1725)
  AUTHORS   Probert,F., Rice,P., Scudamore,C.L., Wells,S., Williams,R.,
            Hough,T.A. and Cox,I.J.
  TITLE     (1)H NMR metabolic profiling of plasma reveals additional
            phenotypes in knockout mouse models
  JOURNAL   J Proteome Res 14 (5), 2036-2045 (2015)
   PUBMED   25849460
REFERENCE   10 (bases 1 to 1725)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075801.1 and CX734756.1.
            
            On Oct 31, 2009 this sequence version replaced NM_026280.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075801.1, BC147321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1516              AK075801.1         2-1517
            1517-1725           CX734756.1         290-498
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.49 cM"
     gene            1..1725
                     /gene="Mxra7"
                     /gene_synonym="1810057P16Rik; E130302J09Rik"
                     /note="matrix-remodelling associated 7"
                     /db_xref="GeneID:67622"
                     /db_xref="MGI:MGI:1914872"
     exon            1..318
                     /gene="Mxra7"
                     /gene_synonym="1810057P16Rik; E130302J09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..585
                     /gene="Mxra7"
                     /gene_synonym="1810057P16Rik; E130302J09Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     matrix-remodeling-associated protein 7; transmembrane
                     anchor protein 1"
                     /codon_start=1
                     /product="matrix-remodeling-associated protein 7 isoform
                     1"
                     /protein_id="NP_080556.1"
                     /db_xref="CCDS:CCDS25677.1"
                     /db_xref="GeneID:67622"
                     /db_xref="MGI:MGI:1914872"
                     /translation="MESPVELLAALPALVTALALLLAWLLLRRGAARVPAPESTASDE
                     APGAPAPPEPPESCAPEPAPEGPSQSERVAEPEESEAEEPAAEGRQDEDSDSEMGPPT
                     EEPEEEDGAAFSFKYSPGQLRGSQYKKMMTKEELEEEHRVQKEQLAAIFKLMKDNKDT
                     FGEMSDGDMQEQLRLYDM"
     exon            319..376
                     /gene="Mxra7"
                     /gene_synonym="1810057P16Rik; E130302J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            377..470
                     /gene="Mxra7"
                     /gene_synonym="1810057P16Rik; E130302J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            471..1725
                     /gene="Mxra7"
                     /gene_synonym="1810057P16Rik; E130302J09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      690..695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mxra7"
                     /gene_synonym="1810057P16Rik; E130302J09Rik"
                     /note="hexamer: TATAAA"
     polyA_site      709
                     /gene="Mxra7"
                     /gene_synonym="1810057P16Rik; E130302J09Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggttccctc ggggtccggg ctggcggcca ctcggcggcc acggcgcgat ggagtcgccg
       61 gtcgagctgc tggccgcgct acccgcgctg gtcacggcgc tggcgctgct gctcgcctgg
      121 ctgctgctgc ggcgtggggc ggcccgggtc ccggccccgg agagcaccgc ctcggacgag
      181 gcccccgggg ctcctgcgcc gcctgaacct ccagagtctt gcgccccgga gcctgcaccg
      241 gagggaccga gccagtccga gcgcgtggcg gagccggagg agtccgaggc ggaggagcca
      301 gcggccgagg ggaggcagga tgaagactca gacagtgaga tggggccacc cactgaagaa
      361 cctgaggaag aagacggagc agccttctcc tttaaataca gccctgggca gctgagggga
      421 agccagtaca agaagatgat gaccaaagaa gaactggagg aggaacacag agttcagaaa
      481 gaacagctgg ctgccatctt caagctcatg aaggacaaca aggacacctt tggcgagatg
      541 tcagacgggg acatgcagga gcaactccga ctctatgaca tgtaggcctg tcacccggca
      601 agatgtgacc caggacatca tgacaactct gagggactcg gcccaggcag ttagttgtga
      661 ctcccagacc tttgtttgaa agactgtctt ataaaaacag agagacctat gttatgtaag
      721 gatctgcaat ttatatatca catcagagga acctacatca tttcttcagg gaggaaaccc
      781 cagatcgccc tggcttcagc ttgctggtgt gggttcagct gggccgtgtt ctacagactc
      841 agagtgggtg ggccagggga gatgatgaga ctcggtgttt ggcacctaag tatttagtgt
      901 agacaaaata cggggcgcta tggggggagg atataggtgt gatctagtaa caccacactc
      961 ttcattctgc cctagggtta tttctggaag catctggggt ggtagttgaa gcaagcagta
     1021 gaggagcaat attttagtaa atgtctgatt gaaaggtcca gccatcaccc tggggcagaa
     1081 ccgtggggtc actgctgaag cttgtcctca gtacagtcac gccttgagtg tgtttgtcac
     1141 acagaagatt atgccagata catagcagga gccctgggta gagcatgtgt gtgctaagat
     1201 caaggcccct gagttccacc cccagcacca gacaccttct tccccacacc ctaccgcagc
     1261 tcaaaaaaga caacataatc agtccctttg gtgagaccaa tggcctttag agaatgagaa
     1321 actaccagaa agcatcccgg tgtcctctag aataagtgcc aagggagatc actcagcaac
     1381 gatgggggtg ggggtcacag cagctccttt atacccacat cttgttctac ttcttatcac
     1441 cccactggcc agaaagttca taggctgagc agacttgagt caaggttatc ctaaggaaag
     1501 aagaaggaag gttttttgtt tttctttttc cagacagggt ttctctgtgt agccccggct
     1561 gtcctggagc tcgctctgta gaccaggctg gtctggaact cagagatcca cctgcctctg
     1621 cctccgagtg ctgggattaa agccttgcgc caccactgcc tggccagtgg gaaagctctt
     1681 aaggtccgtt tttatttgct aaaataaagc taaattgata tagag
//
